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AbstractA stability indicating HPTLC method was developed and validated for the determination of levosulpiride in tablet dosage form using mobile phase consisting of ethyl acetate : methanol : toluene : triethylamine (4.5 : 3.5 : 2 : 0.2v/v/v/v) and detection was carried out at 238 nm. Linearity was observed over the concentration range 100-500 ng/spot. Levosulpiride was subjected to stress conditions including acidic, alkaline, oxidation and photolytic degradation. Levosulpiride is more sensitive towards alkaline degradation. The method was validated as per ICH guidelines. The content of levosulpiride in marketed formulation was found to be 99.13 %±0.38 of labelled amount. The proposed method was found to be reliable, reproducible and specific for the estimation of levosulpiride in tablet dosage form.

The contemporary associations of type 2 diabetes with a wide range of incident cardiovascular diseases have not been compared. Previous studies have focussed on myocardial infarction and stroke, and these conditions are the usual outcomes chosen in clinical trials in type 2 diabetes, but other diseases such as heart failure and angina are also major causes of morbidity in diabetes. We aimed to study associations between type 2 diabetes and 12 initial manifestations of cardiovascular disease.