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1. Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

2. Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

3. Role of reactive metabolites in the circulation in extrahepatic toxicity

4. The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance

5. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.

6. Purification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney Microsomes

7. L-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid

8. L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination.

9. S-(1,2,2-Trichlorovinyl)-L-cysteine Sulfoxide, a Reactive Metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine Formed in Rat Liver and Kidney Microsomes, Is a Potent Nephrotoxicant.

10. Oxidative Metabolism of Seleno-l-methionine to l-Methionine Selenoxide by Flavin-Containing Monooxygenases

11. In Vivo Metabolism of L-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites

12. Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen.

13. Detection of carboxylic acids and inhibition of hippuric acid formation in rats treated with 3-butene-1,2-diol, a major metabolite of 1,3-butadiene.

14. Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse.

15. Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.

16. Sulfoxides as urinary metabolites of S-allyl-L-cysteine in rats: evidence for the involvement of flavin-containing monooxygenases.

17. Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.

18. Methionine S-Oxidation in Human and Rabbit Liver Microsomes: Evidence for a High-Affinity Methionine S-Oxidase Activity That Is Distinct from Flavin-Containing Monooxygenase 3

19. Chemical Modification of Deoxycytidine at Different Sites Yields Adducts of Different Stabilities: Characterization ofN3- andO2-Deoxycytidine andN3-Deoxyuridine Adducts of Butadiene Monoxide

20. Oxidation of Butadiene Monoxide tomeso-and (±)-Diepoxybutane by cDNA-Expressed Human Cytochrome P450s and by Mouse, Rat, and Human Liver Microsomes: Evidence for Preferential Hydration ofmeso-Diepoxybutane in Rat and Human Liver Microsomes

21. Cellular effects of reactive intermediates: Nephrotoxicity of S-conjugates of amino acids

22. Glutathione Conjugation of Perchloroethylene in Rats and Micein Vitro:Sex-, Species-, and Tissue-Dependent Differences

23. Characterization of the MethionineS-Oxidase Activity of Rat Liver and Kidney Microsomes: Immunochemical and Kinetic Evidence for FMO3 Being the Major Catalyst

24. Methimazole as a protectant against cisplatin-induced nephrotoxicity using the dog as a model

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