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The effectiveness of many anticancer agents is dependent on their disposition to the intracellular space of cancerous tissue. Accumulation of anticancer drugs at their sites of action can be altered by both uptake and efflux transport proteins, however the majority of research on the disposition of anticancer drugs has focused on drug efflux transporters and their ability to confer multidrug resistance. Here we review the roles of uptake transporters of the SLC22A and SLCO families in the context of cancer therapy. The many first-line anticancer drugs that are substrates of organic cation transporters (OCTs) organic cation/carnitine transporters (OCTNs) and organic anion- transporting polypeptides (OATPs) are summarized. In addition, where data is available a comparison of the localization of drug uptake transporters in healthy and cancerous tissues is provided. Expression of drug uptake transporters increases the sensitivity of cancer cell lines to anticancer substrates. Furthermore, early observational studies have suggested a causal link between drug uptake transporter expression and positive outcome in some cancers. Quantification of drug transporters by mass spectrometry will provide an essential technique for generation of expression data during future observational clinical studies. Screening of drug uptake transporter expression in primary tumors may help differentiate between susceptible and resistant cancers prior to therapy.

Comments on the implementation of the Information Technology for the 21st Century (IT-21) in naval operations in the United States. Description of the initial outcomes of the IT-21; Ships involved in the IT-21 Battle Group; Critical mass installations of the project; Areas of concern of navy security addressed in the project. INSETS: IT-21 Equipment;Chat, Coordinate & Troubleshoot On Line;E-mail Boosts Morale.

WHEN INFORMATION COUNTS: GRADING THE MEDIA edited by Bernard Rubin (Lexington, MA: Lexington Books/D.C. Heath, 1985—$23.50/13.95)UNTENDED GATES: THE MISMANAGED PRESS by Norman E. Isaacs (New York: Columbia University Press, 1986—$20.00)RESPONSIBILITY & FREEDOM IN THE PRESS: ARE THET IN CONFLICT? edited by Keith S. Collins (Citizen's Choice, 1615 H St. NW, Washington, DC 20036—$9.95, paper)THE MASS MEDIA IN CAMPAIGN '84: ARTICLES FROM PUBLIC OPINION MAGAZINE edited by Michael J. Robinson and Austin Ranney (American Enterprise Institute, 1150 17th St. NW, Washington, DC 20036—price not given, paper)NEWSPAPER USE AND COMMUNITY TIES: TOWARD A DYNAMIC THEORY by Keith R. Stamm (Norwood, NJ: Ablex, 1985—price not given)THE SOUTH REPORTS THE CIVIL WAR and THE NORTH REPORTS THE CIVIL WAR by J. Cutler Andrews (Univ. of Pittsburgh Press—$19.95 each, paper)MINUTE BY MINUTE by Don Hewitt (New York: Random House, 1985—$19.95)SPIKED: THE SHORT LIFE AND DEATH OF THE NATIONAL NEWS COUNCIL by Patrick Brogan (New York: Priority Press, 1985—$8.00, paper)THE MEWS AT ANT COST: HOV JOURNALISTS COMPROMISE THEIR ETHICS TO SHAPE THE NEWS by Tom Goldstein (New York: Simon and Schuster, 1985—$18.95)PR: HOW THE PUBLIC RELATIONS INDUSTRY WRITES THE NEWS by Jeff and Marie Blyskal (New York: Morrow, 1985—$17.95)POLITICAL COMMUMICATION YEARBOOK 1984 edited by Oeith Sanders, et al. (Carbondale: Southern Illinois University Press, 1985—$30.00)

Kinetic studies of an aromatic iodination reaction using benzene or acetanilide, iodine, diiodine pentoxide and sulfuric acid in glacial acetic acid have been carried out. The reaction, followed using FT-Raman spectroscopy to monitor the disappearance of the aromatic over time, exhibits fractional order dependence in benzene but first order dependence in acetanilide. The difference in order between the two aromatics indicates that benzene participates in an equilibrium reaction before the rate limiting step of the reaction. This reversible step is proposed to be the reversible formation of a π-complex between adsorbed I2 and benzene as it adsorbs onto I2O5. Based on the calculated order, acetanilide most likely does not form a π-complex with adsorbed I2, rather it reacts from solution to form a σ-complex with activated I2 on the I2O5 surface. In both reactions, it is proposed that the rate limiting step is the formation of the σ-complex.