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2022 OCT 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in Biotechnology - Genome Mining. According to news [...]

2021 MAY 22 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2020 AUG 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on genome mining are presented in a new report. According [...]

Seragon Pharmaceuticals Inc, a research-based biopharmaceutical company, announces GenomeScore platform, a neural network-trained algorithm combining epigenetic and transcriptome analysis to predict individuals' aging speed and assessing aspects of physiological functions. [...]

2019 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on Biology - Molecular and Cellular Biology are presented in [...]

2019 AUG 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Enzymes and Coenzymes - Aldehyde-Ketone Transferases. According [...]

2016 DEC 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on DNA Research is now available. According to news [...]

Research has been conducted on human genome. The natural selection map of this genome has been developed and the evidence that the extant patterns of human genomic variation have been shaped by selection is presented.

Research has been conducted on genome rearrangements. The results of physical characterization of these rearrangements recovered from mouse somatic tissues are presented.

Background: Bladder cancer is characterized by genomic instability. In this study, we investigated whether genome-wide screening using single-nucleotide polymorphism (SNP) arrays could detect allelic imbalance (loss or gain of at least one allele) in bladder cancers. Methods: For microarray analysis, DNA was isolated from microdissected bladder tumors and leukocytes from 11 patients. The stage T1 tumor (connective tissue invasive) and the subsequent stage T2-4 tumor (muscle invasive) were available from eight of these patients, and only the first muscle-invasive stage T2-4 tumor was available from three of the 11 patients. The microarray contained 1494 biallelic polymorphic sequences. For micro-satellite analyses, DNA was isolated from tumors and leukocytes of nine patients with primary T2-4 tumors and 13 patients with Ta (noninvasive) tumors. All statistical tests were two-sided. Results: We assigned a genotype to 1204 loci, 343 of which were heterozygous. Allelic imbalance was detected in known areas of imbalance on chromosomes 6, 8, 9, 11, and 17, and a new area of imbalance was detected on the p arm of chromosome 6. Microsatellite analysis of nine other T2-4 tumors and 13 Ta tumors showed that allelic imbalance was more frequent in T2-4 tumors than in Ta tumors (P

Research has been conducted on bacterial artificial chromosomes. The authors discuss genome-wide physical map constructed with these chromosomes, and they report that this map links phenotyping traits to the genetic variation in plant and animal genomes.

Research has been conducted on Fugu rubripes genome. The authors describe the sequencing and analysis of expressed sequence tags from different adult and juvenile Fugi tissues, and they report that the clones used to generate these expressed sequence tags are valuable for laboratory investigation of wider community.

Research has been conducted on zebrafish. The authors describe the modifications to the method developed to perform the target-selected mutagenesis in zebrafish which now allow to generate knockouts in zebrafish.

Research has been conducted on protein interaction. The authors describe the two-hybrid strategy developed for facilitating protein interaction map construction on a genome-wide scale.

Research has been conducted on sugarcane genomes. The authors have investigated the genome complexity of sugarcane via the use of large-scale expressed sequence tag program, and they report that a vast number of unique genes has been identified, and that 90% of sugarcane expressed genes have been tagged.

Research has been conducted on molecular haplotyping. The authors describe the method developed for fast and efficient molecular haplotyping which consists of clone pool screening by PCR coupled with a mass spectrometric procedure.

Research has been conducted on human genomes. The authors describe the method developed for collection of randomly pertubed gene-expression profiles from the human genome.

Research has been conducted on gene expression level. The authors have compared the gene expression level to gene conservation via intergation of microarray data from fission yeast with core, yeast-specific and pombe-specific genes in fission yeast cells which grow vegetatively and undergo sexual differentiation.

Research has been conducted on genome-wide links between genotype and phenotype. The authors have investigated this issue via establishing association between RNAi phenotypes in Caenorhabditis elegans and sequence characteristics of DNA and corresponding proteins, and they report that genes possessing RNAi phenotypes are long and highly expressed with little noncoding DNA.

Research has been conducted on mouse olfactory receptor genes expressed in clustered populations of olfactory sensory neurons. The authors have investigated the genomic regions of these genes in order to identify characteristics putative regulatory sequence motifs.

Research has been conducted on protein expression. The authors report that biased codon usage correlates with protein levels, but stop codon and base-pairing potential between the mRNA Shine-Dalgarno sequence and rRNA have less affect on protein expression.

Research has been conducted on DNA methylation in plants and animal genomes. The authors describe the use of PCR-based technique in investigating this issue, and they describe the difference in methylation in plants and mammals and suggest that the mechanistic basis of this difference may involve DNA interference.

Research has been conducted on splice site recognition. The authors describe the use of computational method in investigating splice site recognition, and they report that they have concentrated on constitutive splicing only.

Research has been conducted on genes expressed during early mouse development. The expression patterns of these genes have been investigated, and the results of the cDNAs hybridization analysis has demonstrated that some of these genes have restricted expression patterns.

Research has been conducted on candidate genes. The authors have sequenced and analyzed human and mouse class III portion of the major histocompatibility complex locus to facilitate the identification and function of the candidate genes.

Research has been conducted on gene length and proximity to neighbors. The results have demonstrated that on genome-wide scale highly expressed genes are smaller and produce shorter mRNA.

Research has been conducted on nucleotide variation across human genes. The authors report that the study of this variation has allowed them to average out random fluctuations constituting the noise and uncover systematic trends in nucleotide distribution.

Research has been conducted on honey bee Apis mellifera associated with quantitative trait locus sting-2 for aggressive behavior. The authors have characterized the genomic sequence of A. mellifera, and identified the candidate sting-2 genes via providing the candidate transcripts.

Research has been conducted on functionally related genes. The authors discuss the method used for identification of these genes, and report that the method is based on gene network neighborhood comparisons.

The authors have investigated tandemly arrayed genes. They have studied the distribution of these genes in Arabidopsis thaliana genome, and examined the genes' density with relation to recombination rates.

Research has been conducted on low-copy repeats on chromosome 22q11 (LCR22) whichn mediate chromosome rearrangements. Results have demonstrated that genome shuffling by Alu-mediated rearrangements contributes to genome architecture during primate evolution.

The authors have investigated genome function. They report that available genome sequences are insufficient for the comprehensive identification of multi-species conserved sequences in the human genome.

Research has been conducted on gel matrix. The authors describe the use of small-defined substrates attached to this matrix, and report that the application of these substrates can assay a number of different classes of enzymatic activities within gel after electrophoresis.

Research has been conducted on mutation and polymorphism identification. The authors describe the peptide mass-signature genotyping method developed for identification of mutations and polymorphisms via translating the sequence in more than one frame and measuring the resulting peptide masses via mass spectrometry.

Research has been conducted on cattle and human genomes. The authors report the creation clone-based comparative map of these genomes, and confirm in silico predictions of cattle chromosome location of BAC-ends via the use of radiation hybrid mapping.

Research has been conducted on polymorphism detection. The authors describe the automated method developed for detection of informative combined effects among polymorphisms containing algorithm which considers interaction between polymorphisms as an effect of interest.

Research has been conducted on human secreted and membrate proteins in Escherichia coli. The authors describe the method developed for selecting these proteins followed by secretion direct validation in human cells.

Research has been conducted on gene prediction in eukaryotes. The authors have proposed the discriminating feature for gene prediction based on the arguments of Discrete Fourier Transform, and they report that this measure is a candidate for locating short genes and exons.

Research has been conducted on gene recognition. The authors decribe the system developed for gene start recognition in mammalian genomes, and they report that the system can predict the region containing the gene start or its proximity.

Research has been conducted on genome length. The suthors describe the study carried out in the effort to estimate genome length via estimation of the repeat structure of the genome, and they report that the estimation methods are based on the l-tuple content of the reads.

Research has been conducted on bioinformatics analysis. The authors report that there is a need in a framework which could enable the protocol-based bioinformatics analysis to be described on paper and to be replicable and distributable.

Research has been conducted on transposable elements which exhibit deviation from random distribution across genomes. The authors demonstrate that the transposable element accumulation near the centromer does not neceserally lead to correlation of recombination with transposable element abundance, and that the selection against gene expression transposable element distribution is important in Arabidopsis thaliana.

Research has been conducted on sequence variation between copies within transposable element families. The authors describe the analysis of transposable element family copies, and report that the transposable elements are active within the genome, and that the genetic variability of Drosophila genome can be renewed by the transposable element action.

Research has been conducted on gene maps from mammalian species. The authors describe the study of evolutionary history of human chromosome 1 and its homologs in placental mammals, and report that the number of human chromosome 1 fissions reflects its rate of genomic evolution, and that historic chromosome exchange is disproportionately clustered in breakpoint hotspots on the long arm.