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Background:There is an increasing global demand for traditional medicines because of their efficacy, ease of availability, and few or no side effects. The Unani medicines have long been used in India and abroad for various disorders and diseases. Arqiyat (Arq; distillate) is one of the most widely used Unani formulation prepared by simple distillation from single or combination drugs. Objective:In the present investigation, an attempt has been made to generate data for quality control and stability testing of Arq formulations of the Unani Pharmacopeia of India that includes only three Arq formulations. Method:Arq-e-Nana (AeN), Arq-e-Gazar (AeG), and Arq-e-Brinjasif (AeB) were prepared through hydrodistillation. Quality control and stability analysis were performed by using HPTLC and GC-MS. Results:Dichloromethane extract of AeB showed maximum of 10 bands at different retardation factor values; however, there are 7 bands in AeN as well as in AeG. GC-MS analysis showed presence of 10 metabolites in AeG, 8 in AeN, and 9 in AeB. Stability studies showed that the shelf life of Arq formulations would be enhanced at refrigeration (5 ± 2°C) conditions. Conclusions:The present study highlights quality control and stability analysis of Arq formulations of Unani Pharmacopeia of India using HPTLC and GC-MS.

Background: Application of heat either generalised or localised is among various means employed in Unani medicine for promoting health, preventing as well as treating diseases. The concept of hotness (Ḥarārat) and application of physical heat have been in vogue during different periods of human civilization and it exists even today with certain modifications.Heating Modalities: Unani medicine offers various methods for the application of mild to moderate heat that includes Turkish bath (Ḥammām), massage (Dalk), cupping (Ḥijāma), sitz bath (Ābzan), inducing diaphoresis (Ta‘rīq), douche (Naṭūl), vapour bath (Inkibāb) and footbath (Pāshoya).Application of Heat: Heating modalities are commonly used by Unani physicians for relieving pain and stiffness, relaxing muscles, increasing blood circulation, liquefying the sticky and adherent humours lodged in the peripheral tissues and reducing inflammation. Application of severe heat also finds a place among various modes of treatment mentioned in Unani medicine. Cauterisation (Kayy) is the mode that is employed for the stoppage of bleeding, removing putrefactive matter and destroying lesions.Conclusion: Unani medicine offers classical methods and instruments for heat therapy used for centuries for the promotion of health, prevention and management of diseases. Heat therapy has been found considerably effective in managing certain health problems and diseases.

SARS-CoV-2 has been responsible for over 500 million cumulative cases all over the world since December 2019 and has marked the third introduction of a highly pathogenic virus after SARS-CoV and MERS-CoV. This virus is in a winning situation because scientists are still racing to explore effective therapeutics, vaccines, and event treatment regimens. In view of progress in current disease management, until now none of the preventive/treatment measures can be considered entirely effective to treat SARS-CoV-2 infection. Therefore, it is required to look up substitute ways for the management of this disease. In this context, herbal medicines could be a good choice. This article emphasizes the antiviral potential of some herbal constituents which further can be a drug of choice in SARS-CoV-2 treatment. This article may be a ready reference for discovering natural lead compounds and targets in SARS-CoV-2 associated works.

The core objective of this paper is to investigate the problem of robust nonlinear observer-based controller design for one-sided Lipschitz (OLS) switched systems. This work considers nonlinear switched systems with norm-bounded uncertainties, time-varying delays, and external disturbances. By selecting appropriate Lyapunov-Krasovskii functions and applying the OSL condition together with the quadratic inner boundedness property, we drive certain necessary and sufficient conditions for the observer-based control of the underlying system that assure the exponential convergence of the system states, the observer states, and the error states to zero, in respect of linear matrix inequalities via average dwell-time approach. The devised scheme offers necessary robustness against L 2 -norm bounded perturbations. In the end, the proposed scheme has been validated a suitable practical example. [ABSTRACT FROM AUTHOR]