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In this manuscript, we report the photo-inactivation evaluation of new tetra-cationic porphyrins with peripheral Pt(II) complexes ate meta N-pyridyl positions in the antimicrobial photodynamic therapy (aPDT) of rapidly growing mycobacterial strains (RGM). Four different metalloderivatives were synthetized and applied. aPDT experiments in the strains of Mycobacteroides abscessussubsp. Abscessus(ATCC 19977), Mycolicibacterium fortuitum(ATCC 6841), Mycobacteroides abscessussubsp. Massiliense(ATCC 48898), and Mycolicibacterium smegmatis(ATCC 700084) conducted with adequate concentration of photosensitizers (PS) under white-light conditions at 90 min (irradiance of 50 mW cm−2and a total light dosage of 270 J cm−2) showed that the Zn(II) derivative is the most effective PS significantly reduced the concentration of viable mycobacteria. The effectiveness of the molecule as PS for PDI studies is also clear with mycobacteria, which is strongly related with the porphyrin peripheral charge and coordination platinum(II) compounds and consequently about the presence of metal center ion. This class of PS may be promising antimycobacterial aPDT agents with potential applications in medical clinical cases and bioremediation.

ABSTRACTExpression of the HAHB4 sunflower transcription factor confers drought tolerance to wheat event IND-ØØ412-7 (HB4® wheat). After confirming the compositional equivalence of event IND-ØØ412-7 with conventional wheat, its nutritional similarity to its non-genetically modified (GM) counterpart was analyzed by performing a 42-day broiler feeding study. Isoenergetic diets containing 40% flour from wheat event IND-ØØ412-7, its non-GM counterpart Cadenza, and a commercial variety were included in the study. Broilers’ performance was analyzed by measuring feed intake, weight gain, feed conversion, and time to reach 2.8 kgs. The yield was evaluated by carcass weight, breast meat, and abdominal fat. No differences were found between wheat event IND-ØØ412-7 and the non-GM counterpart. A few significant differences were found with the commercial variety which were associated with the genetic background, different from the other two materials. These results support the nutritional equivalence of event IND-ØØ412-7 with conventional wheat.

A range of bis-triazolylchalcogenium-BTD 3was synthesized by a copper-catalyzed azide–alkyne cycloaddition of azido arylchalcogenides 1and 4,7-diethynylbenzo[c][1,2,5]thiadiazole 2. Eight new compounds were obtained in moderate to good yields using 1 mol % of copper(II) acetate monohydrate under mild reaction conditions. In addition, the synthesized bis-triazolylchalcogenium-BTD 3a–3hwere investigated regarding their photophysical, electrochemical, and biomolecule binding properties in solution. In general, compounds presented strong absorption bands at the 250–450 nm region and cyan to green emission properties. The redox process attributed to the chalcogen atom was observed by electrochemical analysis (CV techniques). In addition, spectroscopic studies by UV–vis, steady-state emission fluorescence, and molecular docking calculations evidenced the ability of each derivative to establish interactions with calf-thymus DNA (CT-DNA) and bovine serum albumin (BSA). The behavior presented for this new class of compounds makes them a promising tool as optical sensors for biomolecules.

The reaction of 1,3‐bis(phenyl)triazene 1‐oxide with VOSO4·5H2O in the presence of potassium ethanolate in ethanol yields yellow vitreous crystals of [{C6H5NNN(O)C6H5}V(O)2(C5H5N)] (1) and [{O2NC6H4NNN(O)C6H5}V(O)2(C5H5N)] (2) after recrystallization from acetone/pyridine. 1and 2complex molecules are associated to [{C6H5NNN(O)C6H5}V(O)2(C5H5N)]2and [{O2NC6H4NNN(O)C6H5}V(O)2(C5H5N)]2dimeric units through centrosymmetric C–H···O interactions, respectively. The centrosymmetric dimers – related to each other by translation – are connected to on‐dimensional chains along to the crystallographic direction [010] in the case of 1, and along to the crystallographic direction [100] in the case of 2, generating a supramolecular 1‐D arrangement, respectively. The single‐crystal X‐ray structural analysis of 1and 2are the first reported in the literature bearing a triazenido 1‐oxide anion stabilizing a cis‐dioxovanadium(V) fragment.