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Background: Interleukin-7 receptor (IL7R) mutation has been demonstrated to be an adverse prognostic factor in acute lymphoblastic leukemia (ALL) patients. However, the effects of the IL7Rmutation on acute myeloid leukemia (AML) have rarely been reported. Here, we investigated IL7Rmutations and their effects on AML patients.Methods: A total of 346 newly diagnosed AML patients from January 2017 to July 2020 at Nanfang Hospital were analyzed in this study. A genomic panel of 167 gene targets was detected by next-generation sequencing.Results: Among 346 patients, 33 (9.5%) AML patients carried IL7Rmutations. With a median follow-up of 50.7 months (95% confidence interval (CI) 17.3–62.2), the 5-year overall survival (OS) rates were 51.5% (95% CI 37.0%–71.0%) and 72.2% (95% CI 67.4%–77.3%; p= 0.008), the 5-year event-free survival (EFS) rates were 36.1% (95% CI 23.2%–57.1%) and 58.1% (95% CI 52.9%–63.8%; p= 0.005), the 5-year non-relapse mortality (NRM) were 21.4% (95% CI 8.5%–38.2%) and 6.2% (95% CI 3.7%–9.5%; p= 0.004) in the IL7R mutant (IL7RMUT) group and non-IL7R mutant (IL7RWT) group, respectively. There is no significant difference in the disease-free survival (75.1% vs 73.5%, p= 0.885) and cumulative incidence of relapse (25.7% vs 25.2%, p= 0.933) between IL7RMUTand IL7RWTgroup. Furthermore, patients who underwent hematopoietic stem cell transplantation (HSCT) still had more adverse outcomes in the IL7RMUTgroup than in the IL7RWTgroup (5-year OS: 61.9% vs 85.3%, p= 0.003). In the TET2(p= 0.013) and DNA methyltransferase 3A (DNMT3A; p= 0.046) mutation subgroups, the presence of IL7Rmutations was associated with worse OS than in AML patients without IL7Rmutations.Conclusion: Our study demonstrated that the IL7Rmutation is associated with an inferior prognosis for AML patients. Patients with IL7Rmutations have higher NRM, shorter OS, and EFS than patients without IL7Rmutations, even patients who have undergone HSCT. Future larger and multicentric prospective studies will be explored.

Two commonly used solid combustible materials in China, PMMA(Polymethyl Methacrylate) and Red Pine of Northeast China, are selected as typical noncharring and charring material respectively. Bench-scale experiments were carried out to measure the heat release rates of these two materials under various external radiant heat fluxes. A comparison of similarity and difference was made between the Heat Release Rate (HRR) of PMMA and that of Red Pine and the influence of external radiant fluxes on HRR was analyzed. Bubble layers and char layers formed near the heated surface of burned noncharring and charring materials, respectively, make them differ greatly in pyrolysis and combustion processes as indicated by different HRR profiles, which are closely related to the material's original structural properties and greatly influenced by external radiant heat flux.

The serious consequences of transmission lines tripping fault induced by wildfires (TLTFIW) urges scholars to pay more attention to the safe operation of transmission lines. To illustrate the evolution process of TLTFIW and quantitatively evaluate the occurrence probability of subsequent events, an algorithm used for TLTFIW is proposed by using ETA, FTA and fuzzy number theory in this paper. The evolution process of TLTFIW is simulated according to ETA, which is divided into six stage including wildfires occurring, early wildfires early-monitoring, Wildfires extinguishing, Wildfires spreading, transmission lines tripping, and re-closing failure. In addition, the reason of the subsequent events in the evolution process are analysed by FTA, and the trapezoidal fuzzy theory is employed to calculate the probability of each events. Finally, based on the evaluation results, suggestions are provided for the evolution links with greater risks. Furthermore, transmission lines located in Xiangxi is introduced to present an application of the algorithm.

In order to study the key influencing factors of emergency rescue for nuclear leakage, based on the five aspects of nuclear emergency capability, reactor characteristics, surrounding environment, weather and climate, and accident time, we constructs a Markov probability transfer model for the influencing factors of emergency rescue for nuclear leakage by combining the cross impact and Markov transfer prediction, and a gulf nuclear power plant is selected as an illustrative case. In addition, the initial probability matrix is reasonably determined by the expert scoring method, and the stable matrix which can reflect the stability probability of each factor is finally obtained after the cross impact analysis and multiple Markov state transitions. The results show that the probability of nuclear emergency capability is increased in the emergency response analysis of nuclear leakage incidents, which truly reflects the development direction and degree of cross impact. Furthermore, it provides reference opinions for the emergency response of nuclear leakage incidents in the future.

In recent years, there are more and more incidents of trans-regional transmission line tripping caused by wildfire. How to reduce the occurrence of such incidents has become a hot topic in domestic academic research. Hence, the associated risk factors of trans-regional transmission lines tripping disaster induced by wildfire is quantified based on system engineering theory of "human - machine - environment". A risk assessment index system is established by the application of analytic hierarchy process (AHP), and a certain transmission line in Hunan Province is taken as an example to conduct risk assessment analysis in this paper. The results indicate that the regional geographic location factors, the frequent meteorological disaster factors and the sacrifice festival burning situation exist relatively serious security risks. Increasing the coniferous trees planting area and enhancing the summer and the force of fall fire supervision are expected to be carried out for reducing security risks.