1. Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection.
- Author
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Aslanidou L, Trachet B, Sasset L, Lovric G, Stergiopulos N, and Di Lorenzo A
- Subjects
- Aortic Dissection chemically induced, Aortic Dissection diagnostic imaging, Aortic Dissection physiopathology, Animals, Aorta, Abdominal diagnostic imaging, Aorta, Abdominal physiopathology, Aortic Aneurysm, Abdominal chemically induced, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal physiopathology, Aortography, Computed Tomography Angiography, Dilatation, Pathologic, Disease Models, Animal, Endothelium, Vascular pathology, Endothelium, Vascular physiopathology, Male, Mice, Inbred C57BL, Mice, Knockout, ApoE, Muscle, Smooth, Vascular pathology, Muscle, Smooth, Vascular physiopathology, Time Factors, Vasoconstriction, X-Ray Microtomography, Aortic Dissection pathology, Angiotensin II, Aorta, Abdominal pathology, Aortic Aneurysm, Abdominal pathology, Vascular Remodeling
- Abstract
Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE-/- mice have been widely used to study aortic aneurysm and dissection, early morphofunctional alterations preceding the onset of these conditions remain unknown. The goal of this study was to unveil early morphofunctional changes underlying the onset of aneurysm and dissection. At 3 days post-AngII infusion, suprarenal abdominal aorta presented significant volumetric dilatation and microstructural damage. Ex vivo assessment of vascular reactivity of the suprarenal dissection-prone aorta and its side branches, showed an endothelial and contractile dysfunctions that were severe in the suprarenal aorta, moderate distally, and absent in the side branches, mirroring the susceptibility to dissection of these different vascular segments. Early and specific morphofunctional changes of the suprarenal aorta may contribute to the regional onset of aortic aneurysm and dissection by exacerbating the biomechanical burden arising from its side branches., (© 2020 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2020
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