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Recent guidelines have emphasized actively avoiding fever to improve outcomes in patients who are comatose following resuscitation from cardiac arrest (ie, out-of-hospital cardiac arrest). However, whether targeted temperature management between 32 °C and 36 °C (TTM32-36) can improve neurologic outcome in some patients remains debated.

DOVER, N.J.--Most of the data in John McDonald's electronic diary is like any business executive's: Telephone numbers, address, favorite restaurants. But search a little deeper and this man's diary reveals [...]

Without Abstract:

Genetic and phenotypic relationships between adipose tissue characteristics of 253 piglets aged 8 d and qualitative characteristics of their backfat at 95 and 145 kg live weight were studied. Heritability of these qualitative aspects was estimated as well. Backfat samples were tested for cellularity, moisture, lipid content and fatty acid composition of the outer and inner layers. Adipose cellularity at birth proved to be correlated with cell volume, moisture and total unsaturated fatty acid, C18:0 and C18:2 contents present in backfat at slaughter. Estimates of heritability calculated for the outer layer of backfat indicated that progress can be made by selecting for water content and fatty acid composition. Neonatal cellularity furnishes a useful indicator not only of the backfat cell size at slaughter but also of the chemical factors important in determining the physical and organoleptic characteristics of porcine fat.

Backfat thickness, carcass length, area of M. longissimus and carcass composition were determined for 253 Large White barrows and gilts to examine the genetic influence on the main characteristics of the carcass and the correlation of these traits with body measurements and fat characteristics at 8 d of age. Pigs were born to 32 sows mated to the same boar. At the age of 8 d, weight, body length and backfat thickness and cellularity were measured. Pigs were slaughtered at 95 and 145 kg live weight. Heritability and genetic correlations were estimated with dam component of variance. Higher adiposity of carcasses was noted for barrows than for gilts and for those animals slaughtered at the heavier vs at the lighter weight. High h2values were observed for carcass length (.89 ± .29), area of the M. longissimus (.67 ± .26) and backfat thickness at the gluteus medius (.77 ± .28). Percentage of commercial cuts also had high heritabilities. Phenotypic and genetic correlations between the characteristics at 8 d and backfat thickness, carcass length and M. longissimus area at slaughter were not statistically significant. However, significant phenotypic correlations were found between cellularity of the outer and inner layers at 8 d and percentage of major cuts (e.g., rp= .27 with total fat cuts); cellularity of the outer layer at 8 d also was correlated genetically with carcass composition (e.g., rg= .50 ± .19 with total fat cuts). Genetic predisposition toward intensive fat deposition was more clearly predicted by cellularity than by thickness of adipose tissue in newborn pigs.

The genetic influence on body and adipose tissue characteristics of newborn pigs and their correlations to growth rate, BW, body length, backfat thickness and adipocyte size in the outer and inner layers of backfat in 8-d-old Large White piglets were determined. Samples of adipose tissue were obtained by biopsy. Pigs were born to 32 sows mated with the same boar. Heritability and genetic correlations were estimated with dam component of variance; therefore, bias due to common environmental effects cannot be excluded. The heritability estimate for adipocyte volume (.89 ± .28) was higher than that for backfat thickness at the first and last thoracic vertebrae (.50 ± .22; .63 ± .24) and for body weight (.59 ± .23) at 8 d. Backfat thickness was more closely related genetically and phenotypically to body weight and length than to adipose tissue cellularity. Heritability estimates were .75 ± .28 for gain from 8 d to weaning and from weaning to 95 d (probably because of common environmental effects) but were .31 ± .20 for ADG from 95 d to slaughter. Characteristics at 8 d were closely correlated phenotypically with growth rate until weaning. These correlations became lower in the two subsequent periods (to 95 d and to slaughter). Corresponding genetic correlations were nonsignificant.

Stiles-Crawford functions (SCF's) were measured for both eyes of an albino observer with a marked pendular nystagmus using an eye position monitoring system. Both eyes demonstrated directional sensitivity as revealed by their SCF's. The directional sensitivity of both eyes was less than that of either the foveal or parafoveal region of normal observers. In addition, there was a significant difference between the SCF's for the albino observer's two eyes. Our results suggest that the psychophysical SCF is predominately the result of the orientational distribution of groups of receptors on the retina.

La PCR SARS-CoV-2 est un élément majeur du diagnostic de COVID-19, toutefois sa sensibilité est variable et l’interprétation d’un résultat négatif peut s’avérer difficile selon le contexte. Le but de ce travail était de déterminer les caractéristiques cliniques, biologiques et/ou radiologiques particulières des patients avec un diagnostic final de COVID-19, mais « faux négatifs » sur leur première PCR, en comparaison des patients avec première PCR positive, et d’évaluer leur pronostic.