1. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial
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Bath, Philip M, Scutt, Polly, Anderson, Craig S, Appleton, Jason P, Berge, Evind, Cala, Lesley, Dixon, Mark, England, Timothy M, Godolphin, Peter J, Havard, Diane, Haywood, Lee, Hepburn, Trish, Krishnan, Kailash, Mair, Grant, Montgomery, Alan A, Muir, Keith, Phillips, Stephen J, Pocock, Stuart, Potter, John, Price, Chris, Randall, Marc, Robinson, Thompson G, Roffe, Christine, Rothwell, Peter M, Sandset, Else C, Sanossian, Nerses, Saver, Jeffrey L, Shone, Angela, Siriwardena, A Niroshan, Wardlaw, Joanna M, Woodhouse, Lisa J, Venables, Graham, Sprigg, Nikola, Amarenco, Pierre, Muir, Keith, Amoils, Shannon, Jarvis, Malcolm, Rothwell, Peter M, Sandercock, Peter, Asplund, Kjell, Baigent, Colin, Ankolekar, Sandeep, Howard, Harriet, Lysons, Christopher, Walker, Gemma, Gregory, Hayley, Kirby, James, Smithson, Jennifer, Keeling, Joanne, Frowd, Nadia, Gray, Robert, Dooley, Richard, Clarke, Wim, Robinson, Patricia, Law, Zhe Kang, Hodgson, Sheila, Millington, Adam, Sakka, Eleni, Buchanan, David, Palmer, Jeb, Shaw, D, Cobb, H, Johnson, R, Payne, T, Spaight, R, Spaight, A, Sajid, M A, Whileman, A, Hall, E, Cripps, H, Toms, J, Gascoyne, R, Wright, S, Cooper, M, Palfreman, A, Rajapakse, A, Wynter, I, Musarrat, K, Mistri, A, Patel, C, Stephens, C, Khan, S, Patras, S, Soliman, M, Elmarimi, A, Hewitt, C, Watson, E, Wahishi, I, Hindle, J, Perkin, L, Wills, M, Arif, S, Leach, S, Butler, S, O'Kane, D, Smith, C, O'Callaghan, J, Sunman, W, Buck, A, Jackson, B, Richardson, C, Wilkes, G, Clarke, J, Ryan, L, Matias, O, Mangion, D, Hardwick, A, Constantin, C, Thomas, I, Netherton, K, Markova, S, Hedstrom, A, Rushton, B, Hyde, C, Scott, J, Blair, M, Maddula, M, Donnelly, R, Keane, S, Johnson, S, McKenzie, H, Banerjee, A, Hutchinson, D, Goodhand, H, Hill, J, Mellows, K, Cheeseman, M, McTaggart, V, Foster, T, Prothero, L, Saksena, P, O'Kelly, A, Wyllie, H, Hacon, C, Nutt, H, North, J, Goffin, K, Potter, J, Wiltshire, A, Ravenhill, G, Metcalf, K, Ford, L, Langley, M, Davison, W, Subramonian, S, Magezi, F, Obi, I, Temple, N, Butterworth-Cowin, N, Oqwusu-Agyei, P, Azim, A F M, Nicolson, A, Imam, J, White, J, Wood, L, Fothergill, R, Thompson, N, Lazarus, J, Werts, H, Sztriha, L, Ho, C, McKenzie, E, Owoyele, E, Lim, J, Aeron-Thomas, J, Dockey, M, Sylvester, N, Rao, P, Bloom, B M, Erumere, E, Norman, G, Skene, I, Cuenoud, L, Howaniec, L, Boulton, O, Daboo, P, Michael, R, Al-Saadi, S, Harrison, T, Syed, H, Argandona, L, Amiani, S, Perry, R, Ashton, A, Banaras, A, Hogan, C, Watchurst, C, Elliott, E, Francia, N, Oji, N, Erande, R, Obarey, S, Feerick, S, Tshuma, S, England, E, Pocock, H, Poole, K, Manchanda, S, Burn, I, Dayal, S, McNee, K, Robinson, M, Hancock, R, South, A, Holmes, C, Steele, A, Guthrie, L B, Oborn, M, Nor, A Mohd, Hyams, B, Eglinton, C, Waugh, D, Cann, E, Wilmhurst, N, Piesley, S, Shave, S, Dutta, D, Obeid, M, Ward, D, Turfrey, J, Glass, J, Bowstead, K, Hill, L, Brown, P, Beames, S, O'Connell, S, Hughes, V, Whiting, R, Gagg, J, Hussain, M, Harvey, M, Karunatilake, D, Pusuluri, B, Witcher, A, Pawley, C, Allen, J, Foot, J, Rowe, J, Lane, C, Ragab, S, Wadams, B, Dube, J, Jupp, B, Ljubez, A, Bagnall, C, Hann, G, Tucker, L, Kelton, M, Orr, S, Harrington, F, James, A, Lydon, A, Courtauld, G, Bond, K, Lucas, L, Nisbett, T, Kubie, J, Bowring, A, Jennings, G, Thorpe, K, Mason, N, Keenan, S, Gbadomishi, L, Howcroft, D, Newton, H, Choulerton, J, Avis, J, Shaw, L, Paterson, P, Kaye, P, Hierons, S, Lucas, S, Clatworthy, P, Faulkner, B, Rannigan, L, Worner, R, Bhaskaran, B, Saulat, A, Bearne, H, Garfield-Smith, J, Horan, K, Fitzell, P, Szabo, S, Haley, M, Simmons, D, Cotterill, D, Saunders, G, Dymond, H, Beech, S, Rashed, K, Tanate, A, Buckley, C, Wood, D, Matthews, L, Board, S, Pitt-Kirby, T, Rees, N, Convery, C, Jones, P, Bryant, C, Tench, H, Dixon, M, Loosley, R, Coetzee, S, Jones, S, Sims, T, Krishnan, M, Davies, C, Quinn, L, Connor, L, Wani, M, Storton, S, Treadwell, S, Anjum, T, Somashekar, C, Chandler, A, Triscott, C, Bevan, L, Sander, M, Buckle, S, Sayed, W, Andrews, K, Hughes, L, Hughes, R, Ward, M, Pretty, A, Rosser, A, Davidson, B, Price, G, Gunson, I, Lumley-Holmes, J, Miller, J, Larden, M, Jhamat, M, Horwood, P, Boldy, R, Jenkins, C, Price, F, Harrison, M, Martin, T, Ahmad, N, Willberry, A, Stevens, A, Fotherby, K, Barry, A, Remegoso, A, Alipio, F, Maquire, H, Hiden, J, Finney, K, Varquez, R, Ispoglou, S, Hayes, A, Gull, D, Evans, R, Epstein, E, Hurdowar, S, Crossley, J, Miles, J, Hird, K, Pilbery, R, Patterson, C, Ramadan, H, Stewart, K, Quinn, O, Bellfield, R, Macquire, S, Gaba, W, Nair, A, Wilson, A, Hawksworth, C, Alam, I, Greig, J, Robinson, M, Gomes, P, Rana, P, Ahmed, Z, Anderston, P, Neal, A, Walstow, D, Fong, R, Brotheridge, S, Bwalya, A, Gillespie, A, Midgley, C, Hare, C, Lyon, H, Stephenson, L, Broome, M, Worton, R, Jackson, S, Rayessa, R, Abdul-Hamid, A, Naylor, C, Clarkson, E, Hassan, A, Waugh, D, Veraque, E, Finch, L, Makawa, L, Carpenter, M, Datta, P, Needle, A, Jackson, L, Brooke, H J, Ball, J, Lowry, T, Punnoose, S, Walker, R, Murray, V, Ali, A, Kamara, C, Doyle, C, Richards, E, Howe, J, Dakin, K, Harkness, K, Lindert, R, Wanklyn, P, Willcoxson, P, Clark-Brown, P, and Mir, R
- Abstract
High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high blood pressure in ultra-acute stroke remains unclear. We investigated whether transdermal glyceryl trinitrate (GTN; also known as nitroglycerin), a nitric oxide donor, might improve outcome when administered very early after stroke onset.
- Published
- 2019
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