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To determine whether serum concentrations of insulin-like growth factor-binding protein-1 (IGFBP-1), a major decidual protein, at 16 weeks' gestation differ between women who later develop pregnancy-related hypertension and normotensive women.

Objective: To determine whether serum concentrations of insulin-like growth factor-binding protein-1 (IGFBP-1), a major decidual protein, at 16 weeks’ gestation differ between women who later develop pregnancy-related hypertension and normotensive women.

To determine whether elevated homocysteine levels precede the development of preeclampsia.

Objective: To determine whether elevated homocysteine levels precede the development of preeclampsia.