1. TREX1 Cuts Down on Cancer Immunogenicity.
- Author
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Yamazaki T and Galluzzi L
- Subjects
- Animals, Humans, Mice, Neoplasms enzymology, Neoplasms immunology, Radiotherapy Dosage, Exodeoxyribonucleases metabolism, Neoplasms radiotherapy, Phosphoproteins metabolism
- Abstract
Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT)., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2017
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