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•There was rarely such massive data to validate the efficiency of algorithms. The Sample 1 and 2 were from the SDSS DR18 combined with the ALLWISE. They were very large and new.•The LightGBM, XGBoost, Catboost, RF, DF, DT, KNN, GBDT and SVR algorithms were used to regress the redshifts of galaxies. These were very popular machine learning methods.•In the LightGBM, we got MAE ∼ 0.018, MSE ∼ 0.001, root mean squared error (RMSE) ∼ 0.033, MAPE ∼ 0.146, R2 ∼ 0.909, bias∼ 0.000233, σ∼ 0.033389, σMAD∼ 0.0181, outliers fraction ∼ 0.0028, the ratio of |∆z| > 2σ∼ 0.0245, biasnorm∼ -0.000404, RMSEnorm∼ 0.025, σNMAD∼ 0.015774 and run time ∼ 31.021s for our Sample 1. Our results were a little better than other's results.•We got MAE ∼ 0.044, MSE ∼ 0.007, RMSE ∼ 0.083, MAPE ∼ 0.149, R2 ∼ 0.895, bias ∼ 0.000489, σbias∼ 0.083065, σMAD∼ 0.0352, outliers fraction ∼ 0.0186, the ratio of |∆z| > 2σ∼ 0.0396, biasnorm∼ -0.00222, RMSEnorm∼ 0.053, σNMAD∼ 0.026093 and run time ∼ 61.847s for our Sample 2. The redshifts of galaxies in the main part with higher redshifts in the Sample 2 were also regressed well up to z <1.

Poly (ADP-ribosylation), known as PARylation, is a post-translational modification catalyzed by poly (ADP-ribose) polymerases (PARP) and primarily removed by the enzyme poly (ADP-ribose) glycohydrolase (PARG). While the aberrant removal of post-translation modifications including phosphorylation and methylation has known tumorigenic effects, deregulation of PARylation has not been widely studied. Increased hydrolysis of PARylation chains facilitates cancer growth through enhancing estrogen receptor (ER)-driven proliferation, but oncogenic transformation has not been linked to increased PARG expression. In this study, we find that elevated PARG levels are associated with a poor prognosis in breast cancers, especially in HER2-positive and triple-negative subtypes. Using both in vitro and in vivo models, we demonstrate that heightened expression of catalytically active PARG facilitates cell transformation and invasion of normal mammary epithelial cells. Catalytically inactive PARG mutants did not recapitulate these phenotypes. Consistent with clinical data showing elevated PARG predicts poor outcomes in HER2+ patients, we observed that PARG acts in synergy with HER2 to promote neoplastic growth of immortalized mammary cells. In contrast, PARG depletion significantly impairs the growth and metastasis of triple-negative breast tumors. Mechanistically, we find that PARG interacts with SMAD2/3 and significantly decreases their PARylation in non-transformed cells, leading to enhanced expression of SMAD target genes. Further linking SMAD-mediated transcription to the oncogenicity of PARG, we show that PARG-mediated anchorage-independent growth and invasion are dependent, at least in part, on SMAD expression. Overall, our study underscores the oncogenic impact of aberrant protein PARylation and highlights the therapeutic potential of PARG inhibition in breast cancer.

Optical observations from a ground-based astrometric instrument provide a unique set of data sensitive to variations of local plumb line, which represent the change of local gravitational field on the ground. The local gravitational change could be caused by density variation or movement of underground mass in addition to tidal action. Earthquake was found to be related with gravitational change. A seismic zone could have abnormal underground material density, causing the variation of plume line on the ground. In this frame, the astrometric telescope can measure the variation of local plumb line by observing the local astronomical longitudes and latitudes from stars in the Hipparcos catalog.

Early cancer cell migration and invasion of neighboring tissues are mediated by multiple events, including activation of focal adhesion signaling. Key regulators include the focal adhesion kinase (FAK) and FAK-related proline-rich tyrosine kinase 2 (Pyk2), whose distinct functions in cancer progression remain unclear. Here, we compared Pyk2 and FAK expression in breast cancer and their effects on ErbB-2-induced tumorigenesis and the potential therapeutic utility of targeting Pyk2 compared with FAK in preclinical models of breast cancer. Pyk2 is overexpressed in tissues from early and advanced breast cancers and overexpressed with both FAK and epidermal growth factor receptor-2 (ErbB-2) in a subset of breast cancer cases. Down-regulation of Pyk2 in ErbB-2-positive, FAK-proficient, and FAK-deficient cells reduced cell proliferation, which correlated with reduced mitogen-activated protein kinase (MAPK) activity. In contrast, Pyk2 silencing had little impact on cell migration and invasion. In vivo, Pyk2 down-regulation reduced primary tumor growth induced by a metastatic variant of ErbB-2-positive MDA 231 breast cancer cells but had little effect on lung metastases in contrast to FAK down-regulation. Dual reduction of Pyk2 and FAK expression resulted in strong inhibition of both primary tumor growth and lung metastases. Together, these data support the cooperative function of Pyk2 and FAK in breast cancer progression and suggest that dual inhibition of FAK and Pyk2 is an efficient therapeutic approach for targeting invasive breast cancer.

The Fe Kα lines in gamma-ray bursts (GRBs) produced with the Cerenkov line mechanism are studied. We theoretically predict the Fe Kα line luminosities in both the early (before 1 hour) and late (~1 day) afterglows. Assuming about 200 GRBs could be detected by Swift per year, we sampled the redshift of these GRBs using the Monte Carlo method according to the GRB formation rate derived from the statistical correlation between the spectral peak energy and the peak luminosity of GRBs. Then we obtain the Fe Kα line flux distributions of the simulated GRB sample in the early and late phases. The simulated results show that the iron line flux is relatively low, so the line detection would be still a rare event at present. In addition, our results suggest that the iron lines from GRBs could be detected in the high redshift: z~3 for the early phase and z~6 for the late phase. Therefore, it is possible that the identification of Fe Kα lines in GRBs provides a tool to directly measure redshift and to study the high-redshift GRBs in the Swift era.

In order to study the three-phase brushless motor control system of electric vehicle, Freescale9S12XS128 chip is used as the control core, and the power MOSFET is used as the inverter device. The software is compiled by Codewarrior software. The speed control link adopts open-loop control, and the control chip collects the external sensor signal voltage Change control PWM signal output control three-phase brushless DC motor speed. The whole system consists of Hall position detection module, current detection module, power drive module and voltage detection module. The basic functions of three-phase brushless DC motor drive control are realized.