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OBJECTIVE--To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥ 120 mL/min/1.73 [m.sup.2]), GFR decline, and nephropathy onset or progression in type 2 diabetic patients with normo- [...]

Hyperfiltering kidney is a typical feature of diabetes. Improvement observed with regard to glucose control and blood pressure control reduces the high glomerular filtration rate and may contribute to retard the appearance and the progression of diabetic renal disease. Although the mechanism of hyperfiltration is still unclear, there is mounting evidence that the increased reabsorption of glucose and sodium by sodium glucose transporter-2 (SGLT-2) is involved in this altered renal function. There is a possibility that SGLT-2 inhibition may correct hyperfiltration in diabetes, adding a new therapeutic approach to halt renal disease in patients with diabetes.