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A study conducted by researchers at Indiana University School of Medicine found that the composition of the gut microbiome in 10-year-old Malian children is associated with susceptibility to febrile malaria. Children with a microbiome enriched for bacteria linked to inflammation and gut permeability were more likely to develop febrile malaria following Plasmodium falciparum infection. The research suggests that modulating the gut microbiome could potentially reduce malaria morbidity in endemic areas. This study was supported by the U.S. Department of Health & Human Services | National Institutes of Health and was published in Nature Communications. [Extracted from the article]

A study conducted at Changhua Christian Hospital in Taiwan analyzed abasic sites in breast cancer patients who had undergone 5 years of postoperative treatment without recurrence. The research found that the number of abasic sites in 5-year survivors was significantly reduced compared to those in breast cancer patients before treatment, and similar to levels in healthy controls. The study suggests that treatment-related effects may contribute to the reduction of abasic sites in breast cancer patients. [Extracted from the article]

A recent study from the University of Cincinnati College of Medicine explores the connection between Streptococcus gallolyticus, subspecies gallolyticus (Sgg) infection and colorectal cancer (CRC). The research suggests that Sgg has specific features that enable it to thrive in the colorectal tumor microenvironment, promoting the development and progression of CRC. The bacterium utilizes various mechanisms, such as adhesion facilitation, bile acid metabolism, and interference with oncogenic cell signaling pathways, to drive CRC progression. This study sheds light on the complex relationship between Sgg infection and colorectal cancer development. [Extracted from the article]

A recent study from the University of California Riverside explores the impact of minor-groove N-2-alkyl-dG lesions on genome integrity by eliciting R-loop accumulation in chromatin and DNA. The research suggests that these lesions may disrupt transcription elongation and compromise genome integrity, potentially leading to genome instability. The findings propose a potential therapeutic strategy involving the combination of R-loop helicase inhibitors with DNA alkylating drugs. This study sheds light on the intricate relationship between DNA damage, R-loop formation, and genome stability, offering insights for future drug research and development. [Extracted from the article]

Researchers at the University of Indonesia have developed an analytical method using ultra high-performance liquid chromatography tandem mass spectrometry to measure N2-Ethyl-2'-deoxyguanosine (N2-Et-dG) in dried blood spots. This method aims to quantify the unstable form of N2-Ethylidene-dG, a carcinogen that can cause DNA damage and lead to cancer. The study followed FDA guidelines and achieved a linear concentration range of 5-200 ng/mL for N2-Et-dG. For more information, readers can access the full article in Heliyon, with contact information available for the researchers involved. [Extracted from the article]

A new study from Loma Linda University Health provides a comprehensive review of the antitumor properties and mechanisms of duocarmycin analogs, a group of potent cytotoxic agents. The study explores the unique chemical structures and powerful mechanism of action of duocarmycins, which selectively bind to the minor groove of DNA and alkylate adenine bases. The review also discusses recent advancements in drug delivery systems, such as antibody-drug conjugates, that enhance the therapeutic potential of duocarmycin analogs. While preclinical studies have shown promise, further research is needed to fully understand the toxicology of these compounds before they can be used in clinical settings. [Extracted from the article]

A recent study conducted by researchers at the University of Georgia explores the biological factors involved in aflatoxin-induced DNA damage, which is a risk factor for liver cancer. The study used a method called tXR-seq to measure the repair of DNA adducts caused by aflatoxin at the single-nucleotide level. The results showed that transcription-coupled repair plays a significant role in the removal of DNA damage. Additionally, the study analyzed the distribution of repair sites within the 3D human genome organization and found that repair activity was higher in chromosomes positioned closer to the nuclear center and regions within A compartments. These findings provide insights into the complex relationship between DNA damage repair, transcription, and genome organization, shedding light on the mechanisms underlying aflatoxin-induced mutagenesis. [Extracted from the article]

A study conducted by Columbia University has found that exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy can have long-term effects on both maternal and adolescent mental health. The study measured PAH exposure through DNA adducts in maternal blood samples taken during the third trimester of pregnancy. It found that higher prenatal PAH exposure was associated with higher levels of maternal distress, which in turn influenced mental health outcomes for adolescents, including anxiety, depression, and externalizing problems. The study suggests that further research is needed to understand the social and biological mechanisms underlying the intergenerational transmission of the negative effects of pollution on mental health. [Extracted from the article]

The article focuses on the central mechanisms of acetaminophen (APAP)-induced liver toxicity, particularly highlighting mitochondrial dysfunction. Topics include the role of mitochondrial protein adducts and oxidative stress, the process of mitochondria-regulated nuclear DNA fragmentation, and adaptive mechanisms such as autophagy that modulate the pathophysiology of APAP overdose.

A recent report from the National Institute of Pharmaceutical Education and Research in Guwahati, India, explores the genotoxicity of smokeless tobacco (ST) and its connection to head and neck cancer. The study involved rats exposed to ST and head and neck cancer patients to examine DNA adduct profiles. The research found that high doses of ST led to elevated levels of nicotine, cotinine, N-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat urine. DNA adductomics identified 17 significant DNA adducts associated with ST exposure, and correlations were observed between DNA adducts and alkaloids-TSNA in ST-exposed rat urine. The study also analyzed human samples and found specific DNA adducts for ST users, controls, and subjects with head and neck cancer. The research provides insights into genotoxic mechanisms and health risks associated with ST exposure, which can inform future preventive and therapeutic strategies. [Extracted from the article]

Fresh data on oxaliplatin therapy is presented in a new report from researchers at the University of Bari 'Aldo Moro' in Italy. The study investigates the effect of the carrier ligand cis-1,3-diaminocyclohexane (cis-1,3-DACH) on the formation, stability, and stereochemistry of the (cis-1,3-DACH)PtG and (cis-1,3-DACH)Pt(d(GpG)) adducts. The research concludes that the (cis-1,3-DACH)Pt(d(GpG)) adduct is present in two isomeric forms, with a dominance of the HH conformer but with some contribution of the DHT conformer. This study provides valuable insights into the interactions of oxaliplatin analogs with DNA models. [Extracted from the article]

A recent report from Yale University highlights the role of genetic factors in attention deficit hyperactivity disorder (ADHD). The study conducted DNA sequencing in 152 families with a child diagnosed with ADHD and found a significant enrichment of rare and ultra-rare de novo gene-damaging mutations in ADHD cases compared to unaffected controls. The researchers identified lysine demethylase 5B (KDM5B) as a high-confidence risk gene for ADHD and estimated that 1057 genes contribute to ADHD risk. These findings provide insight into the biology of ADHD and demonstrate the potential of DNA sequencing in larger parent-child trio cohorts. [Extracted from the article]

A recent preprint abstract discusses the link between tobacco usage and various types of cancer. The study focuses on the mutational signatures of tobacco-specific nitrosamines NNN and NNK, which form pre-mutagenic pyridyloxobutyl (POB) DNA adducts. The researchers identified these mutational signatures in cell lines, rat tumors, and approximately 180 human cancer genomes. The study suggests that the POB pathway may contribute uniquely to the mutational landscapes of certain hematological malignancies and cancers of the kidney, breast, prostate, and pancreas. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

This article discusses a study on the effects of hypochlorous acid (HOCl) on DNA and mutagenesis in lung epithelial cells. Neutrophilic inflammation, which occurs in the airways during irritation, leads to the release of myeloperoxidase (MPO) and neutrophil extracellular traps (NETs) containing DNA. The study found that HOCl produced by MPO can damage the cell genome, leading to mutagenic end-oxidation products. However, the researchers discovered that trapping HOCl-induced DNA-centered radicals with the nitrone spin trap DMPO can reduce the formation of these mutagenic products and prevent gene mutation. This research suggests potential therapeutic avenues for reducing genotoxic damage in sites of neutrophilic inflammation. [Extracted from the article]

A recent study conducted by researchers from Ohio State University has found that lung cancer exhibits sex-related molecular characteristics and epidemiological trends, suggesting the need for sex-specific approaches to understanding its causes and treatment. The study focused on DNA methylation alterations, which play a critical role in lung cancer development and can serve as valuable biomarkers for personalized medicine strategies. The researchers identified sex-related differentially methylated CpG sites (DM-CpGs) in the lungs of healthy individuals and correlated them with gene expression and immune responses. These findings highlight the potential role of sex-related CpGs in influencing sex disparities in lung cancer risk and outcomes, emphasizing the need for further investigation in personalized lung cancer management strategies. [Extracted from the article]

A recent report from the Finnish Institute for Health and Welfare discusses the findings of a study on the association between a risk variant in the UST gene and dementia. The study analyzed data from the Finnish National FINRISK study surveys and the Vantaa 85+ cohort, and found that the risk variant was significantly associated with an increased risk of all-cause dementia and tau pathology. The researchers also discovered a connection between the risk variant and DNA methylation and transcriptional regulation of UST. These findings suggest a common risk variant for both stress-related conditions and dementia. [Extracted from the article]

A recent report from the University of Louisville discusses research on toxicology, specifically focusing on the carcinogenic effects of hexavalent chromium (Cr(VI)) on the lungs. The study found that acute exposure to Cr(VI) caused DNA double-strand breaks in rat lung tissue, with females being more susceptible than males. Additionally, the research showed that homologous recombination repair, a mechanism that prevents DNA breaks from causing chromosome instability, was activated in response to Cr(VI) exposure. These findings suggest that the mechanism observed in cell culture studies translates to lung tissue in vivo. [Extracted from the article]

A recent study conducted by the Chinese Academy of Sciences explores the use of high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) techniques for analyzing DNA damage and epigenetic modifications. The researchers highlight the potential of these techniques as biomarkers for environmental exposures and disease states. The study discusses the advancements in UHPLC-MS/MS-based technologies, including innovative methods for DNA digestion and removal of inorganic salt matrix, as well as strategies for improving detection sensitivity. The researchers also summarize the use of UHPLC-MS/MS coupled with other analysis methods for measuring DNA damage and epigenetic modifications in specific regions and fragments of chromosomes. The research was supported by the National Natural Science Foundation of China. [Extracted from the article]

A recent study conducted by researchers at Indiana University examined the effects of e-cigarette exposure on DNA methylation and gene expression in lung tissue, with a focus on sex-specific differences. The study used a mouse model and analyzed the expression of six specific genes involved in inflammation and oxidative stress. The preliminary results showed that e-cigarette exposure resulted in differential gene expression in lung tissue, with some differences observed between males and females. The researchers emphasized the need for further investigation into the effects of e-cigarette exposure, particularly in relation to flavored e-cigarettes and the underlying mechanisms of gene expression changes. The study was partially funded by the Offce of the Vice Provost of Research at Indiana University and the Indiana Clinical and Translational Sciences Institute. [Extracted from the article]

A new study conducted by researchers at Oregon Health & Science University (OHSU) has found that increased risk for hepatocellular carcinoma (HCC) is influenced by various factors, including hepatitis viral infection and dietary exposure to aflatoxin-producing molds. The study focused on the role of the DNA glycosylase NEIL1 in repairing AFB1-Fapy-dG adducts, which are highly mutagenic and can lead to HCC. The research found that NEIL1 deficiency increased AFB1-induced mutagenesis and ultimately carcinogenesis in male mice. These findings highlight the critical role of NEIL1 in limiting AFB1-induced mutagenesis and provide insights into the mechanisms underlying HCC development. [Extracted from the article]

Researchers from Sapienza University of Rome have conducted a study to gain a better understanding of chronic obstructive pulmonary disease (COPD). The study involved the integration of lung tissue RNA sequencing and DNA methylation data from COPD cases and controls. Through their analysis, the researchers identified potential COPD-associated genes and explored their relationships at the transcriptomics and epigenomics levels. The findings contribute to the current knowledge of COPD pathogenesis and highlight the significant involvement of immune system components in the disease. [Extracted from the article]

A recent report from the First Affiliated Hospital of Xiamen University discusses the role of DNA damage repair in lung squamous cell carcinoma (LUSC) and its impact on immunogenicity. The study focuses on the tumor suppressor zinc finger protein 750 (ZNF750) and its interaction with tenascin C (TNC), an extracellular matrix protein. The research suggests that modulation of the ZNF750-TNC axis may affect the behavior of tumor cells and patient prognosis. The study also explores the involvement of this axis in DNA damage repair and its potential implications for immune cell therapy in LUSC. [Extracted from the article]

A study conducted by researchers at Hong Kong University of Science and Technology has provided new insights into the development of Balkan endemic nephropathy (BEN), a multifactorial environmental disease. The research found that exposure to aristolochic acids (AA) and the resulting DNA adduct formation are key factors in the development of BEN. The study also revealed that coexposure to arsenic, cadmium, and iron increased DNA adduct formation, while coexposure to calcium and copper decreased it. These findings shed light on the endemic nature of BEN and the role of DNA damage in its nephrotoxicity and carcinogenicity. [Extracted from the article]

Researchers at the University of Texas have conducted a study on DNA adducts in cancer chemotherapy. DNA adducts are formed when certain drugs interact with DNA, and while they are known to induce cancer cell death, their specific chemotypes and role in drug therapy response are not well understood. The study aims to investigate the metabolic activation and chemical characterization of DNA adducts formed by FDA-approved drugs, as well as their potential as biomarkers for predicting patient responses to drug efficacy. The researchers hope that this research will encourage further exploration of DNA adducts as biomarkers for personalized cancer treatment. [Extracted from the article]

A study conducted at Samsung Medical Center in Seoul, South Korea, has found that mesenchymal stem cell (MSC) transplantation can reduce inflammation and injury in cases of lung injury. The researchers hypothesized that the release of mitochondrial DNA (mtDNA) could be reduced by MSC transplantation. In both in vitro and in vivo studies, the researchers observed a decrease in extracellular mtDNA levels and inflammatory cytokines after MSC therapy. The study suggests that increased levels of extracellular mtDNA are associated with increased inflammation in hyperoxia-induced lung injury, and MSC therapy can help reduce these levels. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the interplay of environmental and genetic factors in metabolic diseases (MetDs) and their association with an increased risk of cancer. The study focuses on DNA methylation patterns in non-canonical DNA structures, such as G-quadruplexes or R-loops, in two MetD risk genes, GCK and TM6SF2. The researchers found significant differential methylation in these genes in MetD patients compared to healthy controls, and confirmed the formation of G-quadruplex structures in these regions. The study suggests that the elevated blood glucose and fatty acid levels in MetD patients could lead to changes in the non-B DNA landscape, causing differential methylation and altered transcription factor binding. The findings provide new insights into the mechanisms underlying MetDs and their link to cancer, and suggest that non-B DNA structures could be potential targets for therapeutic interventions. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the biological consequences of RNA damage, which is largely unexplored compared to DNA damage. The study demonstrates that a protein called YTHDC1, in association with the THO complex, regulates the response to alkylation damage in RNA. In the absence of YTHDC1, RNA damage leads to increased sensitivity to alkylation damage and DNA breaks. The study also found that RNA damage-induced DNA breaks depend on R-loop formation and can be prevented by YTHDC1-THOC. This research provides evidence for how damaged RNAs can impact genomic integrity. [Extracted from the article]

The following topics are under this section: Breaking Free from Diabetes Burnout Pioneer in Cancer Immunoassay Gaming Technology for Elder Care Coverage of science and technology events and interviews conducted with researchers, industry experts, and thought leaders. This month, we have interviews related to self-management of diabetes, use of immunoassays for measuring chemical carcinogen-induced DNA damage, and gaming technology for elders. [ABSTRACT FROM AUTHOR]

A study conducted by researchers at Ondokuz Mayis University aimed to estimate the applied doses of irradiated anchovy and bluefish for shelf-life extension using image analysis in combination with the DNA comet assay. The researchers found that the head diameter, head DNA, tail DNA, tail length, and tail moment parameters showed a strong correlation with the applied doses of irradiation. They concluded that using image analysis in combination with the comet assay could be a useful tool for quantifying absorbed doses in irradiated fish for local market checks and customs control. The full study can be accessed for free at the provided link. [Extracted from the article]

A study conducted by researchers at the University of Pecs in Hungary has found that maternal nutrition during pregnancy and lactation can have a significant impact on the development of non-communicable diseases in offspring. The study focused on the role of DNA methylation, a process that can be influenced by maternal macronutrient or vitamin intake. The researchers discovered that alterations in DNA methylation caused by maternal under- or overnutrition of certain nutrients were associated with the development of obesity and related metabolic changes in the offspring. This research highlights the importance of maternal nutrition in preventing these health issues. [Extracted from the article]

A recent study conducted by researchers at New York Medical College explores the effects of hexavalent chromium (Cr(VI)) on mitochondria and its implications in carcinogenesis. Hexavalent chromium is a known human carcinogen that can modulate multiple cellular targets and generate reactive oxygen species (ROS) during its reduction process. The study highlights the impact of Cr(VI) on mitochondrial biology, including oxidative phosphorylation, mitophagy, and mitochondrial biogenesis, which can alter the trajectory of Cr(VI)-induced carcinogenesis. The research provides a summary of current knowledge in this area and suggests future directions for further investigation. [Extracted from the article]

A study conducted by the Girona Institute for Biomedical Research examined the impact of maternal pregestational body mass index (BMI) on the placenta and umbilical cord methylomes and their potential effect on the offspring's metabolic phenotype. The researchers assessed the DNA methylome in 24 paired placenta and umbilical cord samples and identified differentially methylated CpGs associated with maternal pregestational BMI. They found that maternal pregestational BMI is associated with the methylation of genes involved in endocrine and developmental pathways, potentially affecting type 2 diabetes and obesity. The study suggests that epigenetic analysis in placenta and umbilical cord may be useful for identifying individual vulnerability to later metabolic diseases. [Extracted from the article]

A recent study conducted by researchers at Gifu University Graduate School of Medicine in Japan explored the genetic and epigenetic factors contributing to schizophrenia (SZ) and bipolar disorder (BD). The study found that individuals with a high genetic risk for SZ had a higher risk of SZ and cognitive impairments. Additionally, the study investigated DNA methylation risk scores (MRSs) derived from blood and brain tissues and their association with SZ risk. The findings suggest that MRSs could serve as a potential genetic marker for understanding SZ, particularly in patients with a genetic SZ risk. [Extracted from the article]

A recent study conducted by researchers at the University of Texas Health San Antonio explores the role of O6-methylguanine-DNA methyltransferase (MGMT) in repairing DNA damage caused by certain cancer treatments. The study highlights the structural and functional roles of MGMT, particularly its N-terminal domain, and discusses its potential as a target for cancer therapeutic strategies. Additionally, the research examines the interaction between MGMT and other DNA repair pathways. This information may be valuable for individuals conducting research on cancer, genetics, oncology, DNA repair, and proteomics. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of DNA repair pathways in preventing mutagenesis caused by acetaldehyde, a metabolite of alcohol and a component of tobacco smoke. The study used Saccharomyces cerevisiae to delete genes involved in various DNA repair pathways and found that deletion of nucleotide excision repair (NER) genes led to an increase in mutagenesis upon acetaldehyde exposure. Whole genome sequencing of mutated isolates showed an increase in specific mutation signatures associated with acetaldehyde exposure. The findings were further supported by analysis of liver cancers with defects in DNA repair genes. This research suggests that multiple DNA repair pathways protect against acetaldehyde-induced mutagenesis. [Extracted from the article]

A recent report from Osaka, Japan discusses the risk factors for urinary bladder cancer, specifically occupational exposure to aromatic amines (AAs). The study aimed to evaluate the toxicity of AAs and analyze the mechanisms of carcinogenesis in rat bladder by analyzing DNA adducts. The researchers found that oxidative stress may be involved in the toxicity of rat bladder epithelium exposed to AAs. Additionally, the administration of an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase resulted in the suppression of simple hyperplastic lesions in the bladder, indicating that oxidative stress may contribute to the development of urinary cancer induced by AAs. [Extracted from the article]

A recent study conducted by researchers at the National Institute of Diabetes and Digestive and Kidney Diseases focused on the hepatitis B virus (HBV), which affects nearly 300 million people worldwide and poses a significant public health threat. The study aimed to identify and understand the role of host factors associated with HBV covalently closed circular DNA (cccDNA), which is responsible for viral transcription and replication. The researchers discovered that nucleolin, a protein, plays a crucial role in HBV cccDNA transcription, potentially through epigenetic regulation. Targeting nucleolin to silence cccDNA transcription in infected hepatocytes could be a promising therapeutic strategy for a functional cure of HBV. [Extracted from the article]

Researchers from the University of Texas Rio Grande Valley have conducted a study on the effects of elevated temperatures on the American oyster. The study found that increased temperatures led to oxidative stress, cellular apoptosis, and DNA damage in the oysters. Biomarkers such as heat shock protein-70 (HSP70) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were significantly increased at higher temperatures, indicating the presence of pro-mutagenic DNA lesions. The study suggests that heat shock-driven oxidative stress alters the oysters' extracellular body fluid conditions and may lead to increased levels of 8-OHdG. [Extracted from the article]

A recent study conducted by researchers at the United Arab Emirates University explored the effects of Azadirachtin (AZD), a compound found in the neem tree, on toxicities induced by benzo(a)pyrene (B(a)P), a component of cigarette smoke known to cause DNA damage and cancer. The study found that treatment with AZD resulted in decreased oxidative stress and apoptosis, partial protection from DNA damage, and improved mitochondrial functions and bioenergetics. The researchers concluded that AZD has potential as a therapeutic agent in combination with anti-cancer drugs. This information may be useful for individuals researching cancer, genetics, and cellular physiology. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventIn a single center retrospective, descriptive study including 40·patients treated from January·2018 to March·2022, et al. patient [age and sex not stated] was described, who developed renal failure during treatment with venetoclax and unspecified DNA-methylation-inhibitor for acute myelogenous leukaemia [doses, routes, duration of treatments to reaction onset not stated] [Extracted from the article]

A recent study conducted by researchers at the Barcelona Institute for Global Health examined the impact of tobacco, alcohol, and marijuana consumption on DNA methylation and its relationship with hypertension. The study analyzed data from a cohort of 3,424 individuals and found that alcohol and tobacco consumption were associated with differential DNA methylation at certain sites, while no significant associations were found with marijuana consumption. The researchers identified specific genes related to the nervous and cardiovascular systems that were affected by alcohol and tobacco consumption. The study suggests that DNA methylation could be a potential target for hypertension prevention and management, particularly in relation to alcohol consumption. Further research is needed to explore the neurological and cardiovascular effects of substance consumption using methylation in blood. [Extracted from the article]

A recent study conducted by ChromaCode Inc. in Carlsbad, California, explored the use of a highly multiplexed research-use-only (RUO) panel for the detection of DNA and RNA biomarkers in non-small cell lung cancer (NSCLC). The panel's analytical sensitivity and concordance with next-generation sequencing (NGS) were evaluated using contrived DNA and RNA mixes, as well as FFPE samples. The results showed that the panel had a high analytical sensitivity and demonstrated over 97% concordance with the comparator method. This research contributes to the understanding of biomarker detection in NSCLC and may help improve patient access to timely biomarker information. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the functions and regulations of DNA polymerase kappa (Pol{kappa}) during translesion DNA synthesis (TLS). TLS is a process that allows cells to bypass lesions encountered during DNA replication and is a target of chemotherapy. Pol{kappa} has the unique ability to bypass minor groove DNA adducts, but its role in overcoming major groove DNA adducts is unclear. The study reveals that Pol{kappa} has two main functions during TLS, which are regulated by its interaction with Rev1. It is essential for replicating across minor groove DNA lesions and stabilizes the Rev1-Pol{zeta} extension complex to allow extension past major groove DNA lesions and abasic sites. The research identifies both catalytic and non-catalytic functions of Pol{kappa} in TLS and sheds light on the regulatory mechanisms of TLS polymerases. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

Keywords: Delhi; India; Asia; Cancer; DNA Damage; DNA Research; Deoxyribonucleic Acid; Drugs and Therapies; Genetics; Health and Medicine; Oncology; Proteomics EN Delhi India Asia Cancer DNA Damage DNA Research Deoxyribonucleic Acid Drugs and Therapies Genetics Health and Medicine Oncology Proteomics 1235 1235 1 10/30/23 20231103 NES 231103 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Cancer have been presented. However, DNA repair mechanisms are devoted to protect the DNA to ensure genetic stability, any aberrations in these calibrated mechanisms provoke cancer occurrence. [Extracted from the article]

Keywords: Biology; Epithelial Cells; Genetics; Life Sciences EN Biology Epithelial Cells Genetics Life Sciences 287 287 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on biology is now available. For more information on this research see: miRNA-214-3p stimulates carcinogen-induced mammary epithelial cell apoptosis in mammary cancer-resistant species. [Extracted from the article]

For more information on this research see: Inhibition of TRAP1 Accelerates the DNA Damage Response, Activation of the Heat Shock Response and Metabolic Reprogramming in Colon Cancer Cells. Keywords: Cancer; Colon Cancer; DNA Damage; DNA Research; Deoxyribonucleic Acid; Genetics; Health and Medicine; Oncology; Proteomics EN Cancer Colon Cancer DNA Damage DNA Research Deoxyribonucleic Acid Genetics Health and Medicine Oncology Proteomics 518 518 1 10/24/23 20231024 NES 231024 2023 OCT 24 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- New research on colon cancer is the subject of a new report. [Extracted from the article]

"We have adapted the tXR-seq method to measure the nucleotide excision repair of AFB1-induced DNA adducts. "These findings provide insights into the complex interplay between repair, transcription, and 3D genome organization, shedding light on the mechanisms underlying AFB1-induced liver cancer." "In the liver, the bioactivated AFB1 intercalates into the DNA double helix to form a bulky DNA adduct which will lead to mutation if left unrepaired. [Extracted from the article]

Keywords: Cytometry; Diagnosis; Diagnostics and Screening; Epigenetics; Health and Medicine; Life Sciences; Sputum Induction EN Cytometry Diagnosis Diagnostics and Screening Epigenetics Health and Medicine Life Sciences Sputum Induction 572 572 1 10/09/23 20231013 NES 231013 2023 OCT 15 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Data detailed on epigenetics have been presented. Cytometry, Diagnosis, Diagnostics and Screening, Epigenetics, Health and Medicine, Life Sciences, Sputum Induction. [Extracted from the article]

Keywords for this news article include: Lodz, Poland, Europe, Life Science, Biological Factors, Biological Toxins, Mycotoxins, University of Lodz. Keywords: Lodz; Poland; Europe; Life Science; Biological Factors; Biological Toxins; Mycotoxins EN Lodz Poland Europe Life Science Biological Factors Biological Toxins Mycotoxins 1037 1037 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Life Science is now available. Lodz, Poland, Europe, Life Science, Biological Factors, Mycotoxins, Biological Toxins. [Extracted from the article]

Keywords: Amino Acids; Cardiovascular Diseases and Conditions; Diseases and Conditions; Genetics; Health and Medicine; Healthcare; Metabolic Syndrome; Neutral Amino Acids; Nutritional and Metabolic Diseases and Conditions; Risk and Prevention; Serine EN Amino Acids Cardiovascular Diseases and Conditions Diseases and Conditions Genetics Health and Medicine Healthcare Metabolic Syndrome Neutral Amino Acids Nutritional and Metabolic Diseases and Conditions Risk and Prevention Serine 604 604 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on metabolic syndrome. In this study, we identified serum metabolites associated with MetS and DNA methylation, and we conducted bidirectional Mendelian randomization (MR) to assess causal relationships between metabolites and methylation. [Extracted from the article]