2,997 results on '"De Luca, A"'
Search Results
2. The integration of technical professionals into the labor market / A insercao de profissionais tecnicos no mercado de trabalho
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Silva, Joel Dimas da, Gomes, Matheus Carvalho, Sartorello, Silvio, Carrer, Celso da Costa, de Lima, Cesar Goncalves, Cardoso, Joao Augusto, and de Luca de Oliveira Ribeiro, Marcelo Machado
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- 2023
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3. Technical, economic and social dimensions of sugar cane (Saccharum officinarum) in animal feed: a study with the application of multivariate data analysis/Dimensoes tecnica, economica e social da cana-de-acucar (Saccharum officinarum) na alimentacao animal: um estudo com aplicacao de analise multivariada de dados/Dimensiones tecnicas, economicas y sociales de la cana de azucar (Saccharum officinarum) en la alimentacion animal: un estudio mediante analisis de datos multivariados
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Aferri, Gabriela, Carrer, Celso da Costa, de Lima, Cesar Goncalves, Ribeiro, Marcelo Machado de Luca de Oliveira, Batista, Karina, and Barbosa, Cristina Maria Pacheco
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- 2024
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4. Bamboo fiber application to industrial system to develop concrete slabs/ Aplicacao da fibra de bambu aos sistemas industrializados para desenvolvimento de placas de concreto
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Vieira, Adalberto Jose Tavares, Moura, Cassiano Rodrigues, Herpich, Marcio Ricardo, Campos, Nilson, and Campos, Guilherme de Luca
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- 2023
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5. Forensic bioacoustics? The advertisement calls of two locally extinct frogs from Colombia
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De La Riva, Ignacio, Lansac, Claudia, Cepeda, Belisario, Cantillo, Guillermo, De Luca, Jacopo, González, Laura, Márquez, Rafael, Burrowes, Patricia A., and BioStor
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- 2020
6. Building a transnational biodiversity geo-database of the protected areas in the Adriatic-Ionian Macro-Region: approaches and results from the IMPRECO Project
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Zangaro, Francesco, Marini, Gabriele, Specchia, Valeria, De Luca, Matteo, Visintin, Francesca, Bullo, Giovanna, Richard, Jacopo, Šalaja, Nataša, Rakar, Bia, Lipej, Bojana, Kurtović Mrčelić, Jelena, Piasevoli, Gvido, Žuljević, Ante, Zaimi, Nada, Bejko, Djana, Diku, Abdulla, Karousou, Aliki, Hatziyanni, Eleni, Pinat, Massimiliano, Pinna, Maurizio, and Pensoft Publishers
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Coastal-Marine Protected Areas ,European Adriatic-Ionian Macro-Region ,EUSAIR ,Natura 2000 ,non-indigenous species ,protected species and habitats ,traditional and innovative biomonitoring tools ,transnational biodiversity geo-database. - Published
- 2021
7. Desnutrición infantil
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De Luca, A.
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La desnutrición es el estado de un organismo en desequilibrio nutricional, caracterizado por un balance energético y/o proteico negativo con efectos deletéreos sobre los tejidos, con alteraciones medibles de las funciones corporales y/o de la composición corporal, asociado a una agravación del pronóstico de las enfermedades. En los niños, se observa esencialmente en los hospitales, donde su prevalencia es del 10-20% y se ha mantenido estable en los últimos 30 años. Su diagnóstico fue objeto de recomendaciones actualizadas por la Haute Autorité de Santé (HAS) francesa en 2019; consiste en combinar un criterio fenotípico (índice de masa corporal, estancamiento o pérdida de peso, disminución de la masa o de la función muscular) con un criterio etiológico (disminución de la ingesta alimentaria y de la absorción, situación de riesgo). Esto implica evaluar la cinética de crecimiento ponderal y estatural y buscar signos clínicos de desnutrición y su causa. No se requieren pruebas complementarias para diagnosticar la desnutrición. Las causas pueden agruparse en tres marcos principales: reducción de la ingesta, incremento de las necesidades y aumento de las pérdidas. La hospitalización es una situación en la que la desnutrición puede desarrollarse o agravarse, dando lugar a complicaciones, en particular infecciosas. El tratamiento debe incluir un objetivo de peso, que sirve de base para calcular los aportes nutricionales. Cuanto más grave sea la desnutrición, más gradual debe ser la renutrición, para prevenir el síndrome de renutrición inapropiada. Esto puede conseguirse enriqueciendo la dieta, utilizando suplementos nutricionales orales, nutrición enteral (por sonda u ostomía) o nutrición parenteral. El tratamiento debe dar prioridad a la utilización del tubo digestivo si es funcional. A continuación, debe reevaluarse la estrategia nutricional. La evaluación sistemática del estado nutricional y del riesgo nutricional ayudará a reducir las situaciones de desnutrición grave.
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- 2024
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8. Requerimientos nutricionales del adolescente
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De Luca, A.
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Los requerimientos nutricionales del adolescente se definen por los gastos relacionados con el metabolismo basal, con la actividad física y también con el crecimiento. Existen varios métodos que permiten estimar los requerimientos nutricionales, desde la medida directa hasta la extrapolación de los datos de los adultos, pasando por la observación de los datos de consumo o el uso de fórmulas para el gasto energético. Los requerimientos varían muchos entre los adolescentes y dependen del sexo, la corpulencia y la actividad física. El crecimiento se acelera durante la pubertad, con una importante ganancia de masa muscular y de masa grasa, pero también de masa ósea, lo que justifica requerimientos en ocasiones superiores al adulto en este período, en particular en proteínas, calcio y fósforo. Medir los requerimientos sirve para orientar los consumos. Las referencias nutricionales para la población (RNP) corresponden a los aportes que permiten cubrir las necesidades de la población; están especificadas para los macronutrientes, los minerales, los oligoelementos y las vitaminas. Se comparan con los estudios de consumos realizados en Francia y en Europa que muestran que los aportes proteicos y lipídicos totales son mayores que las RNP, lo que expone al riesgo de desarrollar obesidad. Otros nutrientes como el calcio, el hierro, los ácidos grasos poliinsaturados de la serie n-3, la vitamina D, los folatos y la vitamina E se consumen en cantidad insuficiente, exponiendo al riesgo de deficiencia. Los profesionales de la salud deben prestar especial atención a estos nutrientes, en una franja etaria en la que los hábitos alimentarios pueden estar desestructurados.
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- 2024
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9. Effects of stabilization splints on the signs and symptoms of temporomandibular disorders of muscular origin: A systematic review
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Honnef, Lia Rosana, Pauletto, Patrícia, Conti Réus, Jéssica, Massignan, Carla, Souza, Beatriz Dulcineia Mendes de, Michelotti, Ambrosina, Flores-Mir, Carlos, and De Luca Canto, Graziela
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ABSTRACTObjectiveTo assess effects of stabilization splints on signs and symptoms of temporomandibular disorders of muscular origin compared to other treatments.MethodsA search for articles via six electronic databases and gray literature was conducted. The risk of bias was evaluated with the Cochrane Collaboration tool. The Grading of Recommendations Assessment, Development and Evaluation approach determined the certainty of evidence.ResultsTen articles were included. Stabilization splints (n = 160 subjects) were reported to be as effective as other treatments (n = 209 patients) on analyzed outcomes (pressure pain threshold, pain during chewing, mouth opening, spontaneous pain intensity and by palpation). Five studies were judged at low and five at some concerns of risk of bias. The certainty of evidence was very low for all outcomes.ConclusionPositive effect on signs and symptoms of temporomandibular disorders of muscular origin, when managed with stabilization splint, could not be confirmed or refuted.
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- 2024
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10. The combined effects of rotation and anisotropy on double diffusive bi-disperse convection
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Capone, Florinda, De Luca, Roberta, and Massa, Giuliana
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In the present paper, double-diffusive convection, taking into account Coriolis effects, in a horizontal layer of Brinkman-anisotropic bi-disperse porous medium is analysed. Via linear instability analysis, we find that convection can set in through stationary or oscillatory motions and the critical Rayleigh numbers for the onset of stationary secondary flow (steady convection) and overstability (oscillatory convection) are determined.
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- 2024
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11. Clinical and optical coherence tomography biomarkers as prognostic factors in dexamethasone intravitreal implant for diabetic macular edema
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Oliverio, Giovanni William, Meduri, Alessandro, Brancati, Valentina Urzì, Ingrande, Irene, De Luca, Laura, Raimondo, Enrico Di, Minutoli, Letteria, Aragona, Emanuela, and Aragona, Pasquale
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Purpose Aim of the study was to evaluate the efficacy of dexamethasone (DEX) 0.7 mg intravitreal implant in patients with diabetic macular edema (DME) and serous retinal detachment (SRD), and to study the prognostic factors on a follow up of 12 months.Methods Forty eyes of twenty- six patients with centre involving DME and SRD, who underwent DEX implant, were enrolled. Best-corrected visual acuity (BCVA), Swept source OCT imaging and intraocular pressure were evaluated. Central macular thickness (CMT), vitreomacular adhesion (VMA), disorganization of retinal inner layers (DRILs), hyperreflective dots (HRD), SRD and ellipsoid zone (EZ) disruption were included in the analysis at baseline and 12 months after implant.Results According to our parametric analysis, at 12 months, BVCA improvement from 48.6 ± 23.4 letters to 53.3 ± 24.5 letters was statistically significant (p= 0.04), CMT decreased from 460 ± 99.52 μm to 322.9 ± 117 μm. The presence at baseline of VMA (p= 0.01), EZ disruption (p= 0.03) and DRILs (p= 0.04), were associated with poor BCVA improvement at the end of follow-up.Conclusion In conclusion, OCT biomarkers can be considered significant prognostic factors for treatment outcome in patients with DME undergoing DEX intravitreal implant.
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- 2024
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12. ATRP with ppb Concentrations of Photocatalysts
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Coskun, Halil Ibrahim, De Luca Bossa, Ferdinando, Hu, Xiaolei, Jockusch, Steffen, Sobieski, Julian, Yilmaz, Gorkem, and Matyjaszewski, Krzysztof
- Abstract
In atom transfer radical polymerization (ATRP), dormant alkyl halides are intermittently activated to form growing radicals in the presence of a CuI/L/X-CuII/L (activator/deactivator) catalytic system. Recently developed very active copper complexes could decrease the catalyst concentration to ppm level. However, unavoidable radical termination results in irreversible oxidation of the activator to the deactivator species, leading to limited monomer conversions. Therefore, successful ATRP at a low catalyst loading requires continuous regeneration of the activators. Such a regenerative ATRP can be performed with various reducing agents under milder reaction conditions and with catalyst concentrations diminished in comparison to conventional ATRP. Photoinduced ATRP (PhotoATRP) is one of the most efficient methods of activator regeneration. It initially employed UV irradiation to reduce the air-stable excited X-CuII/L deactivators to the activators in the presence of sacrificial electron donors. Photocatalysts (PCs) can be excited after absorbing light at longer wavelengths and, due to their favorable redox potentials, can reduce X-CuII/L to CuI/L. Herein, we present the application of three commercially available xanthene dyes as ATRP PCs: rose bengal (RB), rhodamine B (RD), and rhodamine 6G (RD-6G). Even at very low Cu catalyst concentrations (50 ppm), they successfully controlled PhotoATRP. Well-defined polymers with preserved livingness were prepared under green LED irradiation, with subppm concentrations ([PC] ≥ 10 ppb) of RB and RD-6G or 5 ppm of RD. Interestingly, these PCs efficiently controlled ATRP at wavelengths longer than their absorption maxima but required higher loadings. Polymerizations proceeded with high initiation efficiencies, yielding polymers with narrow molecular weight distributions and high chain-end fidelity. UV–vis, fluorescence, and laser flash photolysis studies helped to elucidate the mechanism of the processes involved in the dual-catalytic systems, comprising parts per million of Cu complexes and parts per billion of PCs.
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- 2024
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13. Sustainable Chemical Modification of Natural Polysaccharides: Mechanochemical, Solvent-Free Conjugation of Pectins and Hyaluronic Acid Promoted by Microwave Radiations
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Verdoliva, Valentina, Bedini, Emiliano, and De Luca, Stefania
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The modern chemistry has the main focus of saving resources and developing synthetic strategies characterized by intrinsic efficiency, ease and safety in operation, short reaction time, reduced energy, and waste. Natural polysaccharides are largely distributed in plant/animal cells; in other words, they are often provided by renewable sources. This characteristic makes them suitable compounds to be investigated for their employment as biodegradable material. In addition, natural polysaccharides have been proven to have a wide range of applications, and this prompted researchers to investigate their chemical modifications in order to modulate their properties. Herein we discuss the development of conjugation strategies of some polysaccharides with natural substrates and the effects of the structural modification on their bioactivities. Finally, this work intends to provide suggestions and perspectives on the development of safe and sustainable synthetic processes on polysaccharides.
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- 2024
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14. Mosunetuzumab for the treatment of follicular lymphoma
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Labanca, Caterina, Martino, Enrica Antonia, Vigna, Ernesto, Bruzzese, Antonella, Mendicino, Francesco, De Luca, Paola, Lucia, Eugenio, Olivito, Virginia, Fragliasso, Valentina, Neri, Antonino, Morabito, Fortunato, and Gentile, Massimo
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ABSTRACTIntroductionFollicular lymphoma (FL) is an indolent non-Hodgkin lymphoma that shows a progressive increase in relapses and refractory in its natural history and a median survival of approximately 18–20 years. The advent of anti-CD20 monoclonal antibodies has changed the FL therapeutic algorithm, with an increase in progression-free survival. T-cell-dependent bispecific antibodies (BsAbs) represent an emerging drug class against FL.Areas coveredIn this review, we selected papers from the principal databases (PubMed, Medline, Medscape, ASCO, ESMO) between January 2021 and June 2024, using the keywords ‘mosunetuzumab’ and ‘follicular lymphoma’ to provide an overview of mosunetuzumab-axgb, a pioneering BsAb. Its mechanism of action, efficacy, safety, and future perspectives were analyzed.Expert opinionMosunetuzumab grants a directing T-cell mediated cytotoxicity and allows a step-up dosing that reduces adverse events, such as cytokine release syndrome, with promising tolerability. At the same time, it improves outcomes in the evolving landscape of FL management, even in post-CAR-T FL patients. Prognostic factors and targetable mechanisms of resistance need to be explored.
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- 2024
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15. Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study
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Torres Silva, Mayara Secco, Torres, Thiago Silva, Coutinho, Carolina, Ismério Moreira, Ronaldo, da Costa Leite, Iuri, Cunha, Marcelo, da Costa Leite, Pedro Henrique Amparo, Cáceres, Carlos F, Vega-Ramírez, Hamid, Konda, Kelika A, Guanira, Juan, Valdez Madruga, José, Wagner Cardoso, Sandra, Benedetti, Marcos, Pimenta, Maria Cristina, Hoagland, Brenda, Grinsztejn, Beatriz, Gonçalves Veloso, Valdilea, Lacerda, Marcus Vinicius, Madruga, José Valdez, Farias, Alessandro, Lima, Josué N, Zonta, Ronaldo, Lauria, Lilian, Urbaez-Brito, J. David, d'Albuquerque, Polyana, Palombo, Claudio, Alencastro, Paulo Ricardo, Ito, Raquel Keiko de Luca, Moreira, Júlio, Benedetti, João L., Maria, Fabio V., Luz, Paula M., Freitas, Lucilene, Geraldo, Kim, Derrico, Monica, Nazer, Sandro, Kristic, Tania, Girade, Renato, Lima, Renato, Carvalho, Antônio R., Rocha, Carla, Leite, Pedro, Lessa, Marcio, Santini-Oliveira, Marilia, Bezerra, Daniel R.B., Souza, Cleo de Oliveira, Corrêa, Jacinto, Alves, Marcelo, Souza, Carolina, Portugal, Camilla, Valões, Mônica dos Santos, Mota, Gabriel Lima, Gomes, Joyce Alves, Falcão, Cynthia Ferreira Lima, Riberson, Fernanda Falcão, Melo, Luciano, Oliveira, Talita Andrade, Oliveira Júnior, Agnaldo Moreira, Fonseca, Bruna, Lannoy, Leonor Henriette, Carlos, Ludymilla Anderson Santiago, Cunha, João Paulo, Coracini, Sonia Maria de Alencastro, Rodrigues, Thiago Oliveira, Mettrau, Emília Regina Scharf, Meira, Kelly Vieira, Tavares, Heder, Valeiras, Ana Paula Nunes Viveiros, Rocha, Taiane Miyake Alves de Carvalho, Amorim, Alex, Sabadini, Patrícia, Córdoba, Luiz Gustavo, Gusmão, Caio, Faustino, Erika, Hansen, Julia Soares da Silva, Cunha, Agatha Mirian, Nishimura, Neuza Uchiyama, Santos, Jaime Eduardo Flygare Razo Prereira, Cano, Aline Barnabé, Dias, Willyam Magnum Telles, Tonhon, Magô, Rezende, Tania Regina, Gomes, Alex, Rodrigues, Eloá dos Santos, Carneiro, Maria das Dores Aires, Castilho, Alexandre, Carvalho, Mariana, Bautista-Aredondo, Sergio, Vermandere, Heleen, Diaz, Steven, Diaz-Sosa, Dulce, Guillen-Diaz-Barriga, Centli, Robles, Rebeca, Medina-Mora, Maria Elena, González, Marcela, Icelo, Ivonne Huerta, Davalos, Araczy Martinez, Castro, José Gomez, Valdez, Luis Obed Ocampo, Barajas, Fernanda Ramírez, González, Verónica Ruiz, Guadarrama, Galileo Vargas, Macías, Israel, Sánchez, Jehovani Tena, Noriega, Juan Pablo Osuna, Moheno M., H. Rodrigo, Ramírez, Jorge M. Bernal, Juarez, Víctor Dante Galicia, Vizcaíno, Gerardo, Arjona, Francisco Javier, Osco Tamayo, Cesar Vidal, Salvatierra Flores, Hector Javier, Cabrera Santa Cruz, Yovanna Margot, Moreno Aguayo, Ricardo Martín, Calvo, Gino, Vargas, Silver, Elorreaga, Oliver, Gutierrez, Ximena, Olivos, Fernando, Caviedes, Damaris, Adriazola, Daniella, Juárez, Eduardo, Mariño, Gabriela, Qquellon, Jazmin, Vasquez, Francesca, Jiron, Jean Pierre, Flores, Sonia, and Campos, Karen
- Abstract
The global burden of sexually transmitted infections (STIs) poses a challenge in the context of HIV pre-exposure prophylaxis (PrEP) programmes. We aimed to explore factors associated with prevalent, incident, and recurrent STIs in men who have sex with men (MSM) and transgender women on PrEP in Brazil, Mexico, and Peru.
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- 2024
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16. Dual control over the reignition and combustion performance of hydroxylammonium nitrate-based gel propellants
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Li, Chun-tian, Lu, Zi-yang, Wang, Zhi-wen, Li, Lian, Wang, Zhi-dong, Zhang, Yu-cheng, Shen, Rui-qi, De Luca, Luigi T., and Zhang, Wei
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Hydroxylammonium nitrate (HAN; NH3OH + NO3−), a green and non-toxic monopropellant, finds wide application in liquid and controllable solid propulsion. Gel propulsion enjoys advantages such as a high throttling capacity and encouraging operational safety. This study prepared three HAN-based gel propellant samples with gelling agent contents ranging from 2 to 4 wt%. Their decomposition processes were analyzed using thermogravimetry (TG), differential scanning calorimetry (DSC), and mass spectrometry (MS), and a microthruster was designed to investigate their combustion characteristics under varying voltages and flow rates. Results reveal the presence of three exothermic peaks in the HAN-based gel propellants at temperatures of 204, 306 °C and 441 °C. The gel propellants experienced violent decomposition between 100 °C and 400 °C, producing low-molecular-weight organics such as C3H8, C2H6, H2O, O2, and NH3. For the initial ignition, the flow rate exerts a greater effect of reducing the delay time than the voltage. The reignition exhibited a shorter delay time than the initial ignition, and increasing voltage led to a more significant decrease in the reignition delay time than increasing the flow rate. Under a gelling agent content of approximately 4 wt%, the reignition delay time decreased from 2.35 s to 0.65 s as the voltage increased from 150 V to 250 V, with the flame length and light intensity during the reignition greater than those in the initial ignition. At the end of combustion, the extinguishment delay time changed insignificantly under high voltage. As revealed by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analyses, residues with numerous cavities emerged due to incomplete combustion and the severe agglomeration of the gel propellants, exhibiting a maximum chlorine content of up to 77.73%.
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- 2024
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17. Post-mortem tetramorphism: Four morphological changes within the same corpse
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Zanovello, Claudia, Pallocci, Margherita, Passalacqua, Pierluigi, Mazzuca, Daniela, De Luca, Lucilla, Caparrelli, Valentina, Milano, Filippo, and Treglia, Michele
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Transformative processes generally occur singly and jointly involving the whole body. Rarely, they appear simultaneously as distinct transformative phenomena. The case study relates to a corpse found inside a storage tank in a rather unusual position, during the winter months. On external examination carried out at the crime scene, both legs and feet were out of the well bending over the storage tank and showing skeletonisation and tissue defects due to biting inflicted by the environmental macrofauna. The thighs were also skeletonised, inside the well but not immersed in the water, as was the torso which, however, was entirely corified. The colliquated shoulders, head and upper limbs were fully immersed into the water as well as the macerated hands. The corpse was exposed simultaneously to three different environmental conditions: the external setting with changes in temperature, rainfall and the action of the macro fauna, the unventilated and humid setting inside the tank, and lastly the stored water. The corpse, lying in a specific position and being exposed to different atmospheric conditions, underwent four post-mortem changes at the same time, making it challenging to estimate the time of death, based only on the available data and macroscopic findings.
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- 2024
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18. Comments on: Choroidal and retinal thickness variations in ocular albinism
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Gioia, Marco, La Marca, Aniello, De Luca, Martina, and De Bernardo, Maddalena
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Albinism ,Health - Abstract
Byline: Marco. Gioia, Aniello. La Marca, Martina. De Luca, Maddalena. De Bernardo Dear Editor, We read with great interest the article by Venkatesh et al. titled 'Choroidal and retinal thickness [...]
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- 2023
19. Cardio-oncology rehabilitation: are we ready?
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Bisceglia, Irma, Venturini, Elio, Canale, Maria Laura, Ambrosetti, Marco, Riccio, Carmine, Giallauria, Francesco, Gallucci, Giuseppina, Abrignani, Maurizio G, Russo, Giulia, Lestuzzi, Chiara, Mistrulli, Raffaella, De Luca, Giovanni, Maria Turazza, Fabio, Mureddu, Gianfrancesco, Di Fusco, Stefania Angela, Lucà, Fabiana, De Luca, Leonardo, Camerini, Andrea, Halasz, Geza, Camilli, Massimiliano, Quagliariello, Vincenzo, Maurea, Nicola, Fattirolli, Francesco, Gulizia, Michele Massimo, Gabrielli, Domenico, Grimaldi, Massimo, Colivicchi, Furio, and Oliva, Fabrizio
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Cardio-oncology rehabilitation (CORE) is not only an essential component of cancer rehabilitation but also a pillar of preventive cardio-oncology. Cardio-oncology rehabilitation is a comprehensive model based on a multitargeted approach and its efficacy has been widely documented; when compared with an ‘exercise only’ programme, comprehensive CORE demonstrates a better outcome. It involves nutritional counselling, psychological support, and cardiovascular (CV) risk assessment, and it is directed to a very demanding population with a heavy burden of CV diseases driven by physical inactivity, cancer therapy-induced metabolic derangements, and cancer therapy-related CV toxicities. Despite its usefulness, CORE is still underused in cancer patients and we are still at the dawning of remote models of rehabilitation (tele-rehabilitation). Not all CORE is created equally: a careful screening procedure to identify patients who will benefit the most from CORE and a multidisciplinary customized approach are mandatory to achieve a better outcome for cancer survivors throughout their cancer journey. The aim of this paper is to provide an updated review of CORE not only for cardiologists dealing with this peculiar population of patients but also for oncologists, primary care providers, patients, and caregivers. This multidisciplinary team should help cancer patients to maintain a healthy and active life before, during, and after cancer treatment, in order to improve quality of life and to fight health inequities.
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- 2024
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20. An adapted cardioprotective diet with or without phytosterol and/or krill oil supplement in familial hypercholesterolemia: A pilot study protocol
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de Abreu-Silva, Erlon Oliveira, Machado, Rachel Helena Vieira, dos Santos, Bianca Rodrigues, Kojima, Flávia Soares, Santos, Renato Hideo Nakagawa, Murizine, Gabriela Souza, Homsi, Jordana Rosa, Negrelli, Karina Leal, Barbante, Letícia Galvão, de Barros e Silva, Pedro G.M., de Lima, Andressa Gusmão, Tramujas, Lucas, Bersch-Ferreira, Ângela Cristine, Carvalho, Adriana Bastos, de Oliveira, Thaís Martins, Izar, Maria Cristina, Sampaio, Geni Rodrigues, Damasceno, Nágila Raquel Teixeira, Rogero, Marcelo Macedo, da Silva Torres, Elizabeth Aparecida Ferraz, Costa, Rosana Perim, de Souza Mota, Luís Gustavo, Krey, Julia Pinheiro, da Silva, Lucas Ribeiro, de Luca, Patrícia Vieira, Amaral, Cristiane Kovacs, de Oliveira, Patricia Rodrigues, da Silva, Renata Alves, Moreira, Priscila, dos Santos, Elisa Maia, de Melo, Rodrigo Morel Vieira, Lima, Eduardo Gomes, de Luca, André, Heck, Thiago Gomes, Carvalho, Ana Paula Perillo Ferreira, Garofallo, Silvia Bueno, Cavalcanti, Alexandre Biasi, and Marcadenti, Aline
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A healthy diet is one of the pillars of familial hypercholesterolemia (FH) treatment. However, the best dietary pattern and indication for specific supplementation have not been established. Our aim is to conduct a pilot study to assess the effect of an adapted cardioprotective diet with or without phytosterol and/or krill oil supplement in participants with a probable or definitive diagnosis of FH, treated with moderate/high potency statins.
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- 2024
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21. Living in Limbo
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De Luca, Giusi
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General interest ,Political science - Abstract
At the end of December 2020, a tremendous storm surge hit the seafront of Naples. Waves of more than 30 feet, pushed by a wind that roared at nearly 55 [...]
- Published
- 2021
22. Computed tomography–guided percutaneous cryoablation of hereditary adrenal pheochromocytoma in three patients
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Griffing, Emily, Reading, Brenton, De Luca, Francesco, Agne, Daniel, Juang, David, and Halpin, Kelsee
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- 2024
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23. Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches
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Lombardo, Lisa, Mirabile, Salvatore, Gitto, Rosaria, Cosentino, Giuseppe, Alcaro, Stefano, Dichiara, Maria, Marrazzo, Agostino, Amata, Emanuele, Ortuso, Francesco, and De Luca, Laura
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Sigma-1 receptor (S1R) is involved in a large array of biological functions due to its ability to interact with various proteins and ion channels. Crystal structures of human S1R revealed the trimeric organization for which each protomer comprises the ligand binding pocket. This study applied a multistep computational procedure to develop a pharmacophore model obtained from molecular dynamics simulations of available cocrystal structures of well-known S1R ligands. Apart from the well-established positive ionizable and hydrophobic features, the obtained model included an additional specific hydrophobic feature and different excluded volumes, thus increasing the selectivity of the model as well as a more detailed determination of the distance between two essential features. The obtained pharmacophore model passed the validation test by receiver operating characteristic (ROC) curve analysis of active and inactive S1R ligands. Finally, the pharmacophoric performance was experimentally investigated through the synthesis and binding assay of new 4-phenylpiperazine-based compounds. The most active new ligand 2-(3-methyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)ethanone (3) showed an S1R affinity close to the reference compound haloperidol (Kivalues of 4.8 and 2.6 nM, respectively). The proposed pharmacophore model can represent a useful tool to design and discover new potent S1R ligands.
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- 2024
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24. Permutational Encoding Strategy Accelerates HIT Validation from Single-Stranded DNA-Encoded Libraries
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Puglioli, Sara, Fabbri, Mosè, Comacchio, Claudia, Alvigini, Laura, De Luca, Roberto, Oehler, Sebastian, Gilardoni, Ettore, Bassi, Gabriele, Cazzamalli, Samuele, Neri, Dario, and Favalli, Nicholas
- Abstract
DNA-Encoded Libraries (DELs) allow the parallel screening of millions of compounds for various applications, including de novodiscovery or affinity maturation campaigns. However, library construction and HIT resynthesis can be cumbersome, especially when library members present an unknown stereochemistry. We introduce a permutational encoding strategy suitable for the construction of highly pure single-stranded single-pharmacophore DELs, designed to distinguish isomers at the sequencing level (e.g., stereoisomers, regio-isomers, and peptide sequences). This approach was validated by synthesizing a mock 921,600-member 4-amino-proline single-stranded DEL (“DEL1”). While screening DEL1against different targets, high-throughput sequencing results showed selective enrichment of the most potent stereoisomers, with enrichment factors that outperform conventional encoding strategies. The versatility of our methodology was additionally validated by encoding 24 scaffolds derived from different permutations of the amino acid sequence of a previously described cyclic peptide targeting Fibroblast Activation Protein (FAP-2286). The resulting library (“DEL2”) was interrogated against human FAP, showing selective enrichment of five cyclic peptides. We observed a direct correlation between enrichment factors and on-DNA binding affinities. The presented encoding methodology accelerates drug discovery by facilitating library synthesis and streamlining HIT resynthesis while enhancing enrichment factors at the DEL sequencing level. This facilitates the identification of HIT candidates prior to medicinal chemistry and affinity maturation campaigns.
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- 2024
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25. How should we differentiate hypoglycaemia in non-diabetic patients?
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Modestino, Michele R., Iacono, Olimpia, Ferrentino, Laura, Lombardi, Anna, De Fortuna, Umberto, Verdoliva, Rita, De Luca, Mariarosaria, and Guardasole, Vincenzo
- Abstract
Hypoglycaemic syndromes are rare in apparently healthy individuals and their diagnosis can be a difficult challenge for clinicians as there are no shared guidelines that suggest how to approach patients with a suspect hypoglycaemic disorder. Since hypoglycaemia symptoms are common and nonspecific, it’s necessary to document the Whipple Triad (signs and/or symptoms compatible with hypoglycaemia; relief of symptoms following glucose administration; low plasma glucose levels) before starting any procedure. Once the triad is documented, a meticulous anamnesis and laboratory tests (blood glucose, insulin, proinsulin, C-peptide, β-hydroxybutyrate and anti-insulin antibodies) should be performed. Results can guide the physician towards further specific tests, concerning the suspected disease. In this review, we consider all current causes of hypoglycaemia, including rare diseases such as nesidioblastosis and Hirata’s syndrome, describe appropriate tests for diagnosis and suggest strategies to differentiate hypoglycaemia aetiology.
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- 2024
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26. Resilience of hospitals in an age of disruptions: a systematic literature review on resources and capabilities
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Carbonara, Nunzia, Pellegrino, Roberta, and De Luca, Cristina
- Abstract
ABSTRACTHospitals play a critical role in ensuring continuous and effective healthcare delivery, especially during crises. However, the COVID-19 pandemic exposed vulnerabilities in hospital systems, prompting a need to enhance resilience—the ability to withstand, absorb, respond to, recover from, and learn from disasters. A systematic literature review, grounded in the resource-based view, identified organizational characteristics, in terms of resources and capabilities, and their synergistic effects that bolster hospital resilience. The results demonstrate that digital technologies impact on anticipation and adaptation abilities, organizational capabilities to reorganize roles, tasks, and spaces enhance adaptability, and Inter-organizational collaborations increase the responsiveness of the hospitals. The study provides substantial theoretical and practical contributions. It expands knowledge of hospital resilience in light of recent disruptive events and promotes integration capabilities as determinants for the majority of resilience dimensions. All organisational and inter-organisational collaboration, cooperation, and coordination are deemed crucial for hospital resilience.
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- 2024
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27. The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports
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Bassi, Marta, Bilel, Sabrine, Tirri, Micaela, Corli, Giorgia, Di Rosa, Fabiana, Gregori, Adolfo, Alkilany, Alaaldin M., Rachid, Ousama, Roda, Elisa, De Luca, Fabrizio, Papa, Pietro, Buscaglia, Eleonora, Zauli, Giorgio, Locatelli, Carlo Alessandro, and Marti, Matteo
- Abstract
The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP has recently gained attention due to increasing seizures and involvement in human intoxications which occurred in Europe and Italy in the last years, but currently there is a lack of information about its pharmaco-toxicological effects. With the aim at filling this gap, the present study is endeavoured to (i) evaluate the effects of acute administration of MDPHP (0.01–20 mg/kg; i.p.) on behaviour, cardiorespiratory and cardiovascular parameters in CD-1 male mice, comparing them to those observed after administration of MDPV; (ii) predict the ADMET profile of the two analogues using the Plus ADMET Predictor®; (iii) present clinical data related to MDPHP and MDPV-induced intoxications recorded between 2011 and 2023 by the Pavia Poison Control Centre (PCC) − National Toxicology Information Centre (Istituti Clinici Scientifici Maugeri, IRCCS Pavia, Italy). Our results substantiated that MDPHP and MDPV similarly affect sensorimotor and behavioural responses in mice, importantly increased locomotion and induced aggressive behaviour, and, at higher dosage, increased heart rate and blood pressure. These findings are in line with those observed in humans, revealing severe toxidromes typically characterized by Central Nervous System (CNS) alterations (behavioural/neuropsychiatric symptoms), including psychomotor agitation and aggressiveness, cardiovascular and respiratory disorders (e.g. tachycardia, hypertension, dyspnoea), and other peripheral symptoms (e.g. hyperthermia, acidosis, rhabdomyolysis).
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- 2024
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28. Cuando el gobierno se olvida del medioambiente
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De Luca, Ana
- Published
- 2020
29. Advancing neonatal phototherapy after 70 years of global impact
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De Luca, Daniele and Bhutani, Vinod K
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- 2024
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30. SECONDI ASSAGGI.
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De Luca, Virginia
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- 2024
31. Improving Molecule–Metal Surface Reaction Networks Using the Meta-Generalized Gradient Approximation: CO2Hydrogenation
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Cai, Yuxiang, Michiels, Roel, De Luca, Federica, Neyts, Erik, Tu, Xin, Bogaerts, Annemie, and Gerrits, Nick
- Abstract
Density functional theory is widely used to gain insights into molecule–metal surface reaction networks, which is important for a better understanding of catalysis. However, it is well-known that generalized gradient approximation (GGA) density functionals (DFs), most often used for the study of reaction networks, struggle to correctly describe both gas-phase molecules and metal surfaces. Also, GGA DFs typically underestimate reaction barriers due to an underestimation of the self-interaction energy. Screened hybrid GGA DFs have been shown to reduce this problem but are currently intractable for wide usage. In this work, we use a more affordable meta-GGA (mGGA) DF in combination with a nonlocal correlation DF for the first time to study and gain new insights into a catalytically important surface reaction network, namely, CO2hydrogenation on Cu. We show that the mGGA DF used, namely, rMS-RPBEl-rVV10, outperforms typical GGA DFs by providing similar or better predictions for metals and molecules, as well as molecule–metal surface adsorption and activation energies. Hence, it is a better choice for constructing molecule–metal surface reaction networks.
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- 2024
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32. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Naghavi, Mohsen, Ong, Kanyin Liane, Aali, Amirali, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abtahi, Dariush, Abu Rumeileh, Samir, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Accrombessi, Manfred Mario Kokou, Adal, Tadele Girum, Adamu, Abdu A, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adekanmbi, Victor, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Admass, Biruk Adie Adie, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Aanuoluwapo Adeyimika, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agasthi, Pradyumna, Aggarwal, Manik, Aghamiri, Shahin, Agide, Feleke Doyore, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Mehrunnisha Sharif, Ahmed, Meqdad Saleh, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akara, Essona Matatom, Akbarialiabad, Hossein, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Alahdab, Fares, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Noore, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Al-Azzam, Sayer, Albakri, Almaza, Albashtawy, Mohammed, AlBataineh, Mohammad T, Alcalde-Rabanal, Jacqueline Elizabeth, Aldawsari, Khalifah A, Aldhaleei, Wafa A, Aldridge, Robert W, Alema, Haileselasie Berhane, Alemayohu, Mulubirhan Assefa, Alemi, Sharifullah, Alemu, Yihun Mulugeta, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Amjad, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Shahid, Ali, Syed Shujait Shujait, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Alikhani, Reyhaneh, Alimohamadi, Yousef, Aliyi, Ahmednur Adem, Aljasir, Mohammad A M, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Louay, Almidani, Omar, Alomari, Mahmoud A, Al-Omari, Basem, Alonso, Jordi, Alqahtani, Jaber S, Alqalyoobi, Shehabaldin, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Amani, Reza, Amare, Azmeraw T, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anoushiravani, Amir, Ansari, Hossein, Ansariadi, Ansariadi, Ansari-Moghaddam, Alireza, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arab, Juan Pablo, Arabloo, Jalal, Arafat, Mosab, Aravkin, Aleksandr Y, Areda, Demelash, Aremu, Abdulfatai, Aremu, Olatunde, Ariffin, Hany, Arkew, Mesay, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Asaad, Malke, Asadi-Lari, Mohsen, Asgedom, Akeza Awealom, Asghariahmadabad, Mona, Asghari-Jafarabadi, Mohammad, Ashraf, Muhammad, Aslani, Armin, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atinafu, Bantalem Tilaye Tilaye, Atlaw, Habtamu Wondmagegn, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avan, Abolfazl, Awedew, Atalel Fentahun, Aweke, Amlaku Mulat, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayuso-Mateos, Jose L, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azevedo, Rui M S, Azzam, Ahmed Y, B, Darshan B, Babu, Abraham Samuel, Badar, Muhammad, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadorikhalili, Saeed, Bahmanziari, Najmeh, Bai, Ruhai, Baig, Atif Amin, Baker, Jennifer L, Bako, Abdulaziz T, Bakshi, Ravleen Kaur, Balakrishnan, Senthilkumar, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Bam, Kiran, Banach, Maciej, Bandyopadhyay, Soham, Banik, Palash Chandra, Bansal, Hansi, Bansal, Kannu, Barbic, Franca, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barrero, Lope H, Barrow, Amadou, Barteit, Sandra, Barua, Lingkan, Basharat, Zarrin, Bashiri, Azadeh, Basiru, Afisu, Baskaran, Pritish, Basnyat, Buddha, Bassat, Quique, Basso, João Diogo, Basting, Ann V L, Basu, Sanjay, Batra, Kavita, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Bedi, Neeraj, Beghi, Massimiliano, Behboudi, Emad, Behera, Priyamadhaba, Behnoush, Amir Hossein, Behzadifar, Masoud, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Béjot, Yannick, Belay, Sefealem Assefa, Belete, Chalie Mulu, Bell, Michelle L, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bender, Rose Grace, Bensenor, Isabela M, Beran, Azizullah, Berezvai, Zombor, Berhie, Alemshet Yirga, Berice, Betyna N, Bernstein, Robert S, Bertolacci, Gregory J, Bettencourt, Paulo J G, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhangdia, Kayleigh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Bijit, Bitaraf, Saeid, Bitew, Bikes Destaw, Bitra, Veera R, Bjørge, Tone, Boachie, Micheal Kofi, Boampong, Mary Sefa, Bobirca, Anca Vasilica, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bonakdar Hashemi, Milad, Bonny, Aime, Bora, Kaustubh, Bora Basara, Berrak, Borhany, Hamed, Borzutzky, Arturo, Bouaoud, Souad, Boustany, Antoine, Boxe, Christopher, Boyko, Edward J, Brady, Oliver J, Braithwaite, Dejana, Brant, Luisa C, Brauer, Michael, Brazinova, Alexandra, Brazo-Sayavera, Javier, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle, Brown, Julie, Brugha, Traolach, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cao, Yin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalheiro, Cristina G, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Cederroth, Christopher R, Cegolon, Luca, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chadwick, Joshua, Chahine, Yaacoub, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandika, Rama Mohan, Chandrasekar, Eeshwar K, Chang, Chin-Kuo, Chang, Jung-Chen, Chanie, Gashaw Sisay, Charalampous, Periklis, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chatzimavridou-Grigoriadou, Victoria, Chaurasia, Akhilanand, Chen, Angela W, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Cheru, Wondimye Ashenafi, Chien, Ju-Huei, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Christopher, Devasahayam J, Chukwu, Isaac Sunday, Chung, Eric, Chung, Erin, Chung, Eunice, Chung, Sheng-Chia, Chutiyami, Muhammad, Cindi, Zinhle, Cioffi, Iolanda, Claassens, Mareli M, Claro, Rafael M, Coberly, Kaleb, Cogen, Rebecca M, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Cousin, Ewerton, Couto, Rosa A S, Cowden, Richard G, Cramer, Kenneth Michael, Criqui, Michael H, Cruz-Martins, Natália, Cuadra-Hernández, Silvia Magali, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, Curado, Maria paula, Dadana, Sriharsha, Dadras, Omid, Dai, Siyu, Dai, Xiaochen, Dai, Zhaoli, Dalli, Lachlan L, Damiani, Giovanni, Darega Gela, Jiregna, Das, Jai K, Das, Saswati, Das, Subasish, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, Dastiridou, Anna, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, de Luca, Katie, Debele, Aklilu Tamire, Debopadhaya, Shayom, Degenhardt, Louisa, Dehghan, Azizallah, Deitesfeld, Lee, Del Bo', Cristian, Delgado-Enciso, Ivan, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Ke, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deravi, Niloofar, Dereje, Nebiyu, Dervenis, Nikolaos, Dervišević, Emina, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Meghnath, Dhingra, Sameer, Dhulipala, Vishal R, Dias da Silva, Diana, Diaz, Daniel, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Ding, Huanghe, Dinis-Oliveira, Ricardo Jorge, Dirac, M Ashworth, Djalalinia, Shirin, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Doaei, Saeid, Dodangeh, Masoud, Dodangeh, Milad, Dohare, Sushil, Dokova, Klara Georgieva, Dolecek, Christiane, Dominguez, Regina-Mae Villanueva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorostkar, Fariba, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dsouza, Viola, Du, Mi, Dube, John, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dwyer-Lindgren, Laura, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, E'mar, Abdel Rahman, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Effendi, Diyan Ermawan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elbarazi, Iffat, Elema, Teshome Bekele, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, El-Huneidi, Waseem, Elilo, Legesse Tesfaye, Elmeligy, Omar Abdelsadek Abdou, Elmonem, Mohamed A, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Esezobor, Christopher Imokhuede, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Esubalew, Habtamu, Etaee, Farshid, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Fahimi, Saman, Fakhri-Demeshghieh, Aliasghar, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faris, Pawan Sirwan, Faro, Andre, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Feizkhah, Alireza, Fekadu, Ginenus, Feng, Xiaoru, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flood, David, Florin, Bobirca Teodor, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Behzad, Foroutan, Masoud, Forthun, Ingeborg, Fortuna, Daniela, Foschi, Matteo, Fowobaje, Kayode Raphael, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Fux, Blima, Gaal, Peter Andras, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gakidou, Emmanuela, Galali, Yaseen, Galles, Natalie C, Gallus, Silvano, Ganbat, Mandukhai, Gandhi, Aravind P, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Garcia-Gordillo, MA, Gardner, William M, Garg, Jalaj, Garg, Naval, Gautam, Rupesh K, Gbadamosi, Semiu Olatunde, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremeskel, Teferi Gebru, Georgescu, Simona Roxana, Getachew, Tamirat, Gething, Peter W, Getie, Molla, Ghadiri, Keyghobad, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghasemi, Mohammad-Reza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghashghaee, Ahmad, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Ajnish, Ghoba, Sama, Gholamalizadeh, Maryam, Gholamian, Asadollah, Gholamrezanezhad, Ali, Gholizadeh, Nasim, 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Habibzadeh, Farrokh, Habibzadeh, Parham, Haddadi, Rasool, Hadei, Mostafa, Hadi, Najah R, Haep, Nils, Hafezi-Nejad, Nima, Hailu, Alemayehu, Haj-Mirzaian, Arvin, Halboub, Esam S, Hall, Brian J, Haller, Sebastian, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Hamilton, Erin B, Han, Chieh, Han, Qiuxia, Hanif, Asif, Hanifi, Nasrin, Hankey, Graeme J, Hanna, Fahad, Hannan, Md Abdul, Haque, Md Nuruzzaman, Harapan, Harapan, Hargono, Arief, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Ikramul, Hasan, M Tasdik, Hasani, Hamidreza, Hasanian, Mohammad, Hashi, Abdiwahab, Hasnain, Md Saquib, Hassan, Ikrama, Hassanipour, Soheil, Hassankhani, Hadi, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, He, Jiawei, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Golnaz, Heidari, Mohammad, Heidari-Foroozan, Mahsa, Helfer, Bartosz, Hendrie, Delia, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hesami, Hamed, Hezam, Kamal, Hill, Catherine L, Hiraike, Yuta, Holla, Ramesh, Horita, Nobuyuki, Hossain, Md Mahbub, Hossain, Sahadat, Hosseini, Mohammad-Salar, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hosseinzadeh Adli, Ahmad, Hostiuc, Mihaela, Hostiuc, Sorin, Hsairi, Mohamed, Hsieh, Vivian Chia-rong, Hsu, Rebecca L, Hu, Chengxi, Huang, Junjie, Hultström, Michael, Humayun, Ayesha, Hundie, Tsegaye Gebreyes, Hussain, Javid, Hussain, M Azhar, Hussein, Nawfal R, Hussien, Foziya Mohammed, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ibrahim, Khalid S, Iftikhar, Pulwasha Maria, Ijo, Desta, Ikiroma, Adalia I, Ikuta, Kevin S, Ikwegbue, Paul Chukwudi, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imam, Mohammad Tarique, Immurana, Mustapha, Inamdar, Sumant, Indriasih, Endang, Iqhrammullah, Muhammad, Iradukunda, Arnaud, Iregbu, Kenneth Chukwuemeka, Islam, Md Rabiul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iyamu, Ihoghosa Osamuyi, Iyer, 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A, Khan, M Nuruzzaman, Khan, Maseer, Khan, Mohammad Jobair, Khan, Moien AB, Khan, Zeeshan Ali, Khan suheb, Mahammed Ziauddin, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatami, Fatemeh, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khavandegar, Armin, Khayat Kashani, Hamid Reza, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khorgamphar, Mohammad, Khormali, Moein, Khorrami, Zahra, Khosravi, Ahmad, Khosravi, Mohammad Ali, Kifle, Zemene Demelash, Kim, Grace, Kim, Jihee, Kim, Kwanghyun, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kinzel, Kasey E, Kisa, Adnan, Kisa, Sezer, Klu, Desmond, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M, Kochhar, Sonali, Kocsis, Timea, Koh, David S Q, Kolahi, Ali-Asghar, Kolves, Kairi, Kompani, Farzad, Koren, Gerbrand, Kosen, Soewarta, Kostev, Karel, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Krishna, Hare, Krishna, Varun, Krishnamoorthy, Vijay, Krishnamoorthy, Yuvaraj, Krohn, Kris J, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kuddus, Mohammed, Kuitunen, Ilari, Kulimbet, Mukhtar, Kulkarni, Vishnutheertha, Kumar, Akshay, Kumar, Ashish, Kumar, Harish, Kumar, Manasi, Kumar, Rakesh, Kumari, Madhulata, Kumie, Fantahun Tarekegn, Kundu, Satyajit, Kurmi, Om P, Kusnali, Asep, Kusuma, Dian, Kwarteng, Alexander, Kyriopoulos, Ilias, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Ladan, Muhammad Awwal, Laflamme, Lucie, Lagat, Abraham K, Lager, Anton C J, Lahmar, Abdelilah, Lai, Daphne Teck Ching, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lám, Judit, Landrum, Kelsey R, Lanfranchi, Francesco, Lang, Justin J, Langguth, Berthold, Lansingh, Van Charles, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Latief, Kamaluddin, Latifinaibin, Kaveh, Lauriola, Paolo, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Le, Trang Diep Thanh, Ledda, Caterina, Ledesma, Jorge R, Lee, Munjae, Lee, Paul H, Lee, Seung Won, Lee, Shaun Wen Huey, Lee, Wei-Chen, Lee, 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Ramin, Ravikumar, Nakul, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawlley, Bharat, Raza, Rabail Zehra, Razo, Christian, Redwan, Elrashdy Moustafa Mohamed, Rehman, Faizan Ur, Reifels, Lennart, Reiner Jr, Robert C, Remuzzi, Giuseppe, Reyes, Luis Felipe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Rhee, Taeho Gregory, Riaz, Mavra A, Ribeiro, Antonio Luiz P, Rickard, Jennifer, Riva, Hannah R, Robinson-Oden, Hannah Elizabeth, Rodrigues, Célia Fortuna, Rodrigues, Mónica, Roever, Leonardo, Rogowski, Emma Lynn Best, Rohloff, Peter, Romadlon, Debby Syahru, Romero-Rodríguez, Esperanza, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rout, Himanshu Sekhar, Roy, Nitai, Roy, Priyanka, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, Rwegerera, Godfrey M, Rynkiewicz, Andrzej, S N, Chandan, Saad, Aly M A, Saadatian, Zahra, Saber, Korosh, Saber-Ayad, Maha Mohamed, SaberiKamarposhti, Morteza, Sabour, Siamak, Sacco, Simona, Sachdev, Perminder S, Sachdeva, Rajesh, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Erfan, Sadeghian, Farideh, Saeb, Mohammad Reza, Saeed, Umar, Safaeinejad, Fahimeh, Safi, Sher Zaman, Sagar, Rajesh, Saghazadeh, Amene, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahoo, Umakanta, Sahu, Monalisha, Saif, Zahra, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salam, Nasir, Salamati, Payman, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Saleh, Mohamed A, Salehi, Sana, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salimi, Sohrab, Samadi Kafil, Hossein, Samadzadeh, Sara, Samargandy, Saad, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sanna, Francesca, Santomauro, Damian Francesco, Santos, Itamar S, Santric-Milicevic, Milena M, Sao Jose, Bruno Piassi, Sarasmita, Made Ary, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarkar, Tanmay, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Satpathy, Maheswar, Sayeed, Abu, Sayeed, Md Abu, Saylan, Mete, Sayyah, Mehdi, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schlaich, Markus P, Schlee, Winfried, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Schwendicke, Falk, Šekerija, Mario, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Sethi, Yashendra, Sha, Feng, Shabany, Maryam, Shafaat, Amir, Shafie, Mahan, Shah, Nilay S, Shah, Pritik A, Shah, Syed Mahboob, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Izza, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Ahmed, Shaikh, Masood Ali, Shakeri, Alireza, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Rajesh, Sharma, Saurab, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shi, Peilin, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Min-Jeong, Shin, Youn Ho, Shiri, Rahman, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shokraneh, Farhad, Shokri, Azad, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Shuval, Kerem, Siddig, Emmanuel Edwar, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Garima, Singh, Jasbir, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinto, Robert, Siraj, Md Shahjahan, Sirota, Sarah Brooke, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Socea, Bogdan, Sokhan, Anton, Solanki, Ranjan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stark, Benjamin A, Starnes, Joseph R, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stevanović, Aleksandar, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Haitong Zhe, Sun, Jing, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabish, Mohammad, TADAKAMADLA, JYOTHI, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tang, Hong K, Tarigan, Ingan Ukur, Tariku, Mengistie Kassahun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Rishu, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Thomas, Nikhil Kenny, Thomson, Azalea M, Thrift, Amanda G, Thum, Chern Choong Chern, Thygesen, Lau Caspar, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L
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Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations.
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- 2024
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33. AI-Forecast: an innovative and practical tool for short-term water demand forecasting
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Zanfei, Ariele, Lombardi, Andrea, De Luca, Alberto, and Menapace, Andrea
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- 2024
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34. Association between small vessel function and progressive white matter injury in CADASIL using advanced 7T MRI
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Gimi, Barjor S., Krol, Andrzej, Pham, S. D. T., van den Brink, H., Kopczak, A., De Luca, A., Zwanenburg, J. J. M., Dieleman, N., Duering, M., Dichgans, M., Biessels, G. J., and Siero, J. C. W.
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- 2024
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35. Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) scientific statement on the simplification of the drug regimen for secondary cardiovascular prevention
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De Luca, Leonardo, Di Fusco, Stefania Angela, Iannopollo, Gianmarco, Mistrulli, Raffaella, Rizzello, Vittoria, Aimo, Alberto, Navazio, Alessandro, Bilato, Claudio, Corda, Marco, Di Marco, Massimo, Geraci, Giovanna, Iacovoni, Attilio, Milli, Massimo, Pascale, Vittorio, Riccio, Carmine, Scicchitano, Pietro, Tizzani, Emanuele, Gabrielli, Domenico, Grimaldi, Massimo, Colivicchi, Furio, and Oliva, Fabrizio
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The issue of suboptimal drug regimen adherence in secondary cardiovascular prevention presents a significant barrier to improving patient outcomes. To address this, the utilization of drug combinations, specifically single pill combinations (SPCs) and polypills, was proposed as a strategy to simplify treatment regimens. This approach aims to enhance treatment accessibility, affordability, and adherence, thereby reducing healthcare costs and improving patient health. The document is an Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) scientific statement on simplifying drug regimens for secondary cardiovascular prevention. It discusses the underuse of treatments despite available, effective, and accessible options, highlighting a significant gap in secondary prevention across different socio-economic statuses and countries. The statement explores barriers to implementing evidence-based treatments, including patient, healthcare provider, and system-related challenges. The paper also reviews international guidelines, the role of SPCs and polypills in clinical practice, and their economic impact, advocating for their use in secondary prevention to improve patient outcomes and adherence.
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- 2024
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36. Abnormal conduction-induced cardiomyopathy: a poorly explored entity
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Lalario, Andrea, Rossi, Maddalena, Allegro, Valentina, Gagno, Giulia, Perotto, Maria, De Luca, Antonio, Merlo, Marco, Sanna, Giuseppe Damiano, and Sinagra, Gianfranco
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A dyssynchronous biventricular activation, which can be determined by left bundle branch block, chronic right ventricular pacing, frequent premature ventricular complexes, or pre-excitation, can cause a global abnormal contractility, thus leading to systolic dysfunction and left ventricular remodelling in a unique nosological entities: abnormal conduction-induced cardiomyopathies. In this clinical scenario, the mainstay therapy is eliminating or improving LV dyssynchrony, removing the trigger. This usually ensures the improvement and even recovery of cardiac geometry and left ventricular function, especially in the absence of genetic background. A multidisciplinary approach, integrating advanced multimodal imaging, is essential for the systematic aetiological definition and the subsequent evaluation and aetiology-guided therapies of patients and their families. This review aims to describe mechanisms, prevalence, risk factors, and diagnostic and therapeutic approach to the various abnormal conduction-induced cardiomyopathies, starting from reasonable certainties and then analysing the grey areas requiring further studies.
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- 2024
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37. Italian Association of Hospital Cardiologists position paper—obesity in adults: a clinical primer
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Di Fusco, Stefania Angela, Mocini, Edoardo, Gori, Mauro, Iacoviello, Massimo, Bilato, Claudio, Corda, Marco, De Luca, Leonardo, Di Marco, Massimo, Geraci, Giovanna, Iacovoni, Attilio, Milli, Massimo, Navazio, Alessandro, Pascale, Vittorio, Riccio, Carmine, Scicchitano, Pietro, Tizzani, Emanuele, Gabrielli, Domenico, Grimaldi, Massimo, Colivicchi, Furio, and Oliva, Fabrizio
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Obesity is a chronic and relapsing disease characterized by the interaction between individual predispositions and an obesogenic environment. Recent advances in understanding the mechanisms of energetic homoeostasis paved the way to more effective therapeutic approaches compared with traditional treatments. Since obesity is a complex disease, it necessitates a multi-disciplinary approach whose implementation remains challenging. Nonetheless, emerging pharmacological interventions appear promising. Currently, therapeutic success is discreet in the short term but often fails to maintain long-term weight loss due to a high likelihood of weight regain. Cardiologists play a key role in managing patients with obesity, yet often lack familiarity with its comprehensive management. The aim of this document is to summarize knowledge to consolidate essential knowledge for clinicians to effectively treat patients living with obesity. The paper emphasizes the pivotal role of a strong patient–clinician relationship in navigating successful treatment. We analyse the criteria commonly used to diagnose obesity and point out the strengths and limitations of different criteria. Furthermore, we discuss the role of obesiologists and the contributions of cardiologists. In addition, we detail key components of effective therapeutic strategies, including educational aspects and pharmacological options.
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- 2024
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38. ANMCO/SIMEU consensus document on the use of reversal agents for antithrombotic therapies in patients with ongoing bleeding or at high risk of haemorrhagic events
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De Luca, Leonardo, Pugliese, Francesco Rocco, Susi, Beniamino, Navazio, Alessandro, Corda, Marco, Fabbri, Andrea, Scicchitano, Pietro, Voza, Antonio, Vanni, Simone, Bilato, Claudio, Geraci, Giovanna, Gabrielli, Domenico, Grimaldi, Massimo, Colivicchi, Furio, De Iaco, Fabio, and Oliva, Fabrizio
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In recent decades, an incredible evolution in antithrombotic therapies used for treating patients with atherosclerosis, atrial fibrillation, and venous thromboembolism has been observed, leading to the availability of increasingly safe drugs. Nonetheless, bleeding complications remain a significant concern, with considerable health, social, and economic implications. To improve the acute management of patients experiencing or at risk for major bleeding events, specific reversal agents for antithrombotic drugs have been recently developed. While these agents demonstrate effectiveness in small-scale pharmacodynamic studies and clinical trials, it is imperative to balance the benefits of reversing antiplatelet or anticoagulant therapy against the risk of prothrombotic effects. These risks include the potential loss of antithrombotic protection and the prothrombotic tendencies associated with bleeding, major surgery, or trauma. This joint document of the Italian Association of Hospital Cardiologists (Associazione Nazionale Medici Cardiologi Ospedalieri) and the Italian Society of Emergency Medicine (Società Italiana di Medicina d’Emergenza-Urgenza) delineates the key features and efficacy of available reversal agents. It also provides practical flowcharts to guide their use in patients with active bleeding or those at elevated risk of major bleeding events.
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- 2024
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39. Dry synthesis of bi-layer nanoporous metal films as plasmonic metamaterial
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Caligiuri, Vincenzo, Kwon, Hyunah, Griesi, Andrea, Ivanov, Yurii P., Schirato, Andrea, Alabastri, Alessandro, Cuscunà, Massimo, Balestra, Gianluca, De Luca, Antonio, Tapani, Tlek, Lin, Haifeng, Maccaferri, Nicolò, Krahne, Roman, Divitini, Giorgio, Fischer, Peer, and Garoli, Denis
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Nanoporous metals are a class of nanostructured materials finding extensive applications in multiple fields thanks to their unique properties attributed to their high surface area and interconnected nanoscale ligaments. They can be prepared following different strategies, but the deposition of an arbitrary pure porous metal is still challenging. Recently, a dry synthesis of nanoporous films based on the plasma treatment of metal thin layers deposited by physical vapour deposition has been demonstrated, as a general route to form pure nanoporous films from a large set of metals. An interesting aspect related to this approach is the possibility to apply the same methodology to deposit the porous films as a multilayer. In this way, it is possible to explore the properties of different porous metals in close contact. As demonstrated in this paper, interesting plasmonic properties emerge in a nanoporous Au–Ag bi-layer. The versatility of the method coupled with the possibility to include many different metals, provides an opportunity to tailor their optical resonances and to exploit the chemical and mechanical properties of components, which is of great interest to applications ranging from sensing, to photochemistry and photocatalysis.
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- 2024
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40. The aesthetic and affective matrix of pre-reflective sensemaking at the origins of the relationship between subject and world: A dialogue between Kant’s Third Critiqueand psychoanalysis
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Tossici, Giulia and De Luca Picione, Raffaele
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ABSTRACTThe authors discuss the relevance of aesthetic and affective experience at the heart of the human being’s capability to relate to the world and to found relations of sense. Faced with anguish that the world can be meaningless and with fear of uncertainty/chaos, trust and hope are needed for the world to be a hospitable place for existence. Such experience is aesthetic, sensitive and affective before being rational, reflective and deliberative. Through a dialogue between Kant, Winnicott and Bion, it is shown how foundation of trust is based on two essential aspects: (1) The illusionthat reality was created to allow us to live in it (namely, the fictionalityis a prerequisite for each possible development of psyche) and (2) this illusion is not generated by a solipsistic activity of the human mind; rather, it is made possible starting from the primordial relationship with the other, by containing anguish, nourishing trust and hope, and supporting psychic development and elaboration of progressive forms of symbolisation. The authors discuss how these points have a profound aesthetic implication through deepening the reflection on the ontogenetic development of the psyche, the complex intertwining between primary and secondary processes, and clinical implications.
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- 2024
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41. Exercise-Induced Transient Oxidative Stress Is Mitigated in Down Syndrome: Insights About Redox Balance and Muscle Strength
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Reis, Andrea Lucena, Deus, Lysleine Alves, Passos Neves, Rodrigo Vanerson, Corrêa, Hugo de Luca, Reis, Thaís Lucena, Aguiar, Lucas Soares de, Honorato, Fernando Sousa, Barbosa, Jessica Mycaelle da Silva, Araújo, Thaís Branquinho de, Palmeira, Thalyta Railine Cesar, Simões, Herbert Gustavo, Prestes, Jonato, Sousa, Caio Victor, Ide, Bernardo Neme, and Rosa, Thiago dos Santos
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Reis, AL, Deus, LA, Neves, RVP, Corrêa, HL Reis, TL, Aguiar, LS Honorato, FS, Barbosa, JMS, Araújo, TB, Palmeira, TRC, Simões, HG, Prestes, J, Sousa, CV, Ide, BN, and Rosa, TdS. Exercise-induced transient oxidative stress is mitigated in Down syndrome: insights about redox balance and muscle strength. J Strength Cond Res38(3): e125–e34, 2024—This study aimed to evaluate the acute effects of a session of resistance exercise (RE) performed with elastic tubes on the redox balance and inflammatory profile in individuals with Down syndrome (DS). Subjects (n= 23) were allocated into 2 groups: individuals with DS (DS; n= 11) and individuals without DS (WDS; n= 12), who performed an acute RE session. Diagnostic assessment included medical history, anthropometric measures (body height, body mass, body mass index, and body composition assessment), biological collections, muscle strength assessments (handgrip and maximal voluntary isometric contraction tests), and exercises. The redox balance and inflammatory profile were assessed in urine and saliva samples before and after an acute RE session. There were no differences between WDS and DS groups for body composition (p> 0.05). The DS group presented higher values pre and post an acute RE session with elastic tubes for oxidative and proinflammatory markers compared with WDS (p< 0.05). Uric acid values increased from pre–acute RE session to post–acute RE session for WDS (p< 0.0001). No differences were identified within groups for the delta analysis (p> 0.05). Inverse correlations were found between total force and F2-isoprostane, 8OHdG, uric acid, allantoin, IL-6, TNF-α, and the TNF-α:IL-10 ratio. A positive correlation was found between IL-10 and total force. The DS group presented increased peak force in the knee extension and elbow flexion exercises (∼25 and 12%, respectively) but decreases in handgrip strength of ∼7%. The WDS group showed higher peak force values for knee extension, elbow flexion, and handgrip (∼16, 10, and 14%, respectively). The DS group had lower transient elevation of oxidative stress after an acute RE session compared with WDS. Oxidative stress and inflammation responses of DS to an acute RE session with elastic tubes may be insufficient to induce health adaptations for the same relative load compared with WDS.
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- 2024
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42. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience
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Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria, Piredda, Maria Liliana, Riccardi, Manuela, Laurino, Licia, Roz, Elena, Longo, Domenico, Romeo, Daniela Petronilla, Fazzari, Carmine, Moreno-Manuel, Andrea, Puglia, Giuseppe Diego, Prjibelski, Andrey D., Shafranskaya, Daria, Righi, Luisella, Listì, Angela, Vitale, Domenico, Iaccarino, Antonino, Malapelle, Umberto, and Troncone, Giancarlo
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Introduction: Biomarker testing is mandatory for the clinical management of patients with advanced non-small cell lung cancer (NSCLC). Myriads of technical platforms are now available for biomarker analysis with differences in terms of multiplexing capability, analytical sensitivity, and turnaround time (TAT). We evaluated the technical performance of the diagnostic workflows of 24 representative Italian institutions performing molecular tests on a series of artificial reference specimens built to mimic routine diagnostic samples. Methods: Sample sets of eight slides from cell blocks of artificial reference specimens harboring exon 19 EGFR(epidermal growth factor receptor) p.E746_AT50del, exon 2 KRAS(Kirsten rat sarcoma viral oncogene homologue) p.G12C, ROS1(c-ros oncogene 1)-unknown gene fusion, and MET(MET proto-oncogene, receptor tyrosine kinase) Δ exon 14 skipping were distributed to each participating institution. Two independent cell block specimens were validated by the University of Naples Federico II before shipment. Methodological and molecular data from reference specimens were annotated. Results: Overall, a median DNA concentration of 3.3 ng/µL (range 0.1–10.0 ng/µL) and 13.4 ng/µL (range 2.0–45.8 ng/µL) were obtained with automated and manual technical procedures, respectively. RNA concentrations of 5.7 ng/µL (range 0.2–11.9 ng/µL) and 9.3 ng/µL (range 0.5–18.0 ng/µL) were also detected. KRASexon 2 p.G12C, EGFRexon 19 p.E736_A750del hotspot mutations, and ROS1aberrant transcripts were identified in all tested cases, whereas 15 out of 16 (93.7%) centers detected METexon 14 skipping mutation. Conclusions: Optimized technical workflows are crucial in the decision-making strategy of patients with NSCLC. Artificial reference specimens enable optimization of diagnostic workflows for predictive molecular analysis in routine clinical practice.
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- 2024
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43. Oyster Shell Protein and Atomic Force Microscopy of Oyster Shell Folia
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Sikes, C S, Wheeler, A P, Wierzbicki, A, Dillaman, R M, De Luca, L, and BioStor
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- 1998
44. Virtual Reality and Cognitive Rehabilitation in People With Stroke: An Overview
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Maggio, Maria Grazia, Latella, Desiree, Maresca, Giuseppa, Sciarrone, Francesca, Manuli, Alfredo, Naro, Antonino, De Luca, Rosaria, and Calabro, Rocco Salvatore
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Virtual reality devices -- Usage ,Cognitive therapy -- Technology application -- Patient outcomes ,Stroke -- Care and treatment ,Virtual reality device ,Technology application ,Health care industry - Abstract
Objective: This review evaluates the use of virtual reality (VR) tools in cognitive rehabilitation of stroke-affected individuals. Methods: Studies performed between 2010 and 2017 that fulfilled inclusion criteria were selected from PubMed, Scopus, Cochrane, and Web of Sciences databases. The search combined the terms 'VR,' 'rehabilitation,' and 'stroke.' Results: Stroke patients experienced significant improvement in many cognitive domains (such as executive and visual-spatial abilities and speech, attention, and memory skills) after the use of VR training. Conclusions: Rehabilitation using new VR tools could positively affect stroke patient cognitive outcomes by boosting motivation and participation. Keywords: cognitive rehabilitation, stroke, virtual reality training, Cognitive rehabilitation (CR) helps restore normal function or compensate cognitive deficits in brain-injured or cognitively impaired individuals. In current clinical practice, there are 2 basic types of CR: restorative and [...]
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- 2019
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45. Novel Carbonic Anhydrase Inhibitors with Dual-Tail Core Sulfonamide Show Potent and Lasting Effects for Glaucoma Therapy
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Angeli, Andrea, Chelli, Irene, Lucarini, Laura, Sgambellone, Silvia, Marri, Silvia, Villano, Serafina, Ferraroni, Marta, De Luca, Viviana, Capasso, Clemente, Carta, Fabrizio, and Supuran, Claudiu T.
- Abstract
Glaucoma, a leading cause of irreversible vision loss worldwide, is characterized by elevated intraocular pressure (IOP), a well-established risk factor across all its forms. We present the design and synthesis of 39 novel carbonic anhydrase inhibitors by a dual-tailed approach, strategically crafted to interact with distinct hydrophobic and hydrophilic pockets of CA active sites. The series was investigated against the CA isoforms implicated in glaucoma (hCA II, hCA IV, and hCA XII), and the X-ray crystal structures of compounds 25a, 25f, and 26awith CA II, along with 14bin complex with a hCA XII mimic, were determined. Selected compounds (14a, 25a, and 26a) underwent evaluation for their ability to reduce IOP in rabbits with ocular hypertension. Derivative 26ashowed significant potency and sustained IOP-lowering effects, surpassing the efficacy of the drugs dorzolamide and bimatoprost. This positions compound 26aas a promising candidate for the development of a novel anti-glaucoma medication.
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- 2024
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46. TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity
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Mastrolorito, Fabrizio, Togo, Maria Vittoria, Gambacorta, Nicola, Trisciuzzi, Daniela, Giannuzzi, Viviana, Bonifazi, Fedele, Liantonio, Antonella, Imbrici, Paola, De Luca, Annamaria, Altomare, Cosimo Damiano, Ciriaco, Fulvio, Amoroso, Nicola, and Nicolotti, Orazio
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Despite being extremely relevant for the protection of prenatal and neonatal health, the developmental toxicity (Dev Tox) is a highly complex endpoint whose molecular rationale is still largely unknown. The lack of availability of high-quality data as well as robust nontesting methods makes its understanding even more difficult. Thus, the application of new explainable alternative methods is of utmost importance, with Dev Tox being one of the most animal-intensive research themes of regulatory toxicology. Descending from TIRESIA (Toxicology Intelligence and Regulatory Evaluations for Scientific and Industry Applications), the present work describes TISBE (TIRESIA Improved on Structure-Based Explainability), a new public web platform implementing four fundamental advancements for in silicoanalyses: a three times larger dataset, a transparent XAI (explainable artificial intelligence) framework employing a fragment-based fingerprint coding, a novel consensus classifier based on five independent machine learning models, and a new applicability domain (AD) method based on a double top-down approach for better estimating the prediction reliability. The training set (TS) includes as many as 1008 chemicals annotated with experimental toxicity values. Based on a 5-fold cross-validation, a median value of 0.410 for the Matthews correlation coefficient was calculated; TISBE was very effective, with a median value of sensitivity and specificity equal to 0.984 and 0.274, respectively. TISBE was applied on two external pools made of 1484 bioactive compounds and 85 pediatric drugs taken from ChEMBL (Chemical European Molecular Biology Laboratory) and TEDDY (Task-Force in Europe for Drug Development in the Young) repositories, respectively. Notably, TISBE gives users the option to clearly spot the molecular fragments responsible for the toxicity or the safety of a given chemical query and is available for free at https://prometheus.farmacia.uniba.it/tisbe.
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- 2024
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47. Allele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells
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Cattaneo, C., Enzo, E., De Rosa, L., Sercia, L., Consiglio, F., Forcato, M., Bicciato, S., Paiardini, A., Basso, G., Tagliafico, E., Paganelli, A., Fiorentini, C., Magnoni, C., Latella, M.C., and De Luca, M.
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Epidermolysis bullosa simplex (EBS) is a rare skin disease inherited mostly in an autosomal dominant manner. Patients display a skin fragility that leads to blisters and erosions caused by minor mechanical trauma. EBS phenotypic and genotypic variants are caused by genetic defects in intracellular proteins whose function is to provide the attachment of basal keratinocytes to the basement membrane zone and most EBS cases display mutations in keratin 5 (KRT5) and keratin 14 (KRT14) genes. Besides palliative treatments, there is still no long-lasting effective cure to correct the mutant gene and abolish the dominant negative effect of the pathogenic protein over its wild-type counterpart. Here, we propose a molecular strategy for EBS01 patient’s keratinocytes carrying a monoallelic c.475/495del21 mutation in KRT14exon 1. Through the CRISPR-Cas9 system, we perform a specific cleavage only on the mutant allele and restore a normal cellular phenotype and a correct intermediate filament network, without affecting the epidermal stem cell, referred to as holoclones, which play a crucial role in epidermal regeneration.
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- 2024
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48. Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry
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Riccieri, Valeria, Pellegrino, Greta, Cipolletta, Edoardo, Giuggioli, Dilia, Bajocchi, Gianluigi, Bellando-Randone, Silvia, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Lepri, Gemma, Girelli, Francesco, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Di Vico, Claudio, Gigante, Antonietta, Saccon, Francesca, Grazia Lazzaroni, Maria, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Pagano Mariano, Giuseppa, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Bianchi, Gerolamo, Conti, Fabrizio, Cozzi, Franco, D’Angelo, Salvatore, Doria, Andrea, Fusaro, Enrico, Govoni, Marcello, Guiducci, Serena, Iannone, Florenzo, Salvarani, Carlo, Sebastiani, Gian Domenico, Ferri, Clodoveo, Matucci-Cerinic, Marco, and De Angelis, Rossella
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Background: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset conditions. This study aimed to evaluate the modalities of intravenous iloprost administration within a large cohort of systemic sclerosis patients from the SPRING Registry and to identify any associated clinical-demographic, instrumental or therapeutic data.Patients and Methods: Data of systemic sclerosis patients treated with intravenous iloprost for at least 1 year (case group) were retrospectively analyzed, including different timing and duration of intravenous iloprost session, and compared with those of untreated patients (control group).Results: Out of 1895 analyzed patients, 937 (49%) received intravenous iloprost treatment, while 958 (51%) were assigned to the control group. Among cases, about 70% were treated every 4 weeks, 24% with an interval of more than 4 weeks, and only 6% of less than 4 weeks. Most patients receiving the treatment every 4 weeks, or less, underwent infusion cycle for 1 day only, while if it was scheduled with an interval of more than 4 weeks, a total number of 5 consecutive days of infusions was the preferred regimen. The comparison between the two groups revealed that patients treated with intravenous iloprost had a higher frequency of DUs (p < 0.001), pitting scars (p < 0.001), diffuse cutaneous involvement (p < 0.001), interstitial lung disease (p < 0.002), as well as higher rates of anti-topoisomerase I, “late” scleroderma patternat nailfold videocapillaroscopy. These findings were confirmed by multivariate analysis.Conclusion: Our data provide a picture on the Italian use of intravenous iloprost among systemic sclerosis patients and showed that it was usually employed in patients with a more aggressive spectrum of the disease. The disparity of intravenous iloprost treatment strategies in the different centers suggests the need of a rational therapeutical approach based on the clinical characteristics of different patients’ subsets.
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- 2024
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49. Point-of-care lung ultrasound for continuous positive airway pressure discontinuation in preterm infants
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Myers, Faith, Dasani, Reedhi, Tong, Jacklin, Vallandingham-Lee, Shelby, Manipon, Christine, Dahlen, Alex, De Luca, Daniele, Singh, Yogen, Davis, Alexis S., Chock, Valerie Y., and Bhombal, Shazia
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Objective: To determine if the lung ultrasound score (LUS) is predictive of successful continuous positive airway pressure (CPAP) discontinuation in preterm neonates born <32 weeks’ gestation with history of respiratory distress syndrome. Study design: Retrospective study of preterm infants requiring CPAP. Univariate and multivariate logistic regression performed to formulate a predictive score using clinical variables with and without LUS. Area under the curve (AUC) was compared to determine the added predictive ability of LUS. Results: Forty-one patients with discontinuation attempts associated with a LUS were included. Lower LUS obtained within 0–7 days prior to CPAP discontinuation was associated with successful CPAP discontinuation (OR 0.46 [0.23, 0.91]; p= 0.025). Cross-validated AUC for clinical variables alone (Model 1) was 0.85 (95% CI: 0.74–0.93) versus 0.90 (95% CI: 0.81–0.97) when LUS was incorporated (Model 2, p< 0.001). AUC of LUS alone was 0.83 (95% CI: 0.68–0.93, p< 0.0001). Conclusions: In preterm infants requiring CPAP, LUS aids in the prediction of successful CPAP discontinuation and may significantly improve a predictive tool.
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- 2024
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50. Nutritional support via feeding jejunostomy in esophago-gastric cancers: proposal of a common working strategy based on the available evidence
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Caccialanza, Riccardo, Da Prat, Valentina, De Luca, Raffaele, Weindelmayer, Jacopo, Casirati, Amanda, and De Manzoni, Giovanni
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Malnutrition is common in patients affected by esophago-gastric cancers and has a negative impact on both clinical and economic outcomes. Yet not all patients at risk of malnutrition are routinely assessed and receive appropriate support. Further, available research does not provide a mean for standardization of timing, route, and dosage for nutritional support, and this is particularly true for enteral nutrition via feeding jejunostomy. Herein, we provide an overview of the current evidence and use the gathered knowledge as a starting point for a consensus proposal. As a result, we aim to facilitate the development of appropriate and uniformed interventions, thus fulfilling the need for a multimodal therapeutic approach in these set of cancer patients.
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- 2024
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