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The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of the renal resistive index (RRI) derived from intrarenal

Data on changes in left ventricular diastolic function (LVDF) over time in the general population are sparse. We, therefore, investigated in the population cohort clinical correlates of longitudinal changes in Doppler diastolic indexes analyzed as continuous measures and assessed factors predictive of the changes in LVDF grades over time.

Mitochondrial DNA (mtDNA) molecules are highly susceptible to oxidative stress. Accumulation of mtDNA mutations leads to alterations of mitochondrial biogenesis and function that might result in decrease of mtDNA content within cells. This implies a possible role of mtDNA content as a potential biomarker in processes associated with oxidative stress and inflammation. However, data on correlates of the mtDNA content in a general population are sparse. Therefore, the objectives of the present study were to describe in a randomly recruited population sample the distribution and determinants of the peripheral blood mtDNA content.