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Time-resolved fluorescence spectra have been obtained for Escherichia coli, Pseudomonas fluorescens, Staphylococcus epidermidis, and Enterobacter cloacae. Pseudomonas fluorescenshas been shown to have distinctly different time-resolved spectra. Fluorescence excitation spectra for the three other organisms showing similar time-resolved spectra are very nearly alike, while spectra of Pseudomonas fluorescensare markedly different. This suggests that the changes in the average fluorescence lifetime with emission wavelength are due to the separate contributions from fluorophores of distinctly different lifetimes which have emission maxima at different wavelengths.

Summary: Intravenous fluconazole is used in the treatment of fungal infections in infants. Little is known, however, about the pharmacokinetics of fluconazole after oral administration in premature infants. Oral fluconazole was administered at a dose of 6 mg/kg. The peak serum concentration (Cmax), area under the serum concentration-time curve (AUC), and apparent clearance ranged from 6.0–13.5 μg/ml, 340–636 μg.h/ml, and 0.16–0.29 ml/min/kg, respectively. The Cmax and AUC were comparable after oral and intravenous doses of fluconazole. Oral fluconazole was well absorbed and tolerated. The use of oral fluconazole may offer an important alternative to the intravenous therapy; it may improve patient convenience, reduce the need for venous access and decrease complications and the cost of health care.

Heavy ion radiobiology has been integrated successfully into the research program at the Bevatron/Bevalac for the past several years. During the 1979-1980 year radiotherapy trials have been conducted side-by-side with the demanding program of heavy ion nuclear science research at this national facility. Careful attention is given to the scheduling of research on the SuperHILAC and Bevatron/Bevalac so that the nuclear science and biomedical programs at the Bevatron/Bevalac and the program at the SuperHILAC are served to maximum effect. Efforts to maximize the researchers' time have resulted in hardware, software, and operating improvements that offer a total machine availability of about 90% and a user availability of about 80%. Fast beam switching and beam sharing permit virtually simultaneous use of the Bevatron/Bevalac by two or more users. Current beam delivery systems will be augmented in FY81 to provide two ion energies per Bevatron/Bevalac pulse.

is studied by XPS, residual gas analysis, photogravimetric analysis, and TGA.

The photoreduction of SnS2is studied by XPS, residual gas analysis, photogravimetric analysis, and TGA.

IN work described elsewhere1we showed how to understand the steady-state transport of oxygen through hæmoglobin solution by the application of Fick's law of mass transport. The oxygen flux was shown to depend not only on the pressure difference across the diffusion cell but also on the absolute partial pressures of oxygen at the cell boundaries. This behaviour is a direct consequence of the nonlinear relation between oxyhæmoglobin concentration and oxygen partial pressure. We pointed out, for example, that if the hæmoglobin is saturated with oxygen at both ends of the diffusion path it cannot contribute to the transport of oxygen and all the oxygen transport must therefore take place through the plasma.