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Rotary blood pumps in Extracorporeal Life Support (ECLS) applications are optimized for a specific design point. However, in clinical practice, these pumps are usually applied over a wide range of operation points. Studies have shown that a deviation from the design point in a rotary blood pump leads to an unexpected rise of hemolysis with corresponding clinical complications. Adjustable pumps that can adapt geometric parameters to the respective operation point are commonly used in other industrial branches, but yet not applied in blood pumps. We present a novel mechanism to adjust the impeller geometry of a centrifugal blood pump during operation together with in-vitrodata of its hydraulic performance and efficiency. Three-dimensionalprinted prototypes of the adjustable impeller and a rigid impeller were manufactured and hydraulic performance and efficiency measured (n = 3). In a flow range of 1.5–9.5 L/min, the adjustable pump increased pump performance up to 47% and hydraulic efficiency by an average of 7.3 percentage points compared with a fixed setting. The adjustable pump allows customization of the pump’s behavior (steepness of performance curve) according to individual needs. Furthermore, the hydraulic efficiency of the pump could be maintained at a high level throughout the complete flow range.