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89 results on '"CONTI E"'

1. Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes

Author

Sarkozy, A, Conti, E, Seripa, D, Digilio, MC, Grifone, N, Tandoi, C, Fazio, VM, Di Ciommo, V, Marino, B, Pizzuti, A, and Dallapiccola, B

Subjects
Congenital heart disease -- Complications and side effects -- Research, Gene mutations -- Analysis -- Research, Comorbidity -- Analysis -- Research -- Complications and side effects, Noonan syndrome -- Research -- Complications and side effects, Medical genetics -- Research -- Analysis, Health
Abstract

Noonan syndrome (MIM 163950), an autosomal dominant disorder with an estimated prevalence of 1/10002500 at birth, is characterised by short stature, facial anomalies, pterygium colli, and congenital heart disease. (1 [...]

Published
2003

2. Clinical and radiological outcome after minimally invasive surgical approach for type II unstable odontoid fractures

Author

Fazzolari, B., Jannelli, G., Conti, E., Delitala, A., Tessitore, E., and Brunori, A.

Abstract

Anterior odontoid screw fixation is a valid surgical option for unstable odontoid fractures, as type II Anderson D’Alonzo fractures. Grauer further divided type II fractures in subtypes according to the fracture line, providing recommendations for implementation of screw fixation techniques.

Published
2021
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3. Experimental study of the microwave emission from electrons in air.

Author

Conti, E., Collazuol, G., and Sartori, G.

Subjects
*RADIATION, *MICROWAVES, *ELECTRON beams, *MICROWAVE photonics, *MONTE Carlo method, *COSMIC ray energy spectra
Abstract

We searched for the emission of microwave radiation in the Ku band generated by a 95 keV electron beam in air. We unequivocally detected the radiation, and measured its yield and angular dependence. Both the emitted power and its angular pattern are well described by a model, where microwave photons are generated via bremsstrahlung in the free-electron atomic-nucleus collisions, during the slowdown of the electrons. As a consequence, the radiation is not isotropic but peaked in the forward direction. The emission yield scales proportionally with the number of electrons. This contrasts a previous claim that the yield scales with the number squared, due to coherence. With a Monte Carlo simulation we extrapolate our results to the ultra high energy cosmic ray energy range. [ABSTRACT FROM AUTHOR]

Published
2014
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4. Recombinant Human Insulin-Like Growth Factor-1: A New Cardiovascular Disease Treatment Option?

Author

Conti, E., Musumeci, M., Assenza, G., Quarta, G., Autore, C., and Volpe, M.

Abstract

The Insulin-like growth factor-1 (IGF-1) system is dynamic and complex, involving many binding proteins, binding-proteinrelated proteases, and receptors. It has emerged in time as a powerful defence to life processes of many cytotypes, tissues and systems. Mainly in body metabolism, diabetes and cardiovascular system, but also in brain and kidney, IGF-1 plays a key role in maintaining homeostasis, increasing progenitor cell potential, and improving physiologic performance both in rest and stress conditions. Its vasculoprotective and insulin sensitizing ability exerts a protective role on flow-metabolism coupling and organs function. Therapeutical human use of recombinant human IGF-1 (rhIGF-1) has been widely applied only in Laron syndrome, while being verified in many randomized controlled trials to improve glycemic control in type 1 and type 2 diabetes, and proposed in neurological disease such as amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer disease. Sparse evidence exists moreover about rhIGF-1 use in insulin resistance, burns, catabolic and post-surgery states, acute and chronic renal failure, amyotrophic lateral and multiple sclerosis, brain injury, and immunoincompetence. Along with these data, results are available on cardiovascular benefit of administration of other growth factors, such as erythropoietin and vascular endothelial growth factor, or on cardiovascular side effects of growth factor antagonists such as trastuzumab in cancer therapy. We intended therefore to summarize in this review available human and animals evidence about rhIGF-1 effects on different systems with insights on rhIGF-1 cardiovascular effects. In view of its ability to improve flow-metabolism coupling, IGF-1 could indeed represent a new cardiovascular disease treatment option for many cardiac disorders such as ischemic heart disease and heart failure.

Published
2008

5. Ecology of the calling song of two Namibian armoured ground crickets, Acanthoplus longipes and Acanthoproctus diadematus (Orthoptera Tettigoniidae Hetrodinae)

Author

Conti, E. and Viglianisi, F. M.

Abstract

The calling songs of the Namibian armoured ground crickets Acanthoplus longipes and Acanthoproctus diadematus were analysed and described for the first time. Some differences in the length of the cuticular file and the number of the teeth of the pars stridens are also described. The different song patterns are related to differences in the autecology of the two species. Both utilise a broad frequency bandwidth, but the rare and endemic Acanthoproctus diadematus, which lives in interdunal areas of the desert, emits lower frequency signals. These consist of a repetitive sequence of very simple echemes. In contrast the widespread and invasive Acanthoplus longipes, which inhabits open grasslands, emits complex sequences of high-frequency diplosyllabic echemes. Other ecological features, related to the songs of the two species, are discussed.

Published
2005
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6. Clostridial Orthopedic Infections: Case Reports and Review of the Literature

Author

Lazzarini, L., Conti, E., Ditri, L., Turi, G., and De lalla, F.

Abstract

AbstractClostridia are anaerobic Gram-positive bacilli that can be isolated from the soil and the intestinal tract of humans. These microorganisms are recognized as the cause of devastating soft tissue infections, such as cellulitis, myositis, and gas gangrene. However, such bacteria may also be involved in various postoperative orthopedic infections, including prosthetic joint infection. We present three clinical cases of clostridial orthopedic infection and review the related medical literature.

Published
2004
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9. In VitroCulture of the Teratocytes of Trissolcus basalis(Hymenoptera, Scelionidae) and Their Requirements for Host-Derived Components

Author

Cônsoli, F.L, Conti, E, Dangott, L.J, and Vinson, S.B

Abstract

Teratocytes may control the physiology of the host and/or have trophic or secretory functions that may nutritionally affect the development of their associated parasitoid. The importance of these cells for the development of parasitoids in artificial diets has been investigated and in some cases they have been shown to improve the growth and development of such species. However, little attention has been directed to the functions that teratocytes from egg parasitoids may have on the interactions with the host. We developed an improved artificial medium to culture teratocytes of Trissolcus basalis(Woll.) as a tool to understand their role during parasitoid development. Teratocytes cultured in an insect cell medium supplemented with host-derived components achieved the same size as those reported developing in the natural host. We also found that these cells do not require components derived from the reproductive apparatus of parent females or from the developing larva of the parasitoid for their normal development. However, they require low- (<5-kDa) and high- (>100-kDa) molecular-weight host-derived components to fully grow. Both molecules are proteinaceous, and the high-molecular-weight components were identified as vitellin. The low-molecular-weight components were identified as peptides, and they are in the process of being isolated and identified. We also discuss the possible interactions between the teratocytes and the host and their combined role in the development of the parasitoid.

Published
2001
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20. Cancer Prevalence in Italian Cancer Registry Areas: The Itapreval Study

Author

Micheli, Andrea, Francisci, Silvia, Krogh, Vittorio, Rossi, Annia Giorgi, Crosignani, Paolo, Gatta, G, Sant, M, Rossi, A Giorgi, Francisci, S, Saltarelli, S, Dell'Era, L, Gasparre, N, Verdecchia, A, Capocaccia, R, Mariotto, A, Dally, L, Corazziari, I, Conti, E, Ramazzotti, V, Caperle, M, Vercelli, M, Caselli, C, Parodi, S, Crosignani, P, Tagliabue, G, Berrino, F, Federico, M, Mangone, L, Santacroce, M, de Leon, M Ponz, Roncucci, L, Benatti, P, Zanetti, R, Rosso, S, Patriarca, S, Falchi, F, Milandri, C, Vattiato, R, De Lisi, V, Serventi, L, Barili, A, Gafà, L, Tumino, R, La Rosa, E, Barchielli, A, Balzi, D, Crocetti, E, Paci, E, Guzzinati, S, Simonato, L, and Bovo, E

Abstract

Aim To present data on cancer prevalence for the areas covered by Italian cancer registries, by using a standardized set of data collection and elaboration criteria, and a single method of data analysis.Subjects and Methods Data on over 250,000 patients with cancer, diagnosed between 1978 and 1992, from 11 Italian cancer registries covering about 12% of the Italian population were collected, validated and analyzed according to the unified protocol of the ITAPREVAL project. The method implemented in the PREVAL computer program was used to provide prevalence estimates for the period covered by cancer registration. The total prevalence for each registry and for the pool of all registries was then estimated by correcting for incomplete observations due to the period in which the registration was not yet activated. All prevalence estimates were for 1992.Results Prevalence figures are presented by cancer site, age, sex, years from diagnosis and registry area. For all malignancies combined, total prevalence ranged from 1,350 per 100,000 inhabitants in Ragusa to 3,650 per 100,000 inhabitants in Romagna, the ratio between these two extremes being 2.7. For the pool of the areas covered by registration cancer prevalence was 3,100 per 100,000 females and 2,250 per 100,000 males. About a third of the total female cases and about half the male cases were diagnosed in the previous five years. Among those aged over 75 years, total prevalence was higher for males than for females: 11,300 versus 8,900 per 100,000 respectively.Conclusions This is the first large-scale estimate of the burden of cancer in Italy. It is also one of the first studies in the world which was aimed to study cancer prevalence in detail. These data are necessary for predicting health service needs and help in the evaluation of differences in health service demand by sex, age and Italian regions.

Published
1999
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21. Cancer Prevalence in the Elderly

Author

Vercelli, Marina, Quaglia, Alberto, Parodi, Stefano, Crosignani, Paolo, Micheli, A., Gatta, G., Sant, M., Rossi, A. Giorgi, Francisci, S., Saltarelli, S., Dell'Era, L., Gasparre, N., Verdecchia, A., Capocaccia, R., Mariotto, A., Dally, A., Corazziari, I., Crosignani, P., Tagliabue, G., Falcini, F., Milandri, C., Vattiato, R., Conti, E., Ramazzotti, V., Caperle, M., Zanetti, R., Rosso, S., Patriarca, S., Federico, M., Mangone, L., Santacroce, M., Barchielli, A., Balzi, D., Crocetti, E., Paci, E., De Lisi, V., Serventi, L., Barili, A., Vercelli, M., Casella, C., Parodi, S., De Leon, M. Ponz, Roncucci, L., Benatti, P., Gafà, L., Tumino, R., La Rosa, E., Guzzinati, S., Simonato, L., and Bovo, E.

Abstract

Aims and Background To describe the cancer prevalence in elderly Italian people and analyze the differences, if any, with the prevalence among younger subjects.Methods & Study Design The cancer prevalence among elderly patients (65 years and over), the three age classes encompassing elderly age (65-74 years, 75-84 years, 85 years and over) and younger patients (0-64 years) was computed using the PREVAL method on the basis of the incident cases over the period 1976-1992 followed up to 31 December 1992 (prevalence reference date). Data were collected by 11 Italian cancer registries.Results The observed prevalence figures for all cancers (except skin epitheliomas), both sexes combined and considering the whole elderly group, were 1,090 and 3,601 cases per 100,000 one and five years since diagnosis, respectively; the prevalence increased up to the 75-84 age group and showed a slight decrease after age 85. With regard to specific cancer sites, in men bladder and prostate had the highest prevalence 5 years from diagnosis (more than 800 cases per 100,000), followed by colon and lung (about 500 cases per 100,000) stomach and rectum (about 300 cases per 100,000); in women breast cancer ranked first (more than 1,000 cases per 100,000), followed by colon (about 350 cases per 100,000), corpus uteri, stomach and rectum cancers (between 150 and 200 cases per 100,000). For all malignancies and the two sexes combined the prevalence figures were about six times higher in the older than in the younger age group.Conclusions These figures confirm the important role of aging in determining the increase in cancer prevalence. The resulting prevalence figures clearly indicate the cancer burden placed on health care services; moreover, the figures will probably increase in the next decades due to a possible improvement in survival and to the dramatic aging of the population, assuming a stable trend for incidence rates. This picture will represent a major challenge for politicians and those dealing with health care planning and social policies in general, especially in the light of the reduction of the available financial resources and the specific features of medical and social needs in the elderly.

Published
1999
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22. Education, socioeconomic status and risk of cancer of the colon and rectum.

Author

Tavani, A, Fioretti, F, Franceschi, S, Gallus, S, Negri, E, Montella, M, Conti, E, and La Vecchia, C

Abstract

Socioeconomic correlates of cancer of the large bowel differ in various countries and calendar periods and may differ for the colon and rectum. Thus, the relationship between education and social class and risk of cancers of the colon and rectum was considered.

Published
1999
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25. Succinoglycan production by solid-state fermentation with Agrobacterium tumefaciens

Author

Stredansky, M. and Conti, E.

Abstract

Abstract: Succinoglycan was produced by cultivating Agrobacterium tumefaciens on various solid substrates, including agar medium, spent malt grains, ivory nut shavings, and grated carrots, impregnated with a nutrient solution. Fermentations were performed on a laboratory scale, both under static conditions and with agitation, using bottles and a prototype horizontal bioreactor. Several fermentation parameters were examined and optimized, including carbon and nitrogen composition, water content and layer thickness of the substrate. The yields and rheological properties of the polymers obtained under different fermentation conditions were compared. The highest succinoglycan yield was achieved in static cultivation, reaching 42 g/l of impregnating solution, corresponding to 30 g/kg of wet substrate. The polymer production in the horizontal bioreactor was faster, but the final yield was lower (29 g/l of impregnating solution).

Published
1999
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26. Fed-batch production and simple isolation of succinoglycan from Agrobacterium tumefaciens.

Author

Stredansky, M., Conti, E., Bertocchi, C., Navarini, L., Matulova, M., and Zanetti, F.

Abstract

Succinoglycan production by Agrobacterium tumefaciens was increased from 9.5 g/l to 14 g/l when the microorganism was cultivated under fed-batch condition, as compared to batch fermentation. Cells and broth impurities were removed from the fermentation broth with activated charcoal at a temperature of 90 °C, yielding a clear and odorless solution of the polymer. Viscosity mesurement, NMR spectroscopy and Mw determination proved that the polymer retains its main features, practically unaffected by the heat treatment. [ABSTRACT FROM AUTHOR]

Published
1999
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27. Laparoscopic treatment of benign adnexal cysts

Author

Federici, D., Conti, E., Lacelli, B., Ferrari, S., Muggiasca, L., and Surace, M.

Abstract

Although the use of laparoscopy in the surgical management of adnexal cysts has increased in recent years, there is still considerable concern that it could adversely affect patients' health. In this prospective study we discuss the risks connected with the laparoscopic approach based on a study of 164 patients who underwent operative laparoscopy for the treatment of adnexal cysts. Mean age was 34.6 years (range 14-70). 247 cysts were laparoscopically treated by various procedures: enucleation, stripping, electrocoagulation and adnexectomy. Histologic examination confirmed the benign nature of the cyst in all but three cases of borderline tumour. No conversion to laparotomy was necessary.We conclude that the laparoscopic approach to the surgical treatment of adnexal cysts is a safe and effective treatment. Shorter hospitalisation time, quicker recovery and cosmetic convenience are the main advantages of laparoscopic treatment. The use of strict preoperative criteria can minimise the risk of missing a malignant cyst.

Published
1998
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29. The apolipoprotein E ϵ4 allele causes a faster decline of cognitive performances in Down's syndrome subjects

Author

Del Bo, R, Comi, G.P, Bresolin, N, Castelli, E, Conti, E, Degiuli, A, Ausenda, C.D, and Scarlato, G

Abstract

The apolipoprotein E gene (APOE), located on human chromosome 19, has three common alleles (ϵ2, ϵ3, ϵ4) which encode for the three main isoforms indicated as E2, E3 and E4 respectively. Several findings indicate ϵ4 allele as an important risk factor in both sporadic and familial late-onset Alzheimer's disease (AD). Pathological changes similar to AD are seen in almost all patients with Down's syndrome (DS) aged over 35 (senile plaques, neurofibrillary tangles and neuronal loss); a proportion of these may subsequently develop dementia. Aim of this study is to evaluate the possible pathological role of ϵ4 allele as risk factor for developing AD in a DS population. Apoe ϵ4 allele frequency is not significantly different in DS cases and controls. We found a statistically significant inverse correlation between full scale IQ values and age of patients in the subgroup of DS subjects selected for the presence of at least one ϵ4 allele, while no correlation was observed in DS subjects with other ApoE genotypes. A longitudinal analysis of cognitive performances (available in 38 patients) showed a faster rate of decline in intellectual ability in those subjects carrying at least one ϵ4 allele. Our data support the hypothesis that ApoE ϵ4 allele has a contributory role in accelerating the mental deterioration of AD-type in DS patients. © 1997 Elsevier Science B.V.

Published
1997
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30. Structural Basis for the Inhibition of Firefly Luciferase by a General Anesthetic

Author

Franks, N.P., Jenkins, A., Conti, E., Lieb, W.R., and Brick, P.

Abstract

The firefly luciferase enzyme from Photinus pyralis is probably the best-characterized model system for studying anesthetic-protein interactions. It binds a diverse range of general anesthetics over a large potency range, displays a sensitivity to anesthetics that is very similar to that found in animals, and has an anesthetic sensitivity that can be modulated by one of its substrates (ATP). In this paper we describe the properties of bromoform acting as a general anesthetic (in Rana temporaria tadpoles) and as an inhibitor of the firefly luciferase enzyme at high and low ATP concentrations. In addition, we describe the crystal structure of the low-ATP form of the luciferase enzyme in the presence of bromoform at 2.2-Å resolution. These results provide a structural basis for understanding the anesthetic inhibition of the enzyme, as well as an explanation for the ATP modulation of its anesthetic sensitivity.

Published
1998
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33. Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line.

Author

Ma, Z Q, Spreafico, E, Pollio, G, Santagati, S, Conti, E, Cattaneo, E, and Maggi, A

Abstract

Several reports demonstrate estrogen receptor involvement in specific brain functions. In addition, estrogen receptors are expressed at early stages of brain development, suggesting that estrogens or related molecules may play an instructive role in the differentiation of specific brain areas. The lack of model systems in which these phenomena could be studied prompted us to develop a neuroblastoma cell line expressing the estrogen receptor. The cell line expresses the hormone receptor at levels compatible with a physiological activity. The activated estrogen receptor is capable of blocking proliferation of the cells without exerting toxic effects. Following growth arrest, the cells display a neuron-like morphology and express tau and synaptophysin, two proteins synthesized in differentiating neurons. The cell line generated will provide a valuable model system for molecular and biochemical studies of the activity of estrogens in neural-derived cells.

Published
1993
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34. Abstracts

Author

Derlon, J. M., Petit-taboué, M. C., Dauphin, F., Courtheoux, P., Chapon, F., Creissard, P., Darcel, F., Houtteville, J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go, K. G., Kamman, R. L., Mooyaart, E. L., Heesters, M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn, U., Fröhlich, T., Becker, G., Krone, A., Schlief, R., Schürmann, J., Jachimczak, P., Hofmann, E., Roggendorf, W., Roosen, K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank, G. S., Patterson, J., Hadley, D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone, A., Becker, G., Woydt, M., Roggendorf, W., Hofmann, E., Bogdahn, U., Roosen, K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci, M., Pantano, P., Maleci, A., Pierallini, S., Di Stefano, D., Bozzao, L., Cantore, G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado, D., Rodrigues, M., Salgado, L., Fonseca, A. T., Vieira, M. R., Bravo Marques, J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt, M., Krone, A., Tonn, J. C., Becker, G., Neumann, U., Roggendorf, W., Roosen, K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen, N., Chopra, R. K., Mikkelsen, T., Rosenblum, S. D., Yan, P. S., Knight, R., Windham, J., Rosenblum, M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin, C., Charrier, J., Fayet, G., Sagan, C., Cuillioere, P., Ricolleau, G., Martin, S., Menegalli-Bogeelli, D., Lajat, Y., Resche, F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati, M., Roselli, R., Iacoangeli, M., Pompucci, A., Rossi, G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser, A., Ortler, M., Seiwald, M., Kostron, H., Rajan, B., Ross, G., Lim, C., Ashlcy, S., Goode, D., Traish, D., Brada, M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor, A., Ebmeier, K. P., Jarvis, G., Lander, F., Cull, A., Sellar, R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein, J. J., Goldberg, W. J., Roelcke, U., Von Ammon, K., Hausmann, O., Radu, E. W., Kaech, D., Leenders, K. L., Fitzek, M. M., Aronen, J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra, U. M. U., Sipos, L., Slouik, F., Boiardi, A., Salmaggi, A., Pozzi, A., Farinotti, L., Fariselli, L., Silvani, A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. 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Published
1994
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36. Flux ratios and pump stoichiometries at sites II and III in liver mitochondria. Effect of slips and leaks.

Author

Luvisetto, S, Conti, E, Buso, M, and Azzone, G F

Abstract

Addition of bovine serum albumin to state 4 mitochondria results in a depression of the proton leak and of the resting respiration of 70 and 25%, respectively. The conductance membrane potential diagram, both in the ohmic and in the non-ohmic region, shows that in the presence of bovine serum albumin the level of ohmic conductance is lowered while that of non-ohmic conductance is increased toward higher delta psi values. The same effect is observed during operation of the different proton pumps. Addition of chloroform affects the conductance membrane potential diagram in the following manner: there is no effect in the ohmic region with all pumps, while there is an effect in the non-ohmic region either at site III or at sites II plus III but not at site II. This suggests a possible effect of chloroform at the level of the cytochrome oxidase proton pump. During titration with oligomycin of the ATPase proton pump the conductance potential diagram shows a region of non-ohmicity only in the presence but not in the absence of an ATP-regenerating system. Protonophoric uncouplers such as carbonyl cyanide p(trifluoromethoxy)phenylhydrazone and intrinsic uncouplers such as chloroform have different effects on the relationship between rates of charge translocation and of oxygen consumption, and thus on the pump stoichiometries, in that the slope of the diagram is modified by the latter but not by the former. The differential effects of protonophores and of intrinsic uncouplers on the stoichiometries have been analyzed by computer simulations and represent an additional criterion to distinguish between extrinsic and intrinsic mechanisms of uncoupling.

Published
1991
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37. Hormone replacement treatment and breast cancer risk: a cooperative Italian study

Author

La Vecchia, C, Negri, E, Franceschi, S, Favero, A, Nanni, O, Filiberti, R, Conti, E, Montella, M, Veronesi, A, and Ferraroni, M

Abstract

The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital for a wide spectrum of acute, non-neoplastic, non hormone-related diseases. Ever HRT use was reported by 7.5% of cases and 7.5% of controls, corresponding to a multivariate odds ratio (OR) of 1.2 [95% confidence interval (CI), 0.9-1.5]. The risk increased with increasing duration of use: the ORs were 1.0 for use lasting less than 1 year, 1.3 for 1-4 years and 1.5 for 5 years or more. There was no clear pattern of risk with reference to time since starting use, but the OR was significantly elevated (OR = 2.0, 95% CI 1.3-2.9) for women who had stopped HRT within the last 10 years. No association was observed in those who had stopped HRT more than 10 years ago (OR = 1.0). The increased OR for women who had stopped HRT within the last 10 years was consistent across strata of identified covariates, and was significantly related to duration of use. This study confirms the absence of a strong association between HRT and breast cancer risk, although the risk estimate was above unity for women who had used HRT for 5 years or longer. However, the risk was significantly elevated in the short to medium term after use, particularly for long-term use. This short-term increased risk is consistent with an effect of HRT on one of the later stages of the process of breast carcinogenesis. The flattening of risk with increasing time since stopping, and hence the absence of a long-term cumulative excess in breast cancer risk after stopping HRT exposure, has relevant implications on individual risk assessment and public health.

Published
1995
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38. Nucleotide sequences of rbcL confirm the capparalean affinity of the Australian endemis Gyrostemonaceae

Author

Rodman, JE, Karol, KG, PRice, RA, Conti, E, and Systma, KJ

Abstract

Nucleotide sequences (1452 base pairs) from the chloroplast gene for the large subunit of ribulose-1, 5-bisphosphate carboxylase/oxygenase (rbcL) were obtained for three species of Gyrostemon and Tersonia of the Australian endemic family Gyrostemonaceae. Phylogenetic reconstruction based on parsimony robustly allies the family with other mustard oil-producing plants in Dahlgren's expanded order Capparales. Within this clade, Gyrostemonaceae are the sister group to Resedaceae, but the sequence data provide only weak support for this particular linkage. The new molecular data corroborate recent embryological and ultrastructural findings for Gyrosternonaceae and confirm results from Rodman's cladistic analysis of traditional morphological features of these plants. The rbcL sequences for the three species of Gyrostemonaceae were consistent in possessing a stop codon ending at position 1452, well beyond the usual 1428 site for many dicots. An extended terminus for the rbcL gene appears to be a marker within the expanded order Capparales for a derived clade that comprises the traditional core Capparales (Brassicaceae, Capparaceae, Resedaceae and Tovariaceae) plus Gyrostemonaceae, the sister taxa Batis + Koeberlinia, and Limnanthaceae.

Published
1994
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40. A ‘mathematical’ spider living on gravel plains of the Namib Desert

Author

Costa, G., Petralia, A., Conti, E., and Hänel, C.

Abstract

In certain areas of the Namib gravel plains a new Ariadna sp. was discovered. It rims its vertical burrow with a stone circle, made on average of seven quartz stones. Some mathematical relationships between hole diameter, stone sizes and weight, and animal size were studied. A correlation was found, and stone selection by this spider postulated. Different hypotheses on the adaptive value of stone circle are suggested.

Published
1995
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42. Laparoscopic conservative surgery in tubal pregnancy

Author

Federici, D., Conti, E., Muggiasca, M. L., Ferrari, S., Arcaini, L., Brambilla, T., Meroni, M., and Agarossi, A.

Abstract

A 1-year non-randomized prospective cohort study, commencing in May 1992, compared operative laparoscopy with laparotomy for conservative management of tubal pregnancy. Thirty women underwent conservative surgical treatment: 23 were treated by the laparoscopic technique and seven underwent laparotomy, with treatment allocation depending on the surgical preference and experience of the on-call surgical team. Linear salpingostomy was performed in both groups. There was no difference in mean size and gestational age of the ectopic pregnancy in the two groups. Laparoscopic conservative treatment resulted in shorter operation time, hospitalization and convalescence. There were no immediate or long-term complications in both groups. One case of persistent trophoblastic activity occurred in the laparoscopic group and was managed expectantly with success. To evaluate tubal healing and adhesion formation, 13 women underwent a second-look laparoscopy 3 months later. All the patients had tubal patency and good healing of the linear salpingostomy. Filmy adhesions at the operation site were present in 23% of laparoscopic versus 60% of the laparotomy group. Thus, laparoscopic treatment of tubal pregnancy appears to be as effective and less traumatic than laparotomy. Other advantages are reduction of operating, hospitalization and convalescence time and, thus, of costs.

Published
1994
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45. Estimation and projections of colorectal cancer trends in Italy.

Author

Capocaccia, R, De Angelis, R, Frova, L, Gatta, G, Sant, M, Micheli, A, Berrino, F, Conti, E, Gafà, L, Roncucci, L, and Verdecchia, A

Abstract

Occurrence of and prognosis for tumours of the colon and rectum are thought to be changing rapidly due to simultaneous changes in risk factor prevalence, early diagnosis and treatment. In this paper time trends of morbidity, survival and mortality for colorectal cancer during the period 1970-1990 are estimated and analysed.

Published
1997
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46. Kaposi's sarcoma in Italy before and after the AIDS epidemic

Author

Geddes, M, Franceschi, S, Barchielli, A, Falcini, F, Carli, S, Cocconi, G, Conti, E, Crosignani, P, Gafà, L, and Giarelli, L

Abstract

The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in the registration areas. Elevated incidence rates, standardised to the Italian population of 1981, of 1.05/100,000 men and 0.27/100,000 women emerged in 1976-84 (i.e. from two- to threefold higher than in the USA and Sweden, more than tenfold higher than in England and Wales). These high rates, especially remarkable in the Registry from the south of Italy (i.e. Ragusa, 3.01/100,000 men and 0.54/100,000 women) suggest that the prevalence of the still unknown causative agent for KS was high, at least in some parts of Italy, prior to the AIDS epidemic. In the most recent period (1985-90), an approximately twofold increase in KS incidence rates in Italian men below age 50 was observed (from 0.15 in 1976-84 to 0.47 in 1985-90). Conversely, declines in KS incidence were recorded in older men.

Published
1994
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48. Affinities of the Australian endemic akaniaceae: New evidence from rbcL sequences

Author

Gradek, PA, Quinn, CJ, Rodman, JE, Karol, KG, Conti, E, PRice, RA, and Fernando, ES

Abstract

The affinities of the Australian monotypic endemic family Akaniaceae, traditionally assigned to the Sapindales, are reassessed on the basis of comparative sequence data for the chloroplast encoded gene, rbcL. Cladistic analyses show Akania to cluster robustly with Bretschneidera and then Tropaeolum, within the clade of glucosinolate Capparalean families. Eight species representing six other families assigned to the Sapindales, plus Leitneria, formed a monophyletic cluster in 100% of trees in a bootstrap analysis with 500 replicates. This Sapindalean clade is shown to be supported by 17 synapomorphs, only one of which occurs in Akania. Relationships at the ordinal level, among the Sapindalean, Malvalean, Capparalean and Myrtalean clades, are, however, not well resolved. While the most parsimonious arrangement has the Malvales as sister-group to the Sapindales, with the Capparalean and Myrtalean clades joining in sequence, the occurrence of an apomorphic triplet of bases at positions 294–6 in all members of the Malvales, Myrtales and Sapindales so far examined is tentative evidence that these orders may constitute a monophyletic group.

Published
1992
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50. Family history of cancer and risk of colorectal cancer in Italy

Author

Negri, E, Braga, C, La Vecchia, C, Franceschi, S, Filiberti, R, Montella, M, Falcini, F, Conti, E, and Talamini, R

Abstract

Subjects with a family history of colorectal cancer (CRC) are at increased risk of CRC, but quantification of the risk in different populations, the possible differences in risk according to localization of the cancer and the association of family history of other cancers with CRC risk are still open issues. We have therefore analysed data from a multicentric case-control study conducted in six Italian areas between 1992 and 1996 of 1225 incident cases of colon cancer, 728 cases of rectal cancer and 4154 controls admitted for acute conditions to the same network of hospitals as the cases. Unconditional logistic regression models including terms for gender, age, study centre, years of education and number of siblings were used to estimate the odds ratios (ORs) of CRC according to various aspects of history of CRC and other cancers in first-degree relatives. The OR for family history of CRC was 3.2 (95% confidence interval, CI, 2.5-4.1) for colon cancer and 2.2 (95% CI 1.6-3.1) for rectal cancer. Colon cancer was significantly associated with a family history of stomach (OR 1.4), bone (OR 2.1) and kidney (OR 2.3) cancers, while rectal cancer was significantly associated with a family history of lymphomas (OR 2.8). There was a 30% higher risk of colon and rectal cancer in subjects with a family history of any cancer, excluding intestine. The ORs for family history of CRC were 5.2 for colon and 6.3 for rectum when the proband's age was below 45 years. The ORs were similar when the affected relative was a parent or a sibling and in different strata of age of relative(s). For subjects with two or more first-degree relatives with CRC, the risk was 6.9 for the right colon, 5.8 for the transverse and descending colon, 3.8 for the sigma, 3.2 for the rectosigmoid junction and 1.9 for the rectum. This study confirms that a family history of CRC in first-degree relatives increases the risk of both colon and rectal cancer, the association being stronger at younger ages and for right colon.

Published
1998
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