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Your search keyword '"Jouvet, Philippe"' showing total 70 results
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70 results on '"Jouvet, Philippe"'

1. The authors reply:

Author

Emeriaud, Guillaume, López-Fernández, Yolanda M., Khemani, Robinder G., Emeriaud, Guillaume, López-Fernández, Yolanda M., Khemani, Robinder G., Prabhu Iyer, Narayan, Bembea, Melania, Kwasi Korang, Steven, Steffen, Katherine M., Yehya, Nadir, Smith, Lincoln, Thomas, Neal J., Zimmerman, Jerry J., Erickson, Simon J., Shein, Steven L., Grunwell, Jocelyn R., Dahmer, Mary K., Sapru, Anil, Quasney, Michael W., Flori, Heidi R, Fernandez, Analia, Modesto i Alapont, Vicent, Rimensberger, Peter, Cheifetz, Ira, Rowan, Courtney, Randolph, Adrienne G., Kneyber, Martin, Valentine, Stacey, Kudchadkar, Sapna, Ward, Shan, Nadkarni, Vinay, Curley, Martha A.Q., Bhalla, Anoopindar, Baudin, Florent, Takeuchi, Muneyuki, Cruces, Pablo, Carroll, Christopher L, Napolitano, Natalie, Pons-Odena, Marti, Essouri, Sandrine, Rambaud, Jérome, Barbaro, Ryan, Macrae, Duncan, Dalton, Heidi, Killien, Elizabeth, Maddux, Aline, Man Tse, Sze, Watson, Scott, Nelson Sanchez-Pinto, L., Sauthier, Michaël, Rajapreyar, Prakadeshwari, Jouvet, Philippe, Newth, Christopher, Morrow, Brenda, Agulnik, Asya, Brunow de Carvalho, Werther, Chisti, Mohamod, Hau Lee, Jan, Lobner, Katie, Kysh, Lynn, Pincivy, Alix, and Dodin, Philippe

Published
2024
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2. Humidification performance of 48 passive airway humidifiers

Author

Lellouche, Francois, Taille, Solenne, Lefrancois, Frederic, Deye, Nicolas, Maggiore, Salvatore Maurizio, Jouvet, Philippe, Ricard, Jean-Damien, Fumagalli, Bruno, and Brochard, Laurent

Subjects
Humidifiers -- Comparative analysis, Humidifiers -- Usage, Ventilators -- Comparative analysis, Ventilators -- Usage, Health
Published
2009

3. Gaps in Prehospital Care for Patients Exposed to a Chemical Attack – A Systematic Review

Author

Bourassa, Stephane, Paquette-Raynard, Emmanuelle, Noebert, Daniel, Dauphin, Marc, Akinola, Pelumi Samuel, Marseilles, Jason, Jouvet, Philippe, and Leclerc, Jacinthe

Abstract

AbstractIntroduction:The survivability of mass casualties exposed to a chemical attack is dependent on clinical knowledge, evidence-based practice, as well as protection and decontamination capabilities. The aim of this systematic review was to identify the knowledge gaps that relate to an efficient extraction and care of mass casualties caused by exposure to chemicals.Methods:This systematic review was conducted from November 2018 through September 2020 in compliance with Cochrane guidelines. Five databases were used (MEDLINE, Web of Science Core Collection, Embase, Cochrane, and CINAHL) to retrieve studies describing interventions performed to treat victims of chemical attacks (protection, decontamination, and treatment). The outcomes were patient’s health condition leading to his/her stabilization (primary) and death (secondary) due to interventions applied (medical, protection, and decontamination).Results:Of the 2,301 papers found through the search strategy, only four publications met the eligibility criteria. According to these studies, the confirmed chemical poisoning cases in acute settings resulting from the attacks in Matsumoto (1994), Tokyo (1995), and Damascus (2014) accounted for 1,333 casualties including 11 deaths. No study reported comprehensive prehospital clinical data in acute settings. No mention was made of the integration of specialized capabilities in medical interventions such as personal protective equipment (PPE) and decontamination to prevent a secondary exposure. Unfortunately, it was not possible to perform the planned meta-analysis.Conclusions:This study demonstrated gaps in clinical knowledge application regarding the medical extraction of casualties exposed during a chemical attack. Further research is required to optimize clinical practice integrating mixed capabilities (protection and decontamination) for the patient and medical staff.

Published
2022
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4. Bronchiolitis Management and Unnecessary Antibiotic Use Across 3 Canadian PICUs

Author

Almadani, Ahmed, Noël, Kim C., Aljassim, Nada, Maratta, Christina, Tam, Ingrid, Papenburg, Jesse, Quach, Caroline, Thampi, Nisha, McNally, James D., Lefebvre, Marie-Astrid, Zavalkoff, Samara, O’Donnell, Shauna, Jouvet, Philippe, and Fontela, Patricia S.

Abstract

To describe the patient characteristics, clinical management, and infectious etiology in critically ill children with bronchiolitis. The secondary objective was to determine the association between antibiotic use and hospital length of stay among patients without concomitant bacterial infections.Retrospective cohort study including patients ≤2 years old with bronchiolitis admitted to 3 Canadian pediatric intensive care units between 2016 and 2018.We included 372 patients with a median age of 2.1 months (interquartile range 1.2–6.6) and Pediatric Risk of Mortality III score 3.0 (interquartile range 0–3.0). Initial ventilatory management included high flow nasal cannula (28.2%) and noninvasive positive pressure ventilation (53.7%), of which 41.9% and 87.5%, respectively, did not require escalation of ventilatory support. Chest radiographs (81.7%) and respiratory virus testing (95.4%) were performed in most patients; 14.0% received systemic steroids. Respiratory syncytial virus was detected in 61.3% patients, and 7.5% had a culture-positive concomitant bacterial infection. Of 258 (69.4%) patients with a viral infection, only 45.3% received antibiotics. In this group, antibiotic use beyond 72 hours was not associated with hospital length of stay (ratio 1.14, 95% confidence interval 0.97–1.34).High flow nasal canulae and noninvasive ventilation are commonly used in severe bronchiolitis. Despite contrary evidence, steroids and antibiotics were also frequently used. Evidence-based guidelines specific to children with severe bronchiolitis are needed to improve the care delivered to this patient population.

Published
2022
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5. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Author

Khemani, Robinder G, Smith, Lincoln, Lopez-Fernandez, Yolanda M, Kwok, Jeni, Morzov, Rica, Klein, Margaret J, Yehya, Nadir, Willson, Douglas, Kneyber, Martin C J, Lillie, Jon, Fernandez, Analia, Newth, Christopher J L, Jouvet, Philippe, Thomas, Neal J, Abaleke, Eugenia, Ackerman, Kate G, Acuña, Carlos, Adu-Darko, Michelle, Affolter, Jeremy T, Agbeko, Rachel, Al Amoudi, Ahmed, Alahmadti, Ahmad, Aldairi, Nedaa, Alibrahim, Omar, Allen, Kiona, Allen, Christine, Al-Subu, Awni, Althabe, María, Alvear, Jimena, Anil, Ayse Berna, Anthony, Heather, Aramburo, Angela, Arjona Villanueva, David, Ashtari, Neda, Ávila Vera, Antonio, Baines, Paul, Bales, Melissa, Barr, Samantha, Barry, Dana, Baudin, Florent, Beca, John, Belfield, Holly, Beltramo, Fernando, Benken, Laura, Bhalla, Anoopindar, Blom, Andrea, Botta, Priscila, Bourgoin, Pierre, Brezmes, Marta, Briassoulis, George, Bridier, Armelle, Brierley, Joe, Brio Sanagustin, Sonia, Broden, Elizabeth, Butt, Warwick, Bysani, Kris, Camilo, Cristina, Camporesi, Anna, Campos-Miño, Santiago, Can, Fulya Kamit, Capocasa, Patricia, Caro I, Daniel, Carroll, Christopher, Castellani, Pablo, Castillo, Andres E., Chen, Yang, Chima, Ranjit S., Chiusolo, Fabrizio, Cinquegrani, Karina, Coates, Bria, Coronado-Munoz, Alvaro, Cortéz, Ambar, Cruces Romero, Pablo, Cullimore, Melissa, Cvijanovich, Natalie, Dahmer, Mary K., Deep, Akash, Delzoppo, Carmel, Di Nardo, Matteo, Díaz, Franco, Dijkstra, Sandra, Dockery, W. Keith, Dominguez, Troy E., Dumitrascu, Mariana, Dursun, Oguz, Dwarakanathan, Buvana, Elghuwael, Ismail, Emeriaud, Guillaume, Erickson, Simon, Español, Segundo Fernando, Estil, Jim Brian, Feather, Calandra, Feinstein, Yael, Fernández, Analía, Ferreyra, Marcela, Flori, Heidi, Fortini, Yanina Vanesa, Fortune, Peter-Marc, French, Mary Ellen, Gaboli, Mirella, Gale, Helen, García Casas, Paula, García González, Maria, Gautam, Richa, Gedeit, Rainer, Genuini, Mathieu, Gertz, Shira, Giampieri, Martin, Gil Escobar, Carlos, Giuliano Jr, John S., Godoy Mundaca, Loreto, Goni Orayen, Concepción, Gonzalez Gomez, Jose Manuel, Govantes, Beatriz, Guichoux, Julie, Guzman Rivera, Gustavo Alfredo, Haileselassie, Bereketeab, Han, Yong Y, Harrell, Amy, Hartmann, Silvia, Hazwani, Tarek, Hefley, Glenda, Henderson, Grace, Hsing, Deyin D., Hughes-Schalk, Amber, Hume, Janet, Ilia, Stavroula, Inwald, David, Iolster, Thomas, Izquierdo, Ledys María, Jafari-Namin, Shirin, Jaimon, Nancy, Jarillo Quijada, Alberto E, Jarvis, J. Dean, Jayachandran, Chaandini, Jennings, Claire, Jeyapalan, Asumthia S., Jimenez Rivera, Nestor Javier, Jones, Dawn, Jouvet, Philippe, Kasch, Mary, Keary, Jane't, Kelley, Connor, Kessel, Aaron, Khemani, Robinder, Kida, Yoshiko, King, Caroline, Kneyber, Martin, Kniola, Allison, Krallman, Kelli, Kubis, Sherri, Kustka, Lucinda, Kwok, Jeni, Kyo, Michihito, Landry, Luis Martín, Latifi, Samir, Lawton-Woodhall, Angela, Lillie, Jon, Lin, John C., Llorente de la Fuente, Ana M., Lopez Alarcón, Yurika Paola, López Fernández, Yolanda, Lopez-Herce, Jesús, Lum, Lucy Chai See, Macrae, Duncan, Maddux, Aline B., Madurga Revilla, Paula, Mahapatra, Sidharth, Maria, Matthieu, Martínez, Lidia, Martinez de Azagra, Amelia, Martínez León, Alejandro Fabio, Mazzillo Vega, Liliana, McCorkell, Jenni, McIntyre, Karen, Medina, Tania, Medina, Alberto, Mellish, Christie, Mendizabal, Mikel, Merritt, Courtney, Mildner, Reinout, Milesi, Christophe, Modesto I Alapont, Vicent, Monjes, Cecilia, Monjure, Tracey, Montes, María José, Morales Martinez, Antonio, Morgan, Ryan, Morzov, Rica, Mourani, Peter M., Murkowski, Kathy, Murphy, Marie, Napolitano, Natalie, Nerheim, Dan, Nett, Sholeen T., Newth, Christopher, Nofziger, Ryan, Nunez, Maria Jose, Ohshimo, Shinichiro, Onate Vergara, Eider, Ongun, Ebru A, Orqueda, Daniel, Oruganti, Siva, Pagowska-Klimek, Izabela, Palanca Arias, Daniel, Pappachan, Jon, Pardo Carrero, Rosalba, Parker, Margaret M., Parrilla, Julio, Patankar, Nikhil, Pávez Madrid, Paula, Payen, Valerie, Paziencia, Fernando, Pedraza, Claudia, Perez Lozano, Germán, Pilar Orive, Javier, Piñeres Olave, Byron Enrique, Pintimalla, Alyssa, Pinto, Neethi, Plunkett, Adrian, Pon, Steve, Pons Odena, Marti, Poterala, Rossana, Qiao, Haiping, Quiñonez Lopez, Deyanira, Ralston, Kimberly, Ramirez Cortez, Grimaldo, Ratiu, Anna, Rea, Miriam, Reyes Dominguez, Susana, Rodgers, Chiara, Rodriguez Campoy, Patricia, Ronan, Laurie, Rosemary, Deheza, Rowan, Courtney, Sadasivam, Kalaimaran, Sanchez Diaz, Juan Ignacio, Sanders, Ron, Santanelli, James, Sapru, Anil, Schneider, James, Sforza, Jesica, Shea, Sara, Shein, Steven L., Sherring, Claire, Sheward, Victoria, Shime, Nobuaki, Shukla, Avani, Siaba Serrate, Alejandro, Sierra, Yamila, Sikora, Lindsay, Silvestre, Catarina, Singleton, Marcy, Sloniewsky, Daniel, Smith, Rebecca, Smith, Lincoln, Song, Hanqiu, Sousa Moniz, Marta, Spaeder, Michael, Spear, Debbie, Spinella, Philip, Starck, Julie, Stoneman, Erin, Su, Felice, Subramanian, Gayathri, Sullivan, Erin, Sundararajan, Santosh, Sweberg, Todd, Sykes, Kim, Tabata, Yuichi, Tai, Chian Wern, Tala, Joana, Tang, Swee Fong, Tantalean, José, Taylor, Ryan, Thomas, Neal, Tibby, Shane, Tieves, Kelly S, Torero, Luis, Torres, Silvio Fabia, Totapally, Balagangadhar, Travert, Brendan, Truemper, Edward, Turón, Gonzalo, Typpo, Katri, Valle, Juan Ramón, Vargas G, Sonia I, Vasquez Hoyos, Pablo, Vasquez Miranda, Daniel, Vavrina, Martin, Vidal, Nilda Águeda, Virk, Manpreet, Walsh, Laura, Wegner Araya, Adriana, Weitz, James, Wellisch, Lawren, Wellman, Paul, Willson, Douglas, Woods, Katherine, Yehya, Nadir, Yerovi, Rocio, Yunger, Toni, Zuluaga Orrego, Cesar, and Zurek, Jiri

Abstract

Paediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS.

Published
2019
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6. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy

Author

Raina, Rupesh, Bedoyan, Jirair K., Lichter-Konecki, Uta, Jouvet, Philippe, Picca, Stefano, Mew, Nicholas Ah, Machado, Marcel C., Chakraborty, Ronith, Vemuganti, Meghana, Grewal, Manpreet K., Bunchman, Timothy, Sethi, Sidharth Kumar, Krishnappa, Vinod, McCulloch, Mignon, Alhasan, Khalid, Bagga, Arvind, Basu, Rajit K., Schaefer, Franz, Filler, Guido, and Warady, Bradley A.

Abstract

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.

Published
2020
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8. Framework for Research Gaps in Pediatric Ventilator Liberation

Author

Abu-Sultaneh, Samer, Iyer, Narayan Prabhu, Fernández, Analía, Tume, Lyvonne N., Kneyber, Martin C.J., López-Fernández, Yolanda M., Emeriaud, Guillaume, Ramnarayan, Padmanabhan, Khemani, Robinder G., Abu-Sultaneh, Samer, Baranwal, Arun Kumar, Blackwood, Bronagh, Craven, Hannah J., Curley, Martha A.Q., Emeriaud, Guillaume, Essouri, Sandrine, Fernández, Analía, Fioretto, Jose Roberto, Gaies, Michael, González-Dambrauskas, Sebastián, Hartmann, Silvia M.M., Hotz, Justin Christian, Iyer, Narayan Prabhu, Jouvet, Philippe, Kneyber, Martin C.J., Korang, Steven Kwasi, López-Fernández, Yolanda M., Mastropietro, Christopher W., Napolitano, Natalie, Newth, Christopher J.L., Rafferty, Gerrard F., Ramnarayan, Padmanabhan, Rose, Louise, Rotta, Alexandre T., Tume, Lyvonne N., Werho, David K., Whipple, Elizabeth C., Ming Wong, Judith Ju, and Khemani, Robinder G.

Abstract

The 2023 International Pediatric Ventilator Liberation Clinical Practice Guidelines provided evidence-based recommendations to guide pediatric critical care providers on how to perform daily aspects of ventilator liberation. However, because of the lack of high-quality pediatric studies, most recommendations were conditional based on very low to low certainty of evidence.

Published
2024
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9. A multi-country analysis of COVID-19 hospitalizations by vaccination status

Author

Gonçalves, Bronner P., Jassat, Waasila, Baruch, Joaquín, Hashmi, Madiha, Rojek, Amanda, Dasgupta, Abhishek, Martin-Loeches, Ignacio, Reyes, Luis Felipe, Piubelli, Chiara, Citarella, Barbara Wanjiru, Kartsonaki, Christiana, Lefèvre, Benjamin, López Revilla, José W., Lunn, Miles, Harrison, Ewen M., Kraemer, Moritz U.G., Shrapnel, Sally, Horby, Peter, Bisoffi, Zeno, Olliaro, Piero L., Merson, Laura, Abdukahil, Sheryl Ann, Jabal, Kamal Abu, Salah, Nashat Abu, Airlangga, Eka, Hssain, Ali Ait, Akwani, Chika, Al Qasim, Eman, Alberti, Angela, Aldabbourosama, Osama, Alessi, Marta, Alex, Beatrice, Al-Fares, Abdulrahman, Aliudin, Jeffrey, Alkahlout, Mohammed, Almasri, Lana, Al-Saba’a, Yousef, Alves, Rita, Cabrita, Joana Alves, Amaral, Maria, Ampaw, Phoebe, Anchan, Aditya John, Angheben, Andrea, Arabi, Yaseen, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arora, Rakesh, Ashley, Elizabeth A., Atique, Anika, Atlowly, Moad, Bach, Benjamin, Baillie, John Kenneth, Baird, J. Kevin, Balan, Valeria, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnikel, Michaela, Beer, Netta, Begum, Husna, Bellemare, David, Beltrame, Anna, Bertoli, Giulia, Bianco, Claudia, Humaid, Felwa Bin, Bitton, Jonathan, Blier, Catherine, Bogaert, Debby, Borges, Diogo, Bouhmani, Dounia, Bounphiengsy, Thipsavanh, Bountthasavong, Latsaniphone, Klerk, Bianca Boxma-de, Monteiro, Filipa Brás, Brazzi, Luca, Buchtele, Nina, Buonsenso, Danilo, Burrell, Aidan, Bustos, Ingrid G., Cabrita, Joana, Caceres, Eder, Garcês, Rui Caetano, Campisi, Josie, Canepa, Cecilia, Caoili, Janice, Cardellino, Chiara Simona, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Sofia, Carney, Gayle, Carrier, François Martin, Carson, Gail, Cascão, Mariana, Casimiro, José, Castañeda, Silvia, Castanheira, Nidyanara, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandros, Cevik, Muge, Chaleunphon, Bounthavy, Chan, Adrienne, Chand, Meera, Chen, Anjellica, Cheng, Matthew Pellan, Chommanam, Danoy, Chow, Yock Ping, Christy, Nathaniel, Claure-Del Granado, Rolando, Clohisey, Sara, Codan, Cassidy, Connor, Marie, Cooke, Graham S., Copland, Mary, Corley, Amanda, Cortegiani, Andrea, Crowl, Gloria, Cruz, Claudina, Csete, Marc, Custodio, Paula, da Silva Filipe, Ana, Dagens, Andrew, Daley, Peter, Dalloul, Zaina, Dalton, Heidi, Dalton, Jo, Damas, Juliana, Daneman, Nick, Dankwa, Emmanuelle A., Dantas, Jorge, D'Aragon, Frédérick, De Rose, Cristina, de Silva, Thushan, Dechert, William, Denis, Emmanuelle, Dishon, Yael, Dhangar, k, Docherty, Annemarie B., Donnelly, Christl A., Donohue, Chloe, Douangdala, Phouvieng, Douglas, James Joshua, Downer, Triona, Downing, Mark, Drake, Thomas, Dryden, Murray, Dubot-Pérès, Audrey, Dudman, Susanne, Dunning, Jake, Duplaix, Mathilde, Durham, Lucian, Dyrhol-Riise, Anne Margarita, Edelstein, Michael, Escher, Martina, Esperatti, Mariano, Santo, Catarina Espírito, Estevão, João, Faheem, Amna, Fairfield, Cameron J., Faria, Pedro, Farshait, Nataly, Fernandes, Jorge, Fernandes, Marília Andreia, Ferrão, Joana, Ferraz, Mário, Ferreira, Bernardo, Figueiredo-Mello, Claudia, Fletcher, Tom, Flynn, Brigid, Fontela, Patricia, Forsyth, Simon, Foti, Giuseppe, Fowler, Robert A., Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F., Ribeiro, Ana Freitas, Friedrich, Caren, Fuentes, Nora, G, Argin, Skeie, Linda Gail, Gamble, Carrol, Garcês, Rui, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Gavin, Aisling, Germano, Nuno, Ghadimi, Moji, Ghisulal, Praveen Kumar, Giani, Marco, Gibson, Jess, Girvan, Michelle, Goco, Geraldine, Gómez-Junyent, Joan, Grable, Margarite, Green, Christopher A., Greenhalf, William, Griffiths, Fiona, Gruner, Heidi, Gu, Yusing, Guerguerian, Anne-Marie, Guerreiro, Daniela, Haber, Daniel, Habraken, Hannah, Hafez, Wael, Hall, Matthew, Halpin, Sophie, Hamdan, Shaher, Hamers, Raph L., Hamza, Summer, Hardwick, Hayley, Harrison, Janet, Hartman, Alan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Hesstvedt, Liv, Higgins, Dawn, Higgins, Rupert, Hinton, Samuel, Ho, Antonia, Holter, Jan Cato, Horcajada, Juan Pablo, Ming-Yang Hsu, Jimmy, Hurd, Abby, Ijaz, Samreen, Illana, Carlos Cañada, Inácio, Hugo, Ippolito, Mariachiara, Isidoro, Tiago, Jaber, Hamza, Jackson, Clare, Jaworsky, Denise, Jenum, Synne, Jouvet, Philippe, Kalicinska, Alina, Kandel, Chris, Katz, Kevin, Kaur, Aasmine, Keating, Seán, Kelly, Andrea, Kelly, Sadie, Kennon, Kalynn, Keomany, Sommay, Khalid, Imrana, Kho, Michelle E., Khoo, Saye, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Klenerman, Paul, Bekken, Gry Kloumann, Knight, Stephen R., Korten, Volkan, Kosgei, Caroline, Kumar, Deepali, Kutsogiannis, Demetrios, Lamontagne, François, Lanza, Marina, Law, Andrew, Law, Andy, Lawrence, Teresa, Lee, James, Lee, Jennifer, Lee, Todd C., Leeming, Gary, Letizia, Andrew, Bassi, Gianluigi Li, Liang, Janet, Lim, Wei Shen, Lind, Andreas, Lissauer, Samantha, Lopes, Diogo, Lyons, Ruth, Machado, Sara, Majeed, Nimisha Abdul, Manetta, Frank, Sant`Ana Malaque, Ceila Maria, Marquis, Catherine, Marsh, Laura, Marshall, John, Martín-Quiros, Alejandro, Martins, Ana, Rego, Caroline Martins, Martucci, Gennaro, Maslove, David, Matthew, Christina, Mayxay, Mayfong, McArthur, Colin, McCarthy, Anne, McConnochie, Rachael, McDonald, Sarah E., McGeer, Allison, McKay, Chris, McLean, Kenneth A., Menon, Kusum, Mentzer, Alexander J., Mesquita, António, Meyer, Dan, Meynert, Alison M., Mihelis, Efstathia, Monteiro, Agostinho, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Moro, Lucia, Morton, Ben, Mudara, Caroline, Muhaisen, Mo’nes, Müller, Fredrik, Müller, Karl Erik, Munshi, Laveena, Murthy, Srinivas, Mustafa, Dana, Nagpal, Dave, Narasimhan, Mangala, Nasa, Prashant, Nelder, Matthew, Neumann, Emily, Ng, Pauline Yeung, Nichol, Alistair D., Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nusantara, Dwi Utomo, Occhipinti, Giovanna, O'Hearn, Katie, Oliveira, Larissa, Ong, David S.Y., Oosthuyzen, Wilna, Openshaw, Peter, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Parke, Rachael, Patricio, Patricia, Patterson, Lisa, Paul, Mical, Paulos, Jorge, Paxton, William A., Pejkovska, Mare, Pereira, Rui, Petrovic, Michele, Pettersen, Frank Olav, Pharand, Scott, Phonemixay, Ooyanong, Phoutthavong, Soulichanya, de Piero, Maria, Pimentel, Carlos, Pires, Catarina, Pitaloka, Ayodhia, Pius, Riinu, Poli, Sergio, Pollakis, Georgios, Post, Andra-Maris, Póvoas, Diana, Powis, Jeff, Praphasiri, Viladeth, Pritchard, Mark G., Semedi, Bambang Pujo, Purcell, Gregory, Quesada, Luisa, Quist-Paulsen, Else, Rafael, Aldo, Rahardjani, Mutia, Ramalho, José, Rangappa, Rajavardhan, Rätsep, Indrek, Reeve, Brenda, Reikvam, Dag Henrik, Ren, Hongru, Rewa, Oleksa, Ricchiuto, Antonia, Rishu, Asgar, Rivera Nuñez, Maria Angelica, Roberts, Stephanie, Robertson, David L., Roche-Campo, Ferran, Rodari, Paola, Roessler, Bernhard, Rossanese, Andrea, Rossetti, Matteo, Russell, Clark D., Holten, Aleksander Rygh, Saba, Isabela, Sadat, Musharaf, Sahraei, Valla, Salazar, Leonardo, Sales, Gabriele, Sanchez, Emely, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmiento, Iam Claire E., Saviciute, Egle, Schaffer, Justin, Schwameis, Michael, Schwartz, Gary, Scott, Janet T., Scott-Brown, James, Semple, Malcolm G., Sequeira, Tânia, Shadowitz, Ellen, Shankar, Anuraj, Shaw, Catherine A., Shaw, Victoria, Mohan Shetty, Dr. Rajesh, Sibounheuang, Bountoy, Sigfrid, Louise, Sillaots, Piret, Sin, Wai Ching, Sinatti, Dario, Singh, Mahendra, Skogen, Vegard, Smith, Sue, Solomon, Joshua, Solomon, Tom, Song, Rima, Spinuzza, Elisabetta, Sriskandan, Shiranee, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stiksrud, Birgitte, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, David, Subekti, Decy, Suen, Jacky Y., Sultana, Asfia, Summers, Charlotte, Suwarti, Atie, Sztajnbok, Jaques, Tabrizi, Shirin, Taleb, Sara, Tedder, Richard S., Teixeira, João, Tessier-Grenier, Hubert, Thompson, Shaun, Thomson, Emma C., Thorpe, Mathew, Thwaites, Ryan S., Tonby, Kristian, Torre, Marta, Torres Santos-Olmo, Rosario Maria, Turgeon, Alexis F., Turtle, Lance C.W., Tveita, Anders, Twardowski, Pawel, Ullrich, Roman, Uyeki, Timothy M., Valentini, Piero, Val-Flores, Luís, Varrone, Michael, Vidal, José Ernesto, Vieira, César, Villanueva, Joy Ann, Villar, Judit, Villoldo, Andrea, Vitiello, Chiara, Vongsouvath, Manivanh, Wainstein, Marina, Webb, Steve, Wei, Jia, Wesselius, Sanne, Wham, Murray, White, Nicole, Willems, Sue, Williams, Bailey, Williams, Virginie, Wils, Evert-Jan, Wittman, Jessica, Yerkovich, Stephanie, Yiaye, Touxiong, Zahran, Maram, and Zambon, Maria

Abstract

Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.

Published
2023
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17. Mechanical Ventilation and Decision Support in Pediatric Intensive Care

Author

Newth, Christopher John L., Khemani, Robinder G., Jouvet, Philippe A., and Sward, Katherine A.

Abstract

Respiratory support is required in most children in the pediatric intensive care unit. Decision-support tools (paper or electronic) have been shown to improve the quality of medical care, reduce errors, and improve outcomes. Computers can assist clinicians by standardizing descriptors and procedures, consistently performing calculations, incorporating complex rules with patient data, and capturing relevant data. This article discusses computer decision-support tools to assist clinicians in making flexible but consistent, evidence-based decisions for equivalent patient states.

Published
2017
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19. Time required to initiate outbreak and pandemic observational research

Author

Rishu, Asgar H., Marinoff, Nicole, Julien, Lisa, Dumitrascu, Mariana, Marten, Nicole, Eggertson, Shauna, Willems, Su, Ruddell, Stacy, Lane, Dan, Light, Bruce, Stelfox, Henry T., Jouvet, Philippe, Hall, Richard, Reynolds, Steven, Daneman, Nick, and Fowler, Robert A.

Abstract

Observational research focused upon emerging infectious diseases such as Ebola virus, Middle East respiratory syndrome, and Zika virus has been challenging to quickly initiate. We aimed to determine the duration of start-up procedures and barriers encountered for an observational study focused upon such infectious outbreaks.

Published
2017
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21. Operational Definitions Related to Pediatric Ventilator Liberation

Author

Abu-Sultaneh, Samer, Iyer, Narayan Prabhu, Fernández, Analía, Gaies, Michael, González-Dambrauskas, Sebastián, Hotz, Justin Christian, Kneyber, Martin C.J., López-Fernández, Yolanda M., Rotta, Alexandre T., Werho, David K., Baranwal, Arun Kumar, Blackwood, Bronagh, Craven, Hannah J., Curley, Martha A.Q., Essouri, Sandrine, Fioretto, Jose Roberto, Hartmann, Silvia M.M., Jouvet, Philippe, Korang, Steven Kwasi, Rafferty, Gerrard F., Ramnarayan, Padmanabhan, Rose, Louise, Tume, Lyvonne N., Whipple, Elizabeth C., Wong, Judith Ju Ming, Emeriaud, Guillaume, Mastropietro, Christopher W., Napolitano, Natalie, Newth, Christopher J.L., and Khemani, Robinder G.

Abstract

Common, operational definitions are crucial to assess interventions and outcomes related to pediatric mechanical ventilation. These definitions can reduce unnecessary variability among research and quality improvement efforts, to ensure findings are generalizable, and can be pooled to establish best practices.

Published
2023
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27. Respiratory Dysfunction Associated With RBC Transfusion in Critically Ill Children

Author

Kleiber, Niina, Lefebvre, Émilie, Gauvin, France, Tucci, Marisa, Robitaille, Nancy, Trottier, Helen, Jouvet, Philippe, Ducruet, Thierry, Poitras, Nicole, Lacroix, Jacques, and Emeriaud, Guillaume

Abstract

Respiratory complications associated with RBC transfusions may be underestimated in PICUs because current definitions exclude patients with preexisting respiratory dysfunction. This study aims to determine the prevalence and characterize the risk factors and outcomes of new or progressive respiratory dysfunction observed after RBC transfusion in critically ill children.

Published
2015
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28. Understanding the Global Epidemiology of Pediatric Critical Illness

Author

Weiss, Scott L., Fitzgerald, Julie C., Faustino, Edward Vincent, Festa, Marino S., Fink, Ericka L., Jouvet, Philippe, Bush, Jenny L., Kissoon, Niranjan, Marshall, John, Nadkarni, Vinay M., and Thomas, Neal J.

Abstract

The point prevalence methodology is a valuable epidemiological study design that can optimize patient enrollment, prospectively gather individual-level data, and measure practice variability across a large number of geographic regions and healthcare settings. The objective of this article is to review the design, implementation, and analysis of recent point prevalence studies investigating the global epidemiology of pediatric critical illness.

Published
2014
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29. Acute Rehabilitation Practices in Critically Ill Children

Author

Choong, Karen, Foster, Gary, Fraser, Douglas D., Hutchison, James S., Joffe, Ari R., Jouvet, Philippe A., Menon, Kusum, Pullenayegum, Eleanor, and Ward, Roxanne E.

Abstract

To evaluate acute rehabilitation practices in pediatric critical care units across Canada.

Published
2014
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30. Mechanical Ventilation Strategies in Children With Acute Lung Injury

Author

Santschi, Miriam, Randolph, Adrienne G., Rimensberger, Peter C., and Jouvet, Philippe

Abstract

The aim of this survey was to determine North American and European pediatric intensivists’ knowledge and stated practice in the management of children with acute respiratory distress syndrome with regard to mechanical ventilation settings; blood gas and SO2targets; and use of adjunctive treatments at sites where actual practice had just been assessed.

Published
2013
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31. The Occurrence and Impact of Bacterial Organisms Complicating Critical Care Illness Associated With 2009 Influenza A(H1N1) Infection

Author

Muscedere, John, Ofner, Marianna, Kumar, Anand, Long, Jennifer, Lamontagne, Francois, Cook, Deborah, McGeer, Allison, Chant, Clarence, Marshall, John, Jouvet, Philippe, and Fowler, Robert

Abstract

Although secondary infections are recognized as a cause of morbidity and mortality in seasonal influenza, their frequency, characteristics, and associated clinical outcomes in 2009 influenza A(H1N1) (A[H1N1])-related critical illness are unknown.

Published
2013
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33. Neurally adjusted ventilatory assist improves patient–ventilator interaction in infants as compared with conventional ventilation

Author

Bordessoule, Alice, Emeriaud, Guillaume, Morneau, Sylvain, Jouvet, Philippe, and Beck, Jennifer

Abstract

Background:Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation controlled by the electrical activity of the diaphragm (Edi). The aim was to evaluate patient–ventilator interaction in infants during NAVA as compared with conventional ventilation.Methods:Infants were successively ventilated with NAVA, pressure control ventilation (PCV), and pressure support ventilation (PSV). Edi and ventilator pressure (Pvent) waveforms were compared and their variability was assessed by coefficients of variation.Results:Ten patients (mean age 4.3 ± 2.4?mo and weight 5.9 ± 2.2?kg) were studied. In PCV and PSV, 4 ± 4.6% and 6.5 ± 7.7% of the neural efforts failed to trigger the ventilator. This did not occur during NAVA. Trigger delays were shorter with NAVA as compared with PCV and PSV (93 ± 20?ms vs. 193 ± 87?ms and 135 ± 29?ms). During PCV and PSV, the ventilator cycled off before the end of neural inspiration in 12 ± 13% and 21 ± 19% of the breaths (0 ± 0% during NAVA). During PCV and PSV, 24 ± 11% and 25 ± 9% of the neural breath cycle was asynchronous with the ventilator as compared with 11 ± 3% with NAVA. A large variability was observed for Edi in all modes, which was transmitted into Pvent during NAVA (coefficient of variation: 24 ± 8%) and not in PCV (coefficient of variation 2 ± 1%) or PSV (2 ± 2%).Conclusion:NAVA improves patient–ventilator interaction and delivers adequate ventilation with variable pressure in infants.

Published
2012
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35. Potential pediatric intensive care unit demand/capacity mismatch due to novel pH1N1 in Canada

Author

Stiff, David, Kumar, Anand, Kissoon, Niranjan, Fowler, Robert, Jouvet, Philippe, Skippen, Peter, Smetanin, Paul, Kesselman, Murray, and Veroukis, Stasa

Abstract

To investigate the possibility of pediatric intensive care unit shortfalls, using pandemic models for a range of attack rates and durations. The emergence of the swine origin pH1N1 virus has led to concerns about shortfalls in our ability to provide pediatric ventilation and critical care support.

Published
2011
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36. Acute lung injury in children Therapeutic practice and feasibility of international clinical trials

Author

Santschi, Miriam, Jouvet, Philippe, Leclerc, Francis, Gauvin, France, Newth, Christopher J. L., Carroll, Christopher L., Flori, Heidi, Tasker, Robert C., Rimensberger, Peter C., and Randolph, Adrienne G.

Abstract

To describe mechanical ventilation strategies in acute lung injury and to estimate the number of eligible patients for clinical trials on mechanical ventilation management. In contrast to adult medicine, there are few clinical trials to guide mechanical ventilation management in children with acute lung injury.

Published
2010
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37. Critical illness in children with influenza A/pH1N1 2009 infection in Canada

Author

Jouvet, Philippe, Hutchison, Jamie, Pinto, Ruxandra, Menon, Kusum, Rodin, Rachel, Choong, Karen, Kesselman, Murray, Veroukis, Stasa, André Dugas, Marc, Santschi, Miriam, Guerguerian, Anne-Marie, Withington, Davinia, Alsaati, Basem, Joffe, Ari R., Drews, Tanya, Skippen, Peter, Rolland, Elizabeth, Kumar, Anand, and Fowler, Robert

Abstract

To describe characteristics, treatment, and outcomes of critically ill children with influenza A/pandemic influenza A virus (pH1N1) infection in Canada.

Published
2010
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40. Kinetic Modeling of Plasma Leucine Levels during Continuous Venovenous Extracorporeal Removal Therapy in Neonates with Maple Syrup Urine Disease

Author

Jouvet, Philippe, Hubert, Philippe, Saudubray, Jean Marie, Rabier, Daniel, and Man, Nguyen K

Abstract

A kinetic modeling of leucine plasma concentration changes is proposed to describe the plasma leucine reduction rate during continuous extracorporeal removal therapy (CECRT) in neonates with maple syrup urine disease. Data were obtained from seven neonates using a bicompartmental model for the best fitted curve of plasma leucine decrease during CECRT. During the first 3 h, leucine plasma levels decreased according to an exponential curve: [Leu]t= [Leu]i× 0.95 × 10-0.09twhere [Leu]tis the leucine plasma level (µmol/L) at time t (h) during CECRT and [Leu]Iis the initial plasma level. From h 4 to the end of CECRT, a second exponential curve was observed: [Leu]t= [Leu]i× 0.74 × 10-0.05t. Plasma leucine levels obtained from three other neonates were similar to those predicted by the model. The apparent distribution volumes for leucine that correspond to the two exponential equations obtained were calculated from the leucine mass removal collected in the spent dialysate and ultrafiltrate. The distribution volume was 34 ± 3% of body weight during the first 3 h of CECRT and 72 ± 7% from h 4 to the end of CECRT. These figures are similar to known values for the extracellular water compartment and for total body water in the newborn. The findings suggest that leucine handling during CECRT is similar to that of nonprotein-bound small-molecular-weight solutes such as urea.

Published
2005
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41. Whole‐body cooling after perinatal asphyxia: a pilot study in term neonates

Author

Debillon, Thierry, Daoud, Patrick, Durand, Philippe, Cantagrel, Sylvain, Jouvet, Philippe, Saizou, Carole, and Zupan, Véronique

Abstract

In order to test the practicability and safety of whole‐body cooling in term neonates with moderate‐to‐severe hypoxic‐ischaemic encephalopathy (HIE) and to report outcomes, a prospective pilot study was carried out in 25 term infants (median postmenstrual age 38 weeks, range 36 to 41 weeks; 20 males, five females). Whole‐body cooling, to a target core temperature of 33 to 34C, started within 6 hours of birth and was maintained for 72 hours. Of the 25 newborn infants (19 Sarnat II and six Sarnat III, 18 outborn), 18 survived, including 13 (72%) with normal cerebral signal by MRI. Temperature instability occurred during cooling in 15 infants, but neither severe haemodynamic instability nor renal failure was seen. Thrombocytopenia developed in 12 infants, including seven with biological disseminated intravascular coagulation. One patient had hypoxaemia with right‐to‐left shunting through the ductus arteriosus, and seven had limited meningeal or subdural bleeding. Whole‐body cooling is feasible in term neonates, with no life‐threatening adverse events. Improvements are needed to obtain stable hypothermia for 72 hours.

Published
2003
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42. Primary Human Fibroblasts from a Maple Syrup Urine Disease Patient Undergo Apoptosis following Exposure to Physiological Concentrations of Branched Chain Amino Acids

Author

JOUVET, PHILIPPE, KOZMA, MARY, and MEHMET, HUSEYIN

Abstract

Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a deficiency in branched chain ?-ketoacid dehydrogenase. We have recently found that msud neurodegeneration may result, at least in part, from apoptosis triggered by branched chain amino acids and their ?-ketoacid derivatives. In the present study, we investigated the sensitivity of MSUD fibroblasts to defined mixtures of MSUD metabolites. Defined combinations of MSUD metabolites, at levels comparable to those in MSUD patients, triggered cell death in skin fibroblasts from a MSUD patient, while control fibroblasts were resistant. the mechanism of cell death wasconfirmed as apoptosis by in situend labeling.

Published
2000
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43. Branched Chain Amino Acids Induce Apoptosis in Neural Cells without Mitochondrial Membrane Depolarization or CytochromecRelease: Implications for Neurological Impairment Associated with Maple Syrup Urine Disease

Author

Jouvet, Philippe, Rustin, Pierre, Taylor, Deanna L., Pocock, Jennifer M., Felderhoff-Mueser, Ursula, Mazarakis, Nicholas D., Sarraf, Catherine, Joashi, Umesh, Kozma, Mary, Greenwood, Kirsty, Edwards, A. David, and Mehmet, Huseyin

Abstract

Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a deficiency in branched chain α-keto acid dehydrogenase that can result in neurodegenerative sequelae in human infants. In the present study, increased concentrations of MSUD metabolites, in particular α-keto isocaproic acid, specifically induced apoptosis in glial and neuronal cells in culture. Apoptosis was associated with a reduction in cell respiration but without impairment of respiratory chain function, without early changes in mitochondrial membrane potential and without cytochrome crelease into the cytosol. Significantly, α-keto isocaproic acid also triggered neuronal apoptosis in vivo after intracerebral injection into the developing rat brain. These findings suggest that MSUD neurodegeneration may result, at least in part, from an accumulation of branched chain amino acids and their α-keto acid derivatives that trigger apoptosis through a cytochrome c-independent pathway.

Published
2000
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45. Up-to-date evolution of small bowel transplantation in children with intestinal failure

Author

Jan, Dominique, Michel, Jean-Luc, Goulet, Olivier, Sarnacki, Sabine, Lacaille, Florence, Damotte, Diane, Cezard, Jean-Pierre, Aigrain, Yves, Brousse, Nicole, Peuchmaur, Michel, Rengeval, Annick, Colomb, Virginie, Jouvet, Philippe, Ricour, Claude, and Révillon, Yann

Abstract

Purpose:The aim of the authors was to report an up-to-date review of their experience with 26 intestinal transplantations in children since 1987.

Published
1999
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46. Pharmacokinetics and tolerance of flunitrazepam in neonates and in infants*

Author

Pariente-Khayat, Ann, Tréluyer, Jean-Marc, Rey, Elisabeth, Mokhtari, Mostafa, Werner, Evelyne, Jouvet, Philippe, d'Athis, Philippe, Wood, Chantal, Hubert, Philippe, Hotellier, Françoise, Olive, Georges, and Pons, Gérard

Abstract

Objective: To study the pharmacokinetics of flunitrazepam (used for sedation in neonates and infants), to determine the influence of both gestational and postnatal age on the pharmacokinetic parameters, and to analyze the relationship between the hemodynamic parameters and flunitrazepam plasma concentration.Methods: Flunitrazepam was infused for 20 minutes as a single dose (0.2 mg · kg-1) and as multiple doses (0.1 mg · kg-1). Six to eight 1-mL blood samples were collected per patient. Flunitrazepam plasma concentration was measured by gas chromatography–mass spectrometry.Results: Thirty-one patients (25 neonates and six infants) were included in the study. Only three of them received multiple doses. After the single dose (n = 28), half-life was 22.6 ± 7.3 hours, clearance was 0.15 ± 0.14 L · kg · h-1, and volume of distribution was 4.6 ± 4.1 L · kg-1(mean ± SD). Plasma clearance and volume of distribution significantly increased with posnatal age (P < .05), but no pharmacokinetic parameter varied significantly with gestational age. Diastolic blood pressure significantly decreased with increasing flunitrazepam plasma concentrations (P < .05).Conclusion: Postnatal age but not gestational age influenced flunitrazepam pharmacokinetic parameters in neonates and infants. Diastolic blood pressure was inversely correlated to flunitrazepam plasma concentration.

Published
1999
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50. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial

Author

Hirshberg, Eliotte L., Alexander, Jamin L., Asaro, Lisa A., Coughlin-Wells, Kerry, Steil, Garry M., Spear, Debbie, Stone, Cheryl, Nadkarni, Vinay M., Agus, Michael S.D., Agus, Michael, Wypij, David, Asaro, Lisa, Nadkarni, Vinay, Srinivasan, Vijay, Biagas, Katherine, Mourani, Peter M., Chima, Ranjit, Thomas, Neal J., Li, Simon, Pinto, Alan, Newth, Christopher, Hassinger, Amanda, Bysani, Kris, Rehder, Kyle J., Faustino, Edward Vincent, Kandil, Sarah, Hirshberg, Eliotte, Wintergerst, Kupper, Schwarz, Adam, Bagdure, Dayanand, Marsillio, Lauren, Cvijanovich, Natalie, Pham, Nga, Quasney, Michael, Flori, Heidi, Federman, Myke, Nett, Sholeen, Pinto, Neethi, Viteri, Shirley, Schneider, James, Medar, Shivanand, Sapru, Anil, McQuillen, Patrick, Babbitt, Christopher, Lin, John C., Jouvet, Philippe, Yanay, Ofer, Allen, Christine, Luckett, Peter, Fackler, James, and Rozen, Thomas

Abstract

The use of electronic clinical decision support (CDS) systems for pediatric critical care trials is rare. We sought to describe in detail the use of a CDS tool (Children’s Hospital Euglycemia for Kids Spreadsheet [CHECKS]), for the management of hyperglycemia during the 32 multicenter Heart And Lung Failure-Pediatric Insulin Titration trial.

Published
2021
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