6 results on '"Khan, Zenab"'
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2. Adsorption potential of zirconium-ferrite nanoparticles for phenol, 2-chlorophenol and 2-nitrophenol: thermodynamic and kinetic studies
- Author
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Ali, Shah Raj, Arya, Mahesh Chandra, Kalam, Abul, Al-Sehemi, Abdullah G., Khan, Zenab, Ansari, Sadaf, and Kumar, Rajesh
- Abstract
Adsorption of phenol, 2-chlorophenol and 2-nitrophenol on zirconium-ferrite nanoparticles, has been studied. Zirconium-ferrite nanoparticles were synthesized using a reported method and characterized using different analytical techniques, such as, X-ray diffraction pattern, BET surface area analysis, scanning electron microscopy-energy dispersive X-ray spectroscopy, transmission electron microscopy, thermal gravimetric analysis, zeta potential analysis, Fourier transform infrared spectroscopy and Raman spectral studies. It was found to be associated with improved nanofeatures in terms of high surface area (392 m2/g) and less pore volume (0.1723 cm3/g). The synthesized material showed high adsorption affinity towards all three phenols. The adsorption data were found to follow Langmuir adsorption isotherm with the square of the regression coefficient (R2) 0.994, 0.995 and 0.995 for phenol, 2-chlorophenol and 2-nitrophenol, respectively, at 288 K. The adsorption capacity of zirconium-ferrite nanoparticles was found to be 334.44, 354.61 and 375.93 mg/g for phenol, 2-chlorophenol and 2-nitrophenol, respectively, under the optimized conditions, namely, pH, contact time, concentration of adsorbate, amount of adsorbent and temperature. The thermodynamic parameter, namely, change in Gibbs free energy (ΔG°), enthalpy (ΔH°) and entropy (ΔS°) have been determined by conducting the adsorption experiments at 288, 303, 318 and 333 K. The values of ΔG°, ΔH° and ΔS° were found to be negative which showed that the adsorption was unfavorable by ΔS° but highly favorable by ΔH° and the spontaneity of the adsorption was governed by the overall negative value of ΔG°. The kinetic study showed that the adsorption of all the three phenols on zirconiumferrite nanoparticles showed pseudo-second-order kinetic models.
- Published
- 2020
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3. Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation
- Author
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Vaibhav, Kumar, Braun, Molly, Khan, Mohammad Badruzzaman, Fatima, Sumbul, Saad, Nancy, Shankar, Adarsh, Khan, Zenab T., Harris, Ruth B.S., Yang, Qiuhua, Huo, Yuqing, Arbab, Ali S., Giri, Shailendra, Alleyne, Cargill H., Vender, John R., Hess, David C., Baban, Babak, Hoda, Md Nasrul, and Dhandapani, Krishnan M.
- Abstract
Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent determinant of ICH patient outcomes, making clot resolution a primary goal of clinical management. Herein, remote-limb ischemic post-conditioning (RIC), the repetitive inflation–deflation of a blood pressure cuff on a limb, accelerated hematoma resolution and improved neurological outcomes after ICH in mice. Parabiosis studies revealed RIC accelerated clot resolution via a humoral-mediated mechanism. Whereas RIC increased anti-inflammatory macrophage activation, myeloid cell depletion eliminated the beneficial effects of RIC after ICH. Myeloid-specific inactivation of the metabolic regulator, AMPKα1, attenuated RIC-induced anti-inflammatory macrophage polarization and delayed hematoma resolution, providing a molecular link between RIC and immune activation. Finally, chimera studies implicated myeloid CD36 expression in RIC-mediated neurological recovery after ICH. Thus, RIC, a clinically well-tolerated therapy, noninvasively modulates innate immune responses to improve ICH outcomes. Moreover, immunometabolic changes may provide pharmacodynamic blood biomarkers to clinically monitor the therapeutic efficacy of RIC.
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- 2018
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4. Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
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Diray-Arce, Joann, Fourati, Slim, Doni Jayavelu, Naresh, Patel, Ravi, Maguire, Cole, Chang, Ana C., Dandekar, Ravi, Qi, Jingjing, Lee, Brian H., van Zalm, Patrick, Schroeder, Andrew, Chen, Ernie, Konstorum, Anna, Brito, Anderson, Gygi, Jeremy P., Kho, Alvin, Chen, Jing, Pawar, Shrikant, Gonzalez-Reiche, Ana Silvia, Hoch, Annmarie, Milliren, Carly E., Overton, James A., Westendorf, Kerstin, Abraham, James, Adkisson, Michael, Albert, Marisa, Altamirano Torres, Luz, Alvarenga, Bonny, Anderson, Matthew L., Anderson, Evan J., Arnett, Azlann, Asashima, Hiromitsu, Atkinson, Mark A., Baden, Lindsey R., Barton, Brenda, Beach, Katherine, Beagle, Elizabeth, Becker, Patrice M., Bell, Matthew R., Bernui, Mariana, Bime, Chris, Boddapati Kumar, Arun, Booth, Leland J., Borresen, Brittney, Brakenridge, Scott C., Bristow, Laurel, Bryant, Robert, Calfee, Carolyn S., Carreño Manuel, Juan, Carrillo, Sidney, Chak, Suzanna, Chang, Iris, Connors, Jennifer, Conway, Michelle, Corry, David B., Cowan, David, Croen, Brett, Dela Cruz, Charles S., Cusimano, Gina, Eaker, Lily, Edwards, Carolyn, Ehrlich, Lauren I.R., Elashoff, David, Erickson, Heidi, Erle, David J., Farhadian, Shelli, Farrugia, Keith, Fatou, Benoit, Fernandes, Andrea, Fernandez-Sesma, Ana, Fragiadakis, Gabriela K., Furukawa, Sara, Geltman, Janelle N., Ghale, Rajani, González Carolina Bermúdez, Maria, Goonewardene, Michael I., Guerrero Sanchez, Estella, Guirgis, Faheem W., Hafler, David A., Hamilton, Sydney, Harris, Paul, Hayati Nemati, Arash, Hendrickson, Carolyn M., Higuita Agudelo, Nelson I., Hodder, Thomas, Holland, Steven M., Hough, Catherine L., Huerta, Christopher, Hurley, Kerin C., Hutton, Scott R., Iwasaki, Akiko, Jauregui, Alejandra, Jha, Meenakshi, Johnson, Brandi, Joyner, David, Kangelaris, Kirsten N., Kelly, Geoffrey, Khalil, Zain, Khan, Zenab, Kheradmand, Farrah, Kim, James N., Kimura, Hiroki, Ko, Albert I., Kohr, Bernard, Kraft, Monica, Krummel, Matthew, Kutzler, Michele F., Lasky-Su, Jessica, Lee, Serena, Lee, Deanna, Leipold, Michael, Lentucci, Claudia, Leroux, Carolyn, Lin, Edward, Liu, Shanshan, Love, Christina, Lu, Zhengchun, Maliskova, Lenka, Manning Roth, Brittany, Manohar, Monali, Martens, Mark, McComsey, Grace A., McEnaney, Kerry, McLin, Renee, Melamed, Esther, Melnyk, Nataliya, Mendez, Kevin, Messer, William B., Metcalf, Jordan P., Michelotti, Gregory, Mick, Eran, Mohanty, Subhasis, Mosier, Jarrod, Mulder, Lubbertus C.F., Murphy, Maimouna, Nadeau, Kari R.C., Nelson, Ebony, Nelson, Allison, Nguyen, Viet, Oberhaus, Jordan, Panganiban, Bernadine, Pellegrini, Kathryn L., Pickering, Harry C., Powell, Debra L., Presnell, Scott, Pulendran, Bali, Rahman, Adeeb H., Rashid Sadeed, Ahmad, Raskin, Ariel, Reed, Elaine F., Ribeiro Pereira, Susan, Rivera, Adreanne M., Rogers, Jacob E., Rogers, Angela, Rogowski, Brandon, Rooks, Rebecca, Rosenberg-Hasson, Yael, Rothman, Jessica, Rousseau, Justin F., Salehi-Rad, Ramin, Saluvan, Mehmet, Samaha, Hady, Schaenman, Joanna, Schunk, Ron, Semenza, Nicholas C., Sen, Subha, Sevransky, Jonathan, Seyfert-Margolis, Vicki, Shaheen, Tanzia, Shaw, Albert C., Sieg, Scott, Siegel, Sarah A.R., Sigal, Natalia, Siles, Nadia, Simmons, Brent, Simon, Viviana, Singh, Gagandeep, Sinko, Lauren, Smith, Cecilia M., Smolen, Kinga K., Song, Li-Zhen, Srivastava, Komal, Sullivan, Peter, Syphurs, Caitlin, Tcheou, Johnstone, Tegos, George P., Tharp, Greg K., Tong Ally, Alexandra, Tsitsiklis, Alexandra, Ungaro, Ricardo F., Vaysman, Tatyana, Viode, Arthur, Vita, Randi, Wang, Xiaomei, Ward, Alyssa, Ward, Dawn C., Willmore, Andrew, Woloszczuk, Kyra, Wong, Kari, Woodruff, Prescott G., Xu, Leqi, van Haren, Simon, van de Guchte, Adriana, Zhao, Yujiao, Cairns, Charles B., Rouphael, Nadine, Bosinger, Steven E., Kim-Schulze, Seunghee, Krammer, Florian, Rosen, Lindsey, Grubaugh, Nathan D., van Bakel, Harm, Wilson, Michael, Rajan, Jayant, Steen, Hanno, Eckalbar, Walter, Cotsapas, Chris, Langelier, Charles R., Levy, Ofer, Altman, Matthew C., Maecker, Holden, Montgomery, Ruth R., Haddad, Elias K., Sekaly, Rafick P., Esserman, Denise, Ozonoff, Al, Becker, Patrice M., Augustine, Alison D., Guan, Leying, Peters, Bjoern, and Kleinstein, Steven H.
- Abstract
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 longitudinal blood and nasal samples from 540 participants of the IMPACC cohort, using 14 distinct assays. These unbiased analyses identify cellular and molecular signatures present within 72 h of hospital admission that distinguish moderate from severe and fatal COVID-19 disease. Importantly, cellular and molecular states also distinguish participants with more severe disease that recover or stabilize within 28 days from those that progress to fatal outcomes (TG4 vs. TG5). Furthermore, our longitudinal design reveals that these biologic states display distinct temporal patterns associated with clinical outcomes. Characterizing host immune responses in relation to heterogeneity in disease course may inform clinical prognosis and opportunities for intervention.
- Published
- 2023
- Full Text
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5. A Complete Genome Screening Program of Clinical Methicillin-Resistant Staphylococcus aureusIsolates Identifies the Origin and Progression of a Neonatal Intensive Care Unit Outbreak
- Author
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Sullivan, Mitchell J., Altman, Deena R., Chacko, Kieran I., Ciferri, Brianne, Webster, Elizabeth, Pak, Theodore R., Deikus, Gintaras, Lewis-Sandari, Martha, Khan, Zenab, Beckford, Colleen, Rendo, Angela, Samaroo, Flora, Sebra, Robert, Karam-Howlin, Ramona, Dingle, Tanis, Hamula, Camille, Bashir, Ali, Schadt, Eric, Patel, Gopi, Wallach, Frances, Kasarskis, Andrew, Gibbs, Kathleen, and van Bakel, Harm
- Abstract
Whole-genome sequencing (WGS) of Staphylococcus aureusis increasingly used as part of infection prevention practices. In this study, we established a long-read technology-based WGS screening program of all first-episode methicillin-resistant Staphylococcus aureus(MRSA) blood infections at a major urban hospital.
- Published
- 2019
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6. Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment
- Author
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Furusawa, Yuri, Yamada, Shinya, da Silva Lopes, Tiago Jose, Dutta, Jayeeta, Khan, Zenab, Kriti, Divya, van Bakel, Harm, and Kawaoka, Yoshihiro
- Abstract
The reverse genetics method of influenza virus generation has enabled us to generate recombinant viruses bearing modified viral proteins. Recombinant influenza viruses expressing foreign genes have become useful tools in basic research, and such viruses can be utilized as efficient virus vectors or multivalent vaccines. However, the insertion of a foreign gene into the influenza virus genome often impairs virus replication, and the inserted genes are unstable. Elucidation of the mechanisms of foreign gene stabilization will help us to establish useful recombinant influenza viruses.
- Published
- 2019
- Full Text
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