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The purpose of this paper is to review the rise and development of the 19th century medical journalism in Philadelphia. The city of Philadelphia, the early American medical center, had been so hard attacked by yellow fever that it permitted New York to establish the first medical journal in US. In 1804, however, almost simultaneously Dr. Coxe published the Philadelphia Medical Museum and Dr. Barton the Philadelphia Medical and Physical Journal. Dr. Nathaniel Chapman founded the Philadelphia Journal of the Medical and Physical Sciences in 1820, its contents were of outstanding quality from the beginning. Chapman's Journal was changed in 1827 its name to the American Journal of the Medical Sciences, which holds front rank in medical journalism in US. The author tried to seek the graves, markers, and portraits of the editors in those three medical journals in Philadelphia. [ABSTRACT FROM AUTHOR]