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1. The potential role of hepatitis C virus in the pathogenesis of the neurological syndrome in chronic hepatitis C.

Author

C, Caudai, D, Maimone, P, Almi, P, Annunziata, I, Bastianoni, A, Boggiano C, C, Guazzi G, M, Padula, and E, Valensin P

Abstract

A 72-year-old man developed chronic sensory neuropathy (CSN) during chronic hepatitis C (HCV) infection. Neurological symptoms began one year after acute HCV hepatitis and slowly worsened over three years. No conventional cause for CSN was found. Circulating antinervous tissue antibodies (including anti-Hu) and inflammatory infiltrates in sural nerve biopsy specimens were absent. However, the presence of anti-HCV antibody and HCV-RNA in cerebrospinal fluid indicated that HCV had reached the intrathecal compartment, suggesting the direct viral involvement in the pathogenesis of CSN.

Published
1997

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