1. Antinociceptive Effects of 14-Membered Cyclopeptide Alkaloids
- Author
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Trevisan, Gabriela, Maldaner, Graciela, Velloso, Nádia Aléssio, Sant’Anna, Gabriela da Silva, Ilha, Vinicius, Velho Gewehr, Camila de Campos, Rubin, Maribel Antonello, Morel, Ademir Farias, and Ferreira, Juliano
- Abstract
The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca2+-ATPase and Na+/K+-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
- Published
- 2009
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