1. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vsemtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial
- Author
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Ogbuagu, Onyema, Ruane, Peter J, Podzamczer, Daniel, Salazar, Laura C, Henry, Keith, Asmuth, David M, Wohl, David, Gilson, Richard, Shao, Yongwu, Ebrahimi, Ramin, Cox, Stephanie, Kintu, Alexander, Carter, Christoph, Das, Moupali, Baeten, Jared M, Brainard, Diana M, Whitlock, Gary, Brunetta, Jason M, Kronborg, Gitte, Spinner, Christoph D, Antinori, Andrea, Apea, Vanessa, Asmuth, David, Avery, Ann, Benson, Paul, Bergin, Colm, Berhe, Mezgebe, Brar, Indira, Brinson, Cynthia, Brunetta, Jason, Burack, Jeffrey, Campbell, Thomas, Cespedes, Michelle, Clarke, Amanda, Coleman, Megan, Coll, Josep, Crespo Casal, Manuel, Creticos, Catherine, Crofoot, Gordon, Cruickshank, Frederick, Cua, Eric, Daar, Eric, de Wet, Joseph, DeJesus, Edwin, Del Romero Guerrero, Jorge, Dinges, William, Doblecki-Lewis, Susanne, Donovan, Taylor, Dosekun, Olamide, Flamm, Jason, Gallant, Joel, Gerstoft, Jan, Gilson, Richard, Gladstein, Jay, Grant, Robert, Grossberg, Robert, Haas, Bernhard, Halperin, Jason, Hardy, W. David, Hare, Charles, Hassler, Shawn, Hengel, Richard, Henry, William, Hodge, Theo, Hosek, Sybil, Hurt, Christopher, Iandiorio, Michelle, Jessen, Heiko, Kegg, Stephen, Knecht, Gabriele, Kronborg, Gitte, Krznaric, Ivanka, LaMarca, Anthony, Larsen, Carsten Schade, Larsen, Olav Ditlevsen, Lazzarin, Adriano, Leen, Clifford, Lucasti, Christopher, Mallon, Patrick, Mannheimer, Sharon, Markowitz, Martin, Martorell, Claudia, Mayer, Kenneth, Mills, Anthony, Molina, Jean-Michel, Morris, Sheldon, Mounzer, Karam, Nwokolo, Nneka, Ogbuagu, Onyema, Osiyemi, Olayemi, Petroll, Andrew, Philibert, Patrick, Phoenix, John, Pialoux, Gilles, Podzamczer, Daniel, Post, Frank, Prins, Maria, Ramgopal, Moti, Rashbaum, Bruce, Reeves, Iain, Richmond, Gary, Rieger, Armin, Ruane, Peter, Salazar, Laura, Scarsella, Anthony, Schembri, Gabriel, Scott, Mia, Shalit, Peter, Sinclair, Gary, Sobieszczyk, Magdalena, Spinner, Christoph, Stephens, Jeffrey, Szabo, Jason, Taylor, Stephen, Thompson, Melanie, Tremblay, Cecile, Trottier, Benoit, Voskuhl, Gene, Wade, Barbara, Wohl, David, Workowski, Kimberly, Yawetz, Sigal, and Young, Benjamin
- Abstract
In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mineral density and renal safety biomarkers at week 48. We report outcomes analysed after all participants had completed 96 weeks of follow-up.
- Published
- 2021
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