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Minority contractors face an uphill battle to win the work to which they - and the government - say they are entitled. DOWNTOWN - Rich Allen is still upset. No [...]

Without risk, there is no entrepreneur. By its very nature, the start-up enterprise takes a brazen leap of faith, hurtling itself into the unknown, facing the dark beast of financial [...]

Mayday, mayday, mayday. Wolfpack 55' 'Wolfpack 55. Maintain niner thousand. Wolfpack 55. Is there something wrong? Talk to me.' 'Wolfpack 55 going down.' 'Cessna 59er delta. Traffic right above you [...]

IN 2003, the Governor's Commission on Teaching Success, a diverse group of Ohio educators and business leaders, issued a report titled 'Achieving More: Quality Teaching, School Leadership, Student Success.' In […]

ABSTRACTColleges and universities are paying increasing attention to students’ transition into post-secondary education, including the provision of support to freshmen through structured First-Year Experiences (FYEs). Although low- and-moderate-income students are participating in post-secondary education at increased rates, their performance remains behind that of affluent students. We evaluated the effects of a two-arm experimental-assignment treatment for low- and moderate-income U.S. students eligible for Federal Pell grants at a four-year high-research university (N = 178): 57 control condition, 61 in professional learning communities, 60 in community mentoring, with computerized random assignment conducted by an external evaluator. The intensive (3 credit) two-semester research-based FYE plus mentoring program showed no effect on students’ GPA or likelihood of good academic status, probation, or year two persistence. The treated students also showed no differences in fall-to-spring growth or spring level for non-cognitive measures, including academic engagement, amotivation, peer interaction, faculty interaction, and staff interaction. The null findings are consistent across unadjusted treatment-control comparisons, multivariate regression analyses for continuous outcomes, and logistic, probit, or linear analyses of dichotomous outcomes. Our findings have implications for generalizability about FYE effectiveness for low- and moderate-income students and for the design characteristics of FYE programing to reliably improve student outcomes.

A reclusive South Hills clan holds the key to development along Route 51 Route 51 winds through Pittsburgh's South Hills like an apocalyptic ribbon, littered with empty storefronts, broken windows [...]

OAKLAND - Two months after agreeing to head the Pittsburgh Regional Alliance, Tim Parks is in good spirits, still bubbling with optimism and promise. 'I am twice as energetic,' he [...]

The US Federal Reserve may have little choice but to follow Europe's lead and require US banks to add more capitalization. US banks had argued that guidelines need not be [...]

The effects of cholesterol-lowering drugs, including those that reduce cholesterol synthesis (statins) and those that reduce cholesterol absorption (ezetimibe), on cholesterol absorption and synthesis are well understood. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are a novel class of cholesterol-lowering drugs that robustly reduce LDL-cholesterol (LDL-C), but little is known about their effects on cholesterol absorption and synthesis. We evaluated how treatment with evolocumab, a fully human monoclonal IgG2 antibody to PCSK9, affects markers of cholesterol synthesis and absorption by measuring these markers in patients from an evolocumab clinical trial. At 2 weeks, changes in β-sitosterol/total cholesterol (TC) from baseline were 4% for placebo, 10% for evolocumab 140 mg (nonsignificant vs. placebo), and 26% for evolocumab 420 mg (P< 0.001 vs. placebo). Changes in campesterol/TC at week 2, relative to baseline between placebo and evolocumab, were all nonsignificant. Evolocumab had a modest effect on markers of cholesterol synthesis. At 2 weeks, changes in desmosterol/TC were 1% for placebo, 7% for evolocumab 140 mg (nonsignificant vs. placebo), and 15% for evolocumab 420 mg (P< 0.01 vs. placebo). Changes from baseline in lathosterol/TC at week 2 between placebo and evolocumab were nonsignificant. These results suggest that evolocumab has a modest effect on cholesterol synthesis and absorption despite significant LDL-C lowering.

Downtown, North, West are focal points for coming year DOWNTOWN - This year, local companies will empty more than 1.2 million square feet of Downtown office space. Can Pittsburgh fill [...]

Don Pulver of Philadelphia dropped from project DOWNTOWN - Don Pulver, the Philadelphia real estate developer hired seven years ago to build The Pittsburgh Cultural Trust's new office tower, is [...]

May be largest real estate foreclosure in local history DOWNTOWN - Mellon Bank Corp., hoping to recoup what it can from an unpaid $92 million mortgage, is foreclosing on One [...]

Airport authority will make decision about West Mifflin airport WEST MIFFLIN - Allegheny County's decision to create a new airport authority has scuttled its 'first-in-line' chance at turning the county-owned [...]

Medical center pays $5 million, options more land SCOTT TOWNSHIP - In the health care battle to claim the South Hills, the University of Pittsburgh Medical Center has secured another [...]

Construction companies, architects see thinning talent pool DOWNTOWN - For the first time in years, architects and construction executives have work to do. Lots of it. Yet, they lack the [...]

SOUTH SIDE - A New York developer wants to build single-family homes, townhouses and apartments on the largest unused site in the city - 672 acres overlooklng the Monongahela River [...]

Piatt, and Stout families compete for project CECIL TOWNSHIP - A mix of land, power and politics gave Southpointe its start in 1989. Now, that heady combination is fueling a [...]

Carnegie - Bill Teitelbaum wanted to be different. His task, as chairman and chief executive officer of National Record Mart Inc., was to protect. NRM from a downturn in the [...]

Buyers scramble for developer's Mount Washington portfolio MOUNT WASHINGTON - The tallest hill in Pittsburgh is now awash with real estate agents, land speculators and for-sale signs. One man is [...]

Forest City, which owns much of Station square, may want hotel SOUTH SIDE - One month after buying out its partner's interest in Station square, Forest City Enterprises Inc. is [...]

Software firm trims choices for new home to five sites DOWNTOWN - Transarc Corp., the fast-growing IBM software company that's seeking a new headquarters, has narrowed its search to five [...]

George Miles' idea of feel-good management is a hug and a smile. 'I am a person who likes to embrace people,' said the chief executive officer of WQED Pittsburgh Inc. [...]

North Side, Oakland booked for new construction NORTH SIDE - Oxford Development Co. and Crown American Hotels both want new rooms with new views. Oxford, a Downtown-based real estate company, [...]

DOWNTOWN - Weeks after voters sank a sales tax that would have paid for stadiums and development, the region's future is as uncertain as ever. Business and political leaders, upset [...]

Less federal money, more debt blamed DOWNTOWN - Burdened with debt and a shrinking share of federal funds, the Allegheny County Housing Authority is offering early retirement packages to its [...]

Baker Street Artisan Breads plans big Pittsburgh expansion, starting with new location at The Galleria in Mount Lebanon MOUNT LEBANON - Baker Street Artisan Breads is rising. The Philadelphia-based bread [...]

DOWNTOWN - Leslie Francis, the soft-spoken architect of the failed sales tax campaign, stood alone Tuesday night, the victory cigars in his pocket unsmoked. 'This was one of the toughest [...]

DOWNTOWN - A local real estate investment firm is close to buying the 23-story Clark Building, a historic property at the edge of the Cultural District. Madison Realty Group Inc., [...]

Behind the tax Top five givers to the pro-tax effort Pittsburgh Steelers $699,382.25 Pittsburgh Pirates $699,382.25 USX Corp. $400,000 PNC Bank Corp. $400,000 Mellon Bank Corp. $400,000 Source: Allegheny County [...]

Projects would fill demand for rooms in south, east CECIL TOWNSHIP - Two new hotels are taking form in Washington and Westmoreland counties. Hospitality sources said the first to break [...]

CECIL TOWNSHIP - A German packaging maker is considering a move from the state of Michigan to Washington County, a deal that could create more than 100 jobs here. The [...]

DOWNTOWN - Jack Walsh is playing catch-up. Hired to manage the day-today operations of the Regional Renaissance Partnership's sales tax campaign, Mr. Walsh has less than three weeks to convince [...]

DOWNTOWN - Hoping to keep pace with its burgeoning student population, Pittsburgh Technical Institute wants to build a new campus in the suburbs. Spokeswoman Linda Allan said the 51-year-old post-secondary [...]

Growth is strong, but caution still tinges decisions The year is 1997, but to some in the commercial real estate industry, it is the go-go days of 1985 all over [...]

US Airways crosses signals with the Air Force's 911th unit over a permanent radar system that would interfere with operations at the Moon Township Air Force base. MOON TOWNSHIP - [...]

DOWNTOWN - Urban Retail Properties Co., the Chicago firm that hopes to line Fifth and Forbes avenues with shops and restaurants., has signed a development option and consulting deal with [...]

Megaplex will highlight 450-acre development COLLIER TOWNSHIP - AMC Entertainment Inc., one of the world's largest movie house operators, will make its Pittsburgh debut here with a 30-screen megaplex. When [...]

DOWNTOWN - Was Larry Dunn right? Have Allegheny County commissioners Bob Cranmer and Mike Dawida been participating in a 'secret deal' with Pittsburgh Mayor Tom Murphy to merge the city's [...]

As Pittsburgh remakes its public housing, can the poor find enough private housing to replace units that will be demolished? HILL DISTRICT - Say goodbye to public housing. 'The game [...]

Chicago firm wants most of seven blocks DOWNTOWN - A Lord & Taylor at Smithfield Street and Fifth Avenue. A larger Saks Fifth Avenue, Niketown. Planet Hollywood, Eddie Bauer. These [...]

OAKLAND - The University of Pittsburgh Medical Center, continuing its aggressive expansion, may build a hospital-like medical complex in the South Hills. Jane Duffield, a UPMC spokeswoman, said the academic [...]

Commissioners study sites along Route 22 WASHINGTON - The Washington County commissioners are poking around northwest Washington County, looking for a place to drop another Southpointe-sized office and industrial park. [...]

Winner/Wagner & Mandabach would run fall referendum push DOWNTOWN - To manage its 0.5 percent sales tax campaign. the Regional Renaissance Partnership is expected to hire Winner/Wagner & Mandabach Campaigns, [...]

355,000-square-toot lease is the largest of the year DOWNTOWN - PNC Bank Corp. plans to move 2,000 to 3,000 employees to USX Towor, Pittsburgh's tallest office building. At press time, [...]

DOWNTOWN - In September, the local F.W. Dodge office will shed more than one-third of its Pittsburgh staff. Company officials said the move, which affects eight employees, makes Dodge a [...]