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2. Gemcitabine and paclitaxel combination therapy in transitional cell carcinoma of the urothelium
- Author
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Meluch, A. A., Burris, H. S., Greco, F. A., and Hainsworth, J. D.
- Published
- 2000
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3. 35th Annual Meeting of the European Association for the Study of Diabetes
- Author
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. 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R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Häring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., McKinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnæs, A. M., Andersen, N. Aa., Osterhoff, M., Möhlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Fürnsinn, C., Nowotny, P., Waldhäusl, W., Roden, M., Neeft, M., Meijer, A. J., Båvenholm, P., Pigon, J., Efendic, S., Kästenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Van Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovská, A., Kasalicky, P., Hosová, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefèbvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valéro, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., de Galan, B., Netea, M. G., Hancu, N., Smits, P., Van der Meer, J. W. M., Osterbye, T., Jørgensen, K. H., Tranum-Jensen, J., Fredman, P., Høy, M., Bokvist, K., Olsen, H. 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J., Stein, E., Lemme, L., Rubinstein, A., Maritz, F. J., Soule, S., Market, A., Chajek-Shaul, T., Maislos, M., Tal, S., Stolero, D., Josefsen, K., Beckmann, H., Petersen, C., Ekman, R., Efanova, I., Zaitsev, S., Berggren, P. O., Birkenbach, M., Holl, R. W., Rosenbauer, J., Grabert, M., Icks, A., Schwab, O., Reile, K., Janssen, M. M. J., de Jongh, R. T., Casteleijn, S., Masurel, N., Hoogma, R. P. L. M., Santeusanio, F., Brunetti, P., Fanelli, C. G., Laureti, S., Bartocci, L., Maran, A., Crepaldi, C., Trupiani, S., Macdonald, I. A., Avogaro, A., Bouman, S. D., Keitz, M., Bruggink, J. E., Scheurink, A. J. W., Strubbe, J. H., Steffens, A. B., Ferguson, S. C., McCrimmon, R. J., Perros, P., Best, J. J. K., Deary, I. J., Frier, B. M., Robinson, R. T. C. E., Ireland, N. H., Bedford, C., Fairclough, E., Hudson, S., Heller, S. 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C., Kaya, F., Süsleyici, B., Öztürk, M., Eisner, M., Guldbakke, B., Karpenko, N., Brizgalova, G., Alesina, M., Røder, M. E., Schwartz, R. S., Prigeon, R., Kahn, S. E., Kendereški, A., Micić, D., Šumarac, M., Macut, Dj., Zonć, S., Čolić, M., Cvijović, G., Gligorović, P., Courtney, C. H., Atkinson, A. B., Ennis, C., Sheridan, B., Bell, P. M., Jolly, M., Amin, R., Godsland, I., Horvoka, R., Anyaoku, V., Lawrence, N., Krasova, N., Sergienko, L., Mingrone, G., Plat, L., Balasse, E. O., Zykova, T., Jenssen, T., Strelkova, A., Zykova, S., Tipisova, E., Féry, F., Wijenaike, A. N., Watt, P. W., Jung, R. T., Bolton-Smith, C., Rennie, M. J., Ludvik, B., Aigmueller, Th., Waldhaeusl, W., Courtois, P., Bource, F., Guenat, E., Philippe, J., Jéquier, E., Tappy, L., Benny, Santosa, Grönemeyer, Dietrich, Aygen, Sitke, Scholz, Nicole, Busch, Martin, Tauveron, I., Rochon, C., Dejax, C., Benoit, P., Capitan, P., Bayle, G., Prugnaud, J., Fabricio, A., Champredon, C., Thieblot, P., Grizard, J., Nielsen, M. F., Nyholm, B., Chandramouli, V., Schumann, W. C., Landau, B. R., Rizza, R. A., Mitrakou, A., Meyer, C., Tolias, A., Platanisiotis, D., Vlachos, L., Gerich, J., Wajngot, A., Sprangers, F., Jellema, W. T., Lopuhaä, C. E., van Lieshout, J. J., van der Zee, J. S., Mithieux, G., Croset, M., Zitoun, C., Hurot, J. M., Rajas, F., Montano, S., Willem, R., Verbruggen, I., Grue-Sørensen, G., Björkling, F., Watson, N. D., Burns, S. P., Murphy, H. C., Iles, R. A., Cohen, R. D., Rooney, K., Swan, V., Phuyal, J., Millar, J., Bryson, J., Denyer, G., Caterson, I., Thompson, C., Gaster, M., Handberg, Aa., Schrøder, H. D., Alzaid, A., Sobki, S., Thye-Rønn, P., Alford, F., Christopher, M., Gras, F., Brunmair, B., Neschen, S., Py, G., Lambert, K., Raynaud, E., Mercier, J., Tsuchihashi, K., Sumida, Y., Fujimoto, H., Nakamura, M., Miyata, E., Furuta, M., Katsuki, A., Ito, K., Sasaki, R., Hori, Y., Yano, Y., Adachi, Y., Lauritz, J., Eriksson, J. W., Burén, J., Zhao, L. J., Li, Z.-C., Kullin, M., Karlsson, F. A., Redondo, A., Puente, J., Clemente, F., González, N., Moberg, E., Amer, P., Hagström-Toft, E., Bolinder, J., Björnholm, M., Krook, A., Galuska, D., Myers, M., Zierath, J. R., Wallberg-Henriksson, H., Niklasson, M., Strindberg, L., Sternberg, F., Hebeda, S., Kratzer, W., Salgado, M. I., Hoss, U., Kalatz, B., Lohmann, S., Fussgänger, R., Khomazjuk, A. I., Ncscheret, A. P., Gonchar, I. V., Quinones-Galvan, A., Sironi, A. M., Cominacini, L., Nagai, Y., Yamashita, H., Takamura, T., Kobayashi, K., Szanto, I., Peth, J. A., Kinnick, T. R., Youngblood, E. B., Tritschler, H. J., Henriksen, E. J., Gašperíková, D., Rufo, C., Teran-Garcia, M., Nakamura, M. T., Clarke, S. D., Pye, S., Zhang, Z., Radziuk, J., Guignot, L., Bell, K. S., Lim-Fraser, M., Cooney, G., Kraegen, E. W., Takayama, S., Legare, D. J., Macedo, M. P., Lautt, W. W., Bradley, B., Barron, P., Davies, J., Ader, M., Richey, J. M., Ait El Mkadem, S., Macari, F., Renard, E., Méchaly, I., Brun, J. F., Cros, G., Bringer, J., del Aguila, L. F., Krishnan, R. K., Farrell, P. A., Ulbrecht, J., Correll, P. H., Kirwan, J. P., Mei, J., Rahn-Landström, T., Brindley, D., Manganiello, V., Degerman, E., Ziv, E., Shafrir, E., Kaiman, R., Galer, S., Bar-On, H., Gerő, L., Földes, K., Janssen, J., Járay, J., Perner, F., Haap, M., Houdali, B., Schmit, M. B., Dietze, G. J., Perrini, S., Natalicchio, A., Montrone, C., de Robertis, O., De Pergola, G., Strack, V., Kellerer, M., Kausch, C., Condorelli, G., Beguinot, F., Häring, H.-U., Song, X. M., Chibalin, A. V., Ryder, J. W., Jiang, X. J., Alessi, D. R., Hennige, A. M., Metzinger, E., Seipke, G., Trüb, T., Hey, A., Sørensen, A. R., Schäffer, L., Drejer, K., Kurtzhals, P., Hansen, B. F., Matozaki, T., Noguchi, T., Yamao, T., Takada, T., Ochi, F., Takeda, H., Inagaki, K., Hosoka, T., Kasuga, M., Schürt, M., Meier, M., Drenckhan, M., Meyer, M., Aries, S. P., Klein, H. H., Telting, D., van der Zon, G. C. M., Dorrestijn, J., Maassen, J. A., Clapham, J. C., Holder, J. C., Tomlinson, K. M., Pickavance, L., Buckingham, R., Wilding, J., Jacinto, S. M., Harrold, J., Ljung, B., Kjellstedt, A., Thalén, P., Widdowson, P., Williams, G., Oakes, N., Aoki, K., Saito, T., Satoh, S., Mukasa, K., Kaneshiro, M., Kawasaki, S., Hoshino, K., Okamura, A., Sekihara, H., Smith, U., Johansson, A., Nilsson, E., Olausson, T., Nakazawa, T., Suzuki, M., Martinez, J., Murado, P., Azal, Ö., Yönem, A., Çakır, B., Polat, Z., Kutlu, M., Çorakçı, A., Bayraktar, M., Gürlek, A., Koray, Z., Damian, M. S., Linn, T., Laube, H., Arzner, S., Meißner, H.-P., Giunti, S., Comune, M., Cassader, M., Conte, M. R., Sacchi, C., Musso, G., Mecca, F., Depetris, N., Gambino, R., Perin, P. Cavallo, Kawakami, S., Sandqvist, M., Jansson, P.-A., Šindelka, G., Widimský, J., Haas, T., Prázný, M., Mari, A., Nolan, J. J., Uusitupa, M. I. J., Karşıdağ, K., Hacıhanefioğlu, B., Dinççağ, N., Drivsholm, T., Palacios, R. T., Vølund, A., Pedersen, Oluf B., Letiexhe, M. R., Scheen, A. J., Quiñones Galvan, A., Simeoni, M., Basu, A., Uosukainen, A., Mäkimattila, S., Schlenzka, A., Adler, A. I., Levy, J., Stevens, R., Matthews, D., Holman, R., Boland, B. J., Jeanjean, M., Hermans, M. P., Maudoigt, C., Tonglet, R., Robert, A., Quiñones-Galvan, A., Cini, G., Galetta, F., Sanna, G., Gernone, F., Janssen, M. J., Gonera, R. K., Wolffenbuttel, B. H. R., de Leeuw, P. W., Schaper, N. C., Molęda, P., Kuczerowski, R., Czech, A., Tatoń, J., Taddei, S., Patiag, D., Qu, X., Wilkes, M., Gray, S., Seale, J. P., Donnelly, R., Campión, J., Maestro, B., Dávila, N., Carranza, M. C., Calle, C., Hales, C. N., Fernández-Real, J. M., Grasa, M., Pugeat, M., Barret, C., Ricart, W., Lindmark, S., Olsson, T., Tufvesson, M., Loeblein, K., Mehnert, B., Haering, H. U., Rave, Klaus, Heise, Tim, Clauson, Per, Hirschberger, Sabine, Heinemann, Lutz, Claret, M., Nadal, B., Truc, A., Rossi, L., Hildebrand, P., Ketterer, S., Beglinger, C., Keller, U., Gyr, K., Parvin, S., Overkamp, D., Vayreda, M., González-Huix, F., G-Huix, F., Zavaroni, I., Gasparini, P., Massironi, P., Zuccarelli, A., Delsignore, R., Reaven, G. M., Sheu, W. H. H., Lee, W. J., Chen, Y.-T., Iraklianou, S., Tournis, S., Volonakis, I., Spylopoulou, M., Bilianou, E., Melidonis, A., Foussas, S., Güler, Serdar, çakir, Bekir, Demi̇rbaş, Berrin, Gürsoy, Gül, Serter, Rüştü, Aral, Yalçin, Morton, G., Lee, S., Fahey, R., de Silva, A., Cai, X. J., Buckingham, R. E., Arch, J. R. S., Wilson, S., Clausen, J. T., Kristensen, P., Nielsen, P. F., Wulff, B. S., Thim, L., Holness, M. J., Sugden, M. C., Fryer, L. G. D., Munns, M. J., Mannucci, E., Ognibene, A., Cremasco, F., Bardini, G., Mencucci, A., Ciani, S., Pierazzuoli, E., Tsuchihashil, K., Rigalleau, V., Delafaye, C., Baillet, L., Vergnot, V., Brunou, P., Gatta, B., Gin, H., Felber, J. P., Munger, R., Assimacopoulos, F., Bobbioni, E., Golay, A., Wilken, M., Larsen, F. S., Buckley, D., Molina, L. M., Marquez, L., Arbeo, A., Hernandez, C., Kofod, H., Damholt, A. B., Buchan, A., Márquez, L., Luque, M. A., Sarti, L., Sutton, P. J., Behle, K., Heimesaat, M. M., Hüfner, M., Gravholt, Claus Højbjerg, Mølier, Niels, Christiansen, Jens Sandahl, Schmitz, Ole, Deacon, C. F., Brock, B., Knudsen, L. B., Agersø, H., Huusfeldt, P. O., Kelly, C. M. N., Brunn, C., Schioos, J., Sewing, S., Lemansky, P., Wawro, S., Mest, H. J., Taguchi, T., Motoshima, H., Yoshizato, K., Guenifi, Amel, Henriksson, M., Johansson, J., Shafqat, J., Tally, M., Wahren, J., Jömvall, H., Ekberg, K., Rigler, R., Pramanik, A., Kratz, G., Johansson, B.-L., Uhlén, M., Jörnvall, H., Forst, T., Dufayet De La Tour, D., Kunt, T., Pfützner, A., Goitom, K., Pohlmann, T., Schneider, S., Johansson, B. L., Löbig, M., Engelbach, M., Beyer, J., Ekman, Bertil, Nyström, Fredrik, Arnqvist, Hans J., Halvatsiotis, P. G., Meek, S., Bigelow, M., Nair, K. S., Maghsoudi, S., Fisker, S., Vølund, A. A., Jörgensen, J. O. L., Christiansen, J. S., Hilsted, J., Mazerkina, N. A., Tiulpakov, A. N., Gorelyshev, S. K., Peterkova, V. A., Macut, D. J., Dieguez, C., Casanueva, F. F., Catalina, P. F., Mallo, F., Andrade, A., García-Mayor, R. V. G., Popova, V. V., ter Maaten, J. C., Popp-Snijders, C., Madsen, L., Ukropec, J., Bergene, E., Rnstan, A. C., Berge, R., Arner, P., Wahl, G., Häring, H., Bryson, J. M., Curtis, S. E., Caterson, I. D., Winzell, M. Sörhede, Svensson, H., Ahnén, B., Holm, C., Phillips, C., Madigan, C., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Cabezas, M. Castro, van Oostrom, A. J. H. H. M., Erkelens, D. W., Summers, L. K. M., Fielding, B. A., Ilic, V., Clark, M. L., Frayn, K. N., Pietzsch, J., Julius, U., Nitzsche, S., Fischer, S., Lindgren, C., Amrot-Fors, L., Hoffmann, M. M., Luft, D., Schmülling, R.-M., D’Adamo, M., Leonetti, F., Paoloni, A., Ribaudo, M. C., Basso, M. S., Elmore, U., Restuccia, A., Sbraccia, P., Emilsson, V., O’Dowd, J., Heyman, R., Cawthorne, M. A., Pelikánová, T., Kazdová, L., Žák, A., Chvojková, Š., Özer, E. M., Kadıoğlu, P., Korugan, Ü., Hatemi, H., Rivellese, A. A., Dullaart, R. P. F., Riemens, S. C., Sluiter, W. J., van Tol, A., Farnier, M., Megnien, S., Turpin, G., Stulp, B. K., Brambilla, P., Brunelli, A., Riva, M. C., Manzoni, P., de Poli, S., Riboni, S., Stolk, R. P., Meijer, R., Wink, O., Zelissen, P. M. J., van Gils, A. P. G., Grobbee, D. 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W., Taverna, M., Guerre-Millo, M., Chevalier, A., Pacher, N., Slama, G., Gorshunska, M., Buyken, A. E., Heitkamp, G., Kabir, M., Oppert, J. M., Wursch, P., Bruzzo, F., Rahman, M. H., Fatima, K., Ahmed, S., Mondal, H. N., Yilmaz, M., Öztok, U., Karakoç, A., Çakır, N., Düzgün, E., Yetkin, İ., Arslan, M., Şardaş, S., Wilding, John, Géloën, A., Baret, G., Dalmaz, Y., Peyronnet, J., Clémenceau, B., Martignat, L., Lalain, S., Gouin, E., Kenda-Ropson, N., Miller, A. O. A., You, S., Aguilera, E., Recasens, M., Flores, L., Ricart, M. J., Fernández-Cruz, L., Esmatjes, E., Crenier, L., Noël, C., Le Moine, A., Mahy, M., Danguy, A., Kiss, R., Goldman, M., Bracci, C., De Haan, B., Nilsson, K., Deschamps, J. Y., Glagoličová, A., Smrčková, I., Dieterle, C., Illner, W. D., Land, W., Feldmeier, H., Scheuer, R., Lalli, C., Di Loreto, C., Ellringmann, U., Balks, H. J., v. zur Mühlen, A., Dengler, R., Weissenborn, K., Rasmussen, B. M., Ørskov, L., Watson, J., Owen, G., Barrett, G., Ingleby, J., Weiss, M., Deary, I., Cavan, D., Kerr, D., Bruneiii, A., Cuce’, A., Elsing, H. G., Kühne, D., Quinn, N. D., Warner, D. P., Buysschaert, M., Jamal, R., O’Brien, T., Latare, P., Mullen, J., Rein, A., Wargo, M., Parkes, J. L., Ginsberg, B., Sotiropoulos, A., Peppas, Th. A., Kotsini, V., Apostolou, O., Bousboulas, S., Michailidis, E., Sawala, M., Pappas, S., Nilsson, P. M., Nilsson, J. Å., Berglund, G., Molins, T., Esteban, J. I., Genescà, J., Paris, I., Haufroid, V., Selvais, Ph., Petit, J. M., Duong, M., Grappin, M., Guiguet, M., Rudoni, S., Portier, H., Brun, J. M., Bagg, W., Plank, L., Drury, P. L., Sharpe, N., Braatvedt, G. D., Carrascosa, J. M., Molero, J. C., Fermίn, Y., Andrés, A., Satrústegui, J., Rietzsch, H., Patzak, A., Schwanebeck, U., Simpson, H., Robertson-Mackay, F., Montegriffo, E., Fox, C., Chiasson, J.-L., Josse, R. G., Dorman, J. M., Gerstein, H. C., Lau, D., Leiter, L. A., Maheux, P., Meneilly, G. S., Murphy, L., Rodger, N. W., Ross, S. A., Ryan, E., Yale, J.-F., Wolever, T. M. S., Haller, T., Elias, I., Segal, P., Standi, E., Rybka, J., Sencer, E., Satman, I., Schlcnzka, A., Vakkilainen, J., Tsaglis, H., Ioannidis, I., Giakoumaki, A., Amantou, A., Komitopoulos, N., Georgiou, S., Varsamis, E., Katsilambros, N., El Gayar, M., Shereba, N., Botros, R., Fikry, R., Jackson, D., Balme, M., Silva-Nunes, J., Alves, J., Bogalho, P., Gardete-Correia, L., Nunes-Corrêa, J., Kot’átková, A., Němcová, D., Vrbíková, J., Zamrazil, V., Meyer, L., Delbachian, I., Lehert, P., Cugnardey, N., Drouin, P., Guerci, B., Wagner, O. F., Jones, N. P., Vallance, S. E., Thompson, K. A., Miller, A. K., Inglis, A. M. L., Patterson, S., Jorkasky, D., Freed, M. I., Mathisen, A. L., Schneider, R., Rubin, C., Houser, V., Beebe, K. L., Kortboyer, J. M., Eckland, D. J. A., Cranmer, H., Mori, Y., Kurokawa, N., Komiya, H., Horikoshi, H., Yokoyama, J., Tajima, N., Ikeda, Y., Bakst, A., Hemyari, P., Lönnqvist, F., Owen, S., Vikramadithyan, R. K., Chakrabarti, R., Misra, P., Prem Kumar, M., Sunil Kumar, K. B., Ghosh, A., Rajagopalan, R., Goldstein, B., Katoh, S., Tsuruoka, N., Hata, S., Matsushima, M., Ikemoto, S., Inoue, Y., Edwards, G., Fonseca, V., Biswas, N., Bakris, G., Viberti, G., Rebuck, A. S., Weill, S., Abel, M. G., Klappoth, W., Brodesser, A., Linkeschowa, R., Pushparaj, P., Tan, C. H., Tan, B. K. H., Bahner, A., Parker, J., Waite, G., Lipson, V., Nahar, N., Rokeya, B., Parveen, S., Nur-e-Alam, M., Mosihuzzaman, M., Hansen, A. Kornerup, Lepore°, M., Kurzhals, R., Pampanelli°, S., Fanelli°, C. G., Bolli°, G. B., Ratner, R. E., Hirsch, I. B., Mecca, T. E., Wilson, C. A., Mohideen, P., Mudaliar, S., Deutsch, R., Ciaraldi, T., Armstrong, D., Kim, B., Morrill, B., Sha, X., Henry, R., Meyer, B. H., Scholtz, H. 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- Published
- 1999
- Full Text
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4. One-hour paclitaxel plus carboplatin in the treatment of advanced non-small cell lung cancer: results of a multicentre, phase II trial
- Author
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Hainsworth, J. D., Urba, W. J., Hon, J. K., Thompson, K. A., Stagg, M. P., Hopkins, L. G., Thomas, M., and Greco, F. A.
- Published
- 1998
- Full Text
- View/download PDF
5. Water Extraction by Single Plant Roots
- Author
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Hainsworth, J. M. and Aylmore, L. A. G.
- Abstract
Application of computer assisted tomography to x‐ray attenuation measurements has been used to study the drawdowns in soil‐water content associated with single plant roots. Drawdowns have been measured at different depths along radish (Raphanus sativuscv long scarlet) roots growing in soil at two different initial water contents while the plants were subjected to either a high or low transpirational demand. This novel approach has provided the most detailed observations of this type yet obtained, particularly by a nondestructive technique. Soil resistance to water flow is clearly of significance even at the high soil‐water potentials used since it has been observed to markedly influence water uptake. Comparisons between these experimentally determined drawdowns and those predicted by an analytical approach indicate that this model does not adequately describe the extraction process. In particular, the assumption that a plant root acts as a uniform absorbing cylinder along its length is clearly erroneous. While a numerical model gives a closer fit to the experimental data, it is clear that improvements in the physical concepts on which this is based are necessary to accurately describe the position and shape of the drawdowns.
- Published
- 1986
- Full Text
- View/download PDF
6. The Criticism of an Oral Homer
- Author
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Hainsworth, J. B.
- Abstract
Homer is universally praised for the clarity of his style. Yet even to sympathetic or perceptive readers, if their critical remarks really express their judgments, his poetical intention has been singularly opaque: invited to leave town by Plato, as if he were a bad ethical philosopher; lauded by Aristotle for his dramatic unity, as if he were a pupil of Sophocles; criticised by Longinus for composing an Odysseywithout Iliadic sublimity; abused in more recent times by Scaliger as indecorous, irrational, improper and undisciplined, as if he were seeking (like Virgil) to portray the perfect exemplar of a renaissance prince; defended by Dacier as a sublime primitive, innocent of taste and art, who achieved perfection ‘par la seule force de son genie’. Some of these judgments are no more than the stock responses of their age to epic poetry. The critic regards the poems from his own point of view; he discovers what he expects to find; and he passes a judgment that illuminates the workings of his own mind but sheds nothing but darkness upon Homer's. The announcement, therefore, of a new criticism by Notopoulos and Lord, a criticism based on the results of comparative study and free from the old prejudices of Analysts and Unitarians, is an event of importance. It may even be the case that the despised anachronistic ‘singer’, that unwashed, mendicant figure lurking in the coffee houses of the Balkans, has something to say. But whatever he says, it will be applicable to Homer only by analogy, and will require verification.
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- 1970
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7. Shakespeare, Son of Beckett?
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Hainsworth, J. D.
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- 1964
- Full Text
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8. Notes and news
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Erades, P. A., Forster, Leonard, Mulholland, Joan, Hill, Robert, Schubiger, Maria, Aitken, A. J., Bratley, Paul, Elliott, Ralph, French, A. L., Meier, Hans Heinrich, Vouk, Vera, Derolez, R., Osselton, N. E., Røstvig, Maren-Sofie, Parish, John, Unrau, John, Roe, H. A., Bately, Janet, Isaacs, Neil, van Dorsten, J. A., Hainsworth, J. D., Norton, John, Whitbread, L., Martin, John, and Senn, Fritz
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- 1967
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9. No Flames in the Odyssey
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Hainsworth, J. B.
- Abstract
In one of the most stimulating chapters of his recent contribution to Homeric studies, Professor D. L. Page adduces considerable evidence to suggest that the traditions of the Iliad and the Odyssey diverged at a fairly early date and, like isolated dialects, came to differ appreciably in their diction. Attractive and probable as this suggestion is as a whole, it will always be possible to wonder about the details of the evidence. In this paper it is intended to wonder whether the absence of f???and its cognates from that part of the Odyssey that is certainly ‘Homer's’ is rightly adduced as evidence for this divergence of the traditions.Page's argument runs as follows. The absence of f???must be due either to ignorance or to chance. But it cannot be due to chance, since there are more than fifty opportunities for its use. Therefore the root, so common in the Iliad, must have been ‘wholly unknown to the Odyssean poet’.It appears that in order to show that f???was not part of the Odyssey's traditional vocabulary, since it is this that diverges from the Iliad, Page must claim that the root was not part of the poet's vocabulary at all. Can this be regarded as a probable claim? Our available evidence is scarcely sufficient to differentiate the sub-dialects of Ionic (it is admitted that both poets are Ionians), so that it is impossible to confirm that differences of nontechnical vocabulary were a feature of the differentiation. Our view of the matter has therefore to depend on a subjective estimate of the probabilities. Two points are not unworthy of notice: first, the banishing of f???from the Odyssey is only achieved by the attribution to a rhapsodic hack of the ‘Continuation’, where in ?71, f???appears in just the circumstances where, as I hope to show, it is to be expected; and second, derivatives of the root are used by prose and verse writers both Ionian and Attic, and also in the ?????, in circumstances that make it impossible to suppose that every instance is a reminiscence of a long defunct epic word.
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- 1958
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10. Panel discussion on B cells and rituximab: mechanistic aspects, efficacy and safety in rheumatoid arthritis and non-Hodgkin's lymphoma
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Panayi, G. S., Hainsworth, J. D., Looney, R. J., and Keystone, E. C.
- Abstract
The clinical potential of rituximab (MabThera®/Rituxan®), a selective B-cell-depleting agent, in the treatment of patients with rheumatoid arthritis (RA) is rapidly becoming apparent. The data presented at an official satellite symposium of the European League Against Rheumatism (EULAR) Congress (2003, Lisbon, Portugal), reinforce the rationale for the use of this novel agent in RA and have provided an early indication of its clinical efficacy, safety and tolerability. The symposium presentations were followed by a panel discussion and a question and answer session in which the participants were able to shed further light on specific mechanistic issues relating to effects on B-cell populations based on available data and their own clinical experience of rituximab. Additionally, the implications of current results for longer-term clinical efficacy and safety were discussed. It is becoming clear that rituximab (alone or in combination with disease-modifying anti-rheumatic drugs) is highly efficacious in RA. Extensive data from patients with non-Hodgkin's lymphoma show that early concerns over increased infection rates due to prolonged suppression of B cells have not been realized. The effects of rituximab on long-term RA outcomes, such as joint erosion and duration of response (particularly in patients receiving combination therapy), are eagerly anticipated.
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- 2005
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11. Introduction
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Panayi, G. S. and Hainsworth, J. D.
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- 2005
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12. HOMER AND TROY
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Hainsworth, J. B.
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- 2000
13. Paclitaxel-carboplatin alone or with gemcitabine or vinorelbine for stage IIIB and IV non-small cell lung cancer: Long-term follow-up
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Greco, F. A., Burris, H. A., and Hainsworth, J. D.
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- 2000
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14. Oral Style
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Hainsworth, J. B.
- Published
- 1999
15. K. Stanley: The Shield of Homer: Narrative Structure in the Iliad. Pp. xii + 470. Princeton: Princeton University Press, 1993.
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Hainsworth, J. B.
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- 1998
16. Book Review: The last scenes of the Odyssey
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Hainsworth, J. B.
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- 1980
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17. Book Review: Homer and the oral tradition
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Hainsworth, J. B.
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- 1978
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18. Book Review: Investigaciones sobre el estilo formular epico y sobre la lengua de Homero
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Hainsworth, J. B.
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- 1977
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19. Book Review: Die Komposition der Reden in der Ilias
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Hainsworth, J. B.
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- 1972
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20. Book Review: Athene als göttliche Helferin in der Odyssee: Untersuchungen zur Form der epischen Aristie
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Hainsworth, J. B.
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- 1968
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21. Book Review: Syncope in Greek and Indo-European and the nature of Indo-European accent
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Hainsworth, J. B.
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- 1967
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22. Book Review: Introducción a Homero
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Hainsworth, J. B.
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- 1966
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23. Book Review: The World of Odysseus
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Hainsworth, J. B.
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- 1957
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24. Book Review: Iliad
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Hainsworth, J. B.
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- 1964
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25. Book Review: Beiträge zur Überlieferung der Iliasscholien
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Hainsworth, J. B.
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- 1962
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26. Book Review: Il ‘????’ e i ‘????’ nell'Odissea
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Hainsworth, J. B.
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- 1961
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27. A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 Dosed Q14D without and with Prophylactic G-CSF in Non-Hodgkin (NHL) or Hodgkin Lymphoma (HL).
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O'Connor, Owen A, Gerecitano, J., Van Deventer, H., Afanasyev, B., Hainsworth, J., Chen, M., Saikali, K., Seroogy, J., Escandon, R., Wolff, A., and Conlan, MG.
- Abstract
KSP is a mitotic kinesin essential for cell cycle progression. SB-743921, a selective KSP inhibitor, blocks mitotic spindle assembly with cell cycle arrest in mitosis and cell death. In the first-in-humans (FIH) trial, the maximum tolerated dose (MTD) was 4 mg/m2 q21d. Since neutropenia was the major dose-limiting toxicity (DLT), with recovery by ∼d15, a q14d schedule without (-GCSF) and with prophylactic G-CSF (+GCSF) is being explored.In Phase I of this Phase I/II trial, DLT and MTD of SB-921 given on d1 and d15 q28d (-GCSF) and (+GCSF) were determined. Eligible patients (pts) had relapsed or refractory HL or NHL, aggressive (a) or indolent (i), had at least 1 prior chemotherapy (CT) regimen, and had relapsed after or were not candidates for stem cell transplant. This was a standard 3+3 dose escalation trial design, starting at 2 mg/m2 and escalating by 1 mg/m2. Once DLT (-GCSF) was identified, (+GCSF) dosing started at the (-GCSF) MTD, escalating until (+GCSF) DLT was identified. MTD was defined as one dose level below maximum administered dose (MAD). Response was assessed with IWG criteria (2007).39 pts were treated (-GCSF) at 6 dose levels (2-7 mg/m2). Five pts had DLT: 1/3 at 4 (grade 3 hepatic enzyme elevation; found retrospectively); 2/10 at 6 (both sepsis with neutropenia), and 2/7 DLT-evaluable at 7 (both grade 4 neutropenia lasting >5d) mg/m2. MTD (-GCSF) was 6 mg/m2. 17 pts were treated with SB-743921 (+GCSF) at 6 (n=4), 7 (n=3), 8 (n=3) and 9 (n=7) mg/m2, with 1 DLT of neutropenia lasting >5d at 9 mg/m2. For all 56 pts treated at these dose levels, mean age was 51 yr; 54% were male; 39% HL, 30% aNHL, and 30% iNHL; 79% had ≥3 prior CT regimens. The most frequent grade 3/4 toxicity in Cycle 1 was neutropenia: 47% at ≥MTD (-GCSF) and 41% (+GCSF). Other grade 3/4 AEs (all cohorts combined, Cycle 1) were: thrombocytopenia 14% and anemia 5%; other grade 3/4 AEs were <5%. Nausea and diarrhea occurred in 13-14% of pts, all grade 1/2. There was no neuropathy or alopecia >grade 1. Seven pts were treated at 10 mg/m2 (+GCSF): 2 were not DLT-evaluable; 2/5 DLT-evaluable pts had DLT of grade 4 thrombocytopenia. The SB-743921 (+GCSF) MAD was 10 mg/m2 and the MTD was 9 mg/m2. There were 4 partial responses (PR), 3 in HL (1 at 6; 1 at 8; and 1 at 9 mg/m2) and 1 in marginal zone NHL (at 9 mg/m2); duration of response was 8-28+ weeks. One pt with diffuse large B cell NHL remains on study with stable disease for >17 months.The MTD of SB-743921 on a q14d schedule (-GCSF) was 6 mg/m2 and (+GCSF) was 9 mg/m2. These dose densities (0.43 and 0.64 mg/m2/d) are >2- and 3-fold higher, respectively, than in the FIH trial with a q21d schedule (0.19 mg/m2/d). SB-743921 is well tolerated with minimal toxicity other than hematologic. Activity has been observed in heavily pre-treated HL and NHL, with 4 PRs at doses ≥6 mg/m2. SB-743921 warrants further investigation in lymphoma.Chen: Cytokinetics: Employment. Saikali:Cytokinetics: Employment. Seroogy:Cytokinetics: Employment. Escandon:Cytokinetics: Employment. Wolff:Cytokinetics: Employment. Conlan:Cytokinetics: Employment.
- Published
- 2009
- Full Text
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28. A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 Dosed Q14D without and with Prophylactic G-CSF in Non-Hodgkin (NHL) or Hodgkin Lymphoma (HL).
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O'Connor, Owen A, Gerecitano, J., Van Deventer, H., Afanasyev, B., Hainsworth, J., Chen, M., Saikali, K., Seroogy, J., Escandon, R., Wolff, A., and Conlan, MG.
- Abstract
Abstract 1673
- Published
- 2009
- Full Text
- View/download PDF
29. A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB- 743921 Administered on Days 1 and 15 Every 28 Days without and with Prophylactic G-CSF in Non-Hodgkin or Hodgkin Lymphoma.
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Gerecitano, John, O’Connor, O., Van Deventer, H., Hainsworth, J., Leonard, J., Goy, A., Afanasyev, B., Chen, M., Saikali, K., Conlan, M. G, Escandon, R, and Wolff, A
- Abstract
Background: KSP is a mitotic kinesin essential for cell cycle progression. SB-743921 (SB-921), a selective KSP inhibitor, blocks mitotic spindle assembly with cell cycle arrest in mitosis and cell death. Since neurons lack a mitotic spindle, neurotoxicty, common with anti-tubulins, is not expected. In the first-in-humans (FIH) trial, the maximum tolerated dose (MTD) was 4 mg/m2 q21 days (d), a dose density of 0.2 mg/m2/d. Since neutropenia was the major dose-limiting toxicity (DLT), with nadir at ~d8 and recovery by ~d15, a q14d schedule without (−GCSF) and with prophylactic G-CSF (+GCSF) is being explored in this trial. Methods: In Phase I of this Phase I/II trial, the MTD of SB-921 (−GCSF) and (+GCSF) will be determined. In Phase II, efficacy and safety of the MTD will be further explored. Eligible patients (pts) have relapsed or refractory Hodgkin (HL) or non-Hodgkin (NHL) lymphoma, aggressive (a) or indolent (i), have had at least 1 prior chemotherapy (CT) regimen, and have relapsed after or were not candidates for autologous stem cell transplant. SB-921 is given to cohorts of 3 on d1/d15 q28d, starting at 2 mg/m2 and escalating by 1 mg/m2. Cohorts expand to 6 if 1/3 pts have DLT. Once DLT (−GCSF) is identified, (+GCSF) dosing begins at the (−GCSF) MTD, escalating in 1 mg/m2 increments until (+GCSF) DLT is identified. Results: The (−GCSF) cohort included 39 pts treated at 6 dose levels (2–7 mg/m2) of SB-921. DLT was reported in 4 pts: 2/10 at 6 mg/m2 (both neutropenia with sepsis) and 2/7 at 7 mg/m2 (both Grade 4 neutropenia lasting >5d). MTD (−GCSF) was 6 mg/m2. Ten pts have been treated with SB-921 (+GCSF) at 6 (n=4), 7 (n=3) and 8 (n=3) mg/m2, with no DLT. Enrollment at 9 mg/m2 is ongoing. Among the first 39 pts treated with SB-921 (−GCSF), mean age was 47 yr, 49% were male, histology was 46% HL, 28% aNHL, and 26% iNHL, 67% had ≥3 prior CT regimens. The most common Grade 3/4 adverse event (AE) was neutropenia (42% of pts treated at or above MTD). Other Grade 3/4 AEs were uncommon. No neuropathy or alopecia >Grade 1 was reported. Demographics and AEs in the (+GCSF) cohort are similar with less Grade 3/4 neutropenia. Two partial responses (PRs) have been reported, both in elderly pts with HL, 1 at 6 mg/m2 (−GCSF) after 2 cycles and 1 at 8 mg/m2 (+GCSF) after 2 cycles. Conclusions: The MTD of SB-921 (−GCSF) on a d1/d15 q28d schedule was 6 mg/m2 (dose density = 0.42 mg/m2/d). The current MTD (+GCSF) is ≥8 mg/m2 and dose escalation is continuing. This dose density (0.57 mg/m2/d) is nearly 3-fold higher than observed in the FIH trial with a q21d schedule (0.2 mg/m2/d). SB-921 is well tolerated with few Grade 3/4 AEs other than hematologic. Activity has been observed in HL, with 2 PRs at doses ≥ the (−GCSF) MTD.
- Published
- 2008
- Full Text
- View/download PDF
30. A Phase I/II Trial of the Kinesin Spindle Protein (KSP) Inhibitor SB- 743921 Administered on Days 1 and 15 Every 28 Days without and with Prophylactic G-CSF in Non-Hodgkin or Hodgkin Lymphoma.
- Author
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Gerecitano, John, O'Connor, O., Van Deventer, H., Hainsworth, J., Leonard, J., Goy, A., Afanasyev, B., Chen, M., Saikali, K., Conlan, M. G, Escandon, R, and Wolff, A
- Abstract
Background:KSP is a mitotic kinesin essential for cell cycle progression. SB-743921 (SB-921), a selective KSP inhibitor, blocks mitotic spindle assembly with cell cycle arrest in mitosis and cell death. Since neurons lack a mitotic spindle, neurotoxicty, common with anti-tubulins, is not expected. In the first-in-humans (FIH) trial, the maximum tolerated dose (MTD) was 4 mg/m2q21 days (d), a dose density of 0.2 mg/m2/d. Since neutropenia was the major dose-limiting toxicity (DLT), with nadir at ~d8 and recovery by ~d15, a q14d schedule without (−GCSF) and with prophylactic G-CSF (+GCSF) is being explored in this trial.
- Published
- 2008
- Full Text
- View/download PDF
31. A Phase I-II Study To Determine the Safety, Pharmacokinetics and Potential Efficacy of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 on Days 1 and 15 of a 28 Day Schedule in Patients with Non-Hodgkin’s or Hodgkin’s Lymphoma.
- Author
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O’Connor, Owen A., Goy, A., Orlowski, R.Z., Hainsworth, J., Leonard, J.P., Afanasyev, B., Osmanov, D., Reyno, L.M., Chen, M.M., and Escandon, R.D.
- Abstract
Background: KSP is required for mitotic spindle bipolarity and cell cycle progression. SB-743921 (SB-921) is a selective KSP inhibitor blocking assembly of the mitotic spindle, causing cell cycle arrest in mitosis and subsequent cell death. Neutropenia was the dose-limiting toxicity (DLT) in the first-in-human study of SB-921 and the maximum tolerated dose (MTD) was 4 mg/m2 when given on a Q21 day dosing schedule. Methods: Data from the Phase I portion of this study determining the safety, pharmacokinetics and MTD of SB-921 without prophylactic GCSF in patients (pts) with Non-Hodgkin’s Lymphoma (NHL) or Hodgkin’s Disease (HD) are reported. Pts with relapsed or refractory lymphoma were eligible if they had received at least 1 prior chemotherapy regimen, had relapsed after high-dose therapy with autologous stem cell transplant (ASCT), or were not candidates for ASCT. SB-921 was given in cohorts of 3–6 pts as a 1 hour IV infusion on day 1 and 15 of a Q28 day dosing schedule (cycle). Dosing began at 2 mg/m2 and escalated in 1 mg/m2 increments. Pts without DLT not completing Cycle 1 were replaced. Cohort expansion to 6 pts occurred if 1/3 pts experienced a DLT, defined as any drug-related non-hematologic toxicity ≥ grade 3 or grade 4 neutropenia ≥ 5 days or neutropenic fever/sepsis. Results: Twenty four pts were treated to date, with the highest dose studied being 6 mg/m2. Twenty three patients had > 2 prior regimens and 10 had > 5 prior regimens. The median age was 48 yrs (24–78); Of the 24 patients receiving one dose, 9 pts had HD and 15 had NHL (7 indolent, 8 aggressive); 14 were female, 21 were Caucasian and 3 were African-American. The median number of cycles was 2 (1–9). Two septic DLTs were reported at 6 mg/m2 associated with grade 4 neutropenia. Overall, dose related grade 3 (3 pts) and grade 4 (3 pts) neutropenia was reported in 6 patients. Grade 4 neutropenia resolved in all pts in < 5 days. There was 1 grade 3 and no grade 4 anemia. Two pts had grade 3 thrombocytopenia. Two pts had lymphopenia, 1 grade 3 and the other grade 4. There was 1 report of grade 3 nausea and vomiting but most other non-hematologic adverse events were grade 1–2. There was 1 report each of grade 1 neuropathy and alopecia. A 78 yr old woman with HD in second relapse (after receiving ABVD and ICE) had a partial response at 6 mg/m2 and a 24 year old with small cleaved cell, follicular lymphoma (progressed after R-CHOP chemotherapy, R-ICE and APSCT) initially treated at 3 mg/m2 (subsequently escalated to 5 mg/m2) had stable disease for 9 cycles. Conclusions: These data suggest that SB-921 was well tolerated without prophylactic GCSF in doses < 6 mg/m2 in this Phase I study. The septic DLTs were associated with neutropenia of < 5 days. The cohort at 5 mg/m2 has been expanded and pending data review, dose escalation will continue. A partial response was seen in a patient with refractory HD at 6 mg/m2. Future directions of the study are to try and mitigate the DLT of neutropenia with concurrent growth factor support.
- Published
- 2007
- Full Text
- View/download PDF
32. A Phase I-II Study To Determine the Safety, Pharmacokinetics and Potential Efficacy of the Kinesin Spindle Protein (KSP) Inhibitor SB-743921 on Days 1 and 15 of a 28 Day Schedule in Patients with Non-Hodgkin's or Hodgkin's Lymphoma.
- Author
-
O'Connor, Owen A., Goy, A., Orlowski, R.Z., Hainsworth, J., Leonard, J.P., Afanasyev, B., Osmanov, D., Reyno, L.M., Chen, M.M., and Escandon, R.D.
- Abstract
Background: KSP is required for mitotic spindle bipolarity and cell cycle progression. SB-743921 (SB-921) is a selective KSP inhibitor blocking assembly of the mitotic spindle, causing cell cycle arrest in mitosis and subsequent cell death. Neutropenia was the dose-limiting toxicity (DLT) in the first-in-human study of SB-921 and the maximum tolerated dose (MTD) was 4 mg/m2when given on a Q21 day dosing schedule.
- Published
- 2007
- Full Text
- View/download PDF
33. Safety of Bevacizumab Therapy in Subjects with Brain Metastases due to Non–Small-Cell Lung Cancer (NSCLC)
- Author
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Hainsworth, J., Akerley, W., Oh, Y., Strickland, D.K., Royer-Joo, S., Zhou, X., Xia, Q., and Huang, J.
- Abstract
Bevacizumab in combination with carboplatin/paclitaxel received Food and Drug Administration approval in October 2006 for improving response rates and survival in first-line treatment of patients with advanced non–small-cell lung cancer (NSCLC) without brain metastases. Brain metastases were excluded based on a grade 3 intracerebral hemorrhage from a hepatocellular carcinoma brain metastasis in the original phase I study. Because NSCLC is the most common cause of brain metastases, a large fraction of patients who might benefit from bevacizumab has never been evaluated formally. We report here on the safety of bevacizumab therapy in 24 subjects with NSCLC after local therapy for brain metastases.
- Published
- 2007
- Full Text
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34. P91 Gemcitabine, epirubicin, and docetaxel (GED) asneoadjuvant therapy. Updated results from a multicenter phase II trial in locally advanced breast cancer
- Author
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Yardley, D., Whitworth, P., Greco, F., Dunbar, L., Burris, H., White, M., Melodie, M., Yost, K., and Hainsworth, J.
- Published
- 2005
- Full Text
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35. 7. A novel pretargeting carrier molecule
- Author
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Hainsworth, J. E.S. and Mather, S. J.
- Published
- 2003
36. Paclitaxel, carboplatin and topotecan as initial therapy for small cell lung cancer
- Author
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Hainsworth, J. D., Gray, J. R., Burris, H. A., and Greco, F. A.
- Published
- 2000
- Full Text
- View/download PDF
37. Weekly docetaxel as first-line therapy for elderly patients with advanced non-small cell lung cancer (NSCLC)
- Author
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Hainsworth, J. D., Burris, H. A., Morrissey, L. H., Litchy, S., and Greco, F. A.
- Published
- 2000
- Full Text
- View/download PDF
38. Paclitaxel and carboplatin adjuvant therapy for completely resected non-small cell lung cancer (stage IB-IIIB): A feasibility study of the Minnie Pearl Research Network
- Author
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Greco, F. A., Burris, H. A., Gray, J. R., and Hainsworth, J. D.
- Published
- 2000
- Full Text
- View/download PDF
39. Book Review: Il nome, la persona: saggio sull'etimologia antica.
- Author
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Hainsworth, J. B.
- Published
- 1991
- Full Text
- View/download PDF
40. THE DATE OF DAVID GARRICK'S LINES TO GEORGE LYTTELTON
- Author
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HAINSWORTH, J. D.
- Published
- 1973
- Full Text
- View/download PDF
41. Book Review: Studien zur Odyssee
- Author
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Hainsworth, J. B.
- Published
- 1977
- Full Text
- View/download PDF
42. JAMES TOWNLEY AND THE CLANDESTINE MARRIAGE
- Author
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GOLDSMITH, M A and HAINSWORTH, J D
- Published
- 1978
- Full Text
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43. DAVID GARRICK'S ADDRESS TO THE AUDIENCE ON BEHALF OF THE DRURY LANE THEATRICAL FUND
- Author
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HAINSWORTH, J. D.
- Published
- 1975
- Full Text
- View/download PDF
44. Etoposide phosphate or etoposide with cisplatin in the treatment of small cell lung cancer: randomized Phase II trial
- Author
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Greco, F. A. and Hainsworth, J. D.
- Published
- 1995
- Full Text
- View/download PDF
45. Soil Water Extraction, Measured by Computer-Assisted Tomography, in Seedling Lupinus angustifolius cv. Yandee when Healthy and Infected with Phytophthora cinnamomi
- Author
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GROSE, M. J. and HAINSWORTH, J. M.
- Abstract
The water-mould fungus Phytophthora cinnamomi Rands causes drought-like symptoms on many hosts, and yet the mechanisms by which infection leads to wilting are not fully understood. This is the first study to describe in detail changes in soil water around the root with infection. Computer-assisted tomography (CAT) was used with Lupinus angustifolius L. cv. Yandee to examine drawdowns (removal of soil water) around a central root infected by P. cinnamomi in a white sand. No growth differences in roots or shoots were found between healthy and diseased plants during the 8 d of the experiment.However, drawdowns failed at high levels of inoculum (8–16 /Pc-infected millet seeds/plant) by 8 d. Water contents in pots with uninfected plants were in the range 0·09–0·12 cm3 water cm−3 soil in the centre of the pot, while water contents in pots with infected plants at 16 millet seeds applied were in the range of 0·16–0·19 cm3 water cm−3 soil in the centre of the pot. A higher transpirational demand produced lower soil water contents near the root but this effect was confounded with infection: disease was more pronounced with higher transpirational demand, and disease led to an increase in water content.
- Published
- 1992
- Full Text
- View/download PDF
46. Book Review: Schweigen-Verschweigen-Übergehen: die Darstellung des Unausgesprochenen in der Odyssee
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Hainsworth, J. B.
- Published
- 1968
- Full Text
- View/download PDF
47. THE DATE OF DAVID GARRICK'S LINES TO GEORGE LYTTELTON
- Author
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HAINSWORTH, J D
- Published
- 1973
- Full Text
- View/download PDF
48. Book Review: Die Stellung des 24. Buches der Ilias in der alten Epentradition
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Hainsworth, J. B.
- Published
- 1966
- Full Text
- View/download PDF
49. Book Review: Il poema di Ulisse
- Author
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Hainsworth, J. B.
- Published
- 1956
- Full Text
- View/download PDF
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