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Background:The effect of midodrine on lactate clearance has not been assessed in critically ill patients yet. Objective:The goal of this study was to assess the effect of adjunctive midodrine therapy on lactate clearance in patients with septic shock. Materials & methods:Patients with septic shock were assigned to receive either adjunctive midodrine 10 mg three-times a day for 5 days (midodrine group = 15 patients) or not (control group = 13 patients). Results:The lactate clearance was significantly faster in the midodrine group than the control group (p = 0.049) with a large effect size (ηp2= 0.141). Conclusion:When midodrine was added to intravenous vasopressors, it significantly accelerated lactate clearance in patients with septic shock.Trial registration number: IRCT20100228003449N25 (Clinicaltrials.gov).

Heart failure (HF) has become a global health problem that has affected the quality of life of millions of people. One approach to improving patients’ quality of life (QoL) with chronic diseases such as HF is palliative care. In Iran, the bulk of palliative care research is directed to patients with cancer, with the primary focus on the physical aspect rather than the psychosocial and spiritual aspects of palliative care. To address this gap, this study aims to determine the feasibility and acceptability of this early tele-palliative care intervention to improve quality of life in heart failure patients in Iran.