1. Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1.
- Author
-
Park J, Lee S, Yoon H, Kang E, and Cho S
- Subjects
- Humans, Female, Twist-Related Protein 1 genetics, Twist-Related Protein 1 metabolism, Cell Line, Tumor, Naphthalenes pharmacology, Epithelial-Mesenchymal Transition, Cell Movement, Neoplasm Invasiveness genetics, Gene Expression Regulation, Neoplastic, Breast Neoplasms metabolism
- Abstract
Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. [BMB Reports 2023; 56(7): 410-415].
- Published
- 2023