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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2005.10.817 Byline: Francois Goffinet (a)(b), Marion Carayol (a), Jean-Michel Foidart (c), Sophie Alexander (d), Serge Uzan (e), Damien Subtil (f), Gerard Breart (a)(e) Abstract: A large trial published in 2000 concluded that planned vaginal delivery of term breech births is associated with high neonatal risks. Because the obstetric practices in that study differed from those in countries where planned vaginal delivery is still common, we conducted an observational prospective study to describe neonatal outcome according to the planned mode of delivery for term breech births in 2 such countries. Author Affiliation: (a) INSERM U149, Epidemiological Research Unit on Perinatal Health and Women's Health, Universite Pierre et Marie Curie Paris VI, HA[acute accent]pital Tenon (b) Universite Paris-Descartes Paris 5, Faculte de medecine, Service de gynecologie et obstetrique de Port-Royal, HA[acute accent]pital Cochin Saint-Vincent-de-Paul, Assistance Publique-HA[acute accent]pitaux de Paris, France (c) Department of Obstetrics and Gynaecology, La Citadelle Hospital, Liege, Belgium (d) School of Public Health School, Bruxelles, Belgium (e) Department of Obstetrics and Gynaecology, Tenon Hospital, Assistance Publique-HA[acute accent]pitaux de Paris, Universite Pierre et Marie Curie Paris VI, France (f) Department of Obstetrics and Gynaecology, Jeanne de Flandre Hospital, Lille Cedex, France Article History: Received 30 June 2005; Revised 30 September 2005; Accepted 27 October 2005 Article Note: (footnote) Supported by 2 grants from the Ministry of Health (AOM01123 [PH-RC 2001] and AOM03040 [PH-RC 2003]). It was also partly funded by the French College of Gynecologists and Obstetricians, the French Society of Perinatal Medicine, and the Belgian National Funds for Scientific Research. The funding sources had no role in the study design, data collection, data interpretation, or the writing of the report. Reprints not available from the authors.

The aim of this study was to examine whether the efficacy of transtheoretical model (TTM)–based interventions on physical activity (PA) varied according to the following criteria: (1) interventions targeted the actual stages of change (SOCs) or did not; (2) participants were selected according to their SOC or were not; and (3) its theoretical constructs (decisional balance, temptation, self-efficacy, processes of change).

Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.