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Forty-six reading disabled adolescents were randomly assigned to one of three 25-hr instructional programs. Two programs provided training in expository text comprehension, and a third offered training in academic problem solving and organizational and study skills (an alternative treatment control). One reading comprehension program was designed to remediate a deficient knowledge base, forcing disabled readers to elaborate and further process new text knowledge, focusing on both specific informational content in a text and knowledge of text structure per se. The second program was patterned after the Palincsar and Brown (1984) reciprocal teaching techniques and focused on training four text comprehension strategies used by skilled comprehenders. Both the “knowledge-base” and the “strategy” training approaches were associated with significant improvement in disabled readers' comprehension skills, although training effects did not generalize across all aspects of reading comprehension performance. Strategy-trained readers applied the trained strategies with equal success on instructed and uninstructed text materials, providing strong evidence of transfer of learning. Knowledge-base readers also demonstrated successful transfer of specifically trained procedures (semantic mapping, text analysis) to unfamiliar text. In both programs, the best outcomes were obtained when specific strategies and operations were targeted for training.