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Background: Reverse total shoulder arthroplasty (RSA) is a standard treatment for proximal humeral fractures (PHF) and its sequelae. In this study we analyzed the clinical outcomes of primary vs. secondary RSA for displaced PHF in elderly patients. Methods: We retrospectively reviewed 68 cases of primary or secondary RSA for displaced PHF. For 51 patients (28 primary RSA, 23 secondary RSA), a minimum 12-month follow-up with clinical and radiological assessment was available. Clinical assessment comprised joint active range of motion, DASH, Constant–Murley Score (CMS), Subjective Shoulder Value, and Visual Analog Scale for pain. Outcomes and complications of patients with primary RSA were compared with those of patients with secondary RSA. Results: Follow-up data were available for 45 women and six men with a mean age of 73 years (range, 59–87) at the time of implantation. In 28 cases, primary RSA was performed; in 23 cases, RSA was performed as a revision procedure for fracture sequelae after failed plating, nailing, or hemiarthroplasty. The mean age- and gender-related CMS was 82.2 ± 34.2% (raw mean CMS: 46.8 ± 19.6 points). Among nine of the 51 patients with follow-up data (17.6%), ten complications occurred with six surgical revisions. Primary RSA (n= 28) resulted in better clinical shoulder function compared with secondary RSA (n= 23). Significantly more complications and revision surgeries were observed following secondary than primary RSA (p= 0.013). Conclusion: In this study, primary RSA for displaced PHF in the elderly was associated with better clinical function and lower complication and revision rates than secondary RSA. Predictive parameters for failure of humeral head-preserving fracture fixation and anatomic hemiarthroplasty should be carefully evaluated. Primary RSA should be considered when surgical treatment of PHF is indicated in elderly patients.