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Despite advances in health science and medical technology, health outcomes continue to fall behind in certain communities. A recent study linking health outcomes to zip code may explain part of this disparity, social determinants of health. Although well known that patients in resource-poor environments have worse outcomes than patients with advantages, the exact reason for this disparity may not be so well known. This article aims to explore the physiologic basis for worsening disease states in patients with poor social determinants of health, as well as start a discussion surrounding possible screening and interventions that can be performed in a primary care office to promote patient health.

A selenium analogueof amino‐D‐luciferin, aminoseleno‐D‐luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red‐shifted bioluminescence emission maximum at 600 nm (see scheme) and is suitable for bioluminescence imaging studies in living subjects.

Ein Selenanalogonvon Amino‐D‐luciferin wurde synthetisiert und als vom Enzym Glühwürmchen‐Luciferase akzeptiertes Substrat identifiziert. Aminoseleno‐D‐luciferin hat ein rotverschobenes Emissionsmaximum der Biolumineszenz bei 600 nm (siehe Bild) und ist für Biolumineszenz‐Bildgebungsstudien in lebenden Organismen geeignet.

The catalytic alkoxycarbonylation of 1,2‐diols by (neocuproine)palladium(II) acetate (neocuproine=2,9‐dimethyl‐1,10‐phenanthroline) or palladium(II) acetate/(−)‐sparteine using N‐chlorosuccinimide as the oxidant affords cyclic carbonates. The oxidative carbonylation of diols proceeds under mild conditions, requiring only 1 atm of carbon monoxide, and produces cyclic carbonates in moderate to good yields. Both 1,2‐ and 1,3‐diols can be carbonylated using (neocuproine)Pd(OAc)2and sodium dichloroisocyanuric acid, which serves as a competent oxidant and base for this system, to yield 5‐ and 6‐membered cyclic carbonates.

Inhibitors of the kinase CK2 may halt the growth of an aggressive form of medulloblastoma.