Search

According to a preprint abstract from biorxiv.org, researchers have studied the expression of Hox genes in the sea urchin Strongylocentrotus intermedius during early larval stages. They found that at the blastula stage, only certain Hox genes were expressed, while at the gastrula and prism stages, the expression of Hox genes was lower. However, there was a significant increase in the expression of all Hox genes in the 4-day and 9-day pluteus stages. The researchers suggest that the breakage of sequential Hox expression in echinoderms may be due to the loss of metameric gill slits, which are a characteristic feature of deuterostomes. This research has not yet undergone peer review. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have found that the E3 ubiquitin ligase RNF220 plays a role in maintaining the expression patterns of Hox genes in the hindbrain. The study showed that the expression of Hox genes in the pons was up-regulated in mouse embryos lacking RNF220. The disruption of the Hox pattern in the pontine nuclei of these mice also affected neural circuits. The researchers discovered that this phenomenon was regulated by WDR5, a component of the TrxG complex, which can be degraded by RNF220. The study suggests a new role for RNF220/WDR5 in Hox pattern maintenance and pons development. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

Daiichi Sankyo Company Limited has been granted a patent for a cycloalkane-1,3-diamine derivative, a compound used in the treatment of acute myelogenous leukemia (AML) or acute lymphocytic leukemia (ALL). The patent explains the need for a low-molecular compound that can inhibit the interaction between menin and an MLL protein. It also includes claims for a pharmaceutical composition containing the compound and a selection of drugs for treating or preventing diseases dependent on this interaction. The patent provides comprehensive information about the compound's structure, its various forms, and its use in pharmaceutical compositions, including its combination with other drugs like Venetoclax, a DNA methyltransferase inhibitor, or a pyrimidine antimetabolite. [Extracted from the article]

A biologist at West Virginia University is studying the genes that contribute to whole body regeneration in animals. Christopher Arnold, an assistant professor of biology, aims to understand how genes involved in establishing animal body plans also play a role in regenerative abilities. This research could provide insights into human development and disease, leading to a better understanding of tissue regeneration and potential improvements in human health. Arnold's work focuses on planaria, a type of flatworm that can regenerate its entire body, and has found that Hox genes are required for both asexual reproduction and aspects of body plan preservation necessary for whole body regeneration. [Extracted from the article]

A study conducted in Maharashtra, India, examined the prognostic significance of two immunohistochemistry markers, Caudal-type Homeobox Gene 2 (CDX2) and Sex-determining Region Y-Box 2 (SOX2), in gastric cancer. The researchers found that CDX2 positivity and SOX2 negativity were associated with advanced stages of the disease. Additionally, the CDX2+/SOX2- profile was correlated with poor prognosis. The study suggests that further research should be conducted to explore targeted therapy options based on these markers. [Extracted from the article]

A recent study from Braunschweig, Germany has provided new insights into leukemia, specifically B-cell precursor acute lymphoid leukemia (BCP-ALL). The study focused on the regulatory connections between specific transcription factors (TFs) in pro-B- and pre-B-cells, which are important in early B-cell development. The researchers identified nine TFs involved in early B-cell development, including HLX, MSX1, IRX1, MEIS1, ETS2, ERG, SPIB, EOMES, and TBX21, and determined their activating, inhibitory, or absent connections. Additionally, the study found subtype-specific copy number alterations of the ERG gene and a deletion of the TGFbeta-receptor gene TGFBR2, which resulted in an upregulation of EOMES. The findings contribute to a better understanding of BCP-ALL subtypes and gene regulatory networks controlling early B-cell differentiation. [Extracted from the article]

A new report from Shiraz University of Medical Sciences in Iran presents fresh data on extracellular matrix proteins. The research explores the limited self-repair capacity of articular cartilage and the potential of mesenchymal stem/stromal cells (MSCs) for tissue regeneration. The study compares dental pulp stem cells (DPSCs) with a Hox-negative expression pattern to bone marrow mesenchymal stromal cells (BMSCs) that actively express Hox genes. The results suggest that DPSCs may have higher plasticity and could be considered compelling candidates for future cartilage cell therapy. [Extracted from the article]

This article discusses a study that compares the role of a gene called RPGRIP1L in the development of the spinal cord in humans and mice. RPGRIP1L is associated with severe neurodevelopmental disorders. The study found that mutant mice lacking RPGRIP1L showed a loss of motoneurons and reduced signaling in the Sonic Hedgehog pathway, while mutant human cells did not display these effects. Instead, the human mutant cells showed a defect in anteroposterior specification, resulting in motoneurons acquiring a more anterior identity. The study highlights the distinct functions of ciliopathy proteins in humans and mice and provides insights into the role of cilia in human spinal cord development and neurodevelopmental disorders. [Extracted from the article]

A study conducted at Saveetha University in Tamil Nadu, India, explored the role of two genes, FOXC2 and PROX-1, in oral squamous cell carcinoma (OSCC). The researchers found that FOXC2 acts as an inducer of epithelial-mesenchymal transition (EMT), while PROX-1 functions as a regulator of lymphangiogenesis and angiogenesis. The study analyzed the mRNA expression and protein levels of FOXC2 and PROX-1 in OSCC tissues and found a significant increase in FOXC2 expression and a decrease in PROX-1 expression compared to tumor-free margins. FOXC2 expression correlated with clinicopathological parameters such as staging, perineural invasion, and lymphovascular invasion, while PROX-1 showed a negative correlation with these parameters. The researchers concluded that FOXC2 and PROX-1 could be potential therapeutic targets for OSCC treatment. [Extracted from the article]

A recent report from Johns Hopkins University discusses research on bone regeneration in the craniofacial bones. The study focuses on a specific population of cells called suture mesenchymal progenitors, which have a gene expression profile associated with tendons and ligaments. The researchers developed a mouse model to track these cells and found that they give rise to osteoblasts and osteocytes during normal bone maintenance. The study also revealed that a gene called Mohawk homeobox (Mkx) plays a critical role in inhibiting osteogenic differentiation in these cells, and mechanical stretch regulates its expression. This research provides new insights into the mechanisms of bone repair and could have implications for future treatments. [Extracted from the article]

A recent study conducted by the Van Andel Institute explores the role of DNA methylation in solid cancer. The researchers found that DNA methylation plays a crucial role in defining cancer phenotypes, with global hypomethylation and focal hypermethylation observed in tumors. The study focused on homeobox genes and their relationship to cancer, identifying two homeobox genes, HOXA3 and HOXD10, that are hypermethylated in all 16 cancer types analyzed. The research suggests that these genes could serve as potential biomarkers for cancer screening in the future. Overall, the study provides valuable insights into the unique patterns of DNA methylation in different tumor types and expands our understanding of the interplay between homeobox genes and oncogenesis. [Extracted from the article]

A recent study investigated the activity of the CIC::DUX4 fusion oncoprotein, which is associated with an aggressive form of undifferentiated round cell sarcoma. The study found that most CIC::DUX4 fusions retain the C1 domain, which contributes to DNA binding. Deletion or mutation of the C1 domain reduces the activation of CIC target genes by CIC::DUX4. The study suggests that the C1 domain plays a supercharging role in the activity of CIC::DUX4. However, it should be noted that this preprint has not yet undergone peer review. [Extracted from the article]

According to a preprint abstract, mutations in the microRNA processing genes DICER1 and DROSHA are linked to several cancers resembling embryonic progenitors. To understand how microRNAs regulate tumorigenesis, researchers ablated Drosha or Dicer1 in the developing pineal gland to mimic the pathogenesis of pineoblastoma, a brain tumor resembling undifferentiated precursors of the pineal gland. The study found that tumors driven by loss of microRNA processing can be targeted therapeutically by inhibiting downstream drivers of proliferation. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A study conducted at Washington State University examined the role of the Rhox8 gene in male fertility. The researchers used the CRISPR/Cas9 system to generate Rhox8 knockout mice and found that these mice had low fecundity, disrupted spermatogenic cycles, increased germ cell apoptosis, and reduced sperm count and motility. The study concluded that while Rhox8 is not essential for sex determination and embryonic testis differentiation, it plays an important role in complete spermatogenesis and optimal male fertility. This research provides new insights into the biology of reproduction and may have implications for understanding male infertility in humans. [Extracted from the article]

A patent has been issued to Kura Oncology Inc. for methods of treating hematological malignancies and Ewing's sarcoma. The patent describes the use of a menin inhibitor to block the protein-protein interaction between menin and MLL proteins, which play a role in the development of these diseases. The methods outlined in the patent may be useful for treating diseases dependent on the activity of menin, MLL1, and/or MLL2. The patent provides specific methods for treating acute myeloid leukemia and acute lymphoblastic leukemia by screening for certain genetic abnormalities and administering a menin inhibitor if present. [Extracted from the article]

A recent study conducted by researchers at Louisiana State University System has identified a chondrocyte-specific enhancer in the Hoxc8 gene, which plays a crucial role in the development and differentiation of cells in cartilage. The researchers found that this enhancer is distinct from previously identified regulatory sequences in the gene and allows for targeted investigations into the expression and function of Hox transcription factors in differentiating cell types and adult tissues. This discovery has potential implications for repair processes and regeneration in the future. The study was funded by the Mayo Foundation for Medical Education and Research and the Pennington Biomedical Research Center. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of the N6-methyladenosine (m6A) epitranscriptomic modification in neuroblastoma (NB), a common childhood cancer. The study explores how the m6A modification regulates gene expression in developing trunk neural crest cells (tNCC) and contributes to their differentiation into sympathetic neurons. The researchers also found that overexpression of the MYCN oncogene in tNCC leads to the recruitment of the METTL3 methyltransferase complex to specific genes, resulting in an undifferentiated state. Inhibition of METTL3 in MYCN-amplified patient-derived xenografts (PDX) cells induces DNA damage, differentiation, and increased vulnerability to chemotherapeutic drugs, suggesting that METTL3 inhibition could be a potential therapeutic approach for NB. [Extracted from the article]

A recent report from Goethe-University Frankfurt in Germany discusses a rare anatomical defect called foramina parietalia permagna (FPP), which affects the parietal bones of the human skull. FPP is characterized by large symmetric perforations on either side of the skull, caused by insufficient ossification during embryogenesis. While FPP is usually asymptomatic, it can be accompanied by neurological or vascular conditions in some cases. The diagnosis of FPP is typically determined through clinical findings and diagnostic imaging. This research provides a case report and a review of current literature on FPP. [Extracted from the article]

A recent study conducted in Braunschweig, Germany, has investigated the role of homeobox genes in blastic plasmacytoid dendritic cell neoplasm (BPDCN), a type of cancer. The researchers found that the homeobox gene CUX2 is specifically expressed in plasmacytoid dendritic cells (pDCs), while the gene ONECUT2 is aberrantly expressed in BPDCN patients. The study also revealed the regulatory mechanisms and oncogenic activity of ONECUT2. These findings may contribute to the diagnosis of BPDCN and the identification of potential therapeutic targets. [Extracted from the article]

A study conducted at Guizhou Province People's Hospital in China explores the role of homeobox (HOX) genes in cardiovascular biology and atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition in the arterial wall, leading to various cardiovascular problems. The study highlights the importance of understanding the molecular landscape of atherosclerosis and the potential breakthroughs that could arise from further investigation of HOX genes. However, the translation of this research into targeted therapies remains a significant challenge. This research has been peer-reviewed and provides valuable insights into the field of cardiovascular biology. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of the Obox4 gene in zygotic genome activation (ZGA) in mouse embryos. ZGA is a process in which certain retroviruses are activated by a transcription factor called DUX. However, the study found that embryos lacking the Dux gene can still produce fertile mice, suggesting that other factors are involved in ZGA. The researchers identified the Obox4 gene as a transcription factor that is highly expressed in mouse embryos and redundantly drives ZGA. Depletion of Obox4 alone is tolerated by embryogenesis, but when combined with Dux depletion, it significantly compromises embryonic development. This research provides insights into the genetic mechanisms underlying pre-implantation development. [Extracted from the article]

A recent preprint abstract discusses the expression of Hox genes in the annelid species Streblospio benedicti. Hox genes are responsible for determining cell positional identity in the body plan of different organisms. The study compares the expression of eleven Hox genes in two distinct larval types of Streblospio benedicti and finds that while the patterning is generally similar, there are spatial and temporal differences associated with morphological and life-history variations. This research provides insights into how body plan differences can arise during larval evolution. Please note that this preprint has not yet undergone peer review. [Extracted from the article]

According to a preprint abstract, researchers have discovered that the E3 ubiquitin ligase RNF220 plays a role in maintaining the expression patterns of Hox genes in the hindbrain. The expression of Hox genes in the pons was found to be up-regulated in mouse embryos lacking RNF220, leading to disrupted Hox patterns and affected neural circuits. The researchers also identified WDR5 as a key component involved in this process, which can be degraded by RNF220. These findings suggest a new role for RNF220/WDR5 in Hox pattern maintenance and pons development. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

A recent study conducted by researchers at New York University NYU School of Medicine explores the role of Hox genes in spinal cord development. The study focuses on the subtype diversification of spinal motor neurons and how Hox genes contribute to their differentiation. The research reveals insights into the mechanisms of gene regulation and patterning in vertebrates, shedding light on the development of terminal fates in other systems. The study has been peer-reviewed and published in Seminars in Cell and Developmental Biology. For more information, readers can contact Alexander Miller at New York University NYU School of Medicine. [Extracted from the article]

A recent report from the University of Rome Tor Vergata discusses research findings on the role of OTX homeobox genes in development and their expression in adult tissues. The study suggests that the reactivation of OTX genes in adult tissues indicates an evolutionary amplification of gene functions, with these genes potentially playing a role in various physiological and pathological processes. The researchers propose that OTX genes could serve as diagnostic and prognostic markers, as well as potential therapeutic targets. Further information on this research can be found in the International Journal of Molecular Sciences. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have identified molecular subdomains in the excitatory neurons of the cerebellar nuclei (eCNm) using single-cell RNA sequencing and spatial expression analysis. These subdomains develop during embryogenesis and resemble the adult subdomains. The study also found that the homeobox genes En1 and En2 are important for the survival and differentiation of these neurons, and their mutation leads to cell death and reduced gene expression. This research provides insights into the molecular diversity of embryonic eCNm and the role of En1/2 in the development of cerebellar excitatory neurons. Please note that this preprint has not yet undergone peer review. [Extracted from the article]

A new report from Thompson Rivers University provides fresh data on gliomas, which are malignant brain tumors. The researchers aimed to identify a predictive signature of outcome in IDH-mutant gliomas by conducting an integrative molecular analysis. They found that hypermethylation and overexpression of HOX genes were poor prognosticators in IDH-mutant glioma. The study suggests that HOX gene methylation and expression could provide important prognostic information that is not captured by current molecular diagnostics. [Extracted from the article]

The Caenorhabditis elegans Hox gene set is not clustered and contains only six Hox genes from four of the ancestral groups. "While the archetypical Hox gene cluster consists of members of nine ortholog groups (HOX1-HOX9), arrayed in close linkage in the order in which they have their anterior-posterior patterning effects, nematode Hox gene sets do not fit this model. [Extracted from the article]

Keywords: Cancer; Health and Medicine; Oncology EN Cancer Health and Medicine Oncology 119 119 1 10/16/23 20231017 NES 231017 2023 OCT 17 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on cancer are presented in a new report. Keywords for this news article include: Affiliated Hospital of Weifang Medical University, Shandong, People's Republic of China, Asia, Cancer, Oncology, Health and Medicine. [Extracted from the article]

According to the news reporters, the research concluded: "This review showed that HOXD10 may be a tumor suppressor gene and a new cancer treatment target signaling pathway." Keywords: Tamil Nadu; India; Asia; Bioengineering; Biotechnology; Cancer; Drugs and Therapies; Gene Therapy; Genetics; Health and Medicine; Oncology EN Tamil Nadu India Asia Bioengineering Biotechnology Cancer Drugs and Therapies Gene Therapy Genetics Health and Medicine Oncology 742 742 1 10/03/23 20231006 NES 231006 2023 OCT 3 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Biotechnology - Gene Therapy. [Extracted from the article]

Studies the role of homeobox genes in embryonic development. Features of early development; Determination of the embryo's anteroposterior axis; Amino acid sequences of homeobox gene; Mechanism under which the homeobox genes orchestrate cell differentiation during development; Patterns of homeobox gene expression; Specification of the identities and fates of embryonic cells.

Discusses the role of homeobox genes in the development of embryo. Translation of the homeobox into a protein yielding a stretch of amino acids; Binding of the amino acids to the DNA double helix; Genes controlling the timing of events in embryogenesis; Structure of homeobox genes.

Keywords: Alcohol Oxidoreductases; Carboxylic Acids; Citrates; Dehydrogenase; Enzymes and Coenzymes; Genetics; Gliomas; Health and Medicine; Isocitrate Dehydrogenase; Isocitrates; Oncology; Organic Chemicals EN Alcohol Oxidoreductases Carboxylic Acids Citrates Dehydrogenase Enzymes and Coenzymes Genetics Gliomas Health and Medicine Isocitrate Dehydrogenase Isocitrates Oncology Organic Chemicals 1343 1343 1 09/19/23 20230919 NES 230919 2023 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on gliomas. For more information on this research see: Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in isocitrate dehydrogenase mutant glioma. [Extracted from the article]

Keywords: New York City; State:New York; United States; North and Central America; Genetics; Stem Cell Research EN New York City State:New York United States North and Central America Genetics Stem Cell Research 133 133 1 09/11/23 20230911 NES 230911 2023 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Data detailed on Stem Cell Research have been presented. Keywords for this news article include: New York City, New York, United States, North and Central America, Genetics, Stem Cell Research, New York University (NYU). [Extracted from the article]

Biomarkers, Bladder Cancer, Cancer, Diagnostics and Screening, Genetics, Health and Medicine, Oncology, Prognostic Markers Keywords: Biomarkers; Bladder Cancer; Cancer; Diagnostics and Screening; Genetics; Health and Medicine; Oncology; Prognostic Markers EN Biomarkers Bladder Cancer Cancer Diagnostics and Screening Genetics Health and Medicine Oncology Prognostic Markers 442 442 1 08/28/23 20230829 NES 230829 2023 AUG 29 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on bladder cancer are presented in a new report. [Extracted from the article]

Keywords: Bone Marrow; Bone Research; Gender Health; Gender and Health; Health and Medicine; Women's Health EN Bone Marrow Bone Research Gender Health Gender and Health Health and Medicine Women's Health 471 471 1 08/14/23 20230817 NES 230817 2023 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Researchers detail new data in bone marrow. In this study, we compared the biological properties of vBMA clots and derived vertebral mesenchymal stem cells (MSCs) from female and male patients undergoing spinal fusion procedures and treated with vBMA clot. [Extracted from the article]

Algorithms, Genetics, Gliomas, Health and Medicine, Oncology, Pediatrics Keywords: Algorithms; Genetics; Gliomas; Health and Medicine; Oncology; Pediatrics EN Algorithms Genetics Gliomas Health and Medicine Oncology Pediatrics 1298 1298 1 08/07/23 20230811 NES 230811 2023 AUG 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New study results on gliomas have been published. [Extracted from the article]

Keywords: Asia; Cancer; Carcinomas; China; Genetics; Health and Medicine; Oncology; Squamous Cell Carcinoma EN Asia Cancer Carcinomas China Genetics Health and Medicine Oncology Squamous Cell Carcinoma 1100 1100 1 07/17/23 20230718 NES 230718 2023 JUL 18 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on squamous cell carcinoma have been published. Funders for this research include Natural Science Foundation of Gansu Province of China; Natural Science Foundation of Fujian Province of China. Asia, Cancer, Carcinomas, China, Genetics, Health and Medicine, Oncology, Squamous Cell Carcinoma. [Extracted from the article]

Basal Ganglia Diseases and Conditions, Brain Diseases and Conditions, Cells, Central Nervous System Diseases and Conditions, Genetics, Health and Medicine, Movement Disorders, Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Neurons, Parkinson's Disease, Parkinsonian Disorders Keywords: Basal Ganglia Diseases and Conditions; Brain Diseases and Conditions; Cells; Central Nervous System Diseases and Conditions; Genetics; Health and Medicine; Movement Disorders; Nervous System Diseases and Conditions; Neurodegenerative Diseases and Conditions; Neurons; Parkinson's Disease; Parkinsonian Disorders EN Basal Ganglia Diseases and Conditions Brain Diseases and Conditions Cells Central Nervous System Diseases and Conditions Genetics Health and Medicine Movement Disorders Nervous System Diseases and Conditions Neurodegenerative Diseases and Conditions Neurons Parkinson's Disease Parkinsonian Disorders 1441 1441 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on Parkinson's disease is the subject of a new report. [Extracted from the article]

Keywords: Cadherins; Cell Adhesion Molecules; Cell Research; Genetics; Glycoproteins; Membrane Proteins EN Cadherins Cell Adhesion Molecules Cell Research Genetics Glycoproteins Membrane Proteins 393 393 1 06/12/23 20230615 NES 230615 2023 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- New research on cell adhesion molecules is the subject of a new report. CDH11 promoted chondrocyte proliferation by increasing S-phase cell numbers and increasing cell migration, which is important for tissue morphogenesis. Cadherins, Cell Adhesion Molecules, Cell Research, Genetics, Glycoproteins, Membrane Proteins. [Extracted from the article]

Alphavirus, Cells, Chikungunya Virus, Neurons, RNA Viruses, Risk and Prevention, Togaviridae, Viral, Virology Keywords: Alphavirus; Cells; Chikungunya Virus; Neurons; RNA Viruses; Risk and Prevention; Togaviridae; Viral; Virology EN Alphavirus Cells Chikungunya Virus Neurons RNA Viruses Risk and Prevention Togaviridae Viral Virology 1141 1141 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Chikungunya virus. [Extracted from the article]

Our news editors report that more information may be obtained by contacting Claudia Correia, Pediatrics Unit, Centro Hospitalar e Universitario do Porto - Centro Materno-Infanil do Norte, Porto, Portugal. Keywords: Health and Medicine; Pediatrics EN Health and Medicine Pediatrics 162 162 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on pediatrics have been published. Keywords for this news article include: Centro Hospitalar e Universitario do Porto, Porto, Portugal, Europe, Pediatrics, Health and Medicine. [Extracted from the article]

Keywords for this news article include: Jilin University, Changchun, People's Republic of China, Asia, Life Sciences, Molecular Bioscience. Keywords: Life Sciences; Molecular Bioscience EN Life Sciences Molecular Bioscience 959 959 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on molecular bioscience. [Extracted from the article]