Search

Your search keyword '"Brignole, M."' showing total 11 results
Start Over Author "Brignole, M." Publication Type Magazines
11 results on '"Brignole, M."'

2. Clinical features of adenosine sensitive syncope and tilt induced vasovagal syncope

Author

Brignole, M., Gaggioli, G., Costa, S., Bartoletti, A., Menozzi, C., Bottoni, N., Lolli, G., and Rosso, A.D.

Abstract

AimTo evaluate the possible relation between adenosine sensitive syncope and tilt induced vasovagal syncope. MethodsAn ATP test and a head up tilt test were performed in 175 consecutive patients with syncope of uncertain origin. The ATP test consisted of the rapid intravenous injection of 20 mg of ATP; a positive response was defined as the induction of a ventricular pause (maximum RR interval) ≥ 6000 ms. The head up tilt test was performed at 60° for 45 minutes; if negative, 0.4 mg oral glyceryl trinitrate spray was given and the test continued for a further 20 minutes; a positive response was defined as induction of syncope in the presence of bradycardia, hypotension, or both. ResultsOf the 121 patients with a positive response, 77 (64%) had a positive head up tilt alone, 18 (15%) had a positive ATP test alone, and in 26 (21%) both ATP and head up tilt were positive. Compared with the patients with isolated positive head up tilt, those with isolated positive ATP were older (mean (SD) age, 68 (10) v 45 (20) years), had a lower median number of syncopal episodes (2 v3), a shorter median duration of syncopal episodes (4 v 36 months), a lower prevalence of situational, vasovagal, or triggering factors (11% v 64%), a lower prevalence of warning symptoms (44% v 71%), and a higher prevalence of systemic hypertension (22% v 5%) and ECG abnormalities (28% v 9%). The patients with a positive response to both tests had intermediate features. Of the 44 positive responses to the ATP test, atrioventricular block was the cause of the ventricular pause in 43; of the 29 positive cardioinhibitory responses to head up tilt, sinus arrest was present in 23 cases and atrioventricular block in six. ConclusionsATP and head up tilt tests identify different populations of patients affected by syncope; these have different general clinical features, different histories of syncopal episodes, and different mechanism sites of action. Therefore, adenosine sensitive syncope and tilt induced vasovagal syncope are two distinct clinical entities.

Published
2000

3. The Best + ICD Trial

Author

Cappato, R., Bongiorni, M.G., Brignole, M., Capucci, A., Gaita, F., Mangiameli, S., Montenero, A., Pedretti, R., Raviele, A., Salerno, J., and Sermasi, S.

Abstract

ta-blocker STrategy plus Implantable Cardioverter Defibrillator (BEST + ICD) Trial is a multicenter prospective randomized study in which the hypothesis will be tested of whether, in high-risk post-myocardial infarction (MI) patients already treated with β-blockers, therapy guided by electrophysiologic study (EPS) will improve survival, compared to conventional therapy. Eligible patients for the study are survivors of a recent MI (>5 and <21 days), aged <80 years, who have left ventricular ejection fraction ≤35 % and one or more of the following additional risk factors: ventricular premature beats ≥10/h, reduced heart rate variability (SDNN <70 ms), and presence of ventricular late potentials. These patients represent about 9 % of all patients with recent MI and are expected to have a 2-year all-cause mortality ≥25 %, sudden in 50 % of cases. The main exclusion criteria from the study are a history of sustained ventricular arrhythmias, documentation of non-sustained ventricular tachycardia during the screening phase, need for myocardial revascularization, and contraindications or intolerance to β-blocker therapy. Eligible patients will be randomized with a 2:3 ratio to two different therapeutic strategies: conventional strategy or EPS/ICD strategy. Patients allocated to conventional strategy will be treated, whenever possible, with aspirin, ACE inhibitor, and statine. In addition to the conventional therapy, patients allocated to EPS/ICD strategy will undergo an EPS: inducible patients (35 %) will receive a prophylactic ICD, whereas noninducible patients will be only conventionally treated. The primary endpoint of the study is death from all-causes. The duration of recruitment will be 2 years and that of follow-up will be variable, since all patients will be followed to a common termination date. By hypothesizing a 30 % reduction in the 2-year morality (from 20 % to 14 %) in the EPS/ICD group compared to conventionally treated patients, 1200 patients need to be randomized, of whom 480 to conventional strategy and 720 to EPS/ICD strategy. A triangular, 2-sided sequential design with preset boundaries (p <0.05) will be used to permit early termination of the trial if efficacy, no difference or inefficacy will be found. Data analysis will be done on the basis of both intention-to-treat (primary analysis) and on treatment analysis (secondary analysis). Randomisiert werden sollen Patienten 5–21 Tage nach Myokardinfarkt. Diese Patienten sollen jünger sein als 80 Jahre, eine linksventrikuläre Auswurffraktion von maximal 35 % aufweisen und eine Metoprolol-Therapie von mindestens 25 mg täglich tolerieren. Darüber hinaus sollen einer oder mehrere der folgenden Risikofaktoren vorliegen: ≥ 10 ventrikuläre Extrasystolen pro Stunde, reduzierte Variabilität der Herfrequenz (SDNN < 70 ms), Nachweis von Spätpotential des Ventrikels. Etwa 9 % aller Patienten mit kurz zurückliegendem Myokardinfarkt erfüllen diese Kriterien. Für diese Patienten erwartet man innerhalb der ersten 2 Jahre nach Infarkt eine Mortalität von ≥ 25%; von diesen Todesfällen treten 50% plötzlich ein . Geeignete Patienten werden im Verhältnis 2:3 randomisiert und einer herkömmlichen oder einer EPU-bestimmten Therapie zugeführt. Patienten der EPU-bestimmten Therapie erhalten eine elektrophysiologische Untersuchung. Hier erwartet man einen Anteil von 35 % mit induzierbarer ventrikulärer Tachykardie oder Kammerflimmern. Diesen Patienten wird prophylaktisch ein kardioverter Defibrillator implantiert. Die übrigen Patienten der Gruppe, bei denen solche Arrhythmien nicht induzierbar sind, werden einer herkömmlichen Therapie zugeführt. Primärer Endpunkt der Studie ist die Gesamtmortalität. Unter der Hypothese, daß die übliche Sterblichkeitsrate in der EPU-Gruppe innerhalb der ersten beiden Jahre von 20 % auf 14 %, also um 30 % reduziert werden kann, müssen 1200 Patienten randomisiert werden (480 Patienten unter herkömmlicher und 720 Patienten unter EPU-bestimmter Therapie). Ein trianguläres, 2-seitiges, sequenzielles Design mit vorab festgesetzten Grenzen (p <0,05) soll sicherstellen, daß die Studie vorzeitig abgebrochen werden kann, wenn eine Wirksamkeit, kein Unterschied zwischen den Behandlungen oder mangelnde Wirksamkeit nachgewiesen werden. Die Analyse der Daten wird sowohl auf der Basis der Intention-to-Treat (primäre Analyse) als auch anhand der in Behandlung befindlichen Patienten (Sekundärauswertung) erfolgen.

Published
1999
Full Text
View/download PDF

4. Thromboembolism after atrioventricular node ablation and pacing: long term follow up

Author

Proclemer, A., Gasparini, M., Tognarin, S., Mantica, M., Ometto, R., Turco, P., Acquati, F., Brignole, M., Mantovan, R., Gianfranchi, L., Ferrari, G.M. de, Menozzi, C., Pizzetti, F., Magenta, G., and delise, P.

Abstract

ObjectiveTo assess the incidence of arterial embolic events in patients with high rate, drug resistant, severely symptomatic paroxysmal and chronic atrial fibrillation who have undergone atrioventricular (AV) node ablation and permanent pacing. DesignMulticentre retrospective cohort study. Patients and managementFrom May 1987 to January 1997, AV node ablation was performed in 585 severely symptomatic patients (mean (SD) age 66 (11) years) with high rate, drug resistant paroxysmal atrial fibrillation (308) or chronic atrial fibrillation (277). Lone atrial fibrillation was present in 133 patients, while the remaining 452 suffered from dilated, ischaemic, or valvar heart disease. Patients underwent VVIR (454) or DDDR (131) pacemaker implantation, after AV node ablation. Antiplatelet agents were given to 202 patients, warfarin to 187 patients. ResultsDuring a follow up of 33.6 (24.2) months, thromboembolic events were observed in 17 patients (3%); the actuarial occurrence rates of thromboembolism were 1.1%, 3%, 4.2%, and 7.4% after one, three, five, and seven years, respectively. Among five variables, univariate analysis showed that only the presence of chronic atrial fibrillation at the time of ablation (relative risk (RR) = 1.8, 95% confidence interval (CI) = 1.02 to 3.20, p = 0.04) and the need for warfarin treatment (RR = 1.6, 95% CI 1.00 to 2.71, p = 0.048) were associated with a significantly higher risk of occurrence of thromboembolic events. On multivariate analysis the only predictor of embolic events during the follow up was the presence of chronic atrial fibrillation. ConclusionsData from this large cohort of patients indicate a fairly low incidence (1.04% per year) of thromboembolic events after AV node ablation and pacing for drug refractory, high rate atrial fibrillation.

Published
1999

8. Abstracts

Author

Barthelemy, O., Silvain, J., Brieger, D., Bellemain-Appaix, A., Cayla, G., Beygui, F., Lancar, R., Collet, J.P., Mercadier, A., Montalescot, G., Cha, K.S., Nam, Y.H., Kim, J.H., Park, S.Y., Park, T.H., Kim, M.H., Kim, Y.D., Lee, H.C., Ahn, M.S., Hong, T.J., Blanco, R., Blanco, F., Szarfer, J., Garcia Escudero, A., Gigena, G., Gagliardi, J., Rodriguez, A., Sarmiento, R., Affatatto, S., Riccitelli, M., Petris, A., Datcu, M.D., Pop, C., Radoi, M., Arsenescu-Georgescu, C., Petrescu, I., Petrescu, L., Serban, L., Nechita, E., Tatu-Chitoiu, G., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, C., Ionescu, D.D., Radoi, M., Pop, C., Ginghina, C., Minescu, B., Izzo, A., Mantovani, P., Tomasi, L., Dalloglio, L., Bonatti, S., Rosiello, R., Romano, M., Agostini, F., Zanini, R., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yany, Y.J., Qian, H.Y., Tang, Y.D., Timoteo, A.T., Toste, A., Lousinha, A., Ramos, R., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Cabades, C., Diez Gil, J.L., Aguar, P., Sanmiguel, D., Lopez-March, A., Marmol, R., Guerra, L., Girbes, V., Ferrando, J., Rincon De Arellano, A., Timoteo, A.T., Ramos, R., Toste, A., Oliveira, J.A., Patricio, L., Ferreira, M.L., Ferreira, R.C., Blondal, M., Ainla, T., Marandi, T., Eha, J., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Cunha, P.S., Feliciano, J., Silva, S., Ferreira, R.C., Kanovsky, J., Kala, P., Parenica, J., Poloczek, M., Prymusova, K., Kubkova, L., Spinar, J., Olinic, D., Homorodean, C., Ober, M., Olinic, M., Andrioaia, C., Condac, A., Masmoudi, M., Berdaoui, B., Labidi, S., Tapia Ballesteros, C., Hernandez Luis, C., Sandin, M.G., Vegas, J.M., Andion, R., Martinez, N., Gonzalez, I.A., Alvarado, M., Amat, I.J., San Roman, J.A., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Dorta Martin, M., Marrero Rodriguez, F., Dragu, R., Kapeliovich, M., Hammerman, H., Silva, D., Cortez-Dias, N., Jorge, C., Silva Marques, J., Carilho Ferreira, P., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Fiuza, M., Lopes, M.G., Milicevic, P., Panic, M., Stankovic, I., Milicevic, D., Kalezic, T., Kafedzic, S., Ilic, I., Cerovic, M., Putnikovic, B., Neskovic, A., Rott, D., Leibowitz, D., Monhart, Z., Reissigova, J., Grunfeldova, H., Jansky, P., Timoteo, A.T., Valente, B., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Villanueva Benito, I., Solla, I., Paredes, E., Diaz Castro, O., Calvo, F., Baz, J.A., Iniguez, A., Aleksova, A., Gerloni, R., Belfiore, R., Carriere, C., Barbati, G., Fabris, E., Possa, F., Nait, D., Milo, M., Sinagra, G., Marques, N., Mimoso, J., Gomes, V., Agra Bermejo, R.M., Emad Abu Assi, E.A.A., Sergio Raposeiras Roubin, S.R.R., Pilar Cabanas Grandio, P.C.G., Carlos Pena Gil, C.P.G., Jose Maria Garcia Acuna, J.M.G.A., Jose Ramon Gonzalez Juanatey, J.R.G.J., Daly, M.J., Scott, P., Owens, C.G., Tomlin, A., Smith, B., Adgey, A.A.J., Alvarez-Contreras, L.R., Juarez, U., Altamirano, A., Arias, A., Alvarez-San Gabriel, A., Gonzalez-Pacheco, H., Martinez-Sanchez, C., Rahnavardi, M., Keshtkar-Jahromi, M., Vakili, H., Gholamin, S., Razavi, S.M., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Koerfer, J., Horstkotte, D., Vrsalovic, M., Getaldic, B., Vrkic, N., Pintaric, H., Khan, S., Wasan, B., Moretti, L., Grossi, P., Silenzi, S., Testa, M., Candelori, L., Clementi, L.N., Forlini, M., Lando, L., Pezzuoli, M.L., Corradetti, P., Leurent, G., Pennec, P.Y., Filippi, E., Moquet, B., Hacot, J.P., Druelles, P., Rialan, A., Rouault, G., Coudert, I., Le Breton, H., Gevaert, S., Tromp, F., Vandecasteele, E., De Somer, F., Van Belleghem, Y., Bouchez, S., Martens, F., Herck, I., De Pauw, M., Spinar, J., Ludka, O., Sepsi, M., Miklik, R., Dusek, L., Tomcikova, D., Marques, N., Mimoso, J., Gomes, V., Garcia-Acuna, J.M., Aguiar-Souto, P., Raposeiras Roubin, S., Agra-Bermejo, R., Jacquet, M., Abu-Assi, E., Gonzalez-Juanatey, J.R., Ibatov, A., Labrova, R., Spinar, J., Karlik, R., Kanovsky, J., Lokaj, P., She, Q., Deng, S.B., Huang, S.H., Gu, L.J., Rong, J.I.A.N., Wu, Z.K., Li, Y., Zhang, J., Parascan, L., Campanile, A., Spinelli, L., Santulli, G., Ciccarelli, M., De Gennaro, S., Assante Di Panzillo, E., Trimarco, B., Iaccarino, G., Bobescu, E., Radoi, M., Datcu, G., Dobreanu, D., Doka, B., Charniot, J.-C., Cosson, C., Albertini, J.P., Bittar, R., Giral, P., Cherfils, C., Guillerm, E., Bonnefont-Rousselot, D., Craiu, E., Rusali, A., Cojocaru, L., Parepa, I., Koizumi, T., Iida, S., Sato, J., Kikutani, T., Muramatsu, T., Nishimura, S., Komiyama, N., Lee, W.P., Ong, B.B., Haralambos, K., Townsend, D., Rees, J.A.E., Williams, E.J., Halcox, J.P., Mcdowell, I., Damjanovic, M., Koracevic, G., Djordjevic-Radojkovic, D., Pavlovic, M., Krstic, N., Ciric-Zdravkovic, S., Stojkovic, A., Perisic, Z., Apostolovic, S., Faustino, A., Seca, L., Barra, S., Caetano, F., Providencia, R., Silva, J., Gomes, P., Costa, G., Costa, M., Leitao-Marques, A., Volkova, A.L., Arutyunov, G.P., Bylova, N.A., Dayter, I.I., Jao, Y.T.F.N., Fang, C.C., Chen, Y., Yu, C.L., Wang, S.P., Valencia, J., Perez-Berbel, P., Ruiz-Nodar, J.M., Pineda, J., Bordes, P., Quintanilla, M., Mainar, V., Sogorb, F., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Providencia, R.A., Gomes, P.L., Seca, L., Barra, S., Silva, J., Faustino, A., Caetano, F., Pais, J.R., Mota, P., Leitao-Marques, A.M., Farhan, S., Jarai, R., Tentzeris, I., Vogel, B., Freynhofer, M.K., Wojta, J., Huber, K., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Lettino, M., Casella, G., Conte, M.R., De Luca, L., Geraci, G., Ceravolo, R., Milo, M., Pani, A., Trambaiolo, P., Fradella, G., Schratter, A., Thiele, H., Klemm, T., Demmin, K., Lehmann, D., Mende, M., Schuler, G., Pittl, U., Chernova, A., Nikulina, S.U., Naruke, T., Inomata, T., Yanagisawa, T., Maekawa, E., Mizutani, T., Shinagawa, H., Nishii, M., Takeuchi, I., Takehana, H., Izumi, T., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Nardai, S., Szabo, G.Y., Berta, B., Edes, I., Merkely, B., Delgado Silva, J., Seca, L., Baptista, R., Providencia, R., Mota, P., Costa, M., Leitao-Marques, A., Faria, R., Trigo, J., Gago, P., Mimoso, J., Marques, N., Gomes, V., Gheorghe, G., Nanea, I.T., Cristea, A., Almarichi, S., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Nanea, T., Gheorghe, G.S., Visan, S., Paun, N., Gaber, R., Gaber, R., Delewi, R., Nijveldt, R., De Bruin, H.A., Hirsch, A., Van Der Laan, A., Bouma, B.J., Tijssen, J.P.G., Van Rossum, A.C., Zijlstra, F., Piek, J.J., Rus, H., Radoi, M., Donea, M., Ciurea, C., Ifteni, G., Casolo, G., Chioccioli, M., Magnacca, M., Del Meglio, J., Comella, A., Baratto, M., Lera, J., Salvadori, L., Tessa, C., Vignali, C., Keca, Z., Momcilov Popin, T., Panic, G., White, R., Mateen, F., Weaver, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Timoteo, A.T., Lousinha, A., Santos, N., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Okisheva, E., Tsaregorodtsev, D., Sulimov, V., Amat Santos, I.J., Gonzalez, I.A., Hernandez, C., Sandin, M.G., Tapia, C., Andion, R., Alvarado, M., Campo, A., San Roman, J.A., Fredman, D., Svensson, L., Rosenqvist, M., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Zima, E., Jenei, Z.S., Kovacs, E., Osztheimer, I., Szabo, G.Y., Molnar, L., Horvath, A., Becker, D., Geller, L., Merkely, B., Maggi, R., Furukawa, T., Viscardi, V., Brignole, M., Leal, S.R.N., Dores, H., Rosario, I., Monge, J., Carvalho, M.J., Arroja, I., Leitao, A., Fonseca, C., Aleixo, A., Silva, A., Keuleers, S., Herijgers, P., Herregods, M.C., Budts, W., Dubois, C., Meuris, B., Verhamme, P., Flameng, W., Van De Werf, F., Adriaenssens, T., Badran, H., Elnoamany, M., Lolah, T., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, CRINA., Ionescu, D.D., Olariu, C., Radoi, M., Pop, C., Macarie, C., Mollik, M.A.H., Hassan, A.I., Paul, T.K., Haque, M.Z., Jahan, R., Rahmatullah, M., Khatun, M.A., Rahman, M.T., Chowdhury, M.H., Bustamante Munguira, J., Tamayo, E., Garcia-Cuenca, I., Bustamante, E., Gualis, J., Gomez-Martinez, M.L., Florez, S., Gomez-Herreras, J.I., Ramirez Rodriguez, R., Ramirez Rodriguez, A.M., Garcia-Bello, M.A., Hernadez Ortega, E., Caballero Dorta, E., Garcia Quintana, A., Piro Mastraccio, V., Medina Fernandez Aceytuno, A., Assanelli, E., De Metrio, M., Rubino, M., Lauri, G., Cabiati, A., Campodonico, J., Grazi, M., Moltrasio, M., Marana, I., Marenzi, G., Lovlien, M., Schei, B., Picon-Heras, R., Acebal, C., Garcia Rubira, J.C., Vivas Balcones, D., Nunez-Gil, I., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Vintila, V.D., Enescu, O.A., Stoicescu, C.I., Udroiu, C., Cinteza, M., Tatu – Chitoiu, G., Vinereanu, D., Fresco, C., De Biasio, M., Muser, D., Sappa, R., Morocutti, G., Bernardi, G., Proclemer, A., Fontanella, B., Affatato, A., Ciccarese, C., Sacchini, M., Volpini, M., Bianchetti, F., Verzura, G., Dei Cas, L., Pudil, R., Blaha, V., Vojacek, J., Paraskevaidis, I., Ikonomidis, I., Parissis, J., Papadopoulos, C., Stasinos, V., Bistola, V., Anastasiou-Nana, M., Shochat, M., Shotan, A., Kazatsker, M., Gurovich, V., Asif, A., Noiman, E., Levy, Y., Blondhaim, D., Rabinovich, P., Meisel, S., Koracevic, G., Stojkovic, A., Petrovic, S., Pavlovic, M., Glasnovic, J., Tomasevic, M., Krstic, N., Djordjevic-Radojkovic, D., Sakac, D., Obradovic, S., Londono Sanchez, O., Pacreu, S., Torres, L., Mihaylov, G., Shaban, G.M., Trendafilova, E., Krasteva, V., Mudrov, T.S., Didon, J.P., Panageas, V., Vlachos, N., Pernat, A., Radan, I., Mozina, H., Izzo, A., Tomasi, L., Mantovani, P., Dalloglio, L., Pepi, P., Romano, M., Cionini, F., Baccaglioni, N., Zanini, R., Viertel, A., Havers, J., Ballard, G., Groenefeld, G., Santos, N., Branco, L.M., Oliveira, J.A., Ferreira, L., Timoteo, A.T., Fiarresga, A., Feliciano, J., Ramos, R., Ferreira, R.C., Izzo, A., Tomasi, L., Mantovani, P., Pepi, P., Lettieri, L., Dalloglio, L., Reggiani, A., Zanini, R., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Juarez Prera, R., Blanco Palacios, G., Dorta Martin, M., Marrero Rodriguez, F., Martin, A.-C., Manzo Silberman, S., Chaib, A., Varenne, O., Allouch, P., Salengro, E., Jegou, A., Margot, O., Spaulding, C., Diego, A., De Miguel, A., Cuellas, C., Fraile, E., Martin, J., Vega, B., Bangueses, R., Fernandez-Vazquez, F., Perez De Prado, A., Rosario, I., Dores, H., Leal, S., Correia, M.J., Monge, J.C., Arroja, I., Abecasis, J., Aleixo, A., Silva, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Garcia-Garcia, C., Subirana, I., Sala, J., Bruguera, J., Valle, V., Sanz, G., Fiol, M., Aros, F., Marrugat, J., Elosua, R., Barra, S.N.C., Silva, J., Gomes, P., Providencia, R., Seca, L., Leitao Marques, A., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yang, Y.J., Xu, B., Tang, Y.D., Song, G.Y., G, R.L., Panic, M., Milicevic, P., Stankovic, I., Ilic, I., Kafedzic, S., Kalezic, T., Milicevic, D., Aleksic, A., Putnikovic, B., Neskovic, A., Serpytis, P., Rucinskas, K., Kalinauskas, A., Karvelyte, N., Santos De Sousa, C.I., Ferreira, S., Calaca, J., Lousada, N., Palma Reis, R., Gualandro, D.M., Seguro, L.F.B.C., Braga, F.G.M., Silvestre, O.M., Lage, R.L., Fabri, J., Oliveira, M.T., Urbano Moral, J.A., Torres Llergo, J., Solanilla Rodriguez, R., Sanchez Gonzalez, A., Martinez Martinez, A., Den Uil, C.A., Lagrand, W.K., Van Der Ent, M., Jewbali, L.S.D., Cheng, J.M., Spronk, P.E., Simoons, M.L., Mornos, C., Petrescu, L., Dragulescu, D., Ionac, A., Guardado, J., Azevedo, O., Fernandes, M., Canario-Almeida, F., Sanfins, V., Pereira, A., Almeida, J., Kaplunova, V.U., Belenkov, Y.N., Privalova, E.V., Fomin, A.A., Suvorov, A.Y., Goodkova, A., Rubakova, M.G., Kuznetsova, I.A., Semernin, E.N., Keshavarzi, F., Kojuri, J., Mikhailov, V.M., Vezhenkova, I.V., Goodkova, A.Y.A., Jarai, R., Pavlovic, I., Farhan, S., Schwarz, M., Jakl, G., Huber, K., Jarai, R., Schwarz, M., Smetana, P., Jakl, G., Perkmann, T., Farhan, S., Huber, K., Mayr, A., Mair, J., Klug, G., Schocke, M., Trieb, T., Jaschke, W., Pachinger, O., Metzler, B., Bronze Carvalho, L., Azevedo, J., Andrade, M.L., Arroja, I., Relvas, M.J., Coucello, J., Monge, J., Morais, G., Seabra, M., Aleixo, A., Afamefule, F., Luaces Mendez, M., Teijeiro-Mestre, R., Nunez-Gil, I.J., Leco-Gil, N., Madronal-Cerezo, E., Zannin, I., Ruiz, J., Orynchak, M.A., Vakalyuk, I.I., Vakalyuk, I.P., Berezin, A., Panasenko, T., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Gorenek, B., Unalacak, M., Birdane, A., Yuksel, F., Ata, N., Lee, W.P., Halcox, J.P.J., Cavusoglu, Y., Beyaztas, A., Entok, E., Demirustu, C., Uslu, I., Birdane, A., Gorenek, B., Ata, N., Schaefer, A., Flierl, U., Seydelmann, N., Bauersachs, J., Calmac, L., Craiu, E., Ionescu, D.D., Nanea, T., Pop, C., Marinescu, S., Macarie, C., Tatu Chitoiu, G., Fruntelata, A.G., Dorobantu, M., Hamdi, S., Maazoun, Y., Neji, A., Farhat, O., Majdoub, M., Ben Hamda, K., Maatouk, F., Balanescu, S.M., Benedek, I., Nedelciuc, I., Deleanu, D., Dobreanu, D., Olinic, D., Petrescu, L., Ortan, F., Mot, S., Tatu Chitoiu, G., Sinnaeve, P.R., Moreels, S., Adriaenssens, T., Dubois, C., Coosemans, M., Vydt, T., Desmet, W., Sinnaeve, P.R., Moreels, S., Vydt, T., Dubois, C., Adriaenssens, T., Coosemans, M., Desmet, W., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Tobing, D., Rifnaldi, R., Juzar, D., Firdaus, I., Dharma, S., Irmalita, I., Kalim, H., Bejiqi, R., Retkoceri, R., Bejiqi, H., Kryeziu, L., Kelmendi, M., Borovci, S.H., Victor, S.M., Gnanaraj, A., Deshmukh, R., Mullasari, A.S., Yahalom, M., Kaiyal, R.S., Roguin, N., Bornstein, J., Atar, S., Farah, R., Seca, L.F., Faustino, A., Silva, J., Providencia, R., Gomes, P., Barra, S., Caetano, F., Costa, M., Leitao Marques, A.M., Margato, R., Sousa, P., Ribeiro, H., Rocha, L., Correia, A., Moreira, J.I., Carvalho, H.C., Afifi, M., Abed, N., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Suarez-Barrientos, A., Vivas, D., Castro-Ferreira, F., Nunez-Gil, I., Franco, E., Garcia-Rubira, J.C., Fernandez-Ortiz, A., Fuster, V., Macaya, C., Ibanez Cabeza, B., Salinger, S., Perisic, Z., Milic, D., Stanojlovic, T., Apostolovic, S., Obradovic, S., Djordjevic-Radojkovic, D., Damjanovic, M., Koracevic, G., Kostic, T., Khan, M.A., Vrapi, F., Naeem, K., Davar, J., Hristova, K., Hristova, K., Pencheva, G., Radeva, R., Milanov, S., Trambaiolo, P., Poli, M., De Luca, M., Lukic, V., Mustilli, M., Corsi, F., Simonetti, M., Ferraiuolo, G., Fareed, A., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Sorensen, J.T., Terkelsen, C.J., Lassen, J.F., Trautner, S., Christensen, E.F., Nielsen, T.T., Botker, H.E., Andersen, H.R., Thygesen, K.A., Checco, L., Usmiani, T., Sbarra, P.L., Boffini, M., Saviolo, R., Grasso, C., Conrotto, F., Marchetti, M., Rinaldi, M., Marra, S., Moscoso Costa, F., Ferreira, J., Raposo, L., Aguiar, C., Trabulo, M., Silva, J.A., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Swiatkowski, A., Kowalczyk, J., Lenarczyk, R., Chodor, P., Honisz, G., Was, T., Swierad, M., Sredniawa, B., Polonski, L., Kalarus, Z., Postadzhiyan, A.S., Velinov, H., Velchev, V., Hazarbasanov, D., Apostolova, M., Finkov, B., Petrovic, M., Panic, G., Jovelic, A., Canji, T., Srdanovic, I., Popov, T., Golubovic, M., Pavlovic, K., Cemerlic-Adjic, N., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Nielsen, S.L., Rasmussen, L.S., Hassager, C., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Rasmussen, L.S., Hassager, C., Khan, M., Crolla, E., Morley, H., Akeroyd, L., Beaini, Y., Morley, C., Dores, H., Leal, S., Rosario, I., Abecasis, J., Monge, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Bekeredjian, R.H., Krumsdorf, U., Rottbauer, W., Katus, H.A., Pleger, S., Providencia, R.A., Silva, J., Barra, S., Gomes, P.L., Seca, L., Botelho, A., Quintal, N., Mota, P., Leitao-Marques, A.M., Silva, B., Santos, N., Cafe, H., Faria, P., Serrao, M., Gomes, S., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Roussel, J.C., Senage, T., Perigaud, C., Habash, O., Michel, M., Treilhaud, M., Despins, P., Trochu, J.N., Baron, O., Duveau, D., Kitsiou, A.N., Giannakopoulos, K., Papadimitriou, G., Karas, S., Babic, Z., Nikolic Heitzler, V., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Freynhofer, M., Brozovic, I., Bruno, V., Leherbauer, L., Djurkovic, M., Jarai, R., Willheim, M., Huebl, W., Wojta, J., Huber, K., Vogel, B., Hahne, S., Kozanli, I., Kalla, K., Jarai, R., Freynhofer, M., Smetana, P., Geppert, A., Unger, G., Huber, K., Simoes Marques Assuncao Caetano, A.F., Barra, S., Silva, J., Providencia, R., Faustino, C., Botelho, A., Mota, P., Leitao Marques, A., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Martinez Garcia, V., Salazar Mendiguchia Y Garcia, J., Gomez Hospital, J.A., Maristany Daunert, J., Berdejo Gago, F.J., Esplugas Oliveras, E., Brzozowska-Czarnek, A., Urbanik, A., Kakouros, N., Kakouros, S., Lekakis, J., Rizos, J., Kokkinos, D., Venevtseva, J., Melnikov, A., Valiahmetov, M., Gomova, T., Perelomova, I., Ferrer Hita, J.J., Bosa-Ojeda, F., Sanchez-Grande-Flecha, A., Yanes-Bowden, G., Vargas-Torres, M.J., Rodriguez-Gonzalez, A., Rubio-Iglesias-Garcia, C., Dominguez-Rodriguez, A., Enjuanes-Grau, C., Marrero-Rodriguez, F., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Alexandrescu, L., Dumitru, E., Miu, V., Jitari, V., Craiu, E., Voinea, F.L., Balachandran, K.P., Schofield, R., Sankaranarayanan, R., Helm, K., Crowe, C., Singh, R., Mcdonald, J., Chuen, M.J., Kobusiak-Prokopowicz, M., Preglowska, M., Mysiak, A., Doi, T., Sakoda, T., Akagami, T., Naka, T., Tsujino, T., Masuyama, T., Ohyanagi, M., Kume, N., Mitsuoka, H., Hayashida, K., Tanaka, M., Biasucci, L.M., Della Bona, R., Biasillo, G., Leo, M., Zaninotto, M., Plebani, M., Crea, F., Biasucci, L.M., Dellabona, R., Leo, M., Biasillo, G., Zaninotto, M., Plebani, M., Crea, F., Cavusoglu, Y., Gok, B., Birdane, A., Demirustu, C., Gorenek, B., Unalir, A., Ata, N., Timuralp, B., Nikulina, N., Yakushin, S.S., Nikulina, N., Yakushin, S.S., Furmenko, G.I., Akinina, S.A., Dores, H., Ingrid, R., Leal, S., Correia, M.J., Bronze, L., Monge, J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Djambazov, S., Zhivkov, A., Maznev, I., Ingeliev, M., Slavov, R., Cvetkova, N., Patarinski, V., Groch, L., Horak, J., Dimitrov, N., Hayrapetyan, H.G., Raposeiras Roubin, S., Abu-Assi, E., Cabanas-Grandio, P., Agra-Bermejo, R., Garcia-Acuna, J.M., Pena-Gil, C., Gonzalez-Juanatey, J.R., Barra, S.N.C., Silva, J., Providencia, R., Seca, L., Gomes, P., Leitao Marques, A., Daly, M.J., Mc Keag, N.A., Mc Cann, C.J., Cardwell, C., Young, I.S., Adgey, A.A.J., Mikhalchikova, N., Burova, N., Zaccaria, M., Palmisano, P., Palumbo, V., Ciccone, M.M., Favale, S., Chen, K.C., Yin, W.H., Liu, J.H., Goncalves, S., Santos, J.F., Amador, P., Soares, L.N., Zahidova, K., Guliyev, F., Zahidov, N., Carrilho-Ferreira, P., Cortez-Dias, N., Marques, J.S., Silva, D., Jorge, C., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Carvalho De Sousa, J., Lopes, M.G., Cortez-Dias, N., Calisto, C., Silva, D., Jorge, C., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Correia, M.J., Carvalho De Sousa, J., Lopes, M.G., Uthoff, H., Thalhammer, C., Potocki, M., Reichlin, T., Noveanu, M., Aschwanden, M., Staub, D., Arenja, N., Socrates, T., Mueller, C., Zhao, Y., Wu, X., Xue, Q., Gao, L., Lin, H., Wang, S., Watanabe, K., Kawamura, A., Seko, T., Omura, A., Sakabe, S., Kasai, A., Starodubova, A.V., Storozhakov, G., Kisliak, O., Hautieva, F., Tursheva, M., Fedotova, N., Di Maio, R.C., Mclaughlin, J., Allen, J.D., Anderson, J.M.C., Adgey, A.A.J., Khaled Nagi, H., Abed, N., Tayeh, O., Farok, W., Mousa, A., Neuzil, P., Skoda, J., Petru, J., Sediva, L., Kralovec, S., Holy, F., Holdova, K., Jehlicka, P., Plasil, P., Reddy, V.Y., Alabakovska, S., Labudovic, D., Jovanova, S., Tosheska, K., Alabakovski, M., Jeevaratnam, K., Tee, S.P., Zhang, Y., Guzadhur, L., Gurung, I.S., Duehmke, R., Grace, A.A., Lei, M., Huang, C.L., Ishibashi, Y., Yamauchi, M., Akashi, Y., Musha, H., Miyake, F., Hnatek, T., Kamenik, L., Sedlon, P., Luxova, J., Steuerova, B., Skvaril, J., Cernohous, M., Zavoral, M., Ratkovic, N., Nemanja Djenic, N.R., Aleksandra Jovelic, A.J., Slobodan Obradovic, S.O., Branko Gligic, B.G., Kletsiou, E., Giannakopoulou, M., Bozas, E., Iliodromitis, E.K., Anastasiou-Nana, M., Papathanassoglou, E.D.E., Anton, M., Anton, G., Muraru, M., Stanojlovic, T., Salinger Martinovic, S., Radosavljevic, M., Glasnovic, J., Stanojevic, D., Zivkovic, M., Cortez-Dias, N., Jorge, C., Calisto, C., Silva, D., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Pessoa, T., Fiuza, M., Lopes, M.G., Aspromonte, N., Ronco, C., Tubaro, M., Santini, M., Colivicchi, F., Aiello, A., Cruz, D., Anzoletti Boscolo, A., Vianello, G., Valle, R., Cavusoglu, Y., Parspour, A., Birdane, A., Tek, M., Gorenek, B., Unalir, A., Ata, N., Lee, W.P., Ong, B.B., Watkins, S., Datta, D., Halcox, J.P.J., Providencia, R.A., Barra, S., Gomes, P.L., Seca, L., Silva, J., Botelho, A., Quintal, N., Pais, J.R., Mota, P., Leitao-Marques, A.M., Nikishin, A.G., Pirnazarov, M.M., Nurbaev, T.A., Motovska, Z., Fischerova, M., Osmancik, P., Maly, M., Widimsky, P., Pavli, E., Dibra, A., Mehilli, J., Dibra, L., Schoemig, A., Kastrati, A., Carmo, P., Ferreira, J., Aguiar, C., Almeida, M., Raposo, L., Teles, R., Goncalves, P., Brito, J., Silva, A., Dascenzo, F., Gonella, A., Longo, G., Pullara, A., Moretti, C., Sciuto, F., Omede, P., Biondi Zoccai, G., Trevi, G.P., Sheiban, I., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Cafe, H.M., Silva, B., Santos, N., Faria, P., Oliveira, R., Pereira, A., Caires, G., Pereira, D., Freitas, D., Araujo, J., Pittl, U., Schratter, A., Klemm, T., Lehmann, D., Demmin, K., Mende, M., Schuler, G., Thiele, H., Salazar Mendiguchia Y Garcia, J., Ariza Sole, A., Martinez Garcia, V., Sanchez Salado, J.C., Lorente Tordera, V., Ortiz Berbel, D., Rabasa Baraibar, J.M., Esplugas Oliveras, E., Monge, J., Leal, S., Dores, H., Bronze Carvalho, L., Rosario, I., Abecasis, J., Correia, M.J., Leitao, A., Aleixo, A., Silva, A., Leone, A.M., De Caterina, A., Aurelio, A., Sciahbasi, A., Lioy, E., Trani, C., Burzotta, F., Porto, I., Rebuzzi, A.G., Crea, F., Trusinskis, K., Juhnevica, D., Strenge, K., Sondore, D., Kumsars, I., Jegere, S., Narbute, I., Grave, A., Zakke, I., Erglis, A., Mihaylov, G., Marenzi, G., Assanelli, E., Ferrari, C., Marana, I., Lauri, G., De Metrio, M., Grazi, M., Campodonico, J., Moltrasio, M., Bartorelli, A.L., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Saeed, M., Gaber, R., Mornos, C., Cozma, D., Pescariu, S., Dragulescu, S.I., Kamal, H.S., Abdelfattah, A., Abdelbary, A.M., Elassar, H., Naggar, A., Khaled, M., Fareed, A.M., Pernes, J.M., Gaux, J.C., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Prull, M.W., Sasko, B., Wirdemann, H., Bittlinsky, A., Butz, T., Trappe, H.J., Perazzolo Marra, M., Cacciavillani, L., Marzari, A., De Lazzari, M., Turri, R., China, P., Corbetti, F., Iliceto, S., Stazhadze, L.L., Spiridonova, E.A., Bulanova, N.A., Ermolaev, A.A., Savic, L., Mrdovic, I., Krljanac, G., Perunicic, J., Asanin, M., Lasica, R., Matic, M., Vasiljevic, Z., Ostojic, M., Pudil, R., Tichy, M., Blaha, V., Andrys, C., Vojacek, J., Conti, A., Poggioni, C., Viviani, G., Bulletti, F., Boni, V., Luzzi, M., Vicidomini, S., Donati, M., Del Taglia, B., Pini, R., Sousa, O., Fontes-Carvalho, R., Caeiro, D., Dias Ferreira, N., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Murai, M., Takeda, Y., Shinmyo, T., Tanigawa, J., Hazui, H., Nakakohji, T., Ohishi, Y., Hoshiga, M., Ishihara, T., Hanafusa, T., Belohlavek, J., Rohn, V., Kunstyr, J., Lips, M., Semrad, M., Horak, J., Mlejnsky, F., Tosovsky, J., Linhart, A., Lindner, J., Sablik, Z., Samborska-Sablik, A., Drozdz, J., Gaszynski, W., Ferrer Hita, J.J., Rodriguez-Gonzalez, A., Izquierdo-Gomez, M.M., Enjuanes-Grau, C., Rubio-Iglesias-Garcia, C., Sanchez-Grande-Flecha, A., Juarez-Prera, R., Blanco-Palacios, G., Bosa-Ojeda, F., Marrero-Rodriguez, F., Lakhdar, R., Drissa, M., Drissa, M., Jedaida, B., Drissa, H., Sousa, O., Dias Ferreira, N., Sampaio, F., Caeiro, D., Fontes-Carvalho, R., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Hsin, H.-T., Huang, J.-H., Chiu, K.-M., Chen, Z.-S., Lin, P.-C., Chen, L.-Y., Chu, S.-H., Efthimiadis, I., Skendros, P., Sarantopoulos, A., Boura, P., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Backus, B.E., Six, A.J., Kelder, J.H., Mosterd, A., Mast, E.G., Mast, T.P., Braam, R., Tio, R., Veldkamp, R., Doevendans, P.A., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Paarup Dridi, N., Holmvang, L., Engstroem, T., Rekik, S., Brunet, J., Hager, F.X., Bayet, G., Meille, L., Quatre, J.M., Sainsous, J., Chu, P.-H., Tang, C.-H., Ibatov, A., Pogosova, N., Koltunov, I.E., Sapunova, I.D., Vigodin, V.A., Uhliar, R., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Schmidt, A., Brockmeyer, B., Horstkotte, D., Suzuki, A., Eki, Y., Higuchi, H., Yukawa, A., Yamauchi, R., Sato, Y., Endo, Y., Martinez Garcia, V., Salazar Mendigucha Garcia, J., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Homs Vila, S., Gomez Hospital, J.A., Cequier Fillat, A., Esplugas Oliveras, E., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M., Tapia Ballesteros, C., Vegas Valle, J.M., Gonzalez Garcia, I.A., Duro Aguado, I.A., Palomino Doza, A.J., Gomez Salvador, I., San Roman Calvar, J.A., Nikishin, A.G., Mamarasulov, T.M., Pirnazarov, M.M., Koracevic, G., Pavlovic, M., Glasnovic, J., Damjanovic, M., Stojkovic, A., Kostic, T., Todorovic, L., Petrovic, S., Zivkovic, M., Djordjevic-Radojkovic, D., Cherneva, Z.C.H., Denchev, S.D., Heltai, K., Becker, D., Merkely, B., Nikulina, N., Yakushin, S.S., Akinina, S.A., Furmenko, G.I., Boytsov, A., Yakushin, S.S., Nikulina, N.N., Furmenko, G.I., Akinina, S.A., Dores, H., Leal, S., Rosario, I., Bronze, L., Abecasis, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Dores, H., Leal, S., Rosario, I., Monge, J., Abecasis, J., Correia, M.J., Bronze, L., Arroja, I., Aleixo, A., Silva, A., Rosario, I., Leal, S., Dores, H., Correia, M.J., Monge, J.C., Abecasis, J., Arroja, I., Aleixo, A., Silva, A., Palmisano, P., Zaccaria, M., Zanna, D., Marangelli, V., Caiati, C., Ciccone, M.M., Favale, S., Picon Heras, R., Loureiro, M.J., Nunez-Gil, I., Garcia Rubira, J.C., Acebal, C., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Macaya, C., Rosario, I., Dores, H., Leal, S., Monge, J.C., Correia, M.J., Bronze Carvalho, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Urazovskaya, I., Vinogradova, D., Vasilieva, E., Shpektor, A., Faustino, A., Seca, L., Barra, S., Providencia, R., Silva, J., Gomes, P., Costa, G., Caetano, F., Costa, M., Leitao-Marques, A., Conti, E., Musumeci, M.B., Lauri, F.M., Dito, E., De Giusti, M., Lallo, A., Fusco, D., Davoli, M., Volpe, M., Autore, C., Gamra, H., Dridi, Z., Hassine, M., Addad, F., Gherissi, I., Reda, A., Mahjoub, M., Bouraoui, S., Abdennadher, M., Betbout, F., Mota, P.M.F.P., Silva, J.D., Providencia, R.A., Leitao-Marques, A., Nikolic Heitzler, V., Babic, Z., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Stanojevic, D., Apostolovic, S., Jankovic Tomasevic, R., Pavlovic, M., Djordjevic, V., Djordjevic Radojkovic, D., Salinger Martinovic, S., Koracevic, G., Damjanovic, M., Ilic, I., Scafa Udriste, A., Fruntelata, A., Gainoiu, E., Bogdan, S., Calmac, L., Zamfir, D., Teodorescu, C., Guran, M., Constantinescu, D., Dorobantu, M., Rosario, I., Dores, H., Leal, S., Abecasis, J., Monge, J.C., Bronze, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Konopka, A., Banaszewski, M., Wojtkowska, I., Stepinska, J., Vidergold, J.V., Osipova, I.V., Tavrovskaya, T.V., Galkina, J.V., Timofeev, A.V., Vorobyov, R.I., Vorobyova, E.N., Matos, L., Carvalho, A.C.C., Oliveira, W., Cintra, F., Poyares, D., Andersen, M., Martins, R., Tufik, S., Neuzil, P., Ostadal, P., Skoda, J., Holy, F., Holdova, K., Brada, J., Horakova, S., Mlcek, M., Hrachovina, V., Kittnar, O., Gorudko, I.V., Buko, I.V., Cherenkevich, S.N., Polonetsky, L.Z., Plotkin, V.Y., Timoshina, M.A., Azanchevskaya, S.V., Chromov-Borisov, N.N., Vorlat, A., Snoep, L., Claeys, M.J., Vrints, C.J., Palazzuoli, A., Caputo, M., Quatrini, I., Calabro, A., Antonelli, G., Campagna, M.S., Franci, B., Nuti, R., Maisel, A., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Negrini, M., Minora, T., Marino, P., Seregni, R., Tavlueva, E., Barbarash, O., Barbarash, L., Janota, T., Kudlicka, J., Malik, K., Wichterle, D., Hradec, J., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Body, R., Carley, S.D., Mcdowell, G., Nuttall, M., Wibberley, C., France, M., Cruickshank, J.K., Mackway-Jones, K., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Unalacak, M., Gorenek, B., Birdane, A., Yuksel, F., Ata, N., Leon, M., Cozma, C., Mitu, F., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Barra, S.N.C., Gomes, P., Silva, J., Providencia, R., Seca, L., Leitao Marques, A., Burazor, I., Burazor, M., Krstic, M., Lazovic, M., Stojkovic, A., Vukmanovic, M., Djordjevic, J., Radovanovic, Z., Ilic, D., Bosnjakovic, P., Margato, R., Ferreira, A.C., Mateus, P.S., Ribeiro, H., Fontes, P., Moreira, J.I., Teixeira, T., Silva, J.D., Costa, M., Leitao-Marques, A., Conte, G., Menozzi, A., Solinas, E., Bolognesi, M.G., Tadonio, I., Mantovani, F., Cattabiani, A., Vignali, L., Ardissino, D., Scafa Udriste, A., Fruntelata, A., Tautu, O., Calmac, L., Alexandrescu, A., Niculescu, R., Tatu-Chitoiu, G., Dorobantu, M., Djordjevic Radojkovic, D., Apostolovic, S., Perisic, Z., Damjanovic, M., Jankovic, R., Salinger Martinovic, S., Koracevic, G., Todorovic, L., Bozinovic, N., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Santos, C., Ferreira, J., Carmo, P., Costa, F., Brito, J., Sousa, P., Cardoso, G., Correia, I., Aguiar, C., Silva, A., Fountoulaki, K., Kastellanos, S., Voltirakis, E., Kokotos, A., Michalakeas, C., Kontsas, K., Hasioti, K., Iliodromitis, E.T., Anastasiou-Nana, M., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M.G., Tapia Ballesteros, C., Vegas Valle, J.M., Zatarain Nicolas, E., Amat Santos, I.J., Martinez Uruena, N., Alvarado Montes De Oca, M., San Roman Calvar, J.A., Belohlavek, J., Dytrych, V., Kovarnik, T., Smid, O., Kral, A., Linhart, A., Aroutunov, A.G., Intwala, S., Sondore, D., Juhnevica, D., Trusinskis, K., Strenge, K., Jegere, I., Narbute, I., Grave, A., Erglis, A., Shaalan, H.S.H., Pagava, Z., Agladze, R., Shakarishvili, R., Sharashidze, N., Gujejiani, L., Saatashvili, G., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Gaber, R., Gaber, R., Hristova, K., Katova, T.Z., Kostova, V., Simova, Y., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Voinea, F.L., Craiu, E., Obradovic, S., Salinger, S., Vukotic, S., Rafajlovski, S., Romanovic, R., Koracevic, G., Antonijevic, N., Gligic, B., Hutyra, M., Skala, T., Horak, D., Vindis, D., Taborsky, M., Contine, A., Del Pinto, M., Angeli, F., Verdecchia, P., Borgognoni, F., Grikstaite, E., Pantano, P., Ambrosio, G., Cavallini, C., Bonanad, C., Sanchis, J., Bodi, V., Nunez, J., Bosch, X., Heras, M., Pellicer, M., Llacer, A., Seca, L.F., Fontes-Carvalho, R., Caeiro, D., Adao, L., Oliveira, M., Goncalves, H., Primo, J., Gama, V., Fresco, C., De Biasio, M., Sappa, R., Muser, D., Morocutti, G., Bernardi, G., Proclemer, A., Lombardi, C., Metra, M., Bugatti, S., Pasotti, E., Quinzani, F., Adamo, M., Villa, C., Rovetta, R., Manerba, A., Dei Cas, L., Mariani, M., Dushpanova, A., Baroni, M., Cerone, E., Nardelli, A., Gianetti, J., Berti, S., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Toste, A., Ramos, R., Cunha, P.S., Feliciano, F., Soares, R., Santos, S., Ferreira, R.C., Ostadal, P., Kruger, A., Vondrakova, D., Herget, J., Di Maio, R.C., Navarro, C., Cromie, N.A., Anderson, J.M.C., Adgey, J.A.A., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Caeiro Pereira, D., Braga, P., Fontes Carvalho, R., Sousa, O., Rodrigues, A., Goncalves, H., Ribeiro, J., Goncalves, M., Simoes, L., Gama, V., and Borisov, K.V.

Abstract

Background: Radial access for PCI is increasing but its use in emergency still remains confidential. We report our single center experience where all interventional cardiologists use the radial access as default strategy for primary PCI. Methods and Results: STEMI patients (n = 671) were evaluated for bleeding complications using a web-based registry (e-PARIS). In-hospital bleeding was adjudicated using various definitions (TIMI, GUSTO, STEEPLE). MACE was the composite of death, MI and stroke. In this non-selected, high risk population, 6.1% had cardiogenic shock on admission, 3.9% out-of-hospital cardiac arrest and 51.2% multivessel disease. Radial access (88%) was the default strategy as was abciximab (78%). Clopidogrel loading dose ranged from 300 to 900 mg. Pre-hospital fibrinolysis was used in 7.1%. Hemodynamic support devices (IABP, ECMO, Tandem Heart) were needed in 7.0%. In-hospital bleeding rates varied widely according to the definitions used: 2.5%, 1.5%, 5.7%, 9.2% and 10.9% with TIMI Major, GUSTO Severe, TIMI Major/minor, GUSTO Severe/moderate or STEEPLE Major, respectively. In-hospital death rate was 5.5%. One-year mortality (8.2%) was seriously impacted by in-hospital bleeding (31.6% vs 6.8%, p < 0.001). The most frequent bleeding site was gastro-intestinal (figure). GUSTO Severe/moderate bleeding was independently correlated with MACE (OR 2.60; 95%CI 1.21–5.59; p = 0.01) and radial access was a strong predictor of survival (OR 0.33; 95%CI 0.17–0.56; p = 0.002). Conclusions: The gastro-intestinal tract is the most frequent site of bleeding when the radial artery is the predominant vascular access site for primary PCI. GUSTO Severe/moderate bleeding is an independent predictor of MACE while radial access predicts survival.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results