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The clinical, roentgenological and pathologicanatomical findings in 101 deceased premature and newborn infants, delivered in the years 1968–1971, have been studied by transferring the data on to punch cards for the purposes of comparison and analysis. A full or partial conformity of the X-Ray findings with the pathologic-anatomic diagnosis was found in 72 cases. It has been concluded that a distinct radiomorphologic substrate is often caused by a combination of various pathologic-anatomical changes.

24-h urines of 65 healthy children were examined for epitestosterone and testosterone by the aid of a method using thin-layer chromatography and fluorometric end-determination.

Report of a sporadic case of metaphyseal dysotosis of the type described by Schmid. The 12 year old boy had been treated without benefit since infancy under the false diagnosis of rickets with vitamin D2 preparations. His main symptoms were reduced stature, bowed legs, and a waddling gait. Roentgenography demonstrated marked changes in both femoral and tibial metaphyses. Blood chemistry showed normal values of calcium, phosphorus, and alkaline phosphatase.

In a long-term study 66 boys with CGR and psychosocial problems were treated with low doses of 4-chlor-dehydro-methyl-testosterone (0,1 mg per kg body weight for 8 weeks, intervals of 4 weeks) for 2,7 ± 1,3 years and followed up to the 20th year of life. A control group without such treatment included 26 boys.Results:1. Skeletal maturity at the beginning of therapy and difference of final and predicted body height show a negative correlation. If therapy starts at bone age of less than 10 years the predicted height will not be reached (- 6,1 ± 7,3 cm). On the contrary predicted height is not diminished when treatment with anabolics starts when the bone age is 10 years or more (- 0,5 ± 3,3 cm).2. Matched pairs of 19 treated boys with an identical control group (bone age of 10 years or more at beginning of the therapy) revealed no difference of the predicted and final body height at the age of 20 years.