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1. Role of the front wing/wheel setting-up on the optimal cornering performances of a Formula 1 car

Author: Peri, Daniele and Di Mascio, Andrea
Abstract: We propose a hybrid approach based on meta-modelling techniques and machine-learning algorithms to determine the best car configuration for each circuit. By a specific interpolation model, we obtain an accurate estimation of the car’s speed as a function of the front wing configuration and the bend curvature. Some high-fidelity fluid dynamic simulations train the model and extend it to the entire design space. These data are then used as input for a simplified car dynamics model, providing an accurate estimate of the ideal lap time. Comparison with actual telemetry data confirms that the resulting tool is reliable, fast and easy to use.
Published: 2024
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2. Eco-efficient asphalt recycling for urban slow mobility

Author: Bruno, Salvatore, Loprencipe, Giuseppe, Di Mascio, Paola, Cantisani, Giuseppe, Fiore, Nicola, Polidori, Carlo, Riccio, Gennaro, D’Andrea, Antonio, and Moretti, Laura
Abstract: Cycling infrastructures contribute to advancing zero-impact transport systems, aligning with the European Commission’s proactive climate change mitigation policies. This paper explores the potential of innovative and sustainable pavements for cycling paths with mixtures composed of road-milling materials. This investigation involves low-environmental-impact bituminous-based mixtures differing from recipe, mixing method, and laying. Up to 100% secondary aggregates are used as alternative materials to design the Grande Raccordo Anulare delle Biciclette (GRAB), a 44-km cycling ring in Rome. According to the European standard EN 15804, their “from cradle to gate” life cycle analysis allows a comprehensive assessment and comparison of the environmental impact. Core and additional environmental impact categories and resource use indicators were quantified using primary data from asphalt producers and secondary data from the Ecoinvent database in the SimaPro software. Within the H2020 InfraROB project (grant agreement no. 955337), which aims at enhancing road infrastructure integrity, performance, and safety through autonomous robotic solutions and modularization, experimental sections have been constructed using a cold-mixed asphalt composed entirely of recycled asphalt and a rejuvenating additive. The results underscore the potential of the examined low-impact approach in conserving Earth’s resources, ensuring long-lasting infrastructure for vulnerable urban populations and fostering sustainable environmental management.
Published: 2024
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3. The CrazySquare project for music learning in Italian school-age pre-adolescents: integrating technology into educational practice

Author: Peretti, Sara, Caruso, Federica, Pino, Maria Chiara, Giancola, Marco, D’Amico, Simonetta, and Di Mascio, Tania
Abstract: The daily incorporation of music education and instrumental practice within school settings has been linked to various advantages, such as enhanced language skills and improved peer relationships. Mastering musical skills poses a significant challenge, necessitating proper teaching activities and adherence to specific learning theories. The rapid evolution of technology has emerged as a powerful tool for improving musical education. Nevertheless, crafting technology aligned with specific learning theories, including appropriate educational materials, remains a formidable task. Likewise, music teachers grapple with the challenge of seamlessly integrating technology into their teaching activities without robust support. This paper delves into this challenge, presenting the results from CrazySquare, a project that mainly focuses on guitar musical learning. It leverages the Technological Pedagogical Content Knowledge (TPACK) framework to enable the effective integration of technology into traditional teaching practices for Italian school-age pre-adolescents. The fruitfulness of using the TPACK framework is strengthened since it has been carried out through the Technology Enhanced Learning-oriented User-Centered Design methodology. This methodology inherently necessitates a multidisciplinary team at the core of the design process, and it has an iterative nature encompassing both expert-based and end-user-based evaluation steps. Such an approach can promote the controlled diffusion of technology in education as a scaffold for learning, reducing the barriers typically faced by teachers and students in the digital era.
Published: 2024
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4. Implementation of Ireland’s first state-funded day-case total hip arthroplasty programme

Author: Di Mascio, Nicholas, McGrath, Brid, Doran, Ciara, Cashman, James, Brennan, Adrian, and Flanagan, Anne-Marie
Abstract: Background: Over the last two decades, many elective procedures have transitioned to day-case surgery thanks to the introduction of ‘enhanced recovery’ protocols. Only recently has total hip arthroplasty been considered a candidate for day-case surgery, as it was once associated with significant pain, mobility impairment and prolonged postoperative recovery. The National Orthopaedic Hospital Cappagh became the first public hospital in Ireland to set up a day-case total hip arthroplasty service in June 2018, and since then has performed over 109 such cases.Aims: We outline our day-case total hip arthroplasty pathway, with specific focus on anaesthetic considerations. We report rates of failed discharge and readmissionResults: We achieved successful same-day discharge in 90.8% of our first 109 cases. Readmission rate was 4.6%.Conclusion: Our experience of implementing a day-case total hip arthroplasty pathway was highly positive and congruent with expectations from the literature. With appropriate patient selection and education, day-case total hip arthroplasty is not just safe, but of benefit to both patients and healthcare systems.
Published: 2024
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5. Three-Tiered Fetal Heart Rate Interpretation System and Adverse Neonatal and Maternal Outcomes: A Systematic Review and Meta-analysis

Author: Zullo, Fabrizio, Di Mascio, Daniele, Raghuraman, Nandini, Wagner, Steve, Brunelli, Roberto, Giancotti, Antonella, Mendez-Figueroa, Hector, Cahill, Alison G., Gupta, Megha, Berghella, Vincenzo, Blackwell, Sean C., and Chauhan, Suneet P.
Abstract: (Abstracted from Am J Obstet Gynecol2023;229(4):377–387Electronic fetal monitoring is used on more than 3.8 million parturients a year. Despite its ubiquitous use, fetal heart rate tracing (FHRT) is marred by intraobserver variability and inconsistent use of terms to describe contraction patterns.
Published: 2024
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6. Implementing the NRRP from the Draghi government to the government of Giorgia Meloni: Italian public administration under the pressure of too large a volume of resources

Author: Di Mascio, Fabrizio and Natalini, Alessandro
Abstract: ABSTRACTThe Italian public administration was called upon to spend the largest proportion of the funds made available by the European Union within the framework of the post-pandemic economic recovery programme NextGeneration EU. At the end of 2022, implementation delays drew the attention of the new ruling coalition led by Giorgia Meloni to the lack of administrative capacity, a risk factor that the Italian National Recovery and Resilience Plan had foreseen – to the extent that it had included within it a number of reforms of the public administration. The article analyses the outcomes of the steps taken to increase administrative capacity in accordance with the Plan. It highlights that EU funds are out of all proportion to the actual capacity of Italian authorities to spend them.
Published: 2023
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7. Chemiexcited Neurotransmitters and Hormones Create DNA Photoproducts in the Dark

Author: Gonçalves, Leticia C. P., Angelé-Martínez, Carlos, Premi, Sanjay, Palmatier, Meg A., Prado, Fernanda Manso, Di Mascio, Paolo, Bastos, Erick L., and Brash, Douglas E.
Abstract: In DNA, electron excitation allows adjacent pyrimidine bases to dimerize by [2 + 2] cycloaddition, creating chemically stable but lethal and mutagenic cyclobutane pyrimidine dimers (CPDs). The usual cause is ultraviolet radiation. Alternatively, CPDs can be made in the dark (dCPDs) via chemically mediated electron excitation of the skin pigment melanin, after it is oxidized by peroxynitrite formed from the stress-induced radicals superoxide and nitric oxide. We now show that the dark process is not limited to the unusual structural molecule melanin: signaling biomolecules such as indolamine and catecholamine neurotransmitters and hormones can also be chemiexcited to energy levels high enough to form dCPDs. Oxidation of serotonin, dopamine, melatonin, and related biogenic amines by peroxynitrite created triplet-excited species, evidenced by chemiluminescence, energy transfer to a triplet-state reporter, or transfer to O2resulting in singlet molecular oxygen. For a subset of these signaling molecules, triplet states created by peroxynitrite or peroxidase generated dCPDs at levels comparable to ultraviolet (UV). Neurotransmitter catabolism by monoamine oxidase also generated dCPDs. These results reveal a large class of signaling molecules as electronically excitable by biochemical reactions and thus potential players in deviant mammalian metabolism in the absence of light.
Published: 2023
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8. Advances in small molecule maintenance therapies for high-grade serous ovarian cancer

Author: Fischetti, Margherita, Di Donato, Violante, Palaia, Innocenza, Perniola, Giorgia, Tomao, Federica, Perrone, Chiara, Giancotti, Antonella, Di Mascio, Daniele, Monti, Marco, Muzii, Ludovico, Benedetti Panici, Pierluigi, and Bogani, Giorgio
Abstract: ABSTRACTIntroductionOvarian cancer is one of the most lethal gynecological tumors with a lack of effective treatment modalities especially in advanced/recurrent disease. Nevertheless, recently, new small molecules have emerged as an effective approach for the management of ovarian cancer patients, especially in the maintenance setting.Areas coveredThis review summarizes the role of small molecules used in the management of high-grade serous ovarian cancer. The authors performed a critical review of current evidence and ongoing studies. Of note, tyrosine kinase inhibitors (TKIs) and poly(ADP-ribose) polymerase (PARP) inhibitors are the most intriguing medications in this setting.Expert opinionProtein-targeted therapies against tumor tissues have progressed significantly in the last years due to an enhanced knowledge of the biological and molecular processes of carcinogenesis. Treatment with small molecules allows the targeting of specific proteins involved in cancer biology. TKIs seem promising but further data are necessary to assess the pros and cons of adopting this treatment modality. PARP inhibitors represent the new standard of care for ovarian cancer patients harboring either a BRCA mutation or with homologous recombination deficiency (HRD). Interestingly, the accumulation of data has highlighted that PARP inhibitors provide benefits even in patients with HR proficient tumors.
Published: 2023
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9. An update on current pharmacotherapy for vulvar cancer

Author: Bogani, Giorgio, Palaia, Innocenza, Perniola, Giorgia, Tomao, Federica, Giancotti, Antonella, Di Mascio, Daniele, Capalbo, Giuseppe, Muzii, Ludovico, Benedetti Panici, Pierluigi, and Di Donato, Violante
Abstract: ABSTRACTIntroductionLimited data on the role of pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer are available.Areas coveredThis article aims to provide an overview of the current treatment options for patients with vulvar cancer. PubMed (MEDLINE), Embase, CENTRAL, Scopus, and Web of Science databases, as well as ClinicalTrials.gov were searched to review the current evidence as well as future perspectives on the role of pharmacotherapy in patients with vulvar carcinoma.Expert opinionThere has been no consensus on the pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer. Concurrent platinum-based chemoradiation is the most widely used treatment modality for primary treatment or for neoadjuvant settings. Chemotherapy in metastatic disease is considered a palliative treatment. Anti-EGFR tyrosine kinase inhibitors seem to show promising anti-tumor activity in patients harboring EGFR alteration. Similarly, growing evidence supports the adoption of immune checkpoint inhibitors in both neoadjuvant and metastatic settings. Molecular and genomic profiling is advocated to identify target mutations. The PI3K/AKT/mTORand HER/ErbBpathways might represent two intriguing treatment options. Treatments directed against HPV are discussed as well. Further evidence is warranted to identify the best treatment modalities for patients with locally advanced, recurrent, and metastatic disease.
Published: 2023
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10. Materials study to implement a 3D printer system to repair road pavement potholes

Author: Cantisani, Giuseppe, D'Andrea, Antonio, Di Mascio, Paola, Moretti, Laura, Fiore, Nicola, Petrelli, Marco, Polidori, Carlo, and Venturini, Loretta
Abstract: InfraRob is a research project funded by the European Commission's research programme Horizon 2020 that aims to maintain integrity, performance, and safety of the road infrastructure through autonomous robotized solutions and modularization. A specific task of the project is focused on the development of a system 3D printer able to extrude a specific mixture for filling in small cracks and potholes, to be integrated with an existing small autonomous carrier. The first step of the research deals with the definition of the optimal parameters of the system 3D printer/mixture, by studying in parallel the material design and the printer design. This paper presents the study performed on a mixture chosen among those commonly used for road potholes repair. The mixture is studied to achieve and balance the different conflicting performances: consistence, flowability homogeneity, and internal structure. In addition to the basic components, the use of special additives has also been explored to improve the plasticity and adhesivity of the mixture. The first phase of tests is conducted to define the main printing controls: i) Extrudability control: materials for 3D printing need to have an acceptable degree of extrudability, which is related to the capacity of a material to pass continuously through the printing head; ii) Flowability control, to ensure the mixture can be easy-pumpable in the delivery system and easy-usable on the crack or the pothole to be filed-in; iii) Setting time control: printing material requires a certain setting time to maintain a consistent flow rate for good extrudability, thus appropriate additives are needed to control the setting time. The second phase includes in situ tests to verify the compaction of the mixture under the traffic loads. The paper presents the results of the lab and in situ tests, and the features of the chosen mix, suitable to be managed by the 3D printer
Published: 2023
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11. The Draghi Government put to the Test by the National Recovery and Resilience Plan

Author: Di Mascio, Fabrizio, Natalini, Alessandro, and Profeti, Stefania
Abstract: ABSTRACTThe political and institutional trajectory of Italy was clearly punctuated by the economic upheavals of the pandemic. The articles in the special issue aim to assess the character of the institutional change prompted by the economic response to the pandemic, and in particular by the National Recovery and Resilience Plan (NRRP), in different policy areas. Three contributions analyse the reform dynamics related to the strategic axis of the Italian NRRP, namely digitalization and innovation (Ottone and Barbieri), the ecological transition (Cotta and Domorenok), and social inclusion as concerns labour-market policies (Tassinari). Two contributions focus on two overarching priorities of the NRRP: gender equality (Donà) and development of southern Italy (Cerruto, Cersosimo and Raniolo). Finally, one contribution focuses on reform of the public administration, which has been identified as a key area, affecting horizontally all missions in the NRRP (Di Mascio, Natalini and Profeti). Overall, the articles in the special issue highlight that the pandemic has been followed by a process of institutional change that occurred both incrementally and unevenly, often disguising substantial continuity.
Published: 2022
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12. Administrative reforms in the Italian National Recovery and Resilience Plan: a selective approach to bridge the capacity gap

Author: Di Mascio, Fabrizio, Natalini, Alessandro, and Profeti, Stefania
Abstract: ABSTRACTThe article investigates the impact of the National Recovery and Resilience Plan, complemented by changes in the composition of government at the domestic level, on the patterns of administrative reforms in Italy. We draw on research arguments that rest on historical institutionalism, which constitutes an established approach to the study of administrative reforms. We elaborate on how history has connected well-established patterns of administrative reform to the design and governance of the NRRP measures that aim to provide better public services. We find the strongest support for the research arguments derived from the reactive approach to policy sequencing, entailing the co-existence of pre-pandemic patterns and innovative policy features
Published: 2022
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13. Removal Versus Retention of Cervical Cerclage With Preterm Prelabor Rupture of Membranes: Systematic Review and Meta-analysis

Author: Zullo, Fabrizio, Di Mascio, Daniele, Chauhan, Suneet P., Chrysostomou, Spyridakis, Suff, Natalie, Pecorini, Francesco, D'Ambrosio, Valentina, Sorrenti, Sara, D'Alberti, Elena, Galoppi, Paola, Muzii, Ludovico, Giancotti, Antonella, and Brunelli, Roberto
Abstract: One predictor of preterm birth (PTB) is a short cervical length before 24 weeks of gestation. For pregnant women with short cervical length and a history of PTB, cervical cerclage plus progesterone is offered. This procedure has been shown to reduce the risk of PTB, pregnancy loss, and perinatal morbidity and mortality. However, it also increases the risk of preterm, premature rupture of membrane (pPROM). When pPROM occurs, the decision must be made to either remove or retain the cerclage. This decision is a challenge due to a lack of evidence to support retaining cerclage, which could prolong the duration of pregnancy, or removing it, which may decrease the risk chorioamnionitis. In addition, guidelines from international societies are conflicting: a practice bulletin from the American College of Obstetricians and Gynecologists regards both removal and retention of cerclage in pregnancies complicated with pPROM as reasonable options, whereas a practice guideline from the Royal College of Obstetricians and Gynecologists supports the removal of cerclage. The aim of this study was to compare the removal of cervical cerclage with its retention on maternal and perinatal outcomes.This was a systematic review and meta-analysis using an electronic search of Medline, Embase, and Cochrane electronic databases in February 2023. Included were prospective and retrospective publications, reported in English, which evaluated perinatal outcomes of removing or retaining cervical cerclage complicated by pPROM. Excluded were case reports, case series, review articles, letters to the editors, or editorials. The primary outcomes were pregnancy latency from pPROM >48 hours and >7 days. Quality assessment of the included studies used the Newcastle-Ottawa Scale.A total of 6 studies, representing 377 women (169 in the removal group and 208 in the retention group), were included in this systematic review. The removal group had significantly lower rates of pregnancy latency than the retention group at >48 hours (47% vs 85%; odds ratio [OR], 0.15; 95% confidence interval [CI], 0.07–0.31; P< 0.0001) and >7 days (33% vs 57%; OR, 0.30; 95% CI, 0.11–0.83; P= 0.02). However, the removal group also had lower rates than the retention groups of chorioamnionitis (29% vs 41%; OR, 0.57; 95% CI, 0.34–0.96; P= 0.03) and Apgar score <7 at 5 minutes (16% vs 43%; OR, 0.22; 95% CI, 0.08–0.56; P= 0.002). No significant differences were observed in the rates of postpartum endometritis, cesarean delivery, respiratory distress syndrome, neonatal sepsis, intraventricular hemorrhage, necrotizing enterocolitis, birthweight, fetal death, and neonatal mortality.In conclusion, the group that had cervical cerclage removal had a lower risk of experiencing pregnancy latency at >48 hours and >7 days than the group with cerclage retention. However, the retention group had a higher risk of chorioamnionitis and Apgar <7 at 5 minutes.
Published: 2024
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14. How the European Union responded to populism and its implications for public sector reforms

Author: Ongaro, Edoardo, Di Mascio, Fabrizio, and Natalini, Alessandro
Abstract: A major shift occurred in the European Union (EU) approach to tackle the apparently unstoppable rise of populist parties across European countries and to preserve the integrity of the EU polity. EU economic governance seems to have shifted from a logic of conditionality to a logic of solidarity underpinned by a pan-European strategic view allowing EU governance to support and enable public sector reforms at the national level. By investigating the case of Italy as an EU member state, we find that the European governance shift occurring in the wake of the COVID-19 pandemic was largely mediated by the mutating character of Italian populism. A logic of conditionality which was largely centered around EU governance was largely shifted to a logic of solidarity taking into account political conditions in the member countries.
Published: 2022
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15. The Role of Regulatory Agencies in Agenda‐Setting Processes: Insights from the Italian Response to the COVID‐19 Infodemic

Author: Di Mascio, Fabrizio, Natalini, Alessandro, Barbieri, Michele, and Selva, Donatella
Abstract: International organizations such as the WHO have worked to raise awareness of the massive infodemic that accompanied the COVID‐19 outbreak and made it hard for people to find trustworthy sources of information and reliable guidance for their decisions. Our contribution focuses on the Italian case, where the Communications Regulatory Authority (AGCOM) was able to act as first mover in its field so as to strategically frame the problem of disinformation in the absence of a pre‐existing policy intervention. An emerging body of research shows that the activity of formally independent regulators is not necessarily limited to the implementation of delegated regulatory competencies. We discuss the implications of the activity of independent regulators for the fight against disinformation during the COVID‐19 pandemic. We find that as a political actor in its own right, the Italian media regulator claimed control over sectoral expertise in order to shape the crucial first steps of the response to the infodemic. Internationale Organisationen wie die WHO haben sich bemüht, das Bewusstsein für die massive «Infodemie» zu schärfen, die den COVID‐19‐Ausbruch begleitete und es den Menschen erschwerte, vertrauenswürdige Informationsquellen und verlässliche Entscheidungshilfen zu finden. Unser Beitrag untersucht den Fall Italiens, wo die Regulierungsbehörde für Kommunikation (AGCOM) als First Mover agieren und das Problem der Desinformation in Ermangelung einer bereits bestehenden politischen Intervention strategisch gestalten konnte. Die neuere Forschung zeigt, dass die Tätigkeit formal unabhängiger Regulierungsbehörden nicht notwendigerweise auf die Umsetzung delegierter Regulierungskompetenzen beschränkt ist. Wir diskutieren in diesem Beitrag die Auswirkungen der Tätigkeit unabhängiger Regulierungsbehörden auf den Kampf gegen Desinformation während der COVID‐19‐Pandemie. Wir stellen zudem fest, dass die italienische Medienregulierungsbehörde die Kontrolle über sektorales Fachwissen beanspruchte und so die entscheidenden ersten Schritte der politischen Antwort auf die Infodemie zu gestalten. Des organisations internationales telles que l'OMS se sont efforcées de faire prendre conscience de l' « infodémie » massive qui a accompagné l'épidémie du COVID‐19 et qui a rendu difficile pour les gens de trouver des sources d'information dignes de confiance et des aides fiables à leurs décisions. Notre contribution se concentre sur le cas de l'Italie, où l'Autorité de régulation des communications (AGCOM) a été en mesure d'agir en tant que premier acteur dans son domaine afin d'encadrer stratégiquement le problème de la désinformation en l'absence d'une intervention politique préexistante. Des recherches récentes montrent que l'activité des régulateurs formellement indépendants ne se limite pas nécessairement à la mise en œuvre des compétences réglementaires déléguées. Nous examinons les implications de l'activité des régulateurs indépendants pour la lutte contre la désinformation pendant la pandémie COVID‐19. Nous constatons que le régulateur italien des médias a revendiqué le contrôle de l'expertise sectorielle afin de façonner les premières étapes cruciales de la réponse à l'infodémie.
Published: 2021
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16. Perinatal Death by Bile Acid Levels in Intrahepatic Cholestasis of Pregnancy: A Systematic Review

Author: Di Mascio, Daniele, Quist-Nelson, Johanna, Riegel, Melissa, George, Brandon, Saccone, Gabriele, Brun, Romana, Haslinger, Christian, Herrera, Christina, Kawakita, Tetsuya, Lee, Richard H., Panici, Pierluigi Benedetti, and Berghella, Vincenzo
Abstract: (Abstracted from J Matern Fetal Neonatal Med2021;34(21):3614–3622)Intrahepatic cholestasis of pregnancy (ICP) is characterized by elevated total bile acids (TBAs) and is the most common liver disease during pregnancy. The etiology and pathophysiology of ICP are not well understood, but genetics, ethnicity, hormones, nutrition, and the environment have been cited as risk factors.
Published: 2022
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17. Methodology and evidence from a case study in Rome to increase pedestrian safety along home-to-school routes

Author: Corazza, Maria Vittoria, D'Alessandro, Daniela, Di Mascio, Paola, and Moretti, Laura
Abstract: Home-to-school routes are very sensitive areas: they represent, for children, a learning tool for their everyday activities, but if poorly designed, maintained and equipped they can expose them to traffic risks. Sidewalks' inappropriate level of service and poor maintenance, especially, are main factors contributing to walking unsuitability, thus to poor comfort and safety levels for young pedestrians, and more in general for all the vulnerable non-motorized road users. This paper deals with a methodology specifically developed to highlight the quality of the urban environment where the home-to-school routes are located, according to four main criteria: wellbeing, usage, appearance, and safety and security. Each criterion is associated with a checklist including the most relevant features to assess, with a focus on maintenance as a key parameter to create safe and comfortable routes to school. An application, a case study in Rome, where the lack of regular maintenance results into a network of unsafe sidewalks, is also presented, analyzing three different areas where a number of schools are located. Detours when approaching school premises were surveyed, due to the levels of distresses and linked to the poor comfort and safety levels. As the mutual influence of built environment over road safety and maintenance requirements for home-to-school paths is not largely investigated thus far, the paper's goal is to provide advanced knowledge for studies and applications further afield.
Published: 2020
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18. Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial

Author: Dias, Joseph J, Brealey, Stephen D, Fairhurst, Caroline, Amirfeyz, Rouin, Bhowal, Bhaskar, Blewitt, Neil, Brewster, Mark, Brown, Daniel, Choudhary, Surabhi, Coapes, Christopher, Cook, Liz, Costa, Matthew, Davis, Tim, Di Mascio, Livio, Giddins, Grey, Hedley, Helen, Hewitt, Catherine, Hinde, Sebastian, Hobby, Jonathan, Hodgson, Stephen, Jefferson, Laura, Jeyapalan, Kanagaratnam, Johnston, Phillip, Jones, Jonathon, Keding, Ada, Leighton, Paul, Logan, Andrew, Mason, Will, McAndrew, Andrew, McNab, Ian, Muir, Lindsay, Nicholl, James, Northgraves, Matthew, Palmer, Jared, Poulter, Rob, Rahimtoola, Zulfi, Rangan, Amar, Richards, Simon, Richardson, Gerry, Stuart, Paul, Taub, Nicholas, Tavakkolizadeh, Adel, Tew, Garry, Thompson, John, Torgerson, David, and Warwick, David
Abstract: Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. The use of immediate surgical fixation to manage this type of fracture has increased, despite insufficient evidence of improved outcomes over non-surgical management. The SWIFFT trial compared the clinical effectiveness of surgical fixation with cast immobilisation and early fixation of fractures that fail to unite in adults with scaphoid waist fractures displaced by 2 mm or less.
Published: 2020
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19. Comparing Data-Independent Acquisition and Parallel Reaction Monitoring in Their Abilities To Differentiate High-Density Lipoprotein Subclasses

Author: Silva, Amanda R. M., Toyoshima, Marcos T. K., Passarelli, Marisa, Di Mascio, Paolo, and Ronsein, Graziella E.
Abstract: High-density lipoprotein (HDL) is a diverse group of particles with multiple cardioprotective functions. HDL proteome follows HDL particle complexity. Many proteins were described in HDL, but consistent quantification of HDL protein cargo is still a challenge. To address this issue, the aim of this work was to compare data-independent acquisition (DIA) and parallel reaction monitoring (PRM) methodologies in their abilities to differentiate HDL subclasses through their proteomes. To this end, we first evaluated the analytical performances of DIA and PRM using labeled peptides in pooled digested HDL as a biological matrix. Next, we compared the quantification capabilities of the two methodologies for 24 proteins found in HDL2and HDL3from 19 apparently healthy subjects. DIA and PRM exhibited comparable linearity, accuracy, and precision. Moreover, both methodologies worked equally well, differentiating HDL subclasses’ proteomes with high precision. Our findings may help to understand HDL functional diversity.
Published: 2020
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20. Concrete block pavements in urban and local roads: Analysis of stress-strain condition and proposal for a catalogue

Author: Di Mascio, Paola, Moretti, Laura, and Capannolo, Americo
Abstract: Although the construction of block pavements has grown fast in the last decades, there is still a need for simple tools that could be applied to design them. This paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces (no interlocking effect). The examined blocks were laid on a bedding sand layer, a cement treated base layer and a granular unbound foundation layer. The commercial finite element (FE) software ANSYS® was used to calculate the response of the pavement when subjected to different loading, construction configurations. Three wheel positions, five blocks patterns, three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement materials. Fatigue and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the literature. At the end of this study, a proposal for a catalogue is presented. It has nine pavement sets, because it takes into account three values of subgrade capacity (30, 90, and 150 MPa of resilient modulus) and three levels of traffic (400,000, 1,500,000, and 4,000,000 passages of commercial vehicles during the service life). The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.
Published: 2019
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21. Mediation effects of service features on rapport–dependency link in emerging market

Author: Fatima, Johra Kayeser, di Mascio, Rita, Johns, Raechel, and Quazi, Ali
Abstract: Purpose: The purpose of this paper is to explore the mediation impacts of core, relational and tangible service-quality features on the relationship between customer–frontline employee rapport and customer dependency in an emerging market context. The study examines the moderating effects of relationship age and frequency of customers’ physical visits. Design/methodology/approach: Partial least squares-based structural equation modelling was used to analyse data from a survey of 290 financial services customers in Dhaka, Bangladesh using the convenience sampling technique. Findings: Results show that relational service-quality features had the largest mediation impact on the rapport–dependency relationship, followed by core and tangible service-quality features. Relationship age was not found to be a significant moderator for any relationship. However, the moderation effect of the frequency of customers’ physical visits to the service premises was significant, but only for the link between relational service-quality features and customer dependency and not for the other two types of service-quality features. Research limitations/implications: Data collected from several other emerging markets would provide more rigorous findings: this is recommended as an avenue for further research. Practical implications: Practitioners can manipulate specific relational or tangible service-quality features to increase customer dependency on their firms, thus ensuring longer-term customer retention. Originality/value: This study is the first one to examine the relative significance of the impacts of relational features vs tangible features of services on customer dependency in the emerging market context, with rapport serving as an antecedent.
Published: 2019
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22. The political origins of transparency reform: insights from the Italian case

Author: Di Mascio, Fabrizio, Natalini, Alessandro, and Cacciatore, Federica
Abstract: AbstractThis research contributes to the expanding literature on the determinants of government transparency. It uncovers the dynamics of transparency in the Italian case, which shows an interesting reform trajectory: until the late 1980s no transparency provisions existed; since then, provisions have dramatically increased under the impulse of changing patterns of political competition. The analysis of the Italian case highlights that electoral uncertainty for incumbents is a double-edged sword for institutional reform: on the one hand, it incentivizes the adoption of ever-growing transparency provisions; on the other, it jeopardizes the implementation capacity of public agencies by leading to severe administrative burdens.
Published: 2019
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23. Experimental and DFT Computational Insight into Nitrosamine PhotochemistryOxygen Matters

Author: Ghogare, Ashwini A., Debaz, Ciro J., Silva Oliveira, Marilene, Abramova, Inna, Mohapatra, Prabhu P., Kwon, Kitae, Greer, Edyta M., Prado, Fernanda Manso, Valerio, Hellen Paula, Di Mascio, Paolo, and Greer, Alexander
Abstract: A nitrosamine photooxidation reaction is shown to generate a peroxy intermediate by experimental physical-organic methods. The irradiation of phenyl and methyl-substituted nitrosamines in the presence of isotopically labeled 18-oxygen revealed that an O atom was trapped from a peroxy intermediate to trimethylphosphite or triphenylphosphine, or by nitrosamine itself, forming two moles of nitramine. The unstable peroxy intermediate can be trapped at low temperature in postphotolyzed solution in the dark. Chemiluminescence was also observed upon thermal decomposition of the peroxy intermediate, that is, when a postphotolysis low-temperature solution is brought up to room temperature. A DFT study provides tentative information for cyclic nitrogen peroxide species on the reaction surface.
Published: 2024
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24. VKORC1-Genetik und Marcumar-Dosisfindung

Author: Arnold, M.L, Di Mascio, M.T, Kloss, M, Grond-Ginsbach, C, Ringleb, P.A, and Lichy, C
Published: 2024
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25. Quantitative Analysis of Glutathione and Carnosine Adducts with 4-Hydroxy-2-nonenal in Muscle in a hSOD1G93AALS Rat Model

Author: Reis, Pablo V. M., Vargas, Bianca S., Rebelo, Rafael A., Massafera, Mariana P., Prado, Fernanda M., Oreliana, Hector, de Oliveira, Henrique V., Freitas, Florêncio P., Ronsein, Graziella E., Miyamoto, Sayuri, Di Mascio, Paolo, and Medeiros, Marisa H. G.
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the dysfunction and death of motor neurons through multifactorial mechanisms that remain unclear. ALS has been recognized as a multisystemic disease, and the potential role of skeletal muscle in disease progression has been investigated. Reactive aldehydes formed as secondary lipid peroxidation products in the redox processes react with biomolecules, such as DNA, proteins, and amino acids, resulting in cytotoxic effects. 4-Hydroxy-2-nonenal (HNE) levels are elevated in the spinal cord motor neurons of ALS patients, and HNE-modified proteins have been identified in the spinal cord tissue of an ALS transgenic mice model, suggesting that reactive aldehydes can contribute to motor neuron degeneration in ALS. One biological pathway of aldehyde detoxification involves conjugation with glutathione (GSH) or carnosine (Car). Here, the detection and quantification of Car, GSH, GSSG (glutathione disulfide), and the corresponding adducts with HNE, Car-HNE, and GS-HNE, were performed in muscle and liver tissues of a hSOD1G93AALS rat model by reverse-phase high-performance liquid chromatography coupled to electrospray ion trap tandem mass spectrometry in the selected reaction monitoring mode. A significant increase in the levels of GS-HNE and Car-HNE was observed in the muscle tissue of the end-stage ALS animals. Therefore, analyzing variations in the levels of these adducts in ALS animal tissue is crucial from a toxicological perspective and can contribute to the development of new therapeutic strategies.
Published: 2024
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26. Nicotinamide riboside Induced Energy Stress and Metabolic Reprogramming in BEAS-2B Cells

Author: Cordeiro, Everson Willian Fialho, Marzola, Elisabete Leide, Maekawa, Ricardo Soei, Santos, Matheus Relvas dos, Assunção, Lucas Gade, Massafera, Mariana Pereira, Oliveira, Joseana de, Batista, Thainá Gomes Cury, Sales, Maria Cármen Oliveira Pinho de, Maria-Engler, Silvya Stuchi, Di Mascio, Paolo, Medeiros, Marisa Helena Gennari de, Ronsein, Graziella Eliza, and Loureiro, Ana Paula de Melo
Abstract: Nicotinamide riboside (NR), a NAD+precursor, has received attention due to several health benefits it has induced in experimental models. Studies in cultured cells, animals, and humans consistently show increased NAD+availability after NR supplementation, which is considered the only mode of NR action that leads to health benefits. In the present study, we show that a persistently low NR concentration (1 μM) in the growth medium of BEAS-2B human cells, grown in a monolayer, induces energy stress, which precedes a cellular NAD+increase after 192 h. NR concentrations greater than 1 μM under the specified conditions were cytotoxic in the 2D cell culture model, while all concentrations tested in the 3D cell culture model (BEAS-2B cell spheroids exposed to 1, 5, 10, and 50 μM NR) induced apoptosis. Shotgun proteomics revealed that NR modulated the abundance of proteins, agreeing with the observed effects on cellular energy metabolism and cell growth or survival. Energy stress may activate pathways that lead to health benefits such as cancer prevention. Accordingly, the premalignant 1198 cell line was more sensitive to NR cytotoxicity than the phenotypically normal parent BEAS-2B cell line. The role of a mild energy stress induced by low concentrations of NR in its beneficial effects deserves further investigation. On the other hand, strategies to increase the bioavailability of NR require attention to toxic effects that may arise.
Published: 2024
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27. Outcome of Fetuses With Congenital Cytomegalovirus Infection and Normal Ultrasound at Diagnosis: Systematic Review and Meta-analysis

Author: Buca, D., Di Mascio, D., Rizzo, G., Giancotti, A., D'Amico, A., Leombroni, M., Makatsarya, A., Familiari, A., Liberati, M., Nappi, L., Flacco, M. E., Manzoli, L., Salomon, L. J., Scambia, G., and D'Antonio, F.
Abstract: (Abstracted from Ultrasound Obstet Gynecol2021;57:551–559)Cytomegalovirus (CMV) is the most common congenital viral infection that occurs during pregnancy. Prenatal imaging can detect some congenital anomalies associated with CMV, and the presence of a structural anomaly on ultrasound in pregnancies with CMV is associated with a high risk of symptomatic infection and abnormal neurodevelopmental outcomes.
Published: 2021
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28. Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

Author: Stanley, Christopher P., Maghzal, Ghassan J., Ayer, Anita, Talib, Jihan, Giltrap, Andrew M., Shengule, Sudhir, Wolhuter, Kathryn, Wang, Yutang, Chadha, Preet, Suarna, Cacang, Prysyazhna, Oleksandra, Scotcher, Jenna, Dunn, Louise L., Prado, Fernanda M., Nguyen, Nghi, Odiba, Jephthah O., Baell, Jonathan B., Stasch, Johannes-Peter, Yamamoto, Yorihiro, Di Mascio, Paolo, Eaton, Philip, Payne, Richard J., and Stocker, Roland
Abstract: Singlet molecular oxygen (1O2) has well-established roles in photosynthetic plants, bacteria and fungi1–3, but not in mammals. Chemically generated 1O2oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynurenine4, whereas enzymatic oxidation of tryptophan to N-formylkynurenine is catalysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 15. Under inflammatory conditions, this haem-containing enzyme is expressed in arterial endothelial cells, where it contributes to the regulation of blood pressure6. However, whether indoleamine 2,3-dioxygenase 1 forms 1O2and whether this contributes to blood pressure control have remained unknown. Here we show that arterial indoleamine 2,3-dioxygenase 1 regulates blood pressure via formation of 1O2. We observed that in the presence of hydrogen peroxide, the enzyme generates 1O2and that this is associated with the stereoselective oxidation of l-tryptophan to a tricyclic hydroperoxide via a previously unrecognized oxidative activation of the dioxygenase activity. The tryptophan-derived hydroperoxide acts in vivo as a signalling molecule, inducing arterial relaxation and decreasing blood pressure; this activity is dependent on Cys42 of protein kinase G1α. Our findings demonstrate a pathophysiological role for 1O2in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure under inflammatory conditions.
Published: 2019
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29. The Effect of Wording and Placement of Task Instructions on Problem‐Solving Creativity

Author: Di Mascio, Rita, Kalyuga, Slava, and Sweller, John
Abstract: Prior research has used many variants of “be creative” or brainstorm instructions to enhance creativity in a variety of tasks. However, differences in instruction wording may lead to differences in instruction interpretation, and varying the placement of instructions before or after a written problem description may lead to differences in problem interpretation. This study investigated the effect of varying the wording and placement of creativity instructions on idea novelty, workability, and effectiveness. A randomized field experiment in two classrooms found that: (a) brainstorming and “be creative” instructions impact some dimensions of idea creativity, relative to standard instructions; (b) combining the two instructions increased the number of ideas only slightly compared with the “be creative” instruction; (c) the effect of the combined instruction varied across classrooms; and (d) the placement of instructions before or after a written problem description influenced novelty slightly. These results suggest that participant‐constructed meaning of instruction may differ from the researcher‐ascribed meaning and that enhancing the salience of the creativity requirement in instructions does not enhance novelty. The results also lead to propositions that creativity instructions induce a promotion focus during problem‐solving and that creativity climate may moderate the impact of instructions.
Published: 2018
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30. Towards defining a simplified procedure for COTS system-on-chip TID testing

Author: Di Mascio, Stefano, Menicucci, Alessandra, Furano, Gianluca, Szewczyk, Tomasz, Campajola, Luigi, Di Capua, Francesco, Lucaroni, Andrea, and Ottavi, Marco
Abstract: The use of System-on-Chip (SoC) solutions in the design of on-board data handling systems is an important step towards further miniaturization in space. However, the Total Ionizing Dose (TID) and Single Event Effects (SEE) characterization of these complex devices present new challenges that are either not fully addressed by current testing guidelines or may result in expensive, cumbersome test configurations. In this paper we report the test setups, procedures and results for TID testing of a SoC microcontroller both using standard C60oand low-energy protons beams. This paper specifically points out the differences in the test methodology and in the challenges between TID testing with proton beam and with the conventional gamma ray irradiation. New test setup and procedures are proposed which are capable of emulating typical mission conditions (clock, bias, software, reprogramming, etc.) while keeping the test setup as simple as possible at the same time.
Published: 2018
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31. Safety ranking definition for infrastructures with high PTW flow

Author: Ragnoli, Antonella, Corazza, Maria Vittoria, and Di Mascio, Paola
Abstract: Powered two-wheelers (PTWs) provide a suitable mode for a large portion of population in many cities due to rider's personal convenience and the vehicle supposed easiness of manoeuvring. At the same time PTWs present serious safety issues compared to other motorized vehicles. This paper reports the main outcome of study carried out in Rome, where this mode is very popular and assesses the economic efforts to make infrastructure safer for PTWs. The methodology, extensively described in the paper, includes three steps: the accident analysis, the development of economic indicators of accidents costs, the maintenance priority. In the first step the location of the PTWs local accidents are identified, then the accidents are analyzed by means of the suitable indicators and, among these the safety potential (SAPO). Lastly, according to the results of the analyzed indicators the need of infrastructure maintenance will be defined. Usually SAPO is applied to rural areas, but here it has been adapted to describe the phenomena of the urban area in hand. As a result, the estimation of the saving potential to improve the infrastructure safety levels, thus reducing the amount of accidents, is presented, along with recommendations on how to upscale the SAPO at city level.
Published: 2018
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32. Photosensitized Membrane Permeabilization Requires Contact-Dependent Reactions between Photosensitizer and Lipids

Author: Bacellar, Isabel O. L., Oliveira, Maria Cecilia, Dantas, Lucas S., Costa, Elierge B., Junqueira, Helena C., Martins, Waleska K., Durantini, Andrés M., Cosa, Gonzalo, Di Mascio, Paolo, Wainwright, Mark, Miotto, Ronei, Cordeiro, Rodrigo M., Miyamoto, Sayuri, and Baptista, Mauricio S.
Abstract: Although the general mechanisms of lipid oxidation are known, the chemical steps through which photosensitizers and light permeabilize lipid membranes are still poorly understood. Herein we characterized the products of lipid photooxidation and their effects on lipid bilayers, also giving insight into their formation pathways. Our experimental system was designed to allow two phenothiazinium-based photosensitizers (methylene blue, MB, and DO15) to deliver the same amount of singlet oxygen molecules per second to 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine liposome membranes, but with a substantial difference in terms of the extent of direct physical contact with lipid double bonds; that is, DO15 has a 27-times higher colocalization with ω-9 lipid double bonds than MB. Under this condition, DO15 permeabilizes membranes at least 1 order of magnitude more efficiently than MB, a result that was also valid for liposomes made of polyunsaturated lipids. Quantification of reaction products uncovered a mixture of phospholipid hydroperoxides, alcohols, ketones, and aldehydes. Although both photosensitizers allowed the formation of hydroperoxides, the oxidized products that require direct reactions between photosensitizer and lipids were more prevalent in liposomes oxidized by DO15. Membrane permeabilization was always connected with the presence of lipid aldehydes, which cause a substantial decrease in the Gibbs free energy barrier for water permeation. Processes depending on direct contact between photosensitizers and lipids were revealed to be essential for the progress of lipid oxidation and consequently for aldehyde formation, providing a molecular-level explanation of why membrane binding correlates so well with the cell-killing efficiency of photosensitizers.
Published: 2018
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33. Analysis of natural stone block pavements in urban shared areas

Author: Zoccali, Pablo, Moretti, Laura, Di Mascio, Paola, Loprencipe, Giuseppe, D’Andrea, Antonio, Bonin, Guido, Teltayev, Bagdat, and Caro, Silvia
Abstract: This paper analysed and verified an existing block stone pavement in an urban shared area. Fatigue and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the literature. The commercial finite element (FE) software Abaqus® was used to calculate the response of the pavement when subjected to different loading, construction and geometrical configurations (i.e. type of analysis, shape and size of meshes, boundary conditions, and bonding contacts between the pavements layers). At the end of this study, a static model of a structure with hexahedral blocks having sides of 0.02 m, with full bonded layers and restrained horizontal displacements on the model sides, was implemented to evaluate the maximum tensile stress induced in a block when the load is applied at its centre. This analysis highlighted the need for rigorous criteria for a correct design, in order to avoid inappropriate and expensive use of road materials.
Published: 2018
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34. AO Distal Radius Fracture Classification: Global Perspective on Observer Agreement

Author: Jayakumar, Prakash, Teunis, Teun, Giménez, Beatriz Bravo, Verstreken, Frederik, Di Mascio, Livio, and Jupiter, Jesse B.
Published: 2017
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35. Adolescent with painful vesicular otitis and vertigo

Author: Conversano, Ester, Cozzi, Giorgio, Poropat, Federico, Di Mascio, Alberto, Salis, Simona, Grasso, Domenico Leonardo, and Barbi, Egidio
Published: 2019
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36. Management of lateral epicondylitis (tennis elbow)

Author: Karbowiak, Marta, Holme, Thomas, Thambyrajah, James, and Di Mascio, Livio
Published: 2023
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37. Identification de facteurs de risque d’erreurs médicamenteuses en service de gériatrie : aide à la priorisation de la conciliation médicamenteuse

Author: Di Mascio, T., Correard, F., Montaleytang, M., Honoré, S., Couderc, A.-L., Villani, P., Auquier, P., Daumas, A., and Berbis, J.
Abstract: La iatrogénie médicamenteuse ne cesse de s’accroître avec l’augmentation conséquente de l’espérance de vie des patients et de la polypathologie associée. La polymédication associée à cette hausse de la polypathologie engendre une augmentation du risque d’erreurs médicamenteuses (EM). Le sujet âgé fait donc partie par corrélation des patients les plus à risque d’erreurs médicamenteuses. À ce jour, si l’on suit les recommandations données par la Haute Autorité de santé (HAS), tous les patients hospitalisés les « plus à risque » devraient recevoir une conciliation médicamenteuse.
Published: 2022
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38. Faisabilité et pertinence d’une télé-expertise médicamenteuse dans l’optimisation des prescriptions médicamenteuses des résidents en EHPAD

Author: Berard, C., Di Mascio, T., Montaleytang, M., Couderc, A.-L., Bertault-Peres, P., Villani, P., Honoré, S., Daumas, A., and Correard, F.
Abstract: En établissement d’hébergement pour personnes âgées dépendantes (EHPAD), les résidents sont exposés à un risque élevé d’iatrogénie médicamenteuse en raison des changements physiologiques liés à leur âge avancé et d’une polypathologie conduisant à une polymédication fréquente. Cette iatrogénie médicamenteuse résulte en partie de prescriptions médicamenteuses inappropriées (PMI). Plusieurs stratégies ont été développées pour améliorer la qualité de la prescription et sécuriser le circuit du médicament en EHPAD, notamment la révision systématique des médicaments (ou révision médicamenteuse, RM). Afin d’assurer une collaboration interdisciplinaire essentielle à une RM structurée et permettre une coordination des soins, le déploiement des outils numériques en santé (ex., télémédecine, télé-expertise) semble aujourd’hui primordial.
Published: 2022
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39. Firms’ adoption of self-service technology: how managerial beliefs shape co-production decisions

Author: Di Mascio, Rita
Abstract: The level of service co-production offered to customers through self-service technologies (SSTs) is an important marketing decision. The extant literature reports numerous benefits of SSTs for firms, such as increasing efficiency, reducing costs, boosting loyalty, and reaching new customer segments. However, industry evidence suggests that firms vary in their adoption of SSTs. This article utilizes a managerial cognition perspective to relate the level of SST-based co-production to configurations of beliefs about desired organizational outcomes, customers, and knowledge. The resulting belief model illuminates why firms vary in their utilization of SSTs, and has implications for the judgment of newness of SST-based services, the ethics and politics of customer representation in SST design, and epistemologies of SST-based market exchanges.
Published: 2016
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40. Managing sidewalk pavement maintenance: A case study to increase pedestrian safety

Author: Corazza, Maria Vittoria, Di Mascio, Paola, and Moretti, Laura
Abstract: Comfort is a major requirement in planning pedestrian facilities. Pedestrians walk where they feel comfortable and when they do not feel at ease, they walk elsewhere. A typical example is that filthy, distressed, or too narrow sidewalks induce pedestrians to walk on carriageways. This behaviour jeopardizes road safety and highly dangerous to most users, leave them vulnerable. Unsuitable pavements can be the result of irregular maintenance operations to restore evenness after shock damage, weather phenomena, installation of equipment (e.g., posts, fences, urban furniture) with a reduction of walkable surface, or substandard repair work on pavements and patches due to emergency operations. These problems can be solved with an appropriate maintenance management system, which optimizes financial resources to make smart decisions about how to intervene with an adequate and lasting maintenance operation. This paper defines an evaluation index for sidewalk conditions as a part of an efficient set-up of a Sidewalk Management System, which is similar to the better known Road Management System. The study relies on surveys, as well as the classification and analysis of sidewalk distresses. The authors adapted an index already standardized by ASTM for roads and airports: the Pavement Condition Index (PCI). PCI has been modified to consider the specific types on the sidewalks studied within this paper. To validate the method, a case study of a residential district in Rome, Italy, was carried out. The chosen area lacks regular maintenance and has therefore resulted in a network of unsafe sidewalks. Frequent detour routes were surveyed and related to the level of distresses within a general assessment of safety. This study concentrates on sidewalks with flexible pavements because this type of pavement is the only one adopted in the survey areas and, in general, throughout Italy.
Published: 2016
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41. Supporting Children in Mastering Temporal Relations of Stories: The TERENCE Learning Approach

Author: Di Mascio, Tania, Gennari, Rosella, Melonio, Alessandra, and Tarantino, Laura
Abstract: Though temporal reasoning is a key factor for text comprehension, existing proposals for visualizing temporal information and temporal connectives proves to be inadequate for children, not only for their levels of abstraction and detail, but also because they rely on pre-existing mental models of time and temporal connectives, while in the case of children the system has to induce the development of a mental model not existing yet. Filling this gap was the main goal of the FP7 European project TERENCE, which developed an adaptive learning system shaped around the concepts of repeated interaction experience and of graded text simplification and consistent with consolidated pedagogical approaches built on question-based games. In particular, in this paper the authors present the main features of its learner-oriented read-and-play visual interaction environment that, according to the dual-coding theory, follows a two-tiers approach pairing verbal and visual information.
Published: 2016
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42. Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study

Author: Donahue, Robert E., Srinivasula, Sharat, Uchida, Naoya, Kim, Insook, St. Claire, Alexis, Duralde, Gorka, DeGrange, Paula, St. Claire, Marisa, Reba, Richard C., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Paik, Chang H., Lane, H. Clifford, Tisdale, John F., and Di Mascio, Michele
Abstract: Ionizing irradiation is used routinely to induce myeloablation and immunosuppression. However, it has not been possible to evaluate the extent of ablation without invasive biopsy. For lymphoid recovery, peripheral blood (PB) lymphocytes (PBLs) have been used for analysis, but they represent <2% of cells in lymphoid tissues (LTs). Using a combination of single-photon emission computed tomography imaging and a radiotracer (99mTc-labeled rhesus immunoglobulin G1 anti-CD4R1 (Fab′)2), we sequentially imaged CD4+ cell recovery in rhesus macaques following total body irradiation (TBI) and reinfusion of vector-transduced, autologous CD34+ cells. Our results present for the first time a sequential, real-time, noninvasive method to evaluate CD4+ cell recovery. Importantly, despite myeloablation of circulating leukocytes following TBI, total depletion of CD4+ lymphocytes in LTs such as the spleen is not achieved. The impact of TBI on LTs and PBLs is discordant, in which as few as 32.4% of CD4+ cells were depleted from the spleen. In addition, despite full lymphocyte recovery in the spleen and PB, lymph nodes have suboptimal recovery. This highlights concerns about residual disease, endogenous contributions to recovery, and residual LT damage following ionizing irradiation. Such methodologies also have direct application to immunosuppressive therapy and other immunosuppressive disorders, such as those associated with viral monitoring.
Published: 2015
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43. Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study

Author: Donahue, Robert E., Srinivasula, Sharat, Uchida, Naoya, Kim, Insook, St. Claire, Alexis, Duralde, Gorka, DeGrange, Paula, St. Claire, Marisa, Reba, Richard C., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Paik, Chang H., Lane, H. Clifford, Tisdale, John F., and Di Mascio, Michele
Abstract: Ionizing irradiation is used routinely to induce myeloablation and immunosuppression. However, it has not been possible to evaluate the extent of ablation without invasive biopsy. For lymphoid recovery, peripheral blood (PB) lymphocytes (PBLs) have been used for analysis, but they represent <2% of cells in lymphoid tissues (LTs). Using a combination of single-photon emission computed tomography imaging and a radiotracer (99mTc-labeled rhesus immunoglobulin G1 anti-CD4R1 (Fab′)2), we sequentially imaged CD4+cell recovery in rhesus macaques following total body irradiation (TBI) and reinfusion of vector-transduced, autologous CD34+cells. Our results present for the first time a sequential, real-time, noninvasive method to evaluate CD4+cell recovery. Importantly, despite myeloablation of circulating leukocytes following TBI, total depletion of CD4+lymphocytes in LTs such as the spleen is not achieved. The impact of TBI on LTs and PBLs is discordant, in which as few as 32.4% of CD4+cells were depleted from the spleen. In addition, despite full lymphocyte recovery in the spleen and PB, lymph nodes have suboptimal recovery. This highlights concerns about residual disease, endogenous contributions to recovery, and residual LT damage following ionizing irradiation. Such methodologies also have direct application to immunosuppressive therapy and other immunosuppressive disorders, such as those associated with viral monitoring.
Published: 2015
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44. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson, J. M., Morrison, P. M., Collins, A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni, S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Fiore, Del, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis, B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni, A., Ciafaloni, E., Comi, G. P., Bresolin, N., Robotti, M., Moggio, M., Rigoletto, C., Roses, A., Scarlato, G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. 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L., Barcelo, A., Piqueras, A., Martinez, V., Rango, M., Bamonti, F., Greco, F., Spagnoli, D., Tomei, G., Zetta, L., Honczarenko, K., Jezewski, T., Kojder, I., Verlooy, J., Reempts, Jos V., Deuren, B. V., Borgers, M., Gajda, J. U., Ley-Pozo, J., Louwen, P., Happe, S., Buschmann, H. C., Ringelstein, E. B., Yamawaki, T., Takao, M., Suzuki, N., WeilBenborn, K., Schellong, S., Ehrenheim, C., Wollenhaupt, J., Goetz, C., Lubach, D., Vion-Dury, J., Nicoli, F., Confort-Gouny, S. O., Dhiver, C. O., Lamoureux, S., Salvan, A. M., Gastaut, J. -A., Gastaut, J. -L., Cozzone, P., Ribalta, T., Santamaria, J., Drewes, A. M., Taagholt, S. J., van den Berg, J. S. P., Limburg, M., Valldeoriola, F., Valls-Solé, J., Marti, M. J., Trenkwalder, C., Stiasny, K., Collado-Scidel, V., Wetter, T., Kazenwadel, J., Kohnen, R., Ramm, S., Oertel, W. 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O., Joussen, K., Sonka, K., Chave, B., Confort-Gouny, S., Houallah, T., Neundoerfer, B., Tex, S., Seeber, C., Mokrusch, T., Urdiain, T. X. Arbizu, Yelamos, S. M., Villanueva, P., Serra, J. Peres, Braghi, S., Bonifacio, E., Natali-Sora, M. G., Debbink, Y. N., Marra, T. R., Mossman, S., Timmings, P., Seitz-Dertinger, S., Solbach, W., Mainz, A., Manfredini, E., Calabrese, E., Allaria, S., Mariani, C., Sinaki, M., Lynn, S., Westerlind, K., Ossege, L. M., Voss, B., Wiethege, Th., Sindern, E., Malin, J. p., Le Doze, F., Chapon, F., de la Sayette, V., Schaeffer, S., Dary, M., Lechevalier, B., Viader, F., de Pommery, J., Weill-Fulazza, J., Menetrey, M., Lazzarino, L. G., Nicolai, A., Nappo, A., Blin, J., Mazetti, P., Mazoyer, B., Ayed, S. Ben, Rivaud, S., Vidailhet, M., Pierrot-Deseilligny, C., Chase, T., Jordan, K. G., Gergaud, J. M., Breux, J. P., Roblot, P., Grollier, G., Giraudon, B. Becq, Dobato, J. L., Gilabert, Y. Perez, Blanco, J. L. Munoz, de Kruijk, J., Twijnstra, A., Wilmink, J., Leffers, P., Iniguez, C., Jimenez-Escrig, A., Nocito, M., Villar, M. L., Gonzalez-Porque, P., Gobernado, J. M., Chandler, H. C., Crockard, H. A., Henderson, F., Rossi, T., Maidani, M., Pujol, A., Rimola, A., Beltran, J., Garcia-Valdecasas, J. C., Navasa, M., Grande, L., Galofre, J., Visa, J., Rodes, J., Ruiz, M., Pampols, T., Bruce, L., Tanner, M. J. A., Lefaucheur, J. P., Verroust, J., Taghavy, A., Hamer, H., Benomar, A., Cancel, G., Stevanin, G., Durr, A., Labaune, C., Desnizza, V., Widjaja-Cramer, B., Schulze-Bonhage, A., Kott, H., Ferbert, A., Sanz-Sebastian, C., Pascual, L. F., Alegria, F. Abad, Kushnir, M., Groozman, G. B., Korczyn, A. D., Drory, Ve., Korczyn, A., Guggenheim, H., Baykouchev, St., Struppler, A., Tchalucova, N., Jotova, J., Mokri, B., Parisi, J. E., Scheithauer, B. W., Piepgras, D. G., Miller, M., Kornhuber, A. W., Köhler, A., Hülser, P. J., Kriebel, J., Alonso-Villaverde, C., Castro, A., Masana, L., Urda, A. Martin, Fernandez, J., Mares, R., Torre, L., Mayayo, E., Lossos, A., Gomori, M., Libson, E., Goldfarb, A., Seigal, T., de Louw, A., Praamstra, P., Horstink, M., Cools, A., Tarrats, E. Basart, Calopa, M., Martinez, S., Ballabrina, J., Taussig, D., Marion, M. -H., Mallecourt, J., Ranoux, D., Gasser, T., Kabus, C., Ozelius, L., Wenzel, R., Breakefield, X. O., Boot, H., Poublon, R. M. L., Bogaard, J. M., GinaÏ, A. Z., Cabezas, C., Scholz, J., Nitschke, N., Vieregge, P., Wirk, B., Hochberg, F. H., Hefter, H., Kessler, K., Wirrwar, A., Stocklin, G., Tournier-Lasserves, E., Agundez, J. Garcia, Ruiz, E., Li, X. P., Hedlund, P. B., Fuxe, K., Kulisevsky, J., Avila, A., Berthier, M. L., Gerard, J. -M., Cambier, J., Caucheteur, C., Deuschl, G., Köster, B., Scheidt, C., Lücking, C. H., Mena, M. A., Chedru, F., Oubary, P., Rondot, P., Anagnostou, C. N., Panagopoulos, C. P., Ziogas, D. E., Vermersch, P., Robitaille, Y., Gauvreau, D., Destée, A., Delacourte, A., Ficola, U., Marozzi, P., Piccoli, F., Janelidze, M., Shakarishvili, R., Gagoshidze, T., Vashadze, T., Tsiskaridze, A., Djannelidze, M., Trullen, J. M. Perez, Pardo, P. J. Modrego, Vazquez-Andre, M. L., Bail, L., Naccache, L., Gauvrit, J. L., Panisset, M., Boller, A. F., Giannini, M., Zanette, E., Di Cesare, S., Altieri, M., Maloteaux, J. M., Delwaide, C., Sciaky, M., Newman, S. K., Kennedy, A. M., Frackowiack, R. S. J., Warrington, E. K., Rossor, M. N., Martinez-Lage, Pablo, Martinez Lage, J. Manuel, Manubens, JosÇ M., Lacruz, Francisco, Larumbe, Rosa, Muruzabal, Javier, Locatelli, T., Cursi, M., Mauri, M., Liberati, D., Fornada, C., Iriarte, L. M., Lopez, M., Grilo, A., Repeto, M., Brasic, J. R., Barnett, J. Y., Sheitman, B. B., Young, J. G., Shalit, F., Brodie, C., Sredni, B., Engelien, A., Stern, E., Huber, W., Frith, C., Miralles, F., Albadalejo, M. D., Antem, M., Pastor, I., Estelies, M. A., Del Ser, T., Ochoa, H. Severo, Munoz, D., Hachinski, V., Cucinotta, D., Senin, U., Girardello, R., Crepaldi, G., Croria, F., Schens, D. B., Vigo-Pelfrey, C., SempereE, A. P., Ortega, M. P., Bava, L., Magni, E., Aronovich, B. D., Treves, T. A., Bornstein, N. M., Van Blercom, N., Blecic, S., Violon, Ph., Hildebrand, J., Zamboni, M., Ambrosoli, L., Poli, A., Kuehnen, J., Tilgner, C., Raltzig, M., Moering, B., Faiss, J., Deeb, S. M. Al, Daif, A., Sharif, H., Tatay, J., Caroeller, F., Avendano, C., Vinogradova, T., Pinto, A. N., Canhao, P., Neau, J. -Ph., Pacquereau, J., Meurice, J. -C., Schwab, M., Bauer, R., Deeb, M. AL, Tjan, T. J., Aabed, M., Berges, S., Crepin-Leblond, T., Chavot, D., Cattin, F., Snidaro, M. H., Chopard, J. L., Ley, C. Oliveras, Alameda, F., Alfonso, S., Podobnik-Sarkanji, S., Pniewski, J., Torbicki, A., Mieszkowski, J., Plaza, I., Petrunjashev, V., Velcheva, I., Hadjiev, D., Yancheva, S., Petrov, L., Karakaneva, S., Petkov, A., Nikolov, E., Niehaus, L., Sacchetti, M. L., Toni, D., Fiorelli, M., Gori, C., Argentino, C., Lyrer, Ph., Radu, E. W., Gratzl, O., Rondepierre, Ph., Leclerc, X., Marchau, M., Scheltens, Ph., Hamon, M., Janssens, E., Henon, H., Lucas, C., KuÇukoglu, H., Baybas, S., Dervis, A., YalÇiner, B., Yilmaz, N., Ozturk, M., Arpaci, B., Navarro, J. A., Arenas, J., Perez-Sempere, A., Egido, J. A., Soriano-Soriano, C., Beau, P., Gergaud, J. -M., Coudero, C., Dierckx, R. A., Dobbeleir, A., Timmermans, E., Vandevivere, J., Lucas, C. H., Gomez, M., Aguirre, J., Berenguer, A., Duran, C., Parrilla, J., Gonzalez, F., Gironell, A., Rey, A., Marti-Vilalta, J. L., de Lecinana, M. Alonso, Federico, F., Conte, C., Simone, I. L., Giannini, P., Liguori, M., Lucivero, V., Picciola, E., Tortorella, C., Drislane, F., Wang, A. Ming, Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Levivier, M., del Olmo, A., Caballero, E., Degaey, I., de Bruijn, S. F. T. M., Tchaoussoglou, I., Bastianello, S., Pozzilli, C., Cervello, A., Catala, N., Koskas, F., Kieffer, E., Botia, E., Vivancos, J., Leon, T., Segura, T., Ramo, C., Lopez, F., Karepov, V. G., Gur, A. J., Berlanga, B., Gracia, V., Fiol, C., Kurtel, H., Ozkutlu, U., Yegen, B., Grau, A. J., Buggle, F., Heindle, S., Steichen-Wiehn, C., Banerjee, T., Maiwald, M., Becher, H., Villafana, W., Medina, F., Fernandez-Real, J. M., Soler, S., Planas, E., Iceman, E., Doganer, I., Badlan, G., Genc, B., Yulug, K., Ideman, E., Dural, H., Kutlul, K., Damalik, G., Baklan, Y., Metin, B., Tekinsoy, E., Iriarte, I., Subira, M. L., Crockar, A. D., Treacy, M., McNell, T. A., Grazzi, L., Ediboglu, N., Bilgin, H., Ertas, S., Goument, J. -P., Basset, C., Campos, Y., Garcia-Silva, T., Cabello, A., Bussaglia, E., Tizzano, E., Colomer, J., Gimbergues, P., Campagne, D., Bommelaer, C., Delaguillaume, B., Ramtami, H., Ait-Kaci-Ahmed, M., Pascual, L. F., Fernandez, T., Hortells, M., Sanz, C., Morales, F., Lauritzen, L., Picard, F., Sellal, F., Collard, M., Avramidis, T., Alexiou, E., Anastopoulos, T., Frongillo, D., Delfino, F. A., Cannata, M., Calo, L., Vichi, R., Antonini, G., Fragola, V., Cannata, D., Salas, M., Ruiz, C., Angelard, B., Lacau, J., Guily, St., Sendtner, M., Goadsby, Peter J., Quin, N. P., Gadian, D. G., Roland, P. E., Seitz, Rudiger J., Frackowiak, Richard S. J., Becker, G., Krone, A., Schmidt, K., Hofmann, E., Bogdahn, U., Rosenfeld, M. R., Meneses, P., Kaplitt, M. G., Dalmau, J., Posner, J., Cordon-Cardon, C., Hoang-Xuan, K., Vega, F., Nishisho, I., Moisan, J. P., Theillet, C., Delattre, O., Zhu, Jiahong, Walther, W., Posner, J. B., Roelcke, U., von Ammon, K., Pellikka, R., Lucking, C. H., Walon, C., Boucquey, D., -Van Rijckevorsel, K. Harmant, Lannoy, N., Verellen-Dunoulin, Ch., Liszka, U., Cavaletti, G., Casati, B., Kolig, C., Bogliun, G., Marzorati, L., Johannsen, L., Chio, A., Ruda, R., Vigliani, M. C., Sciolla, R., Seliak, D., Hoang-Xuang, K., Villanueva, J. A., Montalban, X., Arboix, A., Colosimo, C., Albanese, A., Hughes, A. J., de Bruin, V., Lees, A. J., Kowalski, J. W., Banfi, S., Santoro, L., Perretti, A., Castaldo, I., Barbieri, F., Campanella, G., Bhatia, K. P., Mardsen, C. D., de Bruin, V. S., Machedo, C., Ceballos-Baumann, D., Marsden, C. D., Brooks, D. B. J., Wennlng, G. K., Quinn, N., McDonald, W. l., Warner, T. T., Bain, P. C., Davis, M. B., Conway, D., Shaunak, S., O'Sullivan, E., Crawford, T., Lawden, M., Blunt, S., Rapoport, A., Sarova-Pinchas, I., de Beyl, D. Zegers, Mavroudakis, N., Blanc, S., Godinot, C., Lenoir, G., Barkhof, M. S. F., Tas, M. W., Baron, P. L., Constantin, C., Cassatella, M. A., Langdon, D. W., Webb, S., Gasparini, P., Zeviani, A., Kidd, D., Mammi, S., Cahalon, L., Hershkoviz, R., Lahat, N., Wallach, D., Annunziata, P., Martino, T., Maimone, D., Guazzi, G. C., Porrini, A. M., Dell'Arciprete, L., Rothwell, P. M., Stewart, R. R. C., Cull, R. E., Willmes, K., Poeck, K., Russell, D., Braekken, S. K., Brucher, R., Svennevig, J., Hermesl, M., Bruckmann, H., Biraben, A., Sliwka, U., Meyer, B., Schondube, F., Noth, J., Lavenu, I., Lammers, C., Waldecker, B., Haberbosch, W., Stam, J., Schneider, R., Gautier, J. C., Berlit, T. P., Fauser, B., Kuhne, D., Geraud, G., Danielli, A., Larrue, V., Bes, A., Timmerman, E., Bono, F., Bruni, A. C., Valalentino, P., Montesi, M. P., Talerico, G., Zappia, M., Sabatelli, M., Quattrone, A., Pareyson, D., Lorenzetti, D., Sghirlanzoni, A., Castellotti, B., Lupski, J. R., Archidiacono, N., Antonacci, R., Marzella, R., Rocchi, M., Samuel, D., Goulon-Goeau, C., Costa, P. P., Bismuth, H., Said, G., De Jongh, P., Lofgren, A., Timmerman, V., Vance, J. M., Van Broeckhoven, C., Martin, J. -J., Martinez, A. Cruz, Bort, S., Arpa, J., Misra, P., King, R. H. M., Badhia, K., Anderson, M., Caballo, A., Vichez, J., Gabriel, J. M., Erne, B., Miescher, G. C., Ulrich, J., Vital, A., Vital, C., Steck, A., Petry, K., Labatut, I., Hilmi, S., Ellie, E., Ferrini-Strambi, L., Zucconl, M., Marchettini, P., Palazzi, S., Oehlschlager, M., Pepinsky, R. B., Gemignani, F., Marbini, A., Pavesi, G., Di Vittorio, S., Manganelli, P., Mancia, D., Vermersh, P., Roche, J., Durocher, A. M., Dewailly, Ph., Dettmers, C., Fink, G., Lemon, R., Stephan, K., Passingham, D., Weder, B., Knorr, U., Huang, Y., Butterfield, D. A., Peris, M. L., Peiro, C., Pascual, A. Pascual-Leone, Bottini, G., Folnegovic-Smalc, V., Knezevic, S., Bokonjic, R., Ersmark, B., Torres, M. Gonzalez, Guiraud-Chaumeil, B., Haugaard, K., Jovicic, A., Chr, Lang, Levic, Z., Parra, C. Martinez, Ochoa, J. Patrignani, Titlbach, O., Wikkelso, C., Caparros-Lefevre, D., Debachy, B., Verier, A., Cantinho, G., Santos, A. I., Godinho, F., Bagunya, J., Roig, T., Ensenyat, A., Santiag, O., Trabucchi, H., De Leo, D., Koch, Ch., Zeumer, H., Matkovic, Z., Morris, P., Donaghy, M., Köhler, W., Kammer, T., Röther, J., Navon, R., Fontaine, B., Wu, Y., Capdevila, A., Guardiola, M. J., van Dijk, G. W., Notermans, N. C., Kruize, A. A., Kater, L., Bertelt, C., Hesse, S., Friedrich, H., Mauritz, K. -H., Giron, L. T., Watanabe, I. S., Ewing, D., Koepp, M., Lempert, T., Sander, B., Kauerz, U., Mehdorn, H. M., Hezel, J., Eickhoff, W., Kryst, T., Timsit, S., Gardeur, D., Reis, Mitermayer Galvao dos, Secor, E., Filho, A. Andrade, Silva, M. Cardoso, Santos, S. R. Silveira, Vasilaski, G., Reis, E. A. dos, Velupillai, P., Harn, D. A., Tigera, J. Garcia, Dreke, R. Martinez, Crespo, R. Piedra, Besses, C., Acin, P., Massons, J., Florensa, L., Oliveres, M., Sans-Sabrafen, J., Wicklein, E. M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., and Donato, M.
Published: 1994
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45. Marine propellers performance and flow-field prediction by a free-wake panel method

Author: GRECO, Luca, MUSCARI, Roberto, TESTA, Claudio, and DI MASCIO, Andrea
Abstract: A Boundary Element Method (BEM) hydrodynamics combined with a flow-alignment technique to evaluate blades shed vorticity is presented and applied to a marine propeller in open water. Potentialities and drawbacks of this approach in capturing propeller performance, slipstream velocities, blade pressure distribution and pressure disturbance in the flow-field are highlighted by comparisons with available experiments and RANSE results. In particular, correlations between the shape of the convected vortex- sheet and the accuracy of BEM results are discussed throughout the paper. To this aim, the analysis of propeller thrust and torque is the starting point towards a detailed discussion on the capability of a 3-D free-wake BEM hydrodynamic approach to describe the local features of the flow-field behind the propeller disk, in view of applications to propulsive configurations where the shed wake plays a dominant role.
Published: 2014
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46. Interpreting Metadata and Ontologies of Virtual Heritage Artefacts

Author: Pauwels, Pieter and Di Mascio, Danilo
Abstract: Many cultural heritage artefacts are digitised, resulting in a considerable number of virtual heritage artefacts, including 3D models, textual database records, images, point clouds, videos and so forth. These virtual heritage artefacts are often, if not always, accompanied by metadata standards and commonly agreed upon ontologies. These metadata and ontologies allow to build representations of virtual heritage artefacts that can be shared afterwards across different environments. In other words, the information about the artefact is interoperable. In many cases, however, it appears to be not so straightforward to use the artefact information in a context different from what it was initially meant for. This situation is analysed here, indicating that the interpretation of artefacts, both virtual and real, depends not only on the observed entities (virtual and real artefacts), but also on the background knowledge of the interpreter (personal), which can only remotely be captured in metadata and ontologies (cfr. user profiles). From the analysis results, recommendations are proposed about the pragmatic usage of metadata and ontologies in the context of virtual heritage artefacts.
Published: 2014
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47. Surgical Repair of Posterolateral Rotatory Instability of the Elbow Using SurgiligLockDown

Author: Williams, Daniel, Martin, Guy, and Di Mascio, Livio
Abstract: Posterolateral rotatory instability (PLRI) of the elbow is the most common type of chronic elbow instability and is principally due to lateral ulnar collateral ligament injury. We describe a novel surgical technique for the treatment of PLRI using the SurgiligLockDown. Using this tensioned double-braided polyester synthetic ligament to reconstruct the lateral ulnar collateral ligament it is possible to reconstitute elbow stability. Through a global posterior midline incision, a SurgiligLockDown synthetic ligament is first secured to the proximal ulnar and then passed through a bone tunnel from the isometric point of the lateral epicondyle, along the lateral column, exiting the posterior aspect of the supracondylar ridge where it is tensioned and secured with bicortical screw fixation. We present 2 cases where Surgilig has been used to treat PLRI in a primary and revision scenario. Our early findings have found that this method confers good elbow stability and immediate motion without the need for allograft harvesting or multiple tendon routing in both primary and revision reconstruction of the elbow.
Published: 2014
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48. Defining Residual Radial Translation of Distal Radius Fractures: A Potential Cause of Distal Radioulnar Joint Instability

Author: Ross, Mark, Di Mascio, Livio, Peters, Susan, Cockfield, Allen, Taylor, Fraser, and Couzens, Greg
Published: 2014
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49. Procedure to Determine the Geometry of Road Alignment Using GPS Data

Author: Di Mascio, Paola, Di Vito, Michele, Loprencipe, Giuseppe, and Ragnoli, Antonella
Abstract: Traffic safety and road geometry are strictly interlinked because road geometry deeply influences the drivers’ performance. So it is very important to know road alignments geometry. Road centreline data for the geometry definition can be generally collected from existing maps or by static measurements (traditional surveys) or by dynamic measurements (GPS receiver mounted on a car). The procedure to define the road geometry, independently from the survey technique and the data type, must be implemented considering the precision level necessary to road applications. This study tries to define intrinsic limits of this integrated data measurement and processing procedure, with the aim to define the reliability of road alignment geometry according to the final employing of road geometry recognition.
Published: 2012
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50. Distribution of Air Accidents Around Runways

Author: Cardi, Alessandro, Di Mascio, Paola, Di Vito, Michele, and Pandolfi, Costantino
Abstract: The correct planning around airport safeguard the territory from risks of air accidents. Most of accidents are localized along the extended runway centerline and, for this reason, the Land Use compatibility Planshave been defined just in the areas after the thresholds. Nevertheless, in the past, there have been also several events localized in runway lateral zone, so ENAC and Sapienza-University of Rome implemented a data-base of air accidents occurred in last 15 years all over the world, to analyze the occurrence of these events and to define the extension of the safety area on ground and around the runway.
Published: 2012
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