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I'm writing in regards to 'The Sh!%box Derby' in the Jan, '11 issue. I would like to start out saying Hazel, you are a dumb a$$. Is that the best [...]

Several letters to the editor are presented in response to articles in the January 2011 issue including "The Sh!%box Derby," "Michigan Mayhem" and "How to Survive."

A single dose of ethanol increases cellular levels of the mRNA encoding thyrotropin-releasing hormone (TRH) in neurons of the paraventricular nucleus (PVN), but blocks the cold-induced increase in the levels of this mRNA. Because the thyrotropic response to cold is dependent upon TRH secretion, we hypothesized that ethanol uncouples the stimulus-induced regulation of TRH secretion from the stimulus-induced regulation of TRH expression. We employed two complementary strategies to test this hypothesis. The first was to determine whether ethanol alters pituitary sensitivity to TRH. Animals given a single intraperitoneal injection of ethanol (3 g/kg) that produced a blood alcohol concentration of nearly 300 mg/100 mL exhibited the same increase in circulating levels of TSH following an intravenous infusion of TRH. Thus, ethanol does not appear to alter pituitary sensitivity to TRH. Second, we tested whether ethanol blocks the cold induction of c-fosexpression in TRH neurons of the PVN. Both cold exposure and ethanol induced the expression of c-fosin the PVN and in TRH neurons; the effects of cold and ethanol on c-fosexpression were additive. Thus, ethanol clearly does not block the cold activation of TRH neurons.

The article presents questions and answers related to resolving the vicious vibration in a restored 1968 Chevelle, the fabrication work needed for installing a V-6 engine in a 1957 Beauville station wagon and the number markings on the block as to the Vin of a 1967 Chevelle car.

Gives 10 guidelines on how to get the most from a management consultant. Details of guidelines. INSET: Quick tips..

Focuses on skiing vacation strategies for people traveling alone. Resorts recommended to have the facilities catering to solo travelers; Techniques for booking affordable accommodations.