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Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking.

AbstractThe ferroelectric/ferroelastic phase transition of K2ZnCl4at 145 K has been investigated employing the tilter method (Kaminsky and Glazer (1996) Ferroelectrics183, 133) which was adapted to low-temperature experiments. We were able to observe the anisotropy of optical rotation in K2ZnCl4which shows a distinct discontinuity at the transition temperature. A precursor-optical rotation in the ferroelectric phase is discussed in connection with a cluster ordering scheme suggested in an earlier X-ray study. The rotation of the optical indicatrix which accompanies the transition from the orthorhombic to the monoclinic system shows a Landau-type temperature dependence. Model calculations based on the dipole-dipole interaction between the atoms of the structures at different temperatures are in qualitative agreement with the experimental results.

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AbstractThe recently-developed DES model (Kaminsky, W. and A. M. Glazer (1997). Z. Kristallogr., 212, 283–296) is applied to structures of triglycine sulfate at different temperatures. Tensors of electrogyration, linear and quadratic electro-optic effect are calculated and compared with the experimental values (Kaminsky, W. (1994). Phase Transitions, 52, 235–259). Reasonable agreement in sign and magnitude is found for all relevant coefficients.