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The article discusses several major changes happening in college football in the 2024-25 season. The College Football Playoff is expanding to a 12-team format, which will result in more postseason games and more teams involved in the playoff chase. There have also been significant coaching changes, with Nick Saban retiring and several other former national champion coaches moving on. Conference realignment has led to major changes in the composition of power conferences, and the NCAA has agreed to a multibillion-dollar settlement that allows schools to directly pay athletes for the first time. Additionally, there are new rules allowing in-helmet communication and immediate eligibility for transfer athletes. These changes are expected to have a significant impact on the landscape of college sports. [Extracted from the article]

Jalen Milroe, the quarterback for the University of Alabama football team, has decided to stay at the university for another season instead of pursuing the NFL draft or transferring to another school. Despite a disappointing end to the previous season, Milroe appreciates the trust he was given in the final play of the game. He is committed to finishing what he started at Alabama and hopes to make a lasting impact on the program. Milroe will have the opportunity to work with new head coach Kalen DeBoer and further develop his skills as a quarterback. He is also focused on his academic pursuits and building his personal brand. The article highlights Milroe's success in the SEC and nationally, with a high passer rating and a low number of interceptions, ranking second in the SEC and fifth in the country. The article also includes several vibrant photos of Milroe in action. [Extracted from the article]

This article from Sports Illustrated provides an overview of the Ohio State football team's response to their rival, Michigan, winning the national championship in 2023. The Buckeyes have taken steps to improve their team by retaining key players, recruiting star transfers, and making changes to their coaching staff. The article also mentions the financial support from donors and the use of NIL deals to support the team. The article emphasizes the anticipation and pressure for Ohio State to perform well in the upcoming football season, with the team determined to win decisively after recent close elimination game losses. Head coach Ryan Day is focused on learning from the past, planning for the future, and achieving the team's goal of winning a national championship. The article also highlights the personal connection between Day and offensive coordinator Chip Kelly, who will work together to maximize the team's potential. [Extracted from the article]

Byline: Matthew Forde We're rounding up all the best Cyber Monday Nintendo Switch deals as soon as they happen. As Black Friday swiftly makes its exit, what's that staring through [...]

Byline: Matthew Forde We're rounding up all the best Black Friday Nintendo Switch deals as soon as they happen. Black Friday Nintendo Switch deals are flying in at the moment, [...]

The article discusses the challenges that the U.S. swimming team will face at the upcoming Paris Summer Olympics. The dominant U.S. team is facing pressure as the talent gap narrows and other countries, such as France and Canada, produce top swimmers. The article highlights the importance of Caeleb Dressel's return to form and the need for a new generation of male swimmers to step up. It also discusses the rivalry between the U.S. and Australian women's teams and the emergence of young talents like Ariarne Titmus and Summer McIntosh. Additionally, it mentions the success of international swimmers who train in the U.S. but compete for their home countries. [Extracted from the article]

IMPORTANCE: To date, no meta-analyses have comprehensively assessed the association of neoadjuvant chemoimmunotherapy with clinical outcomes in non–small cell lung cancer (NSCLC) in randomized and nonrandomized settings. In addition, there exists controversy concerning the efficacy of neoadjuvant chemoimmunotherapy for patients with NSCLC with programmed cell death 1 ligand 1 (PD-L1) levels less than 1%. OBJECTIVE: To compare neoadjuvant chemoimmunotherapy with chemotherapy by adverse events and surgical, pathological, and efficacy outcomes using recently published randomized clinical trials and nonrandomized trials. DATA SOURCES: MEDLINE and Embase were systematically searched from January 1, 2013, to October 25, 2023, for all clinical trials of neoadjuvant chemoimmunotherapy and chemotherapy that included at least 10 patients. STUDY SELECTION: Observational studies and trials reporting the use of neoadjuvant radiotherapy, including chemoradiotherapy, molecular targeted therapy, or immunotherapy monotherapy, were excluded. MAIN OUTCOMES AND MEASURES: Surgical, pathological, and efficacy end points and adverse events were pooled using a random-effects meta-analysis. RESULTS: Among 43 eligible trials comprising 5431 patients (4020 males [74.0%]; median age range, 55-70 years), there were 8 randomized clinical trials with 3387 patients. For randomized clinical trials, pooled overall survival (hazard ratio, 0.65; 95% CI, 0.54-0.79; I2 = 0%), event-free survival (hazard ratio, 0.59; 95% CI, 0.52-0.67; I2 = 14.9%), major pathological response (risk ratio, 3.42; 95% CI, 2.83-4.15; I2 = 31.2%), and complete pathological response (risk ratio, 5.52; 95% CI, 4.25-7.15; I2 = 27.4%) favored neoadjuvant chemoimmunotherapy over neoadjuvant chemotherapy. For patients with baseline tumor PD-L1 levels less than 1%, there was a significant benefit in event-free survival for neoadjuvant chemoimmunotherapy compared with chemotherapy (hazard ratio, 0.74; 95% CI, 0.62-0.89; I2 = 0%). CONCLUSION AND RELEVANCE: This study found that neoadjuvant chemoimmunotherapy was superior to neoadjuvant chemotherapy across surgical, pathological, and efficacy outcomes. These findings suggest that patients with resectable NSCLC with tumor PD-L1 levels less than 1% may have an event-free survival benefit with neoadjuvant chemoimmunotherapy.

The COVID-19 pandemic highlighted the importance of international data sharing and access to improve health outcomes for all. The International COVID-19 Data Alliance (ICODA) programme enabled 12 exemplar or driver projects to use existing health-related data to address major research questions relating to the pandemic, and developed data science approaches that helped each research team to overcome challenges, accelerate the data research cycle, and produce rapid insights and outputs. These approaches also sought to address inequity in data access and use, test approaches to ethical health data use, and make summary datasets and outputs accessible to a wider group of researchers. This Health Policy paper focuses on the challenges and lessons learned from ten of the ICODA driver projects, involving researchers from 19 countries and a range of health-related datasets. The ICODA programme reviewed the time taken for each project to complete stages of the health data research cycle and identified common challenges in areas such as data sharing agreements and data curation. Solutions included provision of standard data sharing templates, additional data curation expertise at an early stage, and a trusted research environment that facilitated data sharing across national boundaries and reduced risk. These approaches enabled the driver projects to rapidly produce research outputs, including publications, shared code, dashboards, and innovative resources, which can all be accessed and used by other research teams to address global health challenges.

The Atlantic Coast Conference (ACC) is facing an uncertain future as it navigates the competitive world of college athletics. Commissioner Jim Phillips, known for his idealistic and consensus-building approach, is trying to hold the conference together amidst the changing landscape. The ACC, once known for its basketball dominance, is now feeling the pressure to succeed in football and generate revenue. The addition of new schools and ongoing lawsuits, particularly involving Florida State, have further complicated the situation. The ACC's ability to adapt and thrive in this challenging environment remains uncertain. [Extracted from the article]

For patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L)1 checkpoint inhibitors, alone or with platinum-doublet therapy. However, not all patients derive durable benefit and resistance to immune checkpoint blockade is common. Understanding mechanisms of resistance—which can include defects in DNA damage response and repair pathways, alterations or functional mutations in STK11/LKB1, alterations in antigen-presentation pathways, and immunosuppressive cellular subsets within the tumor microenvironment—and developing effective therapies to overcome them, remains an unmet need. Here the phase 2 umbrella HUDSON study evaluated rational combination regimens for advanced NSCLC following failure of anti-PD-(L)1-containing immunotherapy and platinum-doublet therapy. A total of 268 patients received durvalumab (anti-PD-L1 monoclonal antibody)–ceralasertib (ATR kinase inhibitor), durvalumab–olaparib (PARP inhibitor), durvalumab–danvatirsen (STAT3 antisense oligonucleotide) or durvalumab–oleclumab (anti-CD73 monoclonal antibody). Greatest clinical benefit was observed with durvalumab–ceralasertib; objective response rate (primary outcome) was 13.9% (11/79) versus 2.6% (5/189) with other regimens, pooled, median progression-free survival (secondary outcome) was 5.8 (80% confidence interval 4.6–7.4) versus 2.7 (1.8–2.8) months, and median overall survival (secondary outcome) was 17.4 (14.1–20.3) versus 9.4 (7.5–10.6) months. Benefit with durvalumab–ceralasertib was consistent across known immunotherapy-refractory subgroups. In ATM-altered patients hypothesized to harbor vulnerability to ATR inhibition, objective response rate was 26.1% (6/23) and median progression-free survival/median overall survival were 8.4/22.8 months. Durvalumab–ceralasertib safety/tolerability profile was manageable. Biomarker analyses suggested that anti-PD-L1/ATR inhibition induced immune changes that reinvigorated antitumor immunity. Durvalumab–ceralasertib is under further investigation in immunotherapy-refractory NSCLC.

The language of nurse education in the UK has shifted from ‘competency’ to ‘proficiency’ since 2018. The shift in language has been poorly articulated leaving individual higher education institutions, practice supervisors and assessors to interpret what these terms mean in relation to assessing student nurses. There appeared to be some confusion regarding the interpretation of the term proficiency among those who engaged in an exchange on the topic via Twitter. Students may focus on the procedure-based checklists within the standards. The relationship between proficiency and implementing a person-centred approach to care remains unclear.

IntroductionAltered complement component 3 (C3) activation in patients with alpha-1 antitrypsin (AAT) deficiency (AATD) has been reported. To understand the potential impact on course of inflammation, the aim of this study was to investigate whether C3d, a cleavage-product of C3, triggers interleukin (IL)-1β secretion via activation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. The objective was to explore the effect of AAT augmentation therapy in patients with AATD on the C3d/complement receptor 3 (CR3) signalling axis of monocytes and on circulating pro-inflammatory markers.MethodsInflammatory mediators were detected in blood from patients with AATD (n=28) and patients with AATD receiving augmentation therapy (n=19). Inflammasome activation and IL-1β secretion were measured in monocytes of patients with AATD, and following C3d stimulation in the presence or absence of CR3 or NLRP3 inhibitors.ResultsC3d acting via CR3 induces NLRP3 and pro-IL-1β production, and through induction of endoplasmic reticulum (ER) stress and calcium flux, triggers caspase-1 activation and IL-1β secretion. Treatment of individuals with AATD with AAT therapy results in decreased plasma levels of C3d (3.0±1.2 µg/mL vs 1.3±0.5 µg/mL respectively, p<0.0001) and IL-1β (115.4±30 pg/mL vs 73.3±20 pg/mL, respectively, p<0.0001), with a 2.0-fold decrease in monocyte NLRP3 protein expression (p=0.0303), despite continued ER stress activation.DiscussionThese results provide strong insight into the mechanism of complement-driven inflammation associated with AATD. Although the described variance in C3d and NLRP3 activation decreased post AAT augmentation therapy, results demonstrate persistent C3d and monocyte ER stress, with implications for new therapeutics and clinical practice.

Background: County-level barriers (sociodemographic barriers, limited healthcare system resources, healthcare accessibility barriers, irregular healthcare seeking behaviors, low vaccination history) may impact individuals’ reasons for receiving the COVID-19 vaccine. Methods: This study linked data from REACH-US (Race-Related Experiences Associated with COVID-19 and Health in the United States), a nationally representative, online survey of 5475 adults living in the U.S (January-March 2021) to county-level barriers in the COVID-19 Vaccine Coverage Index. County-level vaccination barriers were measured using the COVID-19 Vaccine Coverage Index. Participants reported why they would or would not receive the COVID-19 vaccine in an open-ended item and their responses were coded using thematic analysis. Descriptive statistics and chi-square tests assessed whether reasons for COVID-19 vaccination intentions varied by county-level barriers and whether these distributions varied across racial/ethnic groups. Results: Thematic analysis revealed twelve themes in participants’ reasons why they would or would not receive the COVID-19 vaccine. Themes of societal responsibility (9.8% versus 7.7%), desire to return to normal (8.1% versus 4.7%), and trust in science/healthcare/government (7.7% versus 5.1%) were more frequently reported in counties with low/medium barriers (versus high/very high) (p-values &lt; 0.05). Concerns of COVID-19 vaccine side effects/safety/development (25.3% versus 27.9%) and concerns of access/costs/availability/convenience (1.9% versus 3.6%) were less frequently reported in counties with low/medium barriers (versus high/very high) (p-values &lt; 0.05). Trends in the prevalence of these themes varied across racial/ethnic groups (p-values &lt; 0.05). Conclusions: Future pandemic responses should consider potential ways county-level barriers shape reasons for COVID-19 vaccination.

BackgroundThe identification of germline pathogenic gene variants (PGVs) in triple negative breast cancer (TNBC) is important to inform further primary cancer risk reduction and TNBC treatment strategies. We therefore investigated the contribution of breast cancer associated PGVs to familial and isolated invasive TNBC.MethodsOutcomes of germline BRCA1, BRCA2and CHEK2_c.1100delC testing were recorded in 1514 women (743—isolated, 771—familial), and for PALB2in 846 women (541—isolated, 305—familial), with TNBC and smaller numbers for additional genes. Breast cancer free controls were identified from Predicting Risk Of Cancer At Screening and BRIDGES (Breast cancer RIsk after Diagnostic GEne Sequencing) studies.ResultsBRCA1_PGVs were detected in 52 isolated (7.0%) and 195 (25.3%) familial cases (isolated—OR=58.9, 95% CI: 16.6 to 247.0), BRCA2_PGVs in 21 (2.8%) isolated and 67 (8.7%) familial cases (isolated—OR=5.0, 95% CI: 2.3 to 11.2), PALB2_PGVs in 9 (1.7%) isolated and 12 (3.9%) familial cases (isolated—OR=8.8, 95% CI: 2.5 to 30.4) and CHEK2_c.1100delC in 0 isolated and 3 (0.45%) familial cases (isolated—OR=0.0, 95% CI: 0.00 to 2.11). BRCA1_PGV detection rate was >10% for all familial TNBC age groups and significantly higher for younger diagnoses (familial: <50 years, n=165/538 (30.7%); ≥50 years, n=30/233 (12.9%); p<0.0001). Women with a G3_TNBC were more likely to have a BRCA1_PGV as compared with a BRCA2or PALB2_PGV (p<0.0001). 0/743 isolated TNBC had the CHEK2_c.1100delC PGV and 0/305 any ATM_PGV, but 2/240 (0.83%) had a RAD51D_PGV.ConclusionPGVs in BRCA1are associated with G3_TNBCs. Familial TNBCs and isolated TNBCs <30 years have a >10% likelihood of a PGV in BRCA1. BRCA1_PGVs are associated with younger age of familial TNBC. There was no evidence for any increased risk of TNBC with CHEK2or ATMPGVs.

Neoadjuvant immunotherapy plus chemotherapy improves event-free survival (EFS) and pathologic complete response (0% residual viable tumor (RVT) in primary tumor (PT) and lymph nodes (LNs)), and is approved for treatment of resectable lung cancer. Pathologic response assessment after neoadjuvant therapy is the potential analog to radiographic response for advanced disease. However, %RVT thresholds beyond pathologic complete response and major pathologic response (≤10% RVT) have not been explored. Pathologic response was prospectively assessed in the randomized, phase 3 CheckMate 816 trial (NCT02998528), which evaluated neoadjuvant nivolumab (anti-programmed death protein 1) plus chemotherapy in patients with resectable lung cancer. RVT, regression and necrosis were quantified (0–100%) in PT and LNs using a pan-tumor scoring system and tested for association with EFS in a prespecified exploratory analysis. Regardless of LN involvement, EFS improved with 0% versus >0% RVT-PT (hazard ratio = 0.18). RVT-PT predicted EFS for nivolumab plus chemotherapy (area under the curve = 0.74); 2-year EFS rates were 90%, 60%, 57% and 39% for patients with 0–5%, >5–30%, >30–80% and >80% RVT, respectively. Each 1% RVT associated with a 0.017 hazard ratio increase for EFS. Combining pathologic response from PT and LNs helped differentiate outcomes. When compared with radiographic response and circulating tumor DNA clearance, %RVT best approximated EFS. These findings support pathologic response as an emerging survival surrogate. Further assessment of the full spectrum of %RVT in lung cancer and other tumor types is warranted. ClinicalTrials.gov registration: NCT02998528.

COVID-related discrimination towards historically marginalized racial-ethnic groups in the United States has been well-documented; however, its impact on psychological distress and sleep (overall and within specific racial-ethnic groups) is largely unknown. We used data from our nationally representative, online survey of 5,500 American Indian/Alaska Native, Asian, Black/African American, Native Hawaiian/Pacific Islander, Latino, White, and multiracial adults, conducted from 12/2020-2/2021. Participants were asked how often they experienced discriminatory behaviors “because they think you might have COVID-19” (modified Everyday Discrimination Scale). Psychological distress was captured as having experienced anxiety-depression symptoms (Patient Health Questionairre-4, PHQ-4), perceived stress (modified Perceived Stress Scale), or loneliness-isolation (“How often have you felt lonely and isolated?”). Sleep disturbances were measured using the Patient-Reported Outcomes Information System Short Form Sleep Disturbance scale (PROMIS-SF 4a). Overall, 22.1% reported COVID-related discriminatory behaviors (sometimes/always: 9.7%; rarely: 12.4%). 48.4% of participants reported anxiety-depression symptoms (moderate/severe: 23.7% mild: 24.8%), 62.4% reported feeling stressed (moderate/severe: 34.3%; mild: 28,1%), 61.0% reported feeling lonely-isolated (fairly often/very often: 21.3%; almost never/sometimes: 39.7%), and 35.4% reported sleep disturbances (moderate/severe:19.8%; mild: 15.6%). Discrimination was only associated with increased psychological distress among racial-ethnic minorities. For example, COVID-related discrimination was strongly associated with anxiety-depression among Black/African American adults (mild: aOR=2.12, 95% CI=1.43-5.17; moderate/severe: aOR=5.19, 95% CI=3.35-8.05), but no association was observed among White or multiracial adults. Mitigating pandemic-related discrimination could help alleviate mental and sleep health disparities occurring among minoritized racial-ethnic groups.

This article reflects on the progress made since landmark cases on racial integration in education and explores the unfulfilled promise of integration and educational equity. It discusses Justice Thurgood Marshall's belief in meaningful engagement across racial lines and the concept of "radical integration" as a goal. The article acknowledges the contested nature of integration and the need to address structural inequities. The National Coalition on School Diversity (NCSD) is celebrating its 15th anniversary and remains committed to the fight for integrated and equitable schools. The document provides a comprehensive list of academic articles and journals related to racial integration, social psychology, and racial inequality for library patrons conducting research on these topics. [Extracted from the article]

This article explores the impact of Deion Sanders, the head coach of the Colorado Buffaloes football team. Sanders has brought new life to the campus and community, resulting in a significant increase in first-year applications, particularly from Black, nonresident, and international students. His success on the field has also had a positive economic impact on Boulder. Sanders has made connections with faculty and community members, creating a sense of excitement and unity. While there have been some criticisms, Sanders's influence and improvements to the program are acknowledged, and there is hope for continued success in the future. [Extracted from the article]

From early in the COVID-19 pandemic, evidence suggested a role for cytokine dysregulation and complement activation in severe disease. In the TACTIC-R trial, we evaluated the efficacy and safety of baricitinib, an inhibitor of Janus kinase 1 (JAK1) and JAK2, and ravulizumab, a monoclonal inhibitor of complement C5 activation, as an adjunct to standard of care for the treatment of adult patients hospitalised with COVID-19.

The article discusses the Bay of Quinte in Ontario, Canada, which is known for its world-class walleye fishing. The bay is relatively sheltered compared to Lake Ontario, and it attracts anglers who are looking to catch trophy walleye through the ice. The bay is accessible through various bays and reaches, and anglers can find parking access at parks, boat ramps, and roadside locations. The article also provides tips on where to fish, equipment to use, and safety precautions to take when ice fishing on the bay. [Extracted from the article]

ABSTRACT The practical challenges of mineshaft detection under railway embankments are discussed, together with typical mineshaft properties over the centuries. The paper focuses on the broadside shot seismic transmission method [...]

Brain metastases are common in patients with non-small-cell lung cancer (NSCLC). Because of associated poor prognosis and limited specific treatment options, there is a real need for the development of medical therapies and strategies for affected patients. Novel compounds for epidermal growth factor receptor-dependent and anaplastic lymphoma kinase-dependent lung cancer have demonstrated blood-brain barrier permeability and have led to important improvements in central nervous system outcomes. Studies of targeted therapies for oncogene-driven tumors and of immunotherapies in patients with brain metastases have shown promise and, allied with novel radiation techniques, are driving a rapid evolution in treatment and prognosis for NSCLC brain metastases., Introduction Brain metastases are estimated to occur in 30% to 50% of patients with metastatic non-small-cell lung cancer (NSCLC). [1] Prognosis has historically been poor for these patients and is [...]

Purpose: The paper aims to explore the role of union strategic influence on the adoption of High Performance Work Systems (HPWS) in organisations and examines how the effects of job security and then in turn the industrial relations climate, mediate this relationship in a serial manner. Design/methodology/approach: The research analyses an original quantitative survey of union negotiators and representatives in 382 workplaces in England. The analysis employs structural equation modelling techniques to examine the relationships between union influence, job security, industrial relations climate and HPWS. Findings: Union strategic influence has a positive effect on the take up of HPWS in unionised workplaces. Job security and the industrial relations climate demonstrate a serial mediation effect between union strategic influence and the take up of HPWS: union strategic influence has a positive effect on job security, which in turn positively impacts the industrial relations climate, thereby increasing the likelihood of the adoption of HPWS. The findings for the industrial relations climate are particularly strong. Practical implications: Findings suggest that organisations will benefit from focussing on the development of positive industrial relations, where unions have genuine strategic influence, because this maximises the likelihood that HPWS can be adopted and sustained. Originality/value: The paper provides a novel focus on the take up of HPWS within unionised workplaces. It focusses on the role of union strategic influence and the mediating effects of job security and the industrial relations climate, which are contextual factors that have been underexplored in the HPWS literature to date.

"I think officiating today, honest to God, is as good as it's ever been", says Matt Austin, a former Southeastern Conference official and current ESPN rules analyst. Refs are going to protect refs, and fans are going to be fans. COLLEGE FOOTBALL PREVIEW THIS IS THE paradox of officiating in American sports, and college football in particular. The survey said that nearly 48% of male officials and 45% of female officials have feared for their safety due to fan, coach or athlete behavior. [Extracted from the article]

14 ->TEXAS Coach Steve Sarkisian has a potential star QB in Quinn Ewers and an explosive receiving corps. COLLEGE FOOTBALL PREVIEW THE TOP 25 1 -> GEORGIA Since the Associated Press began crowning national champions in 1936, no school has ever gone back to back to back. New QB Sam Hartman, who threw for nearly 13,000 yards at Wake Forest, is working with a new coordinator and QB coach. [Extracted from the article]

COLLEGE FOOTBALL PREVIEW The last team to be flattened by the Georgia juggernaut was TCU. Kirby Smart has ripped the ruling scepter of college football from the hands of his former boss, Alabama coach Nick Saban. Provided Smart doesn't burn out or repeat Saban's NFL dalliance, there's no telling how far the Georgia coach can take his once-underachieving alma mater. -> HIGH PRAISE Smart (above) and Georgia dominated TCU in the CFP final last year, and Horned Frogs coach Dykes acknowledged that when game-planning he could not find a weakness in the Bulldogs to exploit. [Extracted from the article]

Technology education (TE) has the creating, making, and doing aspects of human activity at its foundation. This article presents a comparison of the teaching sense of efficacy (TSE) of practising TE teachers and teacher candidates (TC) during a forced switch to emergency remote teaching (ERT). In phase 1, the switch to ERT had a significantly negative effect on TE teachers (N= 42; r= −0.60). In phase 2, TE TCs (N= 16) were similarly affected (r= −0.53). Results of a two-way mixed ANOVA in phase 3 suggest that ERT had a greater negative impact on practising TE teachers’ TSE for student engagement (partial eta squared = 0.11) and classroom management (partial eta squared = 0.19) than it did on TE TCs’ TSE. As novice teachers tend to draw more from contextual factors than mastery experiences, this research suggests that experienced teachers were at a greater loss due to the pandemic than TCs.

Change is never easy, especially for historians who have their feet firmly planted in the past. So, in 2013, when American Journalismeditor Barbara G. Friedman and associate editor Kathy Roberts Forde proposed moving from independent university presses to a commercial academic publisher, there was apprehension. But theirs was a utilitarian goal: creating a solid path for journalism and mass communication scholars to achieve tenure and promotion at their universities in an age when metrics matter and expanding the journal’s reach. In this reflection, part of American Journalism’s fortieth anniversary essay series, the former editors explain how the transition from independent to commercial publishing enabled a “gem of a journal” to achieve—and exceed—those initial goals. The authors also offer some considerations for the future.

The aim of this study was to explore the feasibility of using iPad minis as a method of completing competency assessment in clinical practice. Digital technology helps to revolutionize all aspects of our lives. The use of digital technologies in clinical practice can facilitate a move toward a more flexible learning environment and enable students to adapt in a rapidly changing, interconnected world. The introduction of electronic clinical booklets in practice placements could facilitate the sharing of clinical information through connected healthcare systems, thus improving the student experience. A cross-sectional design was used in this study. A sample of BSc nursing students (n = 53) and clinically based healthcare professionals (n = 27) (preceptors and clinical placement coordinators) participated in this study. Data were collected using a modified version of Garrett and colleagues' instrument, the System Usability Scale, a demographics questionnaire, and three open-ended questions. There was a significant difference between the students and preceptors/clinical placement coordinators across all items with higher proportions of students (ranging from 66% to 75.5%), indicating that they agreed or strongly agreed with the reliability, ease of use, and effectiveness of the device in assessing their clinical competency (ranging from 11.1% to 40.7%). In addition, the iPad minis were found to be smaller, lighter, and easier to carry than paper-based booklets and encouraged students to access timely online learning resources during placement to help augment their learning. The use of iPad mini to complete the electronic competency assessment document as a replacement for a paper-based system to assess clinical practice is feasible. The introduction of electronic assessment documents should incorporate a robust training plan and standard operating procedures.

Anti-PD-1/PD-L1 agents have transformed the treatment landscape of advanced non-small cell lung cancer (NSCLC). To expand our understanding of the molecular features underlying response to checkpoint inhibitors in NSCLC, we describe here the first joint analysis of the Stand Up To Cancer-Mark Foundation cohort, a resource of whole exome and/or RNA sequencing from 393 patients with NSCLC treated with anti-PD-(L)1 therapy, along with matched clinical response annotation. We identify a number of associations between molecular features and outcome, including (1) favorable (for example, ATMaltered) and unfavorable (for example, TERTamplified) genomic subgroups, (2) a prominent association between expression of inducible components of the immunoproteasome and response and (3) a dedifferentiated tumor-intrinsic subtype with enhanced response to checkpoint blockade. Taken together, results from this cohort demonstrate the complexity of biological determinants underlying immunotherapy outcomes and reinforce the discovery potential of integrative analysis within large, well-curated, cancer-specific cohorts.

ABSTRACTThis paper highlights the contribution of archival data and historical methods to impactful research in industrial relations, the sociology of work, management studies and Human Resource Management. Whilst archival methods are widely used in some of these fields of research, there has also been considerable debate in these fields over the challenges of conducting impactful research using archival data. The paper draws on archival records from the National Archives in the UK to explore the evolving relationship between private temporary employment agencies and the state over the 1980s. The paper highlights how the actions of specific labour market actors, particularly lobbying activities by private agencies, and the changing economic and political climate over the 1980s, impacted on perceptions and attitudes within government towards temporary employment agencies. In doing so, the paper sheds new light on the early evolution of what are now recognised as important dynamics shaping the contemporary employment agency industry.

I INTRODUCTION For centuries, coal miners took canaries into the mine to alert them that atmospheric conditions were dangerously toxic. (1) If the canary showed signs of distress, it was [...]

Background. Reduced participation in physical activity and increased time spent in sedentary behavior are associated with overweight, chronic disease, and disability. In order to optimize recommendations and interventions to increase physical activity and reduce sedentary behavior in children with cerebral palsy (CP), knowledge of their physical activity and sedentary behavior is needed. Objectives. The aim of this study was to describe light, moderate, and vigorous physical activity and sedentary behavior in preadolescent children with and without CP and compare physical activity and sedentary behavior between the 2 groups. Design. This was a cross-sectional study of 33 children, aged 6 to 10 years, with CP (Gross Motor Function Classification System [GMFCS] levels I-III) and 33 age- and sex-matched children with typical development. Methods. Physical activity was measured using the RT3 accelerometer over 7 days. Results. Children with CP spent more time in sedentary behavior and accumulated less total activity, moderate activity, vigorous activity, and sustained bouts of moderate-to-vigorous activity (MVPA). They also accumulated a fewer number of bouts of MVPA and vigorous activity, despite spending a similar amount of time in each bout. Limitations. The small number of children in GMFCS levels II and III did not allow for adjustment for GMFCS level when comparing physical activity between children with and without CP. Conclusions. Preadolescent children with CP spent less time in moderate and vigorous activity and more time in sedentary behavior than children with typical development. Children with CP also accumulated less continuous MVPA and vigorous activity as a result of achieving fewer sustained bouts of MVPA and vigorous activity throughout the day., Physical activity is defined as 'any bodily movement produced by skeletal muscle that results in energy expenditure.' (1(p26)) Reduced participation in physical activity is associated with stroke, coronary heart disease, [...]

In industrial processes, there is a need for accurate and robust control of actuators that manage process parameters such as flow, temperature, and pressure. Precision analog output modules, known as [...]