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A recent study conducted at Dalian Medical University in China explored the role of the protein KIF15 in promoting the progression of glioblastoma, a highly invasive and lethal form of brain cancer. The researchers found that KIF15 was up-regulated in glioblastoma patients and contributed to cell proliferation, metastasis, and cell cycle progression. The study suggests that targeting the P300/REST/KIF15 signaling axis could be a potential therapeutic strategy for treating glioblastoma. For more information, the full article can be accessed in the International Journal of Biological Sciences. [Extracted from the article]

Researchers from the Catholic University of the Sacred Heart in Rome, Italy, have conducted a study on targeting CBP and p300 as emerging anticancer agents. These transcriptional co-activators play crucial roles in various signaling pathways, including Wnt/b-catenin, p53, and HIF-1a, influencing cellular processes such as proliferation, differentiation, and apoptosis. The study focuses on developing small molecules to inhibit the interaction between b-catenin and CBP/p300, which are involved in tumor cell proliferation, migration, and invasion, with potential therapeutic implications for cancer treatment. The research aims to provide a detailed overview of recent approaches in cancer therapy that selectively target CBP and p300, particularly in Wnt/b-catenin-driven oncogenesis. [Extracted from the article]

The article discusses the role of the histone acetyltransferase CBP in zygotic genome activation, particularly in relation to the pioneer transcription factor Zelda in Drosophila. It highlights the catalytic-dependent and independent functions of CBP in promoting zygotic transcription and embryonic development. The research suggests that CBP plays a crucial role in activating zygotic transcription, separate from the chromatin restructuring function of pioneer factors like Zelda. The study emphasizes the conserved mechanism of pioneer factor-mediated recruitment of CBP for zygotic genome activation. [Extracted from the article]

A recent report discusses research on gastric cancer and the potential link between plasma histone-modifying enzymes and the disease. The study used Mendelian randomization analysis to identify new therapeutic targets and biomarkers for gastric cancer. The findings suggest that the plasma histone methyltransferase complex subunit ASH2L is positively associated with gastric cancer risk, while the histone-lysine N-methyltransferase SETMAR is negatively associated. Additionally, the study found that the expression of plasma histone acetyltransferase KAT6A is negatively correlated with gastric cancer incidence. These enzymes could potentially serve as biomarkers and therapeutic targets for managing gastric cancer. [Extracted from the article]

A recent report from the University Health Network discusses new research on acute myeloid leukemia (AML). The study focuses on leukemia stem cells (LSCs), which are responsible for driving disease relapse in AML. The researchers used mass spectrometry-based metabolomics analysis to identify differences in metabolites between LSCs and normal hematopoietic stem and progenitor cells (HSPCs). They found that spermidine, a type of organic chemical, was highly enriched in LSCs compared to HSPCs. By reducing spermidine concentrations, the researchers were able to decrease LSC function without affecting normal HSPCs. The study also identified a histone acetyltransferase called KAT7 that is down-regulated by spermidine depletion and plays a role in targeting AML clonogenic potential. This research provides insights into the metabolic vulnerabilities of LSCs and may lead to the development of new therapeutic strategies for AML. [Extracted from the article]

A recent study conducted by researchers at NOVA Southeastern University in Florida has found that excessive fluoride ingestion during tooth development can lead to dental fluorosis. The study focused on the effects of fluoride on gene expression in ameloblast-like LS8 cells. The researchers discovered that fluoride alters gene expression through histone acetylation, specifically H3K27 acetylation. This is the first study to demonstrate the epigenetic regulation of fluoride treatment through H3 acetylation. Further research is needed to fully understand the mechanisms of fluoride toxicity in enamel development. [Extracted from the article]

A recent report from researchers at the Indian Institute of Technology Guwahati highlights the complex nature of breast cancer, which is a leading cause of mortality in women. The report focuses on the role of epigenetic modifications, such as DNA methylation and histone alterations, in breast cancer initiation and progression. It also discusses the potential of epi-drugs, including DNA modifying agents and histone inhibitors, for breast cancer treatment. The researchers emphasize the need for combination therapy using epi-drugs and highlight future challenges in this field. [Extracted from the article]

A patent application has been filed for a method of modulating gene expression using CRISPR/Cas9-based repressors. The method involves administering a fusion molecule or a nucleic acid encoding the fusion molecule, which consists of a dCas9 molecule fused to a modulator of gene expression, along with a gRNA that targets the fusion molecule to the gene of interest. The fusion molecule and gRNA can be packaged in a viral vector for delivery. This technology has the potential to advance gene therapies and biomedical research. [Extracted from the article]

A recent study conducted at Soochow University in Jiangsu, China, has found that the gene KAT7 plays an oncogenic role in osteosarcoma, a type of bone cancer commonly found in children. The study revealed that KAT7 is upregulated in osteosarcoma cells, leading to increased cell proliferation and metastasis. Additionally, the researchers discovered a correlation between KAT7 and adaptive immune responses, with CCL3 identified as a downstream target of KAT7. The findings highlight the potential of targeting KAT7 for the treatment of osteosarcoma. [Extracted from the article]

A recent study conducted by researchers at Zagazig University in Egypt explores the potential of chitosan, a substance derived from the shells of crustaceans, to mitigate resistance to the antifungal drug caspofungin in Candida species. The study found that chitosan treatment decreased the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of caspofungin, indicating enhanced efficacy against caspofungin-resistant Candida isolates. Transmission electron microscope (TEM) analysis revealed that chitosan disrupted the integrity of the cell surface and caused changes in cell wall thickness. The study suggests that chitosan could be used in combination with caspofungin for the treatment of candidiasis. [Extracted from the article]

A report from Pfizer discusses the potential of histone lysine acetyltransferase inhibitors as a new class of drugs for cancer therapy. Lysine acetyltransferases (KATs) are enzymes involved in gene expression regulation and have been identified as promising drug targets due to their dysregulation in cancer. Recent advances have led to the development of potent and selective KAT inhibitors, and new chemically induced proximity approaches offer unique target selectivity profiles. Clinical data for certain KAT inhibitors indicate their promise in cancer therapeutics. This research has been peer-reviewed and provides valuable insights into the development of drugs for cancer treatment. [Extracted from the article]

A recent preprint abstract discusses a study on the regulation of tumorigenesis through the Hippo pathway. The study focuses on VGLL and TEAD fusion proteins, which have been found to drive transcription and tumorigenesis independently of the YAP/TAZ proteins. The researchers identified two recurrent fusions, VGLL2-NCOA2 and TEAD1-NCOA2, in spindle cell rhabdomyosarcoma. They found that these fusion proteins activate TEAD-dependent transcription and engage specific epigenetic regulation by recruiting the histone acetyltransferase p300. The study suggests that inhibiting p300 could potentially suppress the oncogenic transformation induced by these fusion proteins. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Researchers from Tulane University School of Medicine have made advances in understanding cholangiocarcinoma, a highly malignant cancer of the biliary tract. The study focused on the histone lysine acetyltransferase KAT2B, which was found to be frequently downregulated in human cholangiocarcinoma. Overexpression of KAT2B suppressed cancer cell growth and enhanced the expression of the tumor suppressor gene NF2, leading to inhibition of oncogenic YAP activity. These findings suggest that targeting the NF2-YAP signaling pathway may be a potential therapeutic strategy for cholangiocarcinoma treatment. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential role of ACSS2, an enzyme involved in histone acetylation and gene regulation, in protecting neurons against neurodegenerative diseases and age-related cognitive decline. The study found that increasing ACSS2 levels in mice improved memory and mitigated tau-induced transcriptional alterations. The researchers suggest that targeting ACSS2 could be a promising therapeutic approach for enhancing brain resilience and function in neurodegenerative diseases. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A study conducted at Sichuan University in Chengdu, China, has found that novel berberine derivatives can inhibit the activity of the p300 histone acetyltransferase (HAT) enzyme, which is closely related to breast cancer. The researchers designed and synthesized a series of berberine derivatives and found that one compound, 7b, exhibited inhibitory potency against p300 HAT. Further evaluation showed that combining compound 7b with the drug doxorubicin significantly inhibited tumor growth and invasion in vitro and in vivo. This research provides potential new avenues for the treatment of breast cancer. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential therapeutic value of a p300 histone acetyltransferase (HAT) inhibitor, A-485, in the treatment of hyperpigmentation disorders. The study found that A-485 treatment reduced the expression of genes involved in melanin synthesis and resulted in a reduction in melanin content in human melanocytes and melanoma cells. These findings suggest that epigenetically targeting melanin synthesis with A-485 may be beneficial for the treatment of hyperpigmentation disorders. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of the microRNA miR-203 in regulating the timing of developmental transitions during early preimplantation embryogenesis in mice. The study found that loss of miR-203 delays developmental timing, leading to the accumulation of delayed embryos with high expression of totipotency-associated markers. The lack of miR-203 also resulted in sustained expression of retroviral elements and reduced expression of Sox2, a pluripotency marker. The study suggests that miR-203 fine-tunes the levels of the coactivator P300, which is involved in epigenetic rewiring during the developmental transition. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the potential role of nobiletin, a natural compound, in preventing and treating heart failure. The study found that nobiletin enhanced the desuccinylase activity of SIRT5, a protein, and prevented heart failure in mice. The researchers suggest that nobiletin may inhibit the activity of p300, an enzyme involved in heart hypertrophy, through its interaction with SIRT5. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of histone deacetylase 10 (HDAC10) in regulating the expression of Secreted Protein Acidic and Rich in Cysteine (SPARC), a glycoprotein important for various biological processes. The study found that depletion or inhibition of HDAC10 leads to an increase in SPARC expression, while overexpression of HDAC10 decreases SPARC expression. Mechanistically, HDAC10 interacts with histone acetyltransferase p300 to modulate the acetylation state of histone H3 lysine 27 (H3K27ac) at SPARC regulatory elements, affecting SPARC transcription. Depletion of HDAC10 and subsequent upregulation of SPARC represses melanoma cell growth and enhances sensitivity to a BRAF inhibitor. The study suggests that targeting HDAC10 and SPARC could be a potential therapeutic strategy for melanoma and other cancers. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Keywords: Acetyltransferases; Acyltransferases; Cadherins; Cancer; Cell Adhesion Molecules; Cell Proliferation; Cell Research; Cervical Cancer; Drugs and Therapies; Enzymes and Coenzymes; Genetics; Glycoproteins; Health and Medicine; Histone Acetyltransferases; Histones; Membrane Proteins; Nucleoproteins; Oncology; Proteins; Women's Health EN Acetyltransferases Acyltransferases Cadherins Cancer Cell Adhesion Molecules Cell Proliferation Cell Research Cervical Cancer Drugs and Therapies Enzymes and Coenzymes Genetics Glycoproteins Health and Medicine Histone Acetyltransferases Histones Membrane Proteins Nucleoproteins Oncology Proteins Women's Health 1325 1325 1 11/06/23 20231110 NES 231110 2023 NOV 7 (NewsRx) -- By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on cervical cancer have been presented. According to the news reporters, the research concluded: "This study demonstrates that the histone acetyltransferase CSRP2BP promotes cervical cancer metastasis partially through increasing the EMT and suggests that CSRP2BP could be a prognostic marker and a potential therapeutic target for combating cervical cancer metastasis.". [Extracted from the article]

Histone acetyltransferase (HAT) is known as an epigenetic enzyme that acetylates specific lysine residues on the histone tail to promote chromatin dynamics and gene expression. In higher plants, HATs have been recognized as playing a fundamental role in plant development, growth, and the response to diverse environmental stresses. In this study, using comprehensive bioinformatic analyses, we identified 15 HATs in genome of chinese cabbage [Brassica rapa (BraHATs)], which are divided into four families. In addition, evolution analysis suggested that the BraHAT genes were duplicated mainly via a segmental duplication event originating 3.05-18.39 million years ago. To determine the effects of abiotic stresses, such as salt, wounding, and drought, on histone H3 acetylation in chinese cabbage, histone H3 acetylation was analyzed via immunoblot analysis, suggesting that the acetylation level of histone H3 increased in response to wounding and salt stresses. Furthermore, the analysis of BraHAT expression patterns using quantitative real-time polymerase chain reaction (qRT-PCR) suggested that the increased acetylation of histone H3 was related to BraHAT transcripts and/or the functional interplay between HAT and histone deacetylase (HDAC) activities. Taken together, our comparative genomic analysis of HAT genes in this important vegetable crop will provide a solid foundation to further our understanding of epigenetically regulated processes in response to environmental stresses. [ABSTRACT FROM AUTHOR]

Two different knockdown plasmids targeting P300 and A-485 (a specific inhibitor of P300) were used to investigate the function of P300 in the ferroptosis of human aortic smooth muscle cells (HASMCs). Keywords: Hubei; People's Republic of China; Asia; Acetyltransferases; Acyltransferases; Enzymes and Coenzymes; Histone Acetyltransferases; Histones; Muscle Cells; Nucleoproteins; Proteins EN Hubei People's Republic of China Asia Acetyltransferases Acyltransferases Enzymes and Coenzymes Histone Acetyltransferases Histones Muscle Cells Nucleoproteins Proteins 1265 1265 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Proteins - Nucleoproteins is now available. [Extracted from the article]

Keywords: Anticancer Agents; Cancer; Cancer Therapy; Drugs and Therapies; Health and Medicine; Histones; Nucleoproteins; Oncology; Protective Agents; Proteins EN Anticancer Agents Cancer Cancer Therapy Drugs and Therapies Health and Medicine Histones Nucleoproteins Oncology Protective Agents Proteins 881 881 1 07/31/23 20230804 NES 230804 2023 AUG 1 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on anticancer agents is now available. Anticancer Agents, Cancer, Cancer Therapy, Drugs and Therapies, Health and Medicine, Histones, Nucleoproteins, Oncology, Protective Agents, Proteins According to news reporting originating from Bogor, Indonesia, by NewsRx correspondents, research stated, "Stress conditions will trigger the histone hyperacetylation process due to histone acetyltransferase p300/CBP (HAT PCAF) constantly transfers acetyl groups from acetyl-CoA to conserved lysine residues on histone proteins to form e-N-acetyllysine.". [Extracted from the article]

Acetyltransferases, Acyltransferases, Enzymes and Coenzymes, Histone Acetyltransferases, Histones, Nucleoproteins, Proteins, Muscle Cells Keywords: Acetyltransferases; Acyltransferases; Enzymes and Coenzymes; Histone Acetyltransferases; Histones; Muscle Cells; Nucleoproteins; Proteins EN Acetyltransferases Acyltransferases Enzymes and Coenzymes Histone Acetyltransferases Histones Muscle Cells Nucleoproteins Proteins 450 450 1 07/24/23 20230728 NES 230728 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on nucleoproteins have been presented. [Extracted from the article]

Keywords: Duarte; State:California; United States; North and Central America; Life Science; Genetics EN Duarte State:California United States North and Central America Life Science Genetics 1021 1021 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Life Science. Keywords for this news article include: Duarte, California, United States, North and Central America, Life Science, Genetics, City of Hope National Cancer Center. [Extracted from the article]

Having discovered that multiple regulators of de novo coenzyme A (CoA) biosynthesis can modulate sensitivity to CBP/p300 HAT inhibition (PANK3, PANK4 and SLC5A6), we determined that elevated acetyl-CoA concentrations can outcompete drug-target engagement to elicit acquired drug resistance. Keywords: La Jolla; State:California; United States; North and Central America; Acetyltransferases; Drug Resistance; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Histones; Nucleoproteins; Proteins EN La Jolla State:California United States North and Central America Acetyltransferases Drug Resistance Drugs and Therapies Enzymes and Coenzymes Health and Medicine Histones Nucleoproteins Proteins 1079 1079 1 06/05/23 20230605 NES 230605 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Drugs and Therapies - Drug Resistance. According to the news editors, the research concluded: "Altogether, this work uncovers CoA metabolism as an unexpected liability of anticancer HAT inhibitors and will therefore buoy future efforts to optimize the efficacy of this new form of targeted therapy.". [Extracted from the article]

Our news reporters obtained a quote from the research from University of Shizuoka: "The histone acetyltransferase p300 plays an important role in the development of heart failure, and may be a target for heart failure therapy. Acetyltransferases, Cardiology, Cardiovascular Diseases and Conditions, Enzymes and Coenzymes, Health and Medicine, Heart Disease, Heart Disorders and Diseases, Heart Failure, Histone Acetyltransferases, Histones, Hypertrophy, Nucleoproteins, Proteins, Surgery, Transverse Aortic Constriction, Acyltransferases Keywords: Acetyltransferases; Acyltransferases; Cardiology; Cardiovascular Diseases and Conditions; Enzymes and Coenzymes; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Heart Failure; Histone Acetyltransferases; Histones; Hypertrophy; Nucleoproteins; Proteins; Surgery; Transverse Aortic Constriction EN Acetyltransferases Acyltransferases Cardiology Cardiovascular Diseases and Conditions Enzymes and Coenzymes Health and Medicine Heart Disease Heart Disorders and Diseases Heart Failure Histone Acetyltransferases Histones Hypertrophy Nucleoproteins Proteins Surgery Transverse Aortic Constriction 788 788 1 05/29/23 20230530 NES 230530 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on heart failure have been presented. [Extracted from the article]

Keywords for this news article include: University of Campania, Naples, Italy, Europe, Cancer, Histones, Oncology, Nucleoproteins, Acetyltransferases, Health and Medicine, Enzymes and Coenzymes. Keywords: Acetyltransferases; Cancer; Enzymes and Coenzymes; Health and Medicine; Histones; Nucleoproteins; Oncology; Proteins EN Acetyltransferases Cancer Enzymes and Coenzymes Health and Medicine Histones Nucleoproteins Oncology Proteins 267 267 1 04/17/23 20230418 NES 230418 2023 APR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on cancer are discussed in a new report. Acetyltransferases, Cancer, Enzymes and Coenzymes, Health and Medicine, Histones, Nucleoproteins, Oncology, Proteins. [Extracted from the article]

Keywords: Sichuan; People's Republic of China; Asia; Acetyltransferases; Acyltransferases; Enzymes and Coenzymes; Histone Acetyltransferases; Histones; Nucleoproteins; Proteins EN Sichuan People's Republic of China Asia Acetyltransferases Acyltransferases Enzymes and Coenzymes Histone Acetyltransferases Histones Nucleoproteins Proteins 2888 2888 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Proteins - Nucleoproteins. Sichuan, People's Republic of China, Asia, Acetyltransferases, Enzymes and Coenzymes, Histone Acetyltransferases, Histones, Nucleoproteins, Proteins, Acyltransferases. [Extracted from the article]

Keywords: Wroclaw; Poland; Europe; Acetyltransferases; Cancer; Enzymes and Coenzymes; Health and Medicine; Histones; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Nucleoproteins; Oncology; Proteins EN Wroclaw Poland Europe Acetyltransferases Cancer Enzymes and Coenzymes Health and Medicine Histones Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Nucleoproteins Oncology Proteins 2023 MAR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Oncology - Non-Small Cell Lung Cancer. Poland, Wroclaw, Europe, Acetyltransferases, Cancer, Enzymes and Coenzymes, Health and Medicine, Histones, Lung Cancer, Lung Diseases and Conditions, Lung Neoplasms, Non-Small Cell Lung Cancer, Nucleoproteins, Oncology, Proteins. [Extracted from the article]

Keywords: Acetyltransferases; Acyltransferases; Aspergillus; Aspergillus fumigatus; Enzymes and Coenzymes; Health and Medicine; Histone Acetyltransferases; Histones; Nucleoproteins; Proteins EN Acetyltransferases Acyltransferases Aspergillus Aspergillus fumigatus Enzymes and Coenzymes Health and Medicine Histone Acetyltransferases Histones Nucleoproteins Proteins 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Aspergillus fumigatus is now available. The news correspondents obtained a quote from the research from Daejeon University: "However, the function of GNAT family HATs, especially Elp3, in the opportunistic human pathogenic fungus Aspergillus fumigatus is largely unknown. [Extracted from the article]

Keywords for this news article include: Bari, Italy, Europe, Acetyltransferases, Acyltransferases, Enzymes and Coenzymes, Genetics, Histones, Nucleoproteins, Proteins, University Hospital. Investigators from University Hospital Report New Data on Nucleoproteins (What Have We Learned From Patients Who Have Arboleda-tham Syndrome Due To a De Novo Kat6a Pathogenic Variant With Impaired Histone Acetyltransferase Function? Keywords: Bari; Italy; Europe; Acetyltransferases; Acyltransferases; Enzymes and Coenzymes; Genetics; Histones; Nucleoproteins; Proteins EN Bari Italy Europe Acetyltransferases Acyltransferases Enzymes and Coenzymes Genetics Histones Nucleoproteins Proteins 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Proteins - Nucleoproteins. [Extracted from the article]

Acetyltransferases, Enzymes and Coenzymes, Genetics, Histones, Neurogenetics, Nucleoproteins, Proteins, Stem Cell Research Keywords: Acetyltransferases; Enzymes and Coenzymes; Genetics; Histones; Neurogenetics; Nucleoproteins; Proteins; Stem Cell Research EN Acetyltransferases Enzymes and Coenzymes Genetics Histones Neurogenetics Nucleoproteins Proteins Stem Cell Research 714 714 1 03/24/23 20230302 NES 230302 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on nucleoproteins have been published. [Extracted from the article]

The article presents information on biology professor Erica Larschan who conducted a study on SAGA complex, a histone acetyltransferase complex that aid in transcriptional activation in yeast. It mentions that she provided the link between general transcription factors and gene-specific activators by using chromatin immunoprecipitation (ChIP). It informs that she was honored with a Presidential Early Career Award for Scientists and Engineers for her remarkable career growth.