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Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Therefore research on the detection of new antimicrobials against Mycobacterium tuberculosisis needed urgently. Essential oils extracted from plants have been shown to have anti-Mycobacterium tuberculosiseffect in in-vitroexperiments. Essential oil contains many chemicals and any one or more than one chemical may have the anti-Mycobacterium tuberculosiseffect. Eugenol is one such chemical in the essential oil and the anti-Mycobacterium tuberculosiseffect of eugenol is investigated.

Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Consequently, it is difficult to cure all the patients with tuberculosis and in future, the incidence of tuberculosis by drug resistant M. tuberculosisis likely to increase, worldwide. Therefore detection and development of new antimicrobials against M. tuberculosisis needed urgently.

•Mutations in katG(71.0%) were more prevalent compared with inhA(29.0%).•The most frequent mutation (63.2%) was observed in MUT1 probe of katG..•19.9% of mutations were observed at position −15 in the inhApromotor region.•Meta-analysis derived a pooled katGS315T resistant TB prevalence of 64.5% (95% CI 59.3–75.4%) for treated TB cases.•Mutations at T8C (6; 0.3%) and T8A (8; 0.4%) have not been published in previous studies.