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1. Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins.

Author

Charalabos, Pothoulakis, Ignazio, Castagliuolo, and Thomas, LaMont J.

Abstract

Experiments in intact animals exposed to enterotoxins demonstrate that neurons and immune cells of the lamina propria regulate toxin-induced diarrhea and tissue damage. Clostridium difficile toxins cause profound diarrhea and acute inflammation by activating a complex cascade initiated by toxin binding to enterocyte receptors.

Published
1998

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