131 results on '"Chaitman, Bernard R."'
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2. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
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Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. 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Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Johnson, Debra K., Siddiqui, Rizwan A., Herrmann, Rebekah R., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Goldberg, Jonathan L., Ann Byrne, Kimberly, Zappernick, Taissa, Goldweit, Richard, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Cohen, Ronny A., Espinosa, Dalisa, Mirrer, Brooks, Quiles, Kirsten J., Navarro, Victor, Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Winchester, David E., Stinson, Susan, Kronenberg, Marvin, Weyand, Terry, Rogal, Philip, Crook, Sherron C., McFarren, Christopher, Heitner, John F., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Dauber, Ira M., Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Siegel, Kathy E., Derbyshire, Susan, Cannan, Charles, Dixon, Michelle, Leonard, Gerald, Sudarshan, Sriram, Heard, Ciarra, Gabriel, Viviana, Desire, Sukie, Mehta, 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Arunima, Huda, Zohra, Wall Jr., Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Wohns, David, Mulder, Abbey, Van Oosterhout, Stacie, Lader, Ellis W., Meyer, Martha, Mumma, Michael, Clapp, Nancy L., Barrentine, Heather, Dharmarajan, Lekshmi, Jose, Jenne M., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Manchery, Jenne, McGarvey Jr, Joseph F.X., McKinney, Vera, Schwarz, Linda, Downes, Thomas R., Kaczkowski, Scott M., Luckasen, Gary J., Jaskowiak, Adam J., Klitch, Joel, Cheong, Benjamin, Dees, Debra, Potluri, Srinivasa, Vasquez, Precilia, Mastouri, Ronald A., Breall, Jeffery A., Hannemann, Elise L., Revtyak, George E., Mae Foltz, Judy, Bazeley, Jonathan W., Li, Dayuan, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Giedd, Kenneth, Old, Wayne, Bariciano, Rebecca, Burt, Francis, Sokhon, Kozhaya, Waldron, Jessica, Mayon, Michelle, Gopal, Deepika, Valeti, Uma S., Ann Peichel, Gretchen, Kobashigawa, Jon, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Bhargava, Balram, Anand, Anjali, Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, Santhosh, Vindhya, R. J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Mathur, Atul, Verma, Atul, Kaul, Upendra, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Christopher, Johann, Manjula Rani, K., Menon, Rajeev, Sowjanya Reddy, M., Kumar, Nirmal, Preethi, K., Oomman, Abraham, sidh, Rinu R, Mao, Robert, Ramakrishnan, T., Solomon, Hilda, Francis, Rajesh, Naik, Sudhir, Vamshi, Priya P., Parveen Khan, Sajeeda, Christopher, Johann, Preethi, Kotiboinna, Kumar, Nirmal, Grant, Purvez, Hande, Shweta, Sonawane, Poonam, Kachru, Ranjan, Dubey, Abhishek, Rawat, Kavita, Kumar, Ajit, Ganapathi, Sanjay, K, Jayakumar, CP, Vineeth, Sivadasanpillai, Harikrishnan, Chacko, Manas, Sasidharan, Bijulal, Babu, Suresh, TR, Kapilamoorthy, Christopher, Johann, Reddy, Sowjanya, Polamuri, Praneeth, Rani, Manjula, Kaul, Upendra, Arambam, Priyadarshani, Singh, Bebek, Senior, Roxy, Fox, Keith AA, Young, Grace M., Carruthers, Kathryn, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Young, Grace M., Shah, Benoy N, Kinsey, Christopher, Trimlett, Richard HJ, Kavalakkat, Raisa, Rubens, Michael B, Evans, Jo, Nicol, Edward D, Hassan, Ikraam, Mittal, Tarun K, Hampson, Reinette, Andreas Gamma, Reto, Williams, Sarah, Holland, Kim, Swan, Karen, de Belder, Mark A, Atkinson, Bev, Thambyrajah, Jeet, Kunhunny, Swapna, Davies, John R, Lindsay, Steven J., Atkinson, Craig, Kurian, John, Krannila, Carita, Jamil, Haqeel, Vinod, Manitha, Raheem, Osama, Hoye, Angela, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Donnelly, Patrick, Kelly, Stephanie, Valecka, Bernardas, Regan, Susan, Turnbull, Dawn, Chauhan, Anoop, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Barr, Craig, Cartwright, Anne, Alfakih, Khaled, Knighton, Abigail, Byrne, Jonathan, Martin, Katherine, Webb, Ian, Henriksen, Peter, Flint, Laura, Harrison, James, OKane, Peter, Lakeman, Nicki, Ljubez, Anja, de Silva, Ramesh, Conway, Dwayne S. G., Wright, Judith, Exley, Donna, Sirker, Alexander A, Andiapen, Mervyn, Richards, Amy J., Hoole, Stephen P, Wong, Lisa, Witherow, Fraser N., Munro, Melanie J., Johnston, Nicola, Harbinson, Mark, McEvoy, Michelle, Walsh, Simon, Brown, Caroline, Douglas, Hanna, Luckie, Matthew, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Sobolewska, Jolanta, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Jeetley, Paramjit, Smit, Angelique, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Gent, Susan, Karimullah, Iqbal, Hussain, Nafisa, Al-Bustami, Mahmud, Braganza, Denise, Haines, Fiona, Taaffe, Joanne, Henderson, Robert, Burton, Jane, Pointon, Kate, Colton, Maria, Naik, Surendra, King, Rachel, Mathew, Thomas, Brown, Ammani, Docherty, Andrew, Berry, Colin, McCloy, Lisa, Collison, Damien, Robb, Kate, Roditi, Giles, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Moriarty, Andrew J, Mackin, Anne, Glover, Jason D., Knight, Janet P, Pradhan, Jiwan, Mikhail, Ghada, Bose, Tuhina, Francis, Darrel P., Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Gosselin, Gilbert, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Alarie, Patricia, Pépin-Dubois, Yanek, Arcand, Linda, Costa, Ricardo, Roy, Isabelle, Tung Sia, Ying, Montpetit, Estelle, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Drouin, Katia, Carl Phaneuf, Denis, Bergeron, Christine, Gosselin, Gilbert, Shelley, Christine, Masson, Christine, Garg, Pallav, Carr, Sandy, Bone, Catherine, Chow, Benjamin J.W., Moga, Ermina, Hessian, Renee C., Kourzenkova, Janetta, Beanlands, Rob S., Walter, Olga, Davies, Richard F., Bainey, Kevin R., Hogg, Norma, Welsh, Suzanne, Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Kushniriuk, Khrystyna, Joseph Graham, John, Hussain, Mohammed, Peterson, Mark, Bello, Olugbenga, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Syed, Ishba, Hussain, Mohammed, Kushniriuk, Khrystyna, Cha, James, Otis, Judy, Otis, Rebecca, Howarth, Andrew G, Seib, Michelle M, Rivest, Sandra M, Sandonato, Rosa, Wong, Graham, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Uxa, Amar, Asif, Nadia, Tavares, Suzana, Galiwango, Paul, Bozek, Bev, Kassam, Saleem, Shier, Maria, Mukherjee, Ashok, Larmand, Lori-Ann, Ricci, A. Joseph, Janmohamed, Amir, Hart, Brenda, Lam, Andy, Marucci, Jane, Tai, Sharon, Mehta, Shamir, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Udell, Jacob, Aprile, Maria, Karlsson, Sara, Webber, Susan, Généreux, Philippe, Mercure, Chantale, Hameed, Adnan, Aedy, Nancy, Daba, Ledjalem, Farquharson, Fran, Siddiqui, Anam, Carlos Carvalho, Antonio, Lopes, Renato D., Hueb, Whady, Emy Takiuti, Myrthes, Cury Rezende, Paulo, Eustáquio Ribeiro Silva, Expedito, Ciappina Hueb, Alexandre, Pizzol Caetano, Leonardo, Schaan de Quadros, Alexandre, Abdala Karam Kalil, Renato, Peixoto Deiro, Aline, Luiz da Costa Vieira, José, Manica Muller, Alice, Antonieta Pereira de Moraes, Maria, Píccaro de Oliveira, Pedro, Maria Ascoli, Bruna, Bridi, Leonardo, Zottis Poletti, Sílvia, Savaris, Simone, Vitola, João V, Cerci, Rodrigo J, Zier, Sandra S., Farias, Fabio R, Veiga Jr, Vilmar, Fernandes, Miguel M, Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Franca da Cunha, Diego, Mendes Oliveira, Ricardo, Reynaldo Abbud Chierice, João, Polanczyk, Carísi A., Rucatti, Guilherme G, Furtado, Mariana V., Igansi, Fernanda, Smidt, Luis F., Haeffner, Mauren P, Carlos Carvalho, Antonio, Almeida, Viviane, Pucci, Gustavo, Sanchez de Souza, Gabriela, Lyra, Flavio, Rabelo Alves Junior, Alvaro, Almeida, Mayana, dos Santos, Viviane, Dracoulakis, Marianna D. A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira Jr., Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, 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3. Survival After Invasive or Conservative Management of Stable Coronary Disease
- Author
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Hochman, Judith S., Anthopolos, Rebecca, Reynolds, Harmony R., Bangalore, Sripal, Xu, Yifan, O’Brien, Sean M., Mavromichalis, Stavroula, Chang, Michelle, Contreras, Aira, Rosenberg, Yves, Kirby, Ruth, Bhargava, Balram, Senior, Roxy, Banfield, Ann, Goodman, Shaun G., Lopes, Renato D., Pracoń, Radosław, López-Sendón, José, Maggioni, Aldo Pietro, Newman, Jonathan D., Berger, Jeffrey S., Sidhu, Mandeep S., White, Harvey D., Troxel, Andrea B., Harrington, Robert A., Boden, William E., Stone, Gregg W., Mark, Daniel B., Spertus, John A., Maron, David J., Hochman, Judith S., Maron, David J., Reynolds, Harmony R., Bangalore, Sripal, Mavromichalis, Stavroula, Chang, Michelle, Contreras, Aira, Esquenazi-Karonika, Shari, Gilsenan, Margaret, Gwiszcz, Ewelina, Mathews, Patenne, Mohamed, Samaa, Naumova, Anna, Roberts, Arline, VanLoo, Kerrie, Anthopolos, Rebecca, Xu, Yifan, Troxel, Andrea B., Lu, Ying, Huang, Zhen, Broderick, Samuel, Guzmán, Luis, Selvanayagam, Joseph, Lopes, Renato D., Goodman, Shaun G., Steg, Gabriel, Juliard, Jean-Michel, Doerr, Rolf, Keltai, Matyas, Bhargava, Balram, Thomas, Boban, Sharir, Tali, Nikolsky, Eugenia, Maggioni, Aldo P., Kohsaka, Shun, Escobedo, Jorge, White, Harvey D., Pracoń, Radosław, Bockeria, Olga, López-Sendón, José, Held, Claes, Senior, Roxy, Banfield, Ann, Shaw, Leslee J., Phillips, Lawrence, Berman, Daniel, Kwong, Raymond Y., Picard, Michael H., Chaitman, Bernard R., Ali, Ziad, Min, James, Mancini, G.B. John, Leipsic, Jonathon, Guzmán, Luis, Hillis, Graham, Thambar, Suku, Joseph, Majo, Selvanayagam, Joseph, Beltrame, John, Lang, Irene, Schuchlenz, Herwig, Huber, Kurt, Goetschalckx, Kaatje, Hueb, Whady, Caramori, Paulo Ricardo, de Quadros, Alexandre, Smanio, Paola, Mesquita, Claudio, Lopes, Renato D., Vitola, João, Marin-Neto, José, da Silva, Expedito Ribeiro, Tumelero, Rogério, Andrade, Marianna, Alves, Alvaro Rabelo, Dall’Orto, Frederico, Polanczyk, Carisi, Figueiredo, Estevão, Howarth, Andrew, Gosselin, Gilbert, Cheema, Asim, Bainey, Kevin, Phaneuf, Denis, Diaz, Ariel, Garg, Pallav, Mehta, Shamir, Wong, Graham, Lam, Andy, Cha, James, Galiwango, Paul, Uxa, Amar, Chow, Benjamin (Ben), Hameed, Adnan, Udell, Jacob, Cheema, Asim, Hamid, Magdy, Hauguel-Moreau, Marie, Furber, Alain, Goube, Pascal, Steg, Philippe-Gabriel, Barone-Rochette, Gilles, Thuaire, Christophe, Slama, Michel, Doerr, Rolf, Nickenig, Georg, Bekeredjian, Raffi, Schulze, P. Christian, Merkely, Bela, Fontos, Geza, Vértes, András, Varga, Albert, Bhargava, Balram, Kumar, Ajit, Nair, Rajesh G., Grant, Purvez, Manjunath, Cholenahally, Moorthy, Nagaraja, Satheesh, Santhosh, Nath, Ranjit Kumar, Wander, Gurpreet, Christopher, Johann, Dwivedi, Sudhanshu, Oomman, Abraham, Mathur, Atul, Gadkari, Milind, Naik, Sudhir, Punnoose, Eapen, Kachru, Ranjan, Christopher, Johann, Kaul, Upendra, Sharir, Tali, Kerner, Arthur, Tarantini, Giuseppe, Perna, Gian Piero, Racca, Emanuela, Mortara, Andrea, Monti, Lorenzo, Briguori, Carlo, Leone, Gianpiero, Amati, Roberto, Salvatori, Mauro, Di Chiara, Antonio, Calabro, Paolo, Galvani, Marcello, Provasoli, Stefano, Fukuda, Keiichi, Kohsaka, Shun, Nakano, Shintaro, Laucevicius, Aleksandras, Kedev, Sasko, Khairuddin, Ahmad, Escobedo, Jorge, Riezebos, Robert, Timmer, Jorik, Heald, Spencer, Stewart, Ralph, Ramos, Walter Mogrovejo, Demkow, Marcin, Mazurek, Tomasz, Drozdz, Jarozlaw, Szwed, Hanna, Witkowski, Adam, Ferreira, Nuno, Pinto, Fausto, Ramos, Ruben, Popescu, Bogdan, Pop, Calin, Bockeria, Leo, Bockeria, Olga, Demchenko, Elena, Romanov, Alexander, Bershtein, Leonid, Jizeeri, Ahmed, Stankovic, Goran, Apostolovic, Svetlana, Adjic, Nada Cemerlic, Zdravkovic, Marija, Beleslin, Branko, Dekleva, Milica, Davidovic, Goran, Chua, Terrance, Foo, David, Poh, Kian Keong, Ntsekhe, Mpiko, Sionis, Alessandro, Marin, Francisco, Miró, Vicente, López-Sendón, José, Blancas, Montserrat Gracida, González-Juanatey, José, Fernández-Avilés, Francisco, Peteiro, Jesús, Luena, Jose Enrique Castillo, Held, Claes, Aspberg, Johannes, Rossi, Mariagrazia, Kuanprasert, Srun, Yamwong, Sukit, Johnston, Nicola, Donnelly, Patrick, Moriarty, Andrew, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Shah, Benoy N., Trimlett, Richard H.J., Rubens, Michael B., Nicol, Edward D., Mittal, Tarun K., Hampson, Reinette, Gamma, Reto, De Belder, Mark, Nageh, Thuraia, Lindsay, Steven, Mavromatis, Kreton, Miller, Todd, Banerjee, Subhash, Reynolds, Harmony, Nour, Khaled, and Stone, Peter
- Published
- 2023
- Full Text
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4. Electrocardiography Screening for Cardiotoxicity after Modified Vaccinia Ankara Vaccination
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Sano, Junko, Chaitman, Bernard R., Swindle, Jason, and Frey, Sharon E.
- Subjects
Electrocardiogram -- Health aspects ,Electrocardiography -- Health aspects ,Pericarditis -- Risk factors ,Pericarditis -- Diagnosis ,Smallpox vaccine -- Complications and side effects ,Health ,Health care industry - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2008.07.025 Byline: Junko Sano (a), Bernard R. Chaitman (a), Jason Swindle (b), Sharon E. Frey (c) Keywords: Early repolarization; Electrocardiography; Modified Vaccinia Ankara; Myopericarditis; Smallpox vaccine Abstract: Symptomatic myopericarditis has been described after smallpox vaccination using replication-competent vaccinia strains. Author Affiliation: (a) The Saint Louis University School of Medicine, Department of Medicine, Division of Cardiology, St Louis, Mo (b) The Saint Louis University School of Medicine, Department of Medicine, Saint Louis University Center for Outcomes Research, St Louis, Mo (c) The Saint Louis University School of Medicine, Department of Medicine, Division of Infectious Disease, St Louis, Mo Article Note: (footnote) Funding: Supported by National Institutes of Health N01-AI-25464, Bethesda, Maryland.
- Published
- 2009
5. Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials
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Chaitman, Bernard R.
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Angina pectoris -- Research ,Angina pectoris -- Drug therapy ,Health - Published
- 2004
6. Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial
- Author
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Nakamura, Kenta, Henry, Timothy D., Traverse, Jay H., Latter, David A., Mokadam, Nahush A., Answini, Geoffrey A., Williams, Adam R., Sun, Benjamin C., Burke, Christopher R., Bakaeen, Faisal G., DiCarli, Marcelo F., Chaitman, Bernard R., Peterson, Mark W., Byrnes, Dawn G., Ohman, E. Magnus, Pepine, Carl J., Crystal, Ronald G., Rosengart, Todd K., Kowalewski, Elaine, Koch, Gary G., Dittrich, Howard C., and Povsic, Thomas J.
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- 2024
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7. Myocardial infarct size and sex-related angiographic differences in myocardial infarction in nonobstructive coronary artery disease
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Alkhawam, Hassan, Chaitman, Bernard R., Salloum, Mohammad N., Abo-Salem, Elsayed, Ghrair, Fadi, Saker, Erfanul, Shahid, Sara, Lieber, Joseph, and Helmy, Tarek
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- 2021
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8. Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity
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Reynolds, Harmony R., Shaw, Leslee J., Min, James K., Page, Courtney B., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Kwong, Raymond Y., O’Brien, Sean M., Huang, Zhen, Mark, Daniel B., Nath, Ranjit K., Dwivedi, Sudhanshu K., Smanio, Paola E.P., Stone, Peter H., Held, Claes, Keltai, Matyas, Bangalore, Sripal, Newman, Jonathan D., Spertus, John A., Stone, Gregg W., Maron, David J., and Hochman, Judith S.
- Abstract
Supplemental Digital Content is available in the text.
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- 2021
- Full Text
- View/download PDF
9. Preoperative clinical assessment and dipyridamole thallium-201 scintigraphy for prediction and prevention of cardiac events in patients having major noncardiovascular surgery and known or suspected coronary artery disease
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Younis, Liwa, Stratmann, Henry, Takase, Bonpei, Byers, Sheila, Chaitman, Bernard R., and Miller, D. Douglas
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Coronary heart disease -- Drug therapy ,Dipyridamole -- Evaluation ,Radioisotope scanning ,Preoperative care -- Methods ,Health - Abstract
The aim of this study was to assess the relative prognostic use of clinical risk stratification and intravenous dipyridamole thallium-201 scintigraphy in patients with an intermediate to high prevalence of coronary artery disease (CAD) who have undergone major noncardiovascular surgery, and to assess the effects of medical therapy or coronary revascularization based on the result of this clinical scintigraphic screening on perioperative cardiac morbidity and mortality. Patients (n = 161) with an intermediate to high likelihood of CAD had clinical assessment and intravenous dipyridamole planar thallium-201 testing which was analyzed semiquantitatively. Cardiac events were cardiac death (n = 9), nonfatal myocardial infarction (n = 6), acute pulmonary edema (n = 6), and unstable angina (n = 4). Multiple [greater than or equal to] 2) clinical risk variables predicted any cardiac event (p = 0.04). Presence of multiple ([greater than or equal to] 2) abnormal thallium-201 segments was the only independent predictor of cardiac death or nonfatal myocardial infarction (p
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- 1994
10. Gender differences in the noninvasive evaluation and management of patients with suspected coronary artery disease
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Shaw, Leslee J., Miller, D. Douglas, Romeis, James C., Kargl, Deborah, Younis, Liwa T., and Chaitman, Bernard R.
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Discrimination in medical care -- Demographic aspects ,Middle aged women -- Care and treatment ,Coronary heart disease -- Care and treatment ,Diagnosis, Noninvasive -- Usage ,Health - Abstract
* Objective:To determine if gender-based differences exist in the post-test management and clinical outcome of patients with clinically suspected coronary artery disease who have stress electrocardiographic or myocardial perfusion imaging evaluation. * Design: Retrospective cohort study. * Setting: University medical center. * Patients: From a cohort of 3975 middle-aged patients referred for outpatient stress testing, 840 (47% women) were evaluated noninvasively for clinically suspected coronary artery disease. * Measurements: The rates of subsequent diagnostic procedures and the incidence of subsequent coronary revascularization, myocardial infarction, or cardiac death were determined for women and men. * Results: Pretest cardiac risk profiles were similar, except hypertension and hypercholesterolemia were more frequent in women. Atypical angina was more common in women than in men (57.5% compared with 44.5%, respectively; P < 0.001). Rates of initial test positivity (defined as exercise-induced horizontal or downsloping ST-segment depression [greater than or equal to]1.0 mm or [greater than or equal to]1 reversible thallium-201 defect) were similar in women and men. Compared with men, most women with an initial positive test result had no additional coronary artery disease evaluation (62.3% compared with 38.0%; P= 0.002). Coronary revascularization procedures were done more frequently in men (4.9% [22 of 449] compared with 2.0% [8 of 391 ]; P = 0.03). Cardiac death or myocardial infarction occurred more often in women during 2 years of follow-up (6.9% [27 of 391] compared with 2.4% [11 of 449]; P = 0.002). * Conclusions: Women with suspected coronary artery disease have fewer additional diagnostic tests than men after an initial abnormal noninvasive stress test result, even though the incidence of typical angina, cardiac risk factors, and initial diagnostic test positivity rates are similar., Women are less likely to receive additional diagnostic tests after an initial abnormal stress test for coronary heart disease than men who have similar symptoms. A group of 847 men and women underwent noninvasive stress testing for coronary artery disease. Participants were followed for an average of two years. Hypertension and hypercholesterolemia occurred more commonly in women. Women were also more likely to have had symptoms longer than men. Tests results were similar between the two groups. While 62.3% of the men were referred for additional diagnostic testing only 38% of the women were referred. Men were also more likely to be started on some form of drug therapy than women. Revascularization procedures were carried out on 4.9% of the men and 2.0% of the women. In the two years following the initial noninvasive tests, 6.9% of the women experienced cardiac death or non-fatal heart attacks, compared to 2.5% of the men.
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- 1994
11. Comparison of the Asymptomatic Cardiac Ischemia Pilot and modified Asymptomatic Cardiac Ischemia Pilot versus Bruce and Cornell exercise protocols
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Tamesis, Beaver, Stelken, Art, Byers, Sheila, Shaw, Leslee, Younis, Liwa, Miller, D. Douglas, and Chaitman, Bernard R.
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Treadmill exercise tests -- Evaluation ,Coronary heart disease -- Diagnosis ,Health - Abstract
The Asymptomatic Cardiac Ischemia Pilot (ACIP) and modified ACIP treadmill exercise protocols were developed to test patients with coronary artery disease and to linearly increase work load between stages. The physiologic changes that occurred with ACIP and modified ACIP were compared to those with the Bruce and Cornell protocols in 28 normal subjects and 16 men with coronary artery disease. The exercise protocols were randomly assigned over 2 days, and gas exchange data were obtained continuously with each test. In normal subjects, the peak heart rate, systolic blood pressure, peak oxygen consumption rate ([VO.sub.2]) and minute ventilation were similar for the 4 protocols tested, with exercise time shortest for the Bruce protocol in comparison with the ACIP, modified ACIP and Cornell protocols (10.2 [+ or -] 3.1 vs 13.4 [+ or -] 4.9, 13.9 [+ or -] 4.5, and 15.0 [+ or -] 4.2 minutes, respectively; p
- Published
- 1993
12. Impact of treatment strategy on predischarge exercise test in the Thrombolysis in Myocardial Infarction (TIMI) II trial
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Chaitman, Bernard R., McMahon, Robert P., Terrin, Michael, Younis, Liwa T., Shaw, Leslee J., Weiner, Donald A., Frederick, Margaret M., Knatterud, Genell L., Sopko, George, and Braunwald, Eugene
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Coronary heart disease -- Prognosis ,Heart attack -- Care and treatment ,Thrombolytic therapy -- Evaluation ,Exercise tests -- Usage ,Health - Published
- 1993
13. Comparison of accuracy for detecting coronary artery disease and side-effect profile of dipyridamole thallium-201 myocardial perfusion imaging in women versus men
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Kong, Barbara A., Shaw, Leslee, Miller, Douglas, and Chaitman, Bernard R.
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Dipyridamole -- Evaluation ,Thallium -- Evaluation ,Perfusion (Physiology) -- Abnormalities ,Coronary heart disease -- Diagnosis ,Health - Published
- 1992
14. Prognostic value of exercise thallium scintigraphy in patients with good exercise tolerance and normal or abnormal exercise electrocardiogram and suspected or confirmed coronary artery disease
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Fagan, Leonard F., Jr., Shaw, Leslee, Kong, Barbara A., Caralis, Dennis G., Wines, Robert D., and Chaitman, Bernard R.
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Radioisotope scanning ,Electrocardiography -- Usage ,Coronary heart disease -- Diagnosis ,Health - Abstract
Exercise thallium scintigraphy is widely used to assess prognosis in patients with suspected or proven coronary artery disease. The incremental prognostic value of technique in patients who have good exercise tolerance has not been well studied. Two hundred ninety-nine patients with known or suspected coronary artery disease without prior myocardial infarction or revascularization procedure referred for exercise myocardial perfusion imaging and able to exercise to [is greater than or equal to] stage III of the Bruce protocol were included. After a mean follow-up of 50 [+ or -] 1- months , there were 15 cardiac events (5%). The incidence of cardiac events was 10 versus (p
- Published
- 1992
15. Prognostic significance of exercise thallium-201 testing in patients aged greater than or equal to 70 years with known or suspected coronary artery disease
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Hilton, Thomas C., Shaw, Leslee J., Chaitman, Bernard R., Stocke, Karen S., Goodgold, Henry M., and Miller, D. Douglas
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Thallium ,Coronary heart disease -- Prognosis ,Isolation perfusion (Physiology) -- Usage ,Exercise tests -- Evaluation ,Aged -- Care and treatment ,Health - Abstract
The prognostic value of exercise thallium-201 myocardial perfusion imaging has not been studied in an elderly (aged [is greater than or equal to]70 years) population. Retrospective analysis of 120 consecutive elderly patients undergoing Bruce protocol exercise stress with quantitative planar thallium-201 scintigraphy, followed clinically for a mean of 36 [+ or -] 12 months after testing, revealed a 10% cardiac event rate (6 cardiac deaths from arrhythmia or congestive heart failure, and 5 fatal and 1 nonfatal myocardial infarction). There were no exercise stress-related complications. Survival without cardiac events was associated with greater exercise duration (5.6 [+ or -] 2.4 vs 3.1 [+ or -] 2.4 minutes; p 15%, respectively.
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- 1992
16. Importance of myocardial infarct artery patency on the prevalence of ventricular arrhythmia and late potentials after thrombolysis in acute myocardial infarction
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Aguirre, Frank V., Kern, Morton J., Hsia, Judith, Serota, Harvey, Janosik, Denise, Greenwalt, Terry, Ross, Allan M., and Chaitman, Bernard R.
- Subjects
Electrocardiography -- Usage ,Thrombolytic therapy -- Physiological aspects ,Arrhythmia -- Physiological aspects ,Heart attack -- Drug therapy ,Coronary arteries ,Thrombolytic drugs -- Physiological aspects ,Coronary heart disease -- Physiological aspects ,Heart attack -- Complications ,Health - Abstract
Sustained infarct artery patency is an important determinant of survival in patients with acute myocardial infarction. We studied 61 patients with acute myocardial infarction who received intravenous recombinant tissue-type plasminogen activator, aspirin or heparin within 6 hours of symptom onset, to determine if infarct artery patency after intravenous thrombolytic therapy influences myocardial electrical stability as measured by the prevalence of spontaneous ventricular ectopy or late potential activity. Infarct artery patency was determined by angiographic evaluation 2.5 [+ or -] 3 days after infarction. Forty-eight patients (79%) had a patent infarct-related artery and 13 (21%) patients had an occluded vessel. The mean number of ventricular premature complexes (VPCs)/hour (p 0.03) after symptom onset. Thus, successful thrombolysis decreases the frequency of ventricular ectopic activity and late potentials in the early postinfarction phase. The reduction in both markers of electrical instability may help explain why the prognosis after successful thrombolysis is improved after acute myocardial infarction., Most heart attacks result from the occlusion of a major blood vessel to the heart by a blood clot, resulting in the infarction of the heart muscle. An important determinant of survival after a heart attack is whether a path for blood flow can be cleared by the body's clot-dissolving enzymes, sometimes with the help of medical treatment. The abnormalities in blood supply to the heart muscle result in a variety of electrophysiological abnormalities during the contraction of the heart; these abnormalities may be recorded using the electrocardiograph. A study was undertaken to correlate the observed electrophysiological abnormalities in heart attack victims with whether the coronary artery involved in the attack was patent (cleared). Electrocardiograms were recorded from 61 patients recovering from heart attacks; these patients had been treated with recombinant plasminogen activator, an enzyme that contributes to the clot-dissolving process. The electrocardiograms were signal-averaged, which means that the electrical recordings from individual heartbeats were averaged together to reveal features not necessarily apparent in any single heartbeat. On examination an average of 2.5 days after heart attack, the infarct artery was patent in 48 patients, but remained occluded in 13. Two electrophysiological abnormalities, ventricular premature complexes and ventricular late potentials, were significantly more common among the 13 patients with occluded arteries than among the remaining patients. Of the 61 patients, 18 were treated with plasminogen activator (thrombolytic therapy) within two hours of the onset of heart attack symptoms. While earlier treatment appeared to improve the likelihood of successful reopening of the artery, it had no direct influence on the likelihood of the electrophysiological abnormalities. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1991
17. Significance of silent myocardial ischemia during exercise testing in patients with diabetes mellitus: a report from the Coronary Artery Surgery Study (CASS) registry
- Author
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Weiner, Donald A., Ryan, Thomas J., Parsons, Lori, Fisher, Lloyd D., Chaitman, Bernard R., Sheffield, L. Thomas, and Tristani, Felix E.
- Subjects
Coronary heart disease -- Complications ,Silent myocardial ischemia -- Prognosis ,Exercise -- Physiological aspects ,Diabetes -- Complications ,Silent myocardial ischemia -- Physiological aspects ,Health - Abstract
To evaluate the significance of ischemic ST depression without anginal chest pain during exercise testing among patients with diabetes mellitus, the data on 45 such patients from the Coronary Artery Surgery Study registry were analyzed. These patients (group 1, silent ischemia) were compared with 37 diabetic patients with both ischemic ST depression and chest pain (group 2, symptomatic ischemia), with 31 diabetic patients without ischemic ST depression or chest pain (group 3, no ischemia), and with 429 patients without diabetes who had silent ischemia during exercise testing. All patients had documented coronary artery disease (CAD) (>70% diameter narrowing). The 6-year survival among patients with silent ischemica was worse in diabetic than nondiabetic patients (59 vs 82%, respectively, p, Acute myocardial infarction, or heart attack, is often preceded or accompanied by intense pain (angina pectoris) caused by decreased blood supply to the heart (myocardial ischemia). It is widely held that in patients with diabetes mellitus (a metabolic disease characterized by an inability to regulate blood glucose levels), acute myocardial infarction (AMI) is often unaccompanied by angina pectoris, perhaps because of the nerve-related damage known to occur in diabetics. Sensory nerves that transmit pain sensations from the heart may be impaired in this patient population. It has also been reported that diabetic patients suffering from coronary artery disease (chronic blockage of the arteries supplying blood to the heart) have a higher incidence of silent ischemia (ischemia not accompanied by angina) than nondiabetics, perhaps for the same reason. To evaluate the significance of silent ischemia in diabetics during exercise testing, data from 45 patients with diabetes and silent ischemia were analyzed and compared with similar data from 37 diabetic patients suffering ischemia that was accompanied by angina and 31 diabetic patients with neither ischemia nor angina. Diabetic patients were compared with a control group consisting of 429 nondiabetic patients suffering from silent ischemia. All patients had greater than 70 percent narrowing of the coronary arteries (coronary artery disease). Diabetic patients with silent ischemia were significantly more likely to die within a six-year period than nondiabetics with the same condition (six-year survival rates were 59 percent and 82 percent, respectively). In contrast, six-year survival was quite similar in diabetic and nondiabetic patients who did not have silent ischemia. Coronary artery bypass grafting performed on diabetic patients with silent ischemia was associated with a significant improvement in survival in this group of patients. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1991
18. Association of Sex With Severity of Coronary Artery Disease, Ischemia, and Symptom Burden in Patients With Moderate or Severe Ischemia: Secondary Analysis of the ISCHEMIA Randomized Clinical Trial
- Author
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Reynolds, Harmony R., Shaw, Leslee J., Min, James K., Spertus, John A., Chaitman, Bernard R., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Bairey-Merz, C. Noel, Cyr, Derek D., Lopes, Renato D., Lopez-Sendon, Jose Luis, Held, Claes, Szwed, Hanna, Senior, Roxy, Gosselin, Gilbert, Nair, Rajesh Gopalan, Elghamaz, Ahmed, Bockeria, Olga, Chen, Jiyan, Chernyavskiy, Alexander M., Bhargava, Balram, Newman, Jonathan D., Hinic, Sasa B., Jaroch, Joanna, Hoye, Angela, Berger, Jeffrey, Boden, William E., O’Brien, Sean M., Maron, David J., and Hochman, Judith S.
- Abstract
IMPORTANCE: While many features of stable ischemic heart disease vary by sex, differences in ischemia, coronary anatomy, and symptoms by sex have not been investigated among patients with moderate or severe ischemia. The enrolled ISCHEMIA trial cohort that underwent coronary computed tomographic angiography (CCTA) was required to have obstructive coronary artery disease (CAD) for randomization. OBJECTIVE: To describe sex differences in stress testing, CCTA findings, and symptoms in ISCHEMIA trial participants. DESIGN, SETTING, AND PARTICIPANTS: This secondary analysis of the multicenter ISCHEMIA randomized clinical trial analyzed baseline characteristics of patients with stable ischemic heart disease. Individuals were enrolled from July 2012 to January 2018 based on local reading of moderate or severe ischemia on a stress test, after which blinded CCTA was performed in most. Core laboratories reviewed stress tests and CCTAs. Participants with no obstructive CAD or with left main CAD of 50% or greater were excluded. Those who met eligibility criteria including CCTA (if performed) were randomized to a routine invasive or a conservative management strategy (N = 5179). Angina was assessed using the Seattle Angina Questionnaire. Analysis began October 1, 2018. INTERVENTIONS: CCTA and angina assessment. MAIN OUTCOMES AND MEASURES: Sex differences in stress test, CCTA findings, and symptom severity. RESULTS: Of 8518 patients enrolled, 6256 (77%) were men. Women were more likely to have no obstructive CAD (<50% stenosis in all vessels on CCTA) (352 of 1022 [34.4%] vs 378 of 3353 [11.3%]). Of individuals who were randomized, women had more angina at baseline than men (median [interquartile range] Seattle Angina Questionnaire Angina Frequency score: 80 [70-100] vs 90 [70-100]). Women had less severe ischemia on stress imaging (383 of 919 [41.7%] vs 1363 of 2972 [45.9%] with severe ischemia; 386 of 919 [42.0%] vs 1215 of 2972 [40.9%] with moderate ischemia; and 150 of 919 [16.3%] vs 394 of 2972 [13.3%] with mild or no ischemia). Ischemia was similar by sex on exercise tolerance testing. Women had less extensive CAD on CCTA (205 of 568 women [36%] vs 1142 of 2418 men [47%] with 3-vessel disease; 184 of 568 women [32%] vs 754 of 2418 men [31%] with 2-vessel disease; and 178 of 568 women [31%] vs 519 of 2418 men [22%] with 1-vessel disease). Female sex was independently associated with greater angina frequency (odds ratio, 1.41; 95% CI, 1.13-1.76). CONCLUSIONS AND RELEVANCE: Women in the ISCHEMIA trial had more frequent angina, independent of less extensive CAD, and less severe ischemia than men. These findings reflect inherent sex differences in the complex relationships between angina, atherosclerosis, and ischemia that may have implications for testing and treatment of patients with suspected stable ischemic heart disease. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01471522
- Published
- 2020
- Full Text
- View/download PDF
19. BARI 2D: A Reanalysis Focusing on Cardiovascular Events
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Genuth, Saul M., Vlachos, Helen, Brooks, Maria Mori, Bantle, John P., Chaitman, Bernard R., Green, Jennifer, Kelsey, Sheryl F., King, Spencer B., McBane, Robert, Sako, Edward Y., Schneider, David J., Steffes, Michael, and Frye, Robert L.
- Abstract
To reanalyze the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial using a new composite cardiovascular disease (CVD) outcome to determine how best to treat patients with type 2 diabetes mellitus and stable coronary artery disease.
- Published
- 2019
- Full Text
- View/download PDF
20. Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
- Author
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Hochman, Judith S., Reynolds, Harmony R., Bangalore, Sripal, O’Brien, Sean M., Alexander, Karen P., Senior, Roxy, Boden, William E., Stone, Gregg W., Goodman, Shaun G., Lopes, Renato D., Lopez-Sendon, Jose, White, Harvey D., Maggioni, Aldo P., Shaw, Leslee J., Min, James K., Picard, Michael H., Berman, Daniel S., Chaitman, Bernard R., Mark, Daniel B., Spertus, John A., Cyr, Derek D., Bhargava, Balram, Ruzyllo, Witold, Wander, Gurpreet S., Chernyavskiy, Alexander M., Rosenberg, Yves D., and Maron, David J.
- Abstract
IMPORTANCE: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE: To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. DESIGN, SETTING, AND PARTICIPANTS: The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (<50% for imaging stress test and <70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. MAIN OUTCOMES AND MEASURES: Enrolled, excluded, and randomized participants’ baseline characteristics. No clinical outcomes are reported. RESULTS: A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. CONCLUSIONS AND RELEVANCE: The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01471522
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- 2019
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21. The year in review: electrocardiogram analysis and acute coronary syndromes
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Chong, Luke and Chaitman, Bernard R
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- 2020
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22. 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials
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Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott D., Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Hai, Mary T. Thanh, Jaff, Michael R., Joffe, Hylton V., Cutlip, Donald E., Desai, Akshay S., Lewis, Eldrin F., Gibson, C. Michael, Landray, Martin J., Lincoff, A. Michael, White, Christopher J., Brooks, Steven S., Rosenfield, Kenneth, Domanski, Michael J., Lansky, Alexandra J., McMurray, John J.V., Tcheng, James E., Steinhubl, Steven R., Burton, Paul, Mauri, Laura, O’Connor, Christopher M., Pfeffer, Marc A., Hung, H.M. James, Stockbridge, Norman L., Chaitman, Bernard R., and Temple, Robert J.
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Supplemental Digital Content is available in the text.This publication describes uniform definitions for cardiovascular and stroke outcomes developed by the Standardized Data Collection for Cardiovascular Trials Initiative and the US Food and Drug Administration (FDA). The FDA established the Standardized Data Collection for Cardiovascular Trials Initiative in 2009 to simplify the design and conduct of clinical trials intended to support marketing applications. The writing committee recognizes that these definitions may be used in other types of clinical trials and clinical care processes where appropriate. Use of these definitions at the FDA has enhanced the ability to aggregate data within and across medical product development programs, conduct meta-analyses to evaluate cardiovascular safety, integrate data from multiple trials, and compare effectiveness of drugs and devices. Further study is needed to determine whether prospective data collection using these common definitions improves the design, conduct, and interpretability of the results of clinical trials.
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- 2018
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23. Prognostic significance of silent myocardial ischemia detected by early treadmill exercise after coronary angioplasty
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Deligonul, Ubeydullah, Vandormael, Michel G., Younis, Liwa T., and Chaitman, Bernard R.
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Silent myocardial ischemia -- Prognosis ,Treadmill exercise tests ,Angioplasty -- Health aspects ,Coronary arteries ,Health - Abstract
Three hundred ninety patients who had successful coronary angioplasty were studied by treadmill exercise testing to determine the incidence and prognostic importance of silent and symptomatic myocardial ischemia in this patient subset. All patients were followed for an average of 11 months. During exercise, 81 patients (20%) had abnormal exercise-induced ST-segment depression without chest pain (group 1). Twenty patients (5%) had chest pain without ST changes (group 2). Twenty-one patients (5%) had both exercise- induced chest pain and ST-T-segment depression (group 3) and 268 patients (70%) had a normal exercise test with no chest pain (group 4). The groups were similar with respect to age, sex, history of previous myocardial infarct and previous coronary bypass surgery. Group 4 included more patients with complete revascularization. Mutually exclusive cardiac events were defined as cardiac death, nonfatal myocardial infarction, class III angina and additional revascularization (coronary angioplasty, coronary artery bypass surgery). The cardiac event rate in groups 1,2 and 3 were significantly higher than in group 4 (40, 45 and 43 vs 22%; p= 0.001). There were 4 cardiac deaths and 4 nonfatal myocardial infarctions in group 1 compared to 2 cardiac deaths and 3 nonfatal myocardial infarctions in group 4 (p = 0.03 and 0.05, respectively). The event rates in groups 1, 2 and 3 patients with multivessel disease were significantly greater than in group 4 (44, 60 and 47 vs 22%; p = 0.002). Thus, exercise-induced myocardial ischemic episodes, both symptomatic and silent, early after coronary angioplasty are predictive of an unfavorable prognosis and serious cardiac events, particularly in patients with multivessel disease and incomplete revascularization. (Am J Cardiol 1989;64:1-5)
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- 1989
24. Prognostic value of intravenous dipyridamole thallium scintigraphy after an acute myocardial ischemic event
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Younis, Liwa T., Byers, Sheila, Shaw, Leslee, Barth, Grace, Goodgold, Henry, and Chaitman, Bernard R.
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Heart attack -- Prognosis ,Radioisotope scanning -- Evaluation ,Coronary heart disease ,Health - Abstract
Seventy-seven patients recovering from an acute coronary event were studied by intravenous dipyridamole thallium scintigraphy to evaluate the prognostic value and safety of the test in this patient subset. Forty-four patients (58%) had unstable angina and 33 (42%) had an acute myocardial infarction. One death occurred within 24 hours of testing. Sixty-eight patients were followed for an average of 12 months; 25, 31 and 23% had a fixed, reversible or combined thallium defect on their predischarge thallium scan. During follow-up, 10 patients died or had a nonfatal myocardial infarction; in each case, a reversible or combined myocardial thallium defect was present. Univariate analysis of 17 clinical, scintigraphic and angiographic variables showed that a reversible thallium defect and the angiographically determined extent of coronary artery disease were predictors of future cardiac events. The extent of coronary disease and global left ventricular ejection fraction were predictors of subsequent reinfarction or death. Logistic regression analyses revealed that a reversible thallium defect (p
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- 1989
25. Abstract 12499: Anomalous Coronary Arteries Are Associated With Ischemia in the Ischemia Trial
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Jaspan, Vita, Leipsic, Jonathon A, Nemeth, Hayley, Mancini, G B, Budoff, Matthew, Hague, Cameron, Min, James, Shaw, Leslee J, Berman, Daniel, Picard, Michael, Chaitman, Bernard R, Kwong, Raymond Y, OBrien, Sean, Hochman, Judith S, Maron, David J, and Reynolds, Harmony
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Introduction:Coronary anomalies are detected in 0.3-2.3% of patients undergoing coronary computed tomography angiography (CCTA). Data are scarce on atherosclerosis severity in anomalous arteries and relationship to ischemia on stress testing.Hypothesis:High risk features of anomalous coronary arteries are associated with ischemia, even in the absence of coronary stenosis on CCTA.Methods:5,903 participants enrolled in the ISCHEMIA trial program with site-determined moderate or severe ischemia underwent CCTA. A core laboratory assessed atherosclerosis severity and made note of anomalous coronary origin. A single reader at the CCTA core laboratory re-evaluated all identified anomalies to assess high risk features and origin, blinded to stress test results. Patients were excluded if stress test results were unavailable. We assessed the relationship between type of anomaly and vessel with ischemia in the subtended territory on stress imaging, and stenosis severity.Results:There was anomalous origin of a coronary artery in 56 of 5,903 CCTA cases (0.9%). Age, sex and CAD risk factors were similar between patients with vs. without anomalies. Anomalous origin affected the left circumflex (LCX) in 28, right coronary artery (RCA) in 21, left main (LM) in 4, and left anterior descending (LAD) in 3. Ischemia was severe on stress testing in 58.2%, moderate in 34.5%, mild in 3.6% and absent in 3.6%. High risk anomalies were present in 17/56 (30.3%, 16/21 RCA and 1/4 LM), including inter-arterial course in 28.6%, intra-mural course in 1.8%, and slit-like orifice in 12.5%. Most anomalous coronaries (82.9%) were associated with ischemia in the subtended territory. Among anomalies associated with ischemia, 37.9% had <50% stenosis and 62.1% had <70% stenosis (Figure). Of those with <70% stenosis, 27.6% had high risk features.Conclusions:Anomalous coronary arteries in stable patients are associated with ischemia, even in the absence of severe atherosclerotic disease.
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- 2022
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26. Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox
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Wolk, Robert, Bertolet, Marnie, Singh, Prachi, Brooks, Maria M., Pratley, Richard E., Frye, Robert L., Mooradian, Arshag D., Rutter, Martin K., Calvin, Andrew D., Chaitman, Bernard R., and Somers, Virend K.
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To evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial.
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- 2016
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27. Cardiovascular and Renal Implications of Myocardial Infarction in the ISCHEMIA-CKD Trial
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Chaitman, Bernard R., Cyr, Derek D., Alexander, Karen P., Pracoń, Radosław, Bainey, Kevin R., Mathew, Anoop, Acharya, Anjali, Kunichoff, Dennis F., Fleg, Jerome L., Lopes, Renato D., Sidhu, Mandeep S., Anthopolos, Rebecca, Rockhold, Frank W., Stone, Gregg W., Maron, David J., Hochman, Judith S., and Bangalore, Sripal
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- 2022
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28. 2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials
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Hicks, Karen A., Tcheng, James E., Bozkurt, Biykem, Chaitman, Bernard R., Cutlip, Donald E., Farb, Andrew, Fonarow, Gregg C., Jacobs, Jeffrey P., Jaff, Michael R., Lichtman, Judith H., Limacher, Marian C., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Smith, Eric E., and Targum, Shari L.
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- 2015
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29. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial
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Carson, Jeffrey L, Sieber, Frederick, Cook, Donald Richard, Hoover, Donald R, Noveck, Helaine, Chaitman, Bernard R, Fleisher, Lee, Beaupre, Lauren, Macaulay, William, Rhoads, George G, Paris, Barbara, Zagorin, Aleksandra, Sanders, David W, Zakriya, Khwaja J, and Magaziner, Jay
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Blood transfusion might affect long-term mortality by changing immune function and thus potentially increasing the risk of subsequent infections and cancer recurrence. Compared with a restrictive transfusion strategy, a more liberal strategy could reduce cardiac complications by lowering myocardial damage, thereby reducing future deaths from cardiovascular disease. We aimed to establish the effect of a liberal transfusion strategy on long-term survival compared with a restrictive transfusion strategy.
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- 2015
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30. Extended-Release Niacin Therapy and Risk of Ischemic Stroke in Patients With Cardiovascular Disease
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Teo, Koon K., Goldstein, Larry B., Chaitman, Bernard R., Grant, Shannon, Weintraub, William S., Anderson, David C., Sila, Cathy A., Cruz-Flores, Salvador, Padley, Robert J., Kostuk, William J., and Boden, William E.
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In Atherothrombosis Intervention in Metabolic Syndrome with low HDLHigh Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental benefit, despite increases in high-density lipoprotein cholesterol. Preliminary analysis based on incomplete end point adjudication suggested increased ischemic stroke risk among participants randomized to ERN.
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- 2013
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31. 2013 ACCFAHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease
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Cannon, Christopher P., Brindis, Ralph G., Chaitman, Bernard R., Cohen, David J., Cross, J. Thomas, Drozda, Joseph P., Fesmire, Francis M., Fintel, Dan J., Fonarow, Gregg C., Fox, Keith A., Gray, Darryl T., Harrington, Robert A., Hicks, Karen A., Hollander, Judd E., Krumholz, Harlan, Labarthe, Darwin R., Long, Janet B., Mascette, Alice M., Meyer, Connie, Peterson, Eric D., Radford, Martha J., Roe, Matthew T., Richmann, James B., Selker, Harry P., Shahian, David M., Shaw, Richard E., Sprenger, Sharon, Swor, Robert, Underberg, James A., Van de Werf, Frans, Weiner, Bonnie H., and Weintraub, William S.
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- 2013
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32. Third universal definition of myocardial infarction
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Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., and White, Harvey D.
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Myocardial infarction is a major cause of morbidity and mortality worldwide. In this consensus document, experts from the ESC, ACCF, AHA, and WHF update the universal definition and classification of myocardial infarction to integrate the latest evidence on the detection of myocardial injury and necrosis using biomarker assays and imaging techniques.
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- 2012
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33. Stable angina pectoris: antianginal therapies and future directions
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Chaitman, Bernard R. and Laddu, Abhay A.
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Drs. Chaitman and Laddu review the various approved and experimental pharmacological approaches to treating angina in the context of data from clinical trials, and discuss ongoing and future studies. They also compare the merits of optimal medical therapy with prompt or delayed revascularization by percutaneous coronary intervention or CABG surgery as antianginal strategies.
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- 2012
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34. Angiographic Disease Progression and Residual Risk of Cardiovascular Events While on Optimal Medical Therapy
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Mancini, G.B. John, Hartigan, Pamela M., Bates, Eric R., Sedlis, Steven P., Maron, David J., Spertus, John A., Berman, Daniel S., Kostuk, William J., Shaw, Leslee J., Weintraub, William S., Teo, Koon K., Dada, Marcin, Chaitman, Bernard R., O'Rourke, Robert A., and Boden, William E.
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The extent to which recurrent events in patients with stable coronary artery disease is attributable to progression of an index lesion originally ≥50 diameter stenosis (DS) but not revascularized or originally <50 DS is unknown during optimal medical therapy (OMT).
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- 2011
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35. Choice of initial medical therapy vs. prompt coronary revascularization in patients with type 2 diabetes and stable ischemic coronary disease with special emphasis on the BARI 2D trial results
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Chaitman, Bernard R, Hadid, Mazen, and Laddu, Abhay A
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To determine whether a strategy of prompt coronary revascularization as compared with an initial strategy of intensive optimal medical therapy (OMT) in patients with type 2 diabetes and stable coronary artery disease (CAD) prevents major adverse cardiac outcomes.
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- 2010
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36. Do Major Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation Trial Differ by Healthcare System?
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Chaitman, Bernard R., Hartigan, Pamela M., Booth, David C., Teo, Koon K., Mancini, G.B. John, Kostuk, William J., Spertus, John A., Maron, David J., Dada, Marcin, O'Rourke, Robert A., Weintraub, William S., Berman, Daniel S., Shaw, Leslee J., and Boden, William E.
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The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial enrolled patients from 3 distinct healthcare systems (HCSs) in North America. The primary aim of this study was to determine whether there is a treatment difference in cardiovascular outcomes by HCS.
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- 2010
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37. Comments and Discussion on the Cocoa-platelet Presentation
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Chaitman, Bernard R.
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- 2006
38. An Academic ECG Core Lab Perspective of the FDA Initiative for Digital ECG Capture and Data Management in Large-Scale Clinical Trials*
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Johanson, Per, Armstrong, Paul W., Barbagelata, N. Alejandro, Chaitman, Bernard R., Clemmensen, Peter, Dellborg, Mikael, French, John, Goodman, Shaun G., Green, Cindy L., Krucoff, Mitchell W., Langer, Anatoly, Pahlm, Olle, Reilly, Paul, and Wagner, Galen S.
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Maximal utility of accessible data is attractive to all partners in clinical research, whether it directly improves patient care or more accurately allows identification of the safety and efficacy of a new drug or procedure. The Food and Drug Administration (FDA) has presented a guideline draft addressing digitization of electrocardiogram (ECG) data in clinical trials to improve the standards for collection, analysis, and storage of safety information on new medical therapies. This FDA initiative has led to discussions and collaboration among the FDA, the pharmaceutical industry, the electrocardiography manufacturers, and the academic as well as the nonacademic ECG core labs. In this article, we present a broad-based viewpoint from two groups of academic ECG core labs, the Alliance of Academic ECG Core Labs and the Virtual Electronic ECG Corelab International Consortium. We have chosen to widen the perspective from using digitized ECG data in safety trials only, as addressed by the FDA guideline draft, to a discussion on the possibilities and the potential problems when using digitized ECG data also in large clinical trials focusing on efficacy measurements. We conclude that the benefit of digital data mining is probably well worth an initial incremental effort and expense.
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- 2005
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39. Prognostic significance of elevated creatine kinase MB after coronary bypass surgery and after an acute coronary syndrome: results from the GUARDIAN trial
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Gavard, Jeffrey A, Chaitman, Bernard R., Sakai, Shunta, Stocke, Karen, Danchin, Nicolas, Erhardt, Leif, Gallo, Richard, Chi, Eric, Jessel, Andreas, and Théroux, Pierre
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To determine if the correlation between magnitude of creatine kinase-myocardial band release after coronary artery bypass surgery and 6-month mortality is comparable to that of patients admitted with an acute coronary syndrome.
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- 2003
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40. Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study
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Bittl, John A., Chaitman, Bernard R., Feit, Frederick, Kimball, William, and Topol, Eric J.
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BackgroundThis study was a reanalysis of the Bivalirudin Angioplasty Study, which compared bivalirudin with high-dose heparin during coronary angioplasty for unstable angina. MethodsDifferences in rates of death, myocardial infarction, or repeat revascularization were compared at 7, 90, and 180 days after angioplasty with intention-to-treat analysis. ResultsThe combined end point occurred in 135 of 2161 patients (6.2%) in the bivalirudin group and in 169 of 2151 patients (7.9%) in the heparin group at 7 days (P= .039). Differences persisted between the groups at 90 days (P= .012) and 180 days (P= .153). Bleeding occurred in 76 patients (3.5%) in the bivalirudin group versus 199 (9.3%) in the heparin group (P< .001). ConclusionsThis analysis supports the hypothesis that bivalirudin reduces ischemic complications and bleeding after angioplasty. Further trials are needed to evaluate bivalirudin versus heparin in conjunction with platelet-glycoprotein IIb/IIIa inhibitors and for coronary stenting. (Am Heart J 2001;142:952-9.)
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- 2001
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41. Increased mortality after coronary artery bypass graft surgery is associated with increased levels of postoperative creatine kinase-myocardial band isoenzyme release
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Klatte, Karen, Chaitman, Bernard R., Theroux, Pierre, Gavard, Jeffrey A., Stocke, Karen, Boyce, Steven, Bartels, Claus, Keller, Birgit, and Jessel, Andreas
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OBJECTIVES
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- 2001
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42. Risk stratification after successful coronary revascularization: the lack of a role for routine exercise testing
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Krone, Ronald J, Hardison, Regina M, Chaitman, Bernard R, Gibbons, Raymond J, Sopko, George, Bach, Richard, and Detre, Katherine M
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OBJECTIVE
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- 2001
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43. Standards for the function of an academic 12-lead electrocardiographic core laboratory
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Anderson, Stanley T., Pahlm, Olle, Bacharova, Ljuba, Barbagelata, Alejandro, Chaitman, Bernard R., Clemmensen, Peter, Goodman, Shaun, Hedén, Bo, Klootwijk, Peter J., Lauer, Michael, MacFarlane, Peter W., Rautaharju, Pentti, Reddy, Shankara, Selvester, Ronald H., Sgarbossa, Elena B., Underwood, Donald, Warner, Robert A., and Wagner, Galen S.
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An academic 12-lead electrocardiogram (ECG) core laboratory aims to provide the highest possible quality ECG recording, measurement, and storage to aid clinicians in research into important cardiovascular outcomes and to maximize the credibility of scientific results based solely, or in part, on ECG data. This position paper presents a guide for the structure and function of an academic ECG core laboratory. The key functional aspects are: 1) Data collection, 2) Staff composition, 3) Diagnostic measurement and definition standards, 4) Data management, 5) Academic considerations, 6) Economic consideration, and 7) Accreditation. An ECG Core Laboratory has the responsibility for rapid and accurate analysis and responsible management of the electrocardiographic data in multicenter clinical trials. Academic Laboratories, in addition, provide leadership in research protocol generation and production of research manuscripts for submission to the appropriate peer-review journals.
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- 2001
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44. Is ST segment elevation non–Q- wave myocardial infarction after thrombolytic therapy a new clinical entity that requires an invasive management strategy?∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
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Chaitman, Bernard R and Bitar, Saad R
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- 2001
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45. Rapid ventricular repolarization in rodents: Electrocardiographic manifestations, molecular mechanisms, and clinical insights
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Gussak, Ihor, Chaitman, Bernard R., Kopecky, Stephen L., and Nerbonne, Jeanne M.
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This article examines specific electrocardiographic (ECG) and electrophysiological features of ventricular repolarization in rats and mice, and the role of depolarization-activated potassium currents in mediating the unique features of ECG recordings in these rodents. This article describes the currents that underlie ventricular repolarization in these rodents, identifies terminology that appropriately describes the unique features of murine ECG recordings, and correlates these unique findings with selected human ECG ventricular repolarization abnormalities. The absence of a distinct isoelectric interval between the QRS complex and the T wave, accompanied by a relatively short QT interval, are common features of ECG recordings in mice and rats, but not in ECGs in guinea pigs. The murine ECG morphology is apparently attributable to the presence of large outward K+currents that dominate the early phase of ventricular repolarization. In rats and mice, the predominant current underlying the early phase of repolarization appears to be the rapidly activating and inactivating 4-aminopyridine-sensitive transient outward current (ie, I10). Importantly, the density of I10in rats and mice is high, whereas this current is not evident in the ventricular myocytes of guinea pigs. The high density of I10appears to underlie the prominent J wave or downsloping ST-segment elevation seen in rats and mice, whereas the ST-segment is isoelectric in guinea pigs. The unusual J wave and ST-segment pattern in murine ECGs, however, does bear some resemblance to ECG features observed in humans with Brugada syndrome, and with hypothermia and ischemia. These patterns in rats and mice might, therefore, serve as an experimental model for the idiopathic J wave.
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- 2000
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46. Relationship of extent of revascularization with angina at one year in the bypass angioplasty revascularization investigation (BARI)
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Whitlow, Patrick L., Dimas, Alexios P., Bashore, Thomas M., Califf, Robert M., Bourassa, Martial G., Chaitman, Bernard R., Rosen, Allan D., Kip, Kevin E., Stadius, Michael L., and Alderman, Edwin L.
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OBJECTIVES
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- 1999
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47. Is a strategy of intended incomplete percutaneous transluminal coronary angioplasty revascularization acceptable in nondiabetic patients who are candidates for coronary artery bypass graft surgery?
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Bourassa, Martial G, Kip, Kevin E, Jacobs, Alice K, Jones, Robert H, Sopko, George, Rosen, Allan D, Sharaf, Barry L, Schwartz, Leonard, Chaitman, Bernard R, Alderman, Edwin L, Holmes, David R, Roubin, Gary S, Detre, Katherine M, and Frye, Robert L
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OBJECTIVES
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- 1999
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48. Relationship among mental stress–induced ischemia and ischemia during daily life and during exercise: the Psychophysiologic Investigations of Myocardial Ischemia (PIMI) Study
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Stone, Peter H, Krantz, David S, McMahon, Robert P, Goldberg, A.David, Becker, Lewis C, Chaitman, Bernard R, Taylor, Herman A, Cohen, Jerome D, Freedland, Kenneth E, Bertolet, Barry D, Coughlan, Cecil, Pepine, Carl J, Kaufmann, Peter G, and Sheps, David S
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OBJECTIVES
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- 1999
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49. Prognostic value of dipyridamole thallium‐201 screening to minimize perioperative cardiac complications in diabetics undergoing kidney or kidney‐pancreas transplantation
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Mistry, Bhargav M., Bastani, Bahar, Solomon, Harvey, Hoff, Judy, Aridge, Della L., Lindsey, Lisa M., Schmid, Sandra, Chaitman, Bernard R., and Garvin, Paul J.
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To minimize perloperative cardiac events, we utilize a screening protocol consisting of intravenous dipyridamole thallium‐201 myocardial imaging (DPT), with the selective use of coronary angiography based on the presence of reversible defect(s) on DPT test. A retrospective study was performed to determine the prognostic value of this protocol and to identify any clinical parameters predictive of an abnormal DPT test. To accomplish this, a detailed chart analysis of 176 consecutive kidney (n = 89) and kidney‐pancreas (n = 87) transplant. recipients who had undergone pretransplant DPT testing was performed. The results of the DPT test were interpreted as normal in 111, fixed defect in 15, and reversible defect(s) in 50 patients. Forty‐two of the 50 patients with reversible defect(s) underwent coronary angiography. Twelve of the 27 patients with significant coronary artery disease (CAD, 50% stenosis in one or more coronary arteries) underwent pretransplant revascularization and the remaining 15 were treated medically. Cardiac events (documented acute myocardial infarction or sudden cardiac death) within 6 wk of transplant were stratified by the results of this protocol. Also, various clinical parameters were compared between patients with normal and abnormal (fixed and reversible defect) DPT tests. Only one of the 111 (0.9%) transplant recipients with a normal DPT test had a perioperative cardiac event. None of the 15 (0%) patients with a fixed defect and none of the 15 (0%) patients with reversible defect(s), but a nonsignificant (<50% narrowing) coronary angiogram, had a perioperative cardiac event. Three of the 27 (11.1%) patients with reversible defect(s) and significant disease on coronary angiography, who had undergone pre‐transplant revascularization or were managed medically, had perioperative coronary event. Of 14 recipients parameters analyzed, age 50 yr was the only variable predictive of an abnormal DPT test. We conclude that the incidence of perioperative cardiac events in patients with a normal or fixed defect, or reversible defect(s) but a nonsignificant (<50% narrowing) coronary angiogram is very low, indicating the high correlation of these findings on DPT and an uneventful (cardiac) post‐transplant course. The incidence of perioperative cardiac complications amongst the high‐risk transplant recipients with reversible defect(s) and significant CAD on coronary angiogram may be minimized by appropriate preoperative medical management or revascularization. None of the clinical variables except age > 50 yr was predictive of an abnormal DPT test.
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- 1998
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50. Operative Risk Factors in Patients with Left Main Coronary-Artery Disease
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Chaitman, Bernard R., Rogers, Willliam J., Davis, Kathryn, Tyras, Denis H., Berger, Robert, Bourassa, Martial G., Fisher, Lloyd, Hertzberg, Vicki Stover, Judkins, Melvin P., Mock, Michael B., and Killip, Thomas
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- 1980
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