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PDN: Why do you think the $2 billion figure underestimates the size of the stock photo market? DH: Because it just aggregates the sales volumes of what are perceived to [...]

Utah was the third fastest growing state in the U.S. in 2005 (behind Idaho and Nevada), and the state had a job growth rate of 4.8 percent, well above the [...]

Dihydrexidine (DHX), the first high-affinity D(1) dopamine receptor full agonist, is only 10-fold selective for D(1) versus D(2) receptors, having D(2) affinity similar to the prototypical agonist quinpirole. The D(2) functional properties of DHX and its more D(2) selective analog N-n-propyl-dihydrexidine (PrDHX) were explored in rat brain and pituitary. DHX and PrDHX had binding characteristics to D(2) receptors in rat striatum typical of D(2) agonists, binding to both high- and low-affinity sites and being sensitive to guanine-nucleotides. Consistent with these binding data, both DHX and PrDHX inhibited forskolin-stimulated cAMP synthesis in striatum with a potency and intrinsic activity equivalent to that of quinpirole. Unexpectedly, however, DHX and PrDHX had little functional effect at D(2) receptors expressed on dopaminergic neurons that mediate inhibition of cell firing, dopamine release, or dopamine synthesis. Quantitative receptor competition autoradiography demonstrated that DHX bound to D(2) receptors in striatum (predominantly postsynaptic receptor sites) with equal affinity as D(2) sites in the substantia nigra (autoreceptor sites). The data from these experiments, coupled with what is known about the location of specific dopamine receptor isoforms, lead to the hypothesis that DHX, after binding to D(2L) and D(2S) receptors, causes agonist-typical functional changes only at some of these receptors. This phenomenon (herein termed "functional selectivity") suggests that drugs may be targeted not only at specific receptor isoforms but also at separate functions mediated by a single isoform, yielding novel approaches to drug discovery.

Between November 1977 and February 1978 sixty-three major American public libraries were surveyed concerning their holdings of the fifty-five leading mass consumer magazines sold on the newsstand. The 97 percent response is discussed and tabulated as is the coverage of the titles in eight popular magazine indexes. For ease of discussion the fifty-five titles surveyed are grouped into fourteen subject categories and the results of the survey summarized. It is concluded that the major public libraries in the United States adequately represent the current state of the nation's popular culture as reflected in newsstand sales of popular magazines.

During a two year study ending in February 1978, nearly 13,000 serial publications received at Colorado State University were examined to determine if they contained an ISSN printed on or in each piece. Approximately 25% of the total population of titles contained an ISSN in one or more of seven dominant locations, representing 5O countries and the United Nations. It was concluded that reliance on the ISSN printed on each serial piece as a primary data entry point into an automated serials subsystem is not recommended at this time; nevertheless, the future looks optimistic.

The Universal Product Code (UPC) symbol is appearing on mass circulation periodicals sold in supermarkets. A description of the UPC and comments about magazine sales in supermarkets are presented. The relationship between the UPC, supermarkets, and periodicals and serials sold in supermarkets is illustrated with a short survey taken in a college town during August and September 1976. As a coding system already utilizing the ISBN in the symbol marking ofpaperbacks, the relationship of the UPC to serials may also h u e an impact upon serials librarianship.

Reports on the move of move of Ohio University to remove Larry Nighswander from his position as Director of the School of Visual Communications in reaction to a sexual harassment lawsuit filed against him by a student.

Reports on the grievance filed by the Washington Baltimore Newspaper Guild with the AFP management over AFP's distribution alliance with Getty Images.

Reports on the 19th annual Infinity awards given by the International Center of Photography.