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Background: Hypertensive disorders of pregnancy (HDP) are a leading cause of severe maternal morbidity (SMM). We sought to explore trends in HDP and related morbidity outcomes in Canada. Methods: In this retrospective population-based study, we used hospital discharge data from Canada, excluding Quebec, to identify females who had an HDP diagnosis during a birth admission between 2012 and 2021. We analyzed temporal and geographical trends in HDP, as well as temporal trends in adverse outcomes associated with HDP. Results: Among 2 804 473 hospital admissions for birth between 2012 and 2021, the rate of any HDP increased from 6.1% to 8.5%, including pre-existing hypertension (0.6% to 0.9%), gestational hypertension (3.9% to 5.1%), and preeclampsia (1.6% to 2.6%). For 2017-2021 combined, relative to Ontario (6.9%), HDP were significantly more prevalent in nearly all other Canadian regions. For example, in Newfoundland and Labrador, the rate was 10.7% (unadjusted rate ratio 1.56, 95% confidence interval 1.49-1.63). Among females with any HDP, rates of cesarean delivery rose from 42.0% in 2012 to 44.3% in 2021, as did acute renal failure (0.4% to 0.6%), while rates of early preterm delivery, intrauterine fetal death, maternal hospital length of stay ([greater than or equal to] 7 d), admission to the maternal intensive care unit, severe hemorrhage, and SMM trended downward. Interpretation: The rate of HDP has risen across Canada, with a concomitant decline in some HDP-associated morbidities. Ongoing surveillance of HDP is needed to assess the factors associated with temporal trends, including the effectiveness of evolving HDP prevention and management efforts., Hypertensive disorders of pregnancy (HDP) include pre-existing (chronic) hypertension, gestational hypertension, and preeclampsia or eclampsia. Globally, hypertensive disorders affect 5%-10% of pregnancies and are responsible for more than 50 000 [...]

Every now and then, you see a vehicle build that just went above and beyond what your brain thinks is possible. Upon seeing Leroy Edwards' open-air hot rod at Sick [...]

As societal needs change, adaptive reuse projects to repurpose existing buildings or structures are becoming an increasingly crucial strategy for real estate developers. Changing the use of these pre-existing structures [...]

Security is mostly a superstition. It does not exist in nature, nor do the children of men as a whole experience it.--Helen Keller, The Open Door (1957). Privacy, as a [...]

Over more than 30 years, research on the interactions between multinational corporations (MNCs) and their institutional host environments has produced rich but scattered insights, which this review organises and integrates. We map the current state of knowledge and build an integrative model involving motivation and host context as antecedents; interaction strategy and actors as the phenomenon; and consequences, especially at the organisational level, as outcomes. By reviewing 176 articles published in leading journals, we reveal previously hidden relationships between host-country institutional context, proactive and reactive strategies, and positive and negative outcomes for the focal organisation. We also identify three future research frontiers focused on understudied aspects of interactions between MNCs and institutions: dynamics of strategies, dynamics of impact, and microfoundational dynamics. We suggest that combining organisational institutionalism and comparative institutionalism offers a pathway to push the outlined research frontiers. Keywords Multinational corporations (MNCs) * Institutions * Organisational institutionalism * Comparative institutionalism * Varieties of capitalism * Review, 1 Introduction The relationship between institutions and multinational corporations (MNCs) is a main theme of international business (IB) research (Kostova et al., 2008). Prior work tends to explore how the [...]

Autor(en): John Edwards Effizienz führt zu höherer Produktivität und Kostenreduzierungen. Sieben Möglichkeiten, wie Sie die IT-Effizienz nachhaltig steigern können. Kein CIO möchte eine ineffiziente IT-Organisation leiten. Doch durch Unachtsamkeit oder [...]

Byline: Molly Edwards Opinion | The Rings of Power altering Tolkien's canon is a good thing The Rings of Power season 2 is the latest in a long line of [...]

Byline: Molly Edwards Prepare to never sleep again A behind the scenes video from the set of Alien: Romulus will likely scar you for life, because it gives a terrifying [...]

Byline: Richard Edwards Here's everything we know so far about Ahsoka season 2, which is in early development at Lucasfilm. Ahsoka season 2: key information - Announced in January 2024 [...]

The United States border, for noncitizens, has a unique quality to it. Each time a noncitizen crosses that border, they are no longer private individuals. They can no longer choose to give up their information--instead, there is a forced exchange: data for entry. Who they are, what they are, and everything that connects them to the world is given up in exchange for a new life in a new land. Once the border is crossed, noncitizens no longer have the privacy that they may have known before. This Note first builds on scholarship theorizing that noncitizens do have a right to privacy. Whenever anyone is forced to give up information about themselves, their privacy is violated, and noncitizens are no exception to this rule. Unfortunately, this right is often disrupted by one of three powerful branches of the United States government: the Executive Branch. The Executive Branch has statutory and constitutional immigration authority, as well as Executive Departments that influence immigration policy daily-all of which comprise what this Note calls 'powers.' While previous scholarship has focused on the President's immigration authority, this Note proposes that the Executive Branch uses its 'powers ' to not only impact immigration policy but also the individual privacy of noncitizens. As technology continues to advance, the Executive Branch increasingly wields its 'powers,' in conjunction with different technological systems and databases, in ways that threaten the privacy of every noncitizen who dares to cross the border., TABLE OF CONTENTS INTRODUCTION 233 I. EXECUTIVE BRANCH POWERS 235 A. The Many 'Powers' of the Executive Branch 235 B. The Executive Branch 'Powers' Often Utilize Technology 237 In Pursuit [...]

As businesses strive to adapt and stay competitive, the need for effective leadership has never been greater. Executive coaching has emerged as a cornerstone for personal and professional growth. The [...]

I. INTRODUCTION The Communications Decency Act of 1996, among other things, created certain immunity protections for service providers to control the onslaught of lawsuits that threatened to snuff out the [...]

Background: Pharmacogenomic testing to identify variations in genes that influence metabolism of antidepressant medications can enhance efficacy and reduce adverse effects of pharmacotherapy for major depressive disorder. We sought to establish the cost-effectiveness of implementing pharmacogenomic testing to guide prescription of antidepressants. Methods: We developed a discrete-time microsimulation model of care pathways for major depressive disorder in British Columbia, Canada, to evaluate the effectiveness and cost-effectiveness of pharmacogenomic testing from the public payer's perspective over 20 years. The model included unique patient characteristics (e.g., metabolizer phenotypes) and used estimates derived from systematic reviews, analyses of administrative data (2015-2020) and expert judgment. We estimated incremental costs, life-years and quality-adjusted life-years (QALYs) for a representative cohort of patients with major depressive disorder in BC. Results: Pharmacogenomic testing, if implemented in BC for adult patients with moderate-severe major depressive disorder, was predicted to save the health system $956 million ($4926 per patient) and bring health gains of 0.064 life-years and 0.381 QALYs per patient (12 436 life-years and 74 023 QALYs overall over 20 yr). These savings were mainly driven by slowing or avoiding the transition to refractory (treatment-resistant) depression. Pharmacogenomic-guided care was associated with 37% fewer patients with refractory depression over 20 years. Sensitivity analyses estimated that costs of pharmacogenomic testing would be offset within about 2 years of implementation. Interpretation: Pharmacogenomic testing to guide antidepressant use was estimated to yield population health gains while substantially reducing health system costs. These findings suggest that pharmacogenomic testing offers health systems an opportunity for a major value-promoting investment., Pharmacogenomic testing offers the possibility of enhanced efficacy and fewer adverse effects from more appropriately targeted drug therapies. One clinical area for which pharmacogenomics could have particular promise is major [...]

Ranked by total value of loans made to Arkansas borrowers in FY 2023 Lender No. of Total Loan Main Location Loans Value 1 First Financial Bank 27 $35,579,800 El Dorado [...]

Byline: Molly Edwards The first trailer for Creature Commandos is here While there was no dedicated DC panel at this year's SDCC, the fledgling cinematic universe's presence has certainly been [...]

Byline: Molly Edwards Exclusive: Here's a brand new look at WandaVision spin-off Agatha All Along Agatha Harkness is making her highly anticipated return to the MCU later this year - [...]

Autor(en): John Edwards Sich das Scheitern eines Projekts einzugestehen, fällt selten leicht. In manchen Fällen ist ein harter Schnitt jedoch die beste Entscheidung. Wir sagen Ihnen, wann Ihre Projekte auf [...]

Byline: Molly Edwards Exclusive: Ewan Mitchell teases what's coming for Aemond in House of the Dragon season 2 House of the Dragon season 2 is almost here - and, judging [...]

Autor(en): John Edwards Das Jahr bietet viele Chancen und Herausforderungen. Lesen Sie, wie CIOs die wichtigsten Aufgaben für 2024 priorisieren und in den Griff bekommen. Das vergangene Jahr war zweifellos [...]

In recent years, advancements in technology and workflow automation have been revolutionizing the landscape of medical diagnostics, giving rise to the concept of 'Dark Labs.' The potential of fully automated [...]

Eight years after ASA conducted its first national labor study of the PHCP/PVF industry, the association has repeated the study to understand the current state of the industry's workforce and [...]

I am not normally moved to write but felt compelled in this instance, having just received my latest copy of Prog. I've been waiting patiently to read the review of [...]

THE COMPARISON A An 11-year-old Hispanic boy with allergic contact dermatitis (ACD) on the abdomen. The geometric nature of the eruption and proximity to the belt buckle were highly suggestive [...]

Maximilian Davis was in a music video. I learned this while talking to the singer Kelela, a friend of his, about the period when they first met several years ago [...]

INTRODUCTION U.S. Military Working Dogs (MWDs) and Multipurpose Canines (MPCs) are critical force multipliers and invaluable assets for combatant commanders due to their explosives and narcotics detection, specialized search, and [...]

This article discusses the recent advances in spintronics for low-power computing. Topics include a discussion of anti-ferromagnets with work by research in the groups of Paolo Radaelli at the University of Oxford, Mathias Kläui at the University of Mainz, and Anthony Tan at the University of Cambridge. Topics include quasiparticles, magnetometry, and reservoir computing.

Lawyers and bar associations have a critical role to play in activating decarbonization and adaptation, and creating a more climate-conscious legal practice. The American Bar Association (ABA) has been working [...]

Todos los directores de sistemas de información saben que el mercado de la nube siempre se mueve en nuevas direcciones. Pero lo que quizá no sepan es que es posible [...]

Byline: Luke Edwards A refurbished Apple Watch could save you money, but is there a catch? Sustainability Week 2024 This article is part of a series of sustainability themed articles [...]

Cuando Rebecca Fox, CIO en la consultora de seguridad NCC Group, observa el mercado de TI empresarial actual, ve un futuro moldeado por múltiples tendencias, pero sobre todo por la [...]

Byline: Richard Edwards These are the best Disney Plus movies to stream today, including Marvel, Star Wars, Pixar, Disney, and other classics. It should come as no surprise that the [...]

Byline: Richard Edwards These are the best Disney Plus movies to stream today, including Pixar, Star Wars, Disney, and 20th Century Fox classics. Our selection of the best Disney Plus [...]

Autor(en): John Edwards Viele Unternehmen halten zu lange an Projekten fest, die den erwünschten Vorteil nicht mehr einbringen werden. Lesen Sie, woran Sie erkennen, dass Sie ein totes Pferd reiten. [...]

Ningún CIO quiere liderar una organización de TI ineficiente. Eso es un hecho. Sin embargo, debido a la falta de atención o al apegarse a prácticas obsoletas, la TI puede volverse progresivamente [...]

Byline: Molly Edwards Another trailer for Inside Out 2 has landed Pixar has dropped a fresh look at Inside Out 2, and it's a chaotic trip inside Riley's head. The [...]

What is the Supply Industry? We are a vast sophisticated and technology-driven sector of our economy Why do we call it the '--Supply Industry?' Because distributors, manufacturers and independent manufacturer [...]

This article focuses on the use of non-intoxicating, over-the-counter (OTC) cannabidiol (CBD) preparations in children. Evidence of therapeutic benefits of OTC CBD is minimal and evolving. Much of what is available to review regarding OTC CBD use in pediatric patients is anecdotal based on real-world utilization, which creates a challenge for the pediatric nurse when defining best practices. The use of OTC hemp products containing CBD with less than 0.3% tetrahydro-cannabinol (THC) is increasingly common in adults. Many adults use these non-hallucinogenic CBD products regularly. The use of these readily available CBD products in children is more controversial, with conflicting evidence regarding safety and efficacy. Federally, use of OTC CBD products with less than 0.3% THC is legal; however, state laws vary. Commonly, pediatric nurses encounter patients who have an interest in or are currently using CBD. Legal implications coupled with the lack of U.S. Federal Drug Administration approval of these OTC products may lead to difficulty educating patients about CBD. This fact also complicates development of associated policies or procedures for usage. Pediatric nurses should know about OTC CBD, the endocannabinoid system's physiology, and legal implications of CBD in the pediatric population, and provide education to patients and families who consider CBD as part of a treatment plan. Key Words: Cannabidiol, CBD, hemp, pediatrics, policy, education, tetrahydrocannabinol, THC., The use of over-the-counter (OTC) hemp products containing cannabidiol (CBD) with less than 0.3% tetrahy-drocannabinol (THC) has increased in popularity (Consumer Reports, 2019). To date, the U.S. Food and Drug [...]

* Seen yet Unseen: A Black Woman Crashes the Tech Fraternity. By Barf A. Williams. May 2024. Blackstone, $27.99 (9798212009881). 658.4. The experiences described by technology-sector executive Williams (formerly of [...]