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1. In preeclampsia endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteries

Author

Nikitina, Elena R, Mikhailov, Anton V, Nikandrova, Ekaterina S, Frolova, Elena V, Fadeev, Artem V, Shman, Vera V, Shilova, Victoria Y, Tapilskaya, Natalia I, Shapiro, Joseph I, Fedorova, Olga V, and Bagrov, Alexei Y

Abstract

Marinobufagenin (MBG), a bufadienolide cardiotonic steroid, induces cardiovascular fibrosis. Because levels of MBG in preeclampsia are increased, and anti-MBG monoclonal antibody reduces blood pressure (BP) in a rat model of preeclampsia, we hypothesized that in preeclampsia, elevated MBG levels would be associated with the development of fibrosis in feto-placental circulation and with impairment of vascular relaxation.

Published
2011
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