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Purpose: To assess the performance of ADC values in stratifying high- and low-risk groups of Gleason score of prostate cancer. Materials and methods: 370 cases of prostate cancer who met the selection criteria between October 2015 and May 2019 were collected in the study. MRI sequences included high-resolution transverse T2WI and DWI (b= 0, 1000, 2000 and 3000 s/mm2). Surgical pathological results were obtained in all cases. The ADC values of prostate cancer lesions were measured by two radiologists and the consistency and reproducibility analysis were done. The ADC values were compared between high-risk group and low-risk group lesions and the receiver operating characteristic (ROC) curve was used to evaluate the value of ADC values of different bvalues in distinguishing high-risk group from low-risk group of Gleason of prostate cancer. Results: The consistency and reproducibility of ADC values measured by two radiologists in high- and low-risk group of Gleason of prostate cancer were excellent. The ADC values for high-risk group of Gleason of prostate cancer were significantly lower than those for low-risk group (p< 0.05). The area under the ROC curve (AUC) of different bvalues distinguishing high-risk group from low-risk group of Gleason of prostate cancer were 0.651, 0.656, 0.692 (reader1) and 0.658, 0.653, 0.695 (reader2), respectively. The diagnostic efficacy of bvalue (3000 s/mm2) is the highest. Conclusions: The bvalue of 3000 s/mm2is the most useful in differentiating high-risk group from low-risk group of Gleason of prostate cancer.