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The combination of well-defined molecular cavities and chemical functionality makes crystalline porous solids attractive for a great number of technological applications, from catalysis to gas separation. However, in contrast to other widely applied synthetic solids such as polymers, the lack of processability of crystalline extended solids hampers their application. In this work, we demonstrate that metal–organic frameworks, a type of highly crystalline porous solid, can be made solution processable via outer surface functionalization using N-heterocyclic carbene ligands. Selective outer surface functionalization of relatively large nanoparticles (250 nm) of the well-known zeolitic imidazolate framework ZIF-67 allows for the stabilization of processable dispersions exhibiting permanent porosity. The resulting type III porous liquids can either be directly deployed as liquid adsorbents or be co-processed with state-of-the-art polymers to yield highly loaded mixed matrix membranes with excellent mechanical properties and an outstanding performance in the challenging separation of propylene from propane. We anticipate that this approach can be extended to other metal–organic frameworks and other applications.

6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the metaposition of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine as an arginine isostere also provided active compounds. Compounds from this series provided substantial systemic exposure in the rat following oral administration.

Seven adsorption materials of various kinds were investigated by inverse gas chromatography. For 25 different organic compounds, specific retention volume (Vg) and adsorption enthalpy (ΔH)with these adsorbents were calculated. According to the measured adsorbent retention ability, the materials can be characterized as follows: Amberlite XAD-4 (styrene-divinyl-benzene-copolymer)and Porapak R (N-vinyl pyrrolidine-polymer) were found to be useful for sampling polar and nonpolar low-volatility compounds, whereas Amberlite XAD-8 (methacrylic acid-polymer)retained only polar high-melting substances. Quantitative sampling of high-melting nonpolar pollutants was possible with Tenax GC (2,6-diphenyl-p-phenylenoxide-polymer). The retention ability of these polymers for volatile compounds such as methylene chloride was very small, hence quantitative collection was impossible. Polar highly volatile compounds can be adsorbed on silica gel, with preference to a modified version for amines. Activated charcoal was the only investigated adsorbent suitable for the efficient sampling of nonpolar highly volatile pollutants.